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  1. Article ; Online: Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failure.

    Masotti, Luca / Cioni, Elisa / Grifoni, Elisa / Cei, Francesco / Tarquini, Roberto

    European journal of internal medicine

    2022  Volume 103, Page(s) 111–112

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Biomarkers ; Humans ; Inflammation ; RNA, Viral ; Respiratory Insufficiency ; SARS-CoV-2 ; Treatment Failure ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers ; RNA, Viral ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  2. Article ; Online: Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review.

    Al Refaie, Antonella / Baldassini, Leonardo / Mondillo, Caterina / De Vita, Michela / Giglio, Elisa / Tarquini, Roberto / Gonnelli, Stefano / Caffarelli, Carla

    Nutrients

    2024  Volume 16, Issue 8

    Abstract: Nowadays, the interest in the extraskeletal effects of vitamin D is growing. In the literature, its several possible actions have been confirmed. Vitamin D seems to have a regulatory role in many different fields-inflammation, immunity, and the endocrine ...

    Abstract Nowadays, the interest in the extraskeletal effects of vitamin D is growing. In the literature, its several possible actions have been confirmed. Vitamin D seems to have a regulatory role in many different fields-inflammation, immunity, and the endocrine system-and many studies would demonstrate a possible correlation between vitamin D and cardiovascular disease. In this paper, we deepened the relationship between vitamin D and dyslipidemia by reviewing the available literature. The results are not entirely clear-cut: on the one hand, numerous observational studies suggest a link between higher serum vitamin D levels and a beneficial lipid profile, while on the other hand, interventional studies do not demonstrate a significant effect. Understanding the possible relationship between vitamin D and dyslipidemia may represent a turning point: another link between vitamin D and the cardiovascular system.
    MeSH term(s) Humans ; Dyslipidemias/blood ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/blood ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/etiology ; Lipids/blood
    Chemical Substances Vitamin D (1406-16-2) ; Lipids
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16081144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock.

    Colombini, Barbara / Dinu, Monica / Murgo, Emanuele / Lotti, Sofia / Tarquini, Roberto / Sofi, Francesco / Mazzoccoli, Gianluigi

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: Ageing is a multifactorial physiological manifestation that occurs inexorably and gradually in all forms of life. This process is linked to the decay of homeostasis due to the progressive decrease in the reparative and regenerative capacity of tissues ... ...

    Abstract Ageing is a multifactorial physiological manifestation that occurs inexorably and gradually in all forms of life. This process is linked to the decay of homeostasis due to the progressive decrease in the reparative and regenerative capacity of tissues and organs, with reduced physiological reserve in response to stress. Ageing is closely related to oxidative damage and involves immunosenescence and tissue impairment or metabolic imbalances that trigger inflammation and inflammasome formation. One of the main ageing-related alterations is the dysregulation of the immune response, which results in chronic low-level, systemic inflammation, termed "inflammaging". Genetic and epigenetic changes, as well as environmental factors, promote and/or modulate the mechanisms of ageing at the molecular, cellular, organ, and system levels. Most of these mechanisms are characterized by time-dependent patterns of variation driven by the biological clock. In this review, we describe the involvement of ageing-related processes with inflammation in relation to the functioning of the biological clock and the mechanisms operating this intricate interaction.
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11112228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clock Genes, Metabolism, and Cardiovascular Risk.

    Tarquini, Roberto / Mazzoccoli, Gianluigi

    Heart failure clinics

    2017  Volume 13, Issue 4, Page(s) 645–655

    Abstract: The molecular clockwork drives rhythmic oscillations of signaling pathways managing intermediate metabolism; the circadian timing system synchronizes behavioral cycles and anabolic/catabolic processes with environmental cues, mainly represented by light/ ... ...

    Abstract The molecular clockwork drives rhythmic oscillations of signaling pathways managing intermediate metabolism; the circadian timing system synchronizes behavioral cycles and anabolic/catabolic processes with environmental cues, mainly represented by light/darkness alternation. Metabolic pathways, bile acid synthesis, and autophagic and immune/inflammatory processes are driven by the biological clock. Proper timing of hormone secretion, metabolism, bile acid turnover, autophagy, and inflammation with behavioral cycles is necessary to avoid dysmetabolism. Disruption of the biological clock and mistiming of body rhythmicity with respect to environmental cues provoke loss of internal synchronization and metabolic derangements, causing liver steatosis, obesity, metabolic syndrome, and diabetes mellitus.
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2017.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6554: Show issues Location:
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  5. Article ; Online: Daylight saving time and circadian rhythms in the neuro-endocrine-immune system: impact on cardiovascular health.

    Tarquini, Roberto / Carbone, Annalucia / Martinez, Micaela / Mazzoccoli, Gianluigi

    Internal and emergency medicine

    2018  Volume 14, Issue 1, Page(s) 17–19

    MeSH term(s) Cardiovascular System ; Circadian Rhythm ; Humans ; Immune System ; Time
    Language English
    Publishing date 2018-11-28
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-018-1984-x
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    Zs.A 6673: Show issues Location:
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  6. Article: Transthyretin Cardiac Amyloidosis: A Cardio-Orthopedic Disease.

    Perfetto, Federico / Zampieri, Mattia / Bandini, Giulia / Fedi, Roberto / Tarquini, Roberto / Santi, Raffaella / Novelli, Luca / Allinovi, Marco / Argirò, Alessia / Cappelli, Francesco

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Orthopaedic manifestations of wild-type transthyretin amyloidosis are frequent and characteristic, including idiopathic bilateral carpal tunnel syndrome, idiopathic lumbar canal stenosis, atraumatic rupture of the brachial biceps tendon, and, more rarely, ...

    Abstract Orthopaedic manifestations of wild-type transthyretin amyloidosis are frequent and characteristic, including idiopathic bilateral carpal tunnel syndrome, idiopathic lumbar canal stenosis, atraumatic rupture of the brachial biceps tendon, and, more rarely, finger disease and rotator cuff. These manifestations often coexisting in the same patient, frequently male and aged, steadily precede cardiac involvement inducing a rapidly progressive heart failure with preserved ejection fraction. Although transthyretin cardiac amyloidosis remains a cardiac relevant disease, these extracardiac localisation may increase diagnostic suspicion and allow for early diagnosis assuming the role of useful diagnostic red flags, especially in light of new therapeutic opportunities that can slow or stop the progression of the disease. For the cardiologist, the recognition of these extracardiac red flags is of considerable importance to reinforce an otherwise less emerging diagnostic suspicion. For orthopedists and rheumatologists, the presence in an old patient with or without clinical manifestations of cardiovascular disease, of an unexpected and inexplicable constellation of musculoskeletal symptoms, can represent a fundamental moment for an early diagnosis and treatment is improving a patient's outcome.
    Language English
    Publishing date 2022-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A rapid and cost-effective diagnostic algorithm for the detection of SARS-CoV-2 infection in the emergency area by combining highly sensitive antigenic test and RT-PCR.

    Salvetti, Sara / Lavinia, Federica / Rosi, Nico / Vanni, Simone / Masotti, Luca / Tarquini, Roberto / Guarducci, Silvia / Rossolini, Gian Maria / Montenora, Iolanda

    Diagnostic microbiology and infectious disease

    2022  Volume 103, Issue 4, Page(s) 115727

    Abstract: A diagnostic algorithm for SARS-CoV-2 infection in patients admitted to the emergency area, based on a combination of rapid antigen and molecular testing, has been evaluated with 3070 nasopharyngeal swabs. Compared to molecular test alone, the proposed ... ...

    Abstract A diagnostic algorithm for SARS-CoV-2 infection in patients admitted to the emergency area, based on a combination of rapid antigen and molecular testing, has been evaluated with 3070 nasopharyngeal swabs. Compared to molecular test alone, the proposed algorithm allowed to significantly reduce costs and average time to results.
    MeSH term(s) Algorithms ; COVID-19/diagnosis ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Cost-Benefit Analysis ; Humans ; Nasopharynx ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Sensitivity and Specificity
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2022.115727
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
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  8. Article: Arrhythmic Burden in Cardiac Amyloidosis: What We Know and What We Do Not.

    Argirò, Alessia / Del Franco, Annamaria / Mazzoni, Carlotta / Allinovi, Marco / Tomberli, Alessia / Tarquini, Roberto / Di Mario, Carlo / Perfetto, Federico / Cappelli, Francesco / Zampieri, Mattia

    Biomedicines

    2022  Volume 10, Issue 11

    Abstract: Cardiac amyloidosis (CA), caused by the deposition of insoluble amyloid fibrils, impairs different cardiac structures, altering not only left ventricle (LV) systo-diastolic function but also atrial function and the conduction system. The consequences of ... ...

    Abstract Cardiac amyloidosis (CA), caused by the deposition of insoluble amyloid fibrils, impairs different cardiac structures, altering not only left ventricle (LV) systo-diastolic function but also atrial function and the conduction system. The consequences of the involvement of the cardiac electrical system deserve more attention, as well as the study of the underlying molecular mechanisms. This is an issue of considerable interest, given the conflicting data on the effectiveness of conventional antiarrhythmic strategies. Therefore, this review aims at summarizing the arrhythmic burden related to CA and the available evidence on antiarrhythmic treatment in this population.
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10112888
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  9. Article: Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway.

    Savino, Maria / Guida, Claudio Carmine / Nardella, Maria / Murgo, Emanuele / Augello, Bartolomeo / Merla, Giuseppe / De Cosmo, Salvatore / Savino, Antonio Fernando / Tarquini, Roberto / Cei, Francesco / Aucella, Filippo / Mazzoccoli, Gianluigi

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias. ... ...

    Abstract Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias. Protein levels and activity of enzymes involved in the heme biosynthetic pathway and especially 5'-Aminolevulinate Synthase 1 are featured by 24-h rhythmic oscillations driven by the biological clock. Heme biosynthesis and circadian pathways intermingle with mutual modulatory roles. Notably, heme is a ligand of important cogs of the molecular clockwork, which upon heme binding recruit co-repressors and inhibit the transcription of numerous genes enriching metabolic pathways and encoding functional proteins bringing on crucial cell processes. Herein, we assessed mRNA levels of circadian genes in patients suffering from porphyrias and found several modifications of core clock genes and clock-controlled genes expression, associated with metabolic and electrolytic changes. Overall, our results show an altered expression of circadian genes accompanying heme biosynthesis disorders and confirm the need to deepen the knowledge of the mechanisms through which the alteration of the circadian clock circuitry could take part in determining signs and symptoms of porphyria patients and then again could represent a target for innovative therapeutic strategies.
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The CALL Score for Predicting Outcomes in Patients With COVID-19.

    Grifoni, Elisa / Valoriani, Alice / Cei, Francesco / Vannucchi, Vieri / Moroni, Federico / Pelagatti, Lorenzo / Tarquini, Roberto / Landini, Giancarlo / Masotti, Luca

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 1, Page(s) 182–183

    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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