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  1. Article: Comparing Indirect and Combined Effects of Mindfulness and Compassion Practice Among Schoolchildren on Inter- and Intra-personal Abilities.

    Tarrasch, Ricardo / Berger, Rony

    Mindfulness

    2022  Volume 13, Issue 9, Page(s) 2282–2298

    Abstract: Objectives: During the last decade, mindfulness-based interventions have been implemented in the educational system. Such programs could follow several approaches, including an indirect approach, in which interventions are delivered only to teachers and ...

    Abstract Objectives: During the last decade, mindfulness-based interventions have been implemented in the educational system. Such programs could follow several approaches, including an indirect approach, in which interventions are delivered only to teachers and a combination in which interventions are delivered to both teachers and students. Because of the importance of teacher's involvement in programs designed to help children, we compared students' impact of indirect, combined, and control groups over time. The indirect program delivered was the "Call to Care - Israel for Teachers," and the direct program was the "Call to Care Israel" for students. Both programs employ mindfulness, compassion, and training of social-emotional skills, with a unique emphasis on care.
    Methods: Two hundred 4th and 5th grade students were divided into indirect (2 classrooms), combined (3 classrooms), or control groups (3 classrooms). Each condition was implemented in a different school; schools were randomly divided into groups. The interventions were delivered by trained facilitators and included 20 weekly meetings. Outcomes for students were measured before the intervention, after it ended, and 6 months later.
    Results: Hierarchical linear models revealed that both the indirect and the combined approaches were effective in improving well-being, anxiety, attention, and teacher's availability and acceptance, while only the combined approach was effective in improving mindfulness, somatization, classroom atmosphere, and pro-social behavior.
    Conclusions: Our results suggest that the combined approach is more beneficial than the indirect approach. However, given the scalability and cost of the indirect approach, it should also be considered an effective alternative.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12671-022-01955-y.
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2543424-X
    ISSN 1868-8535 ; 1868-8527
    ISSN (online) 1868-8535
    ISSN 1868-8527
    DOI 10.1007/s12671-022-01955-y
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  2. Article: Critical Dynamics in Spontaneous Resting-State Oscillations Are Associated With the Attention-Related P300 ERP in a Go/Nogo Task.

    Herzog, Nadine D / Steinfath, Tim P / Tarrasch, Ricardo

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 632922

    Abstract: Sustained attention is the ability to continually concentrate on task-relevant information, even in the presence of distraction. Understanding the neural mechanisms underlying this ability is critical for comprehending attentional processes as well as ... ...

    Abstract Sustained attention is the ability to continually concentrate on task-relevant information, even in the presence of distraction. Understanding the neural mechanisms underlying this ability is critical for comprehending attentional processes as well as neuropsychiatric disorders characterized by attentional deficits, such as attention deficit hyperactivity disorder (ADHD). In this study, we aimed to investigate how trait-like critical oscillations during rest relate to the P300 evoked potential-a biomarker commonly used to assess attentional deficits. We measured long-range temporal correlations (LRTC) in resting-state EEG oscillations as index for criticality of the signal. In addition, the attentional performance of the subjects was assessed as reaction time variability (RTV) in a continuous performance task following an oddball paradigm. P300 amplitude and latencies were obtained from EEG recordings during this task. We found that, after controlling for individual variability in task performance, LRTC were positively associated with P300 amplitudes but not latencies. In line with previous findings, good performance in the sustained attention task was related to higher P300 amplitudes and earlier peak latencies. Unexpectedly, we observed a positive relationship between LRTC in ongoing oscillations during rest and RTV, indicating that greater criticality in brain oscillations during rest relates to worse task performance. In summary, our results show that resting-state neuronal activity, which operates near a critical state, relates to the generation of higher P300 amplitudes. Brain dynamics close to criticality potentially foster a computationally advantageous state which promotes the ability to generate higher event-related potential (ERP) amplitudes.
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.632922
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  3. Article ; Online: The functional significance of the P600: Some linguistic P600's do localize to language areas.

    Gonda, Shahar / Tarrasch, Ricardo / Ben Shalom, Dorit

    Medicine

    2020  Volume 99, Issue 46, Page(s) e23116

    Abstract: A recent paper in the journal Neuroreport suggested that, upon source localization, the semantic P600 localizes to executive function areas, that is, outside language. But is this true for all types of linguistic P600? We report a cross-sectional source ... ...

    Abstract A recent paper in the journal Neuroreport suggested that, upon source localization, the semantic P600 localizes to executive function areas, that is, outside language. But is this true for all types of linguistic P600? We report a cross-sectional source localization study of a classical (agreement) syntactic paradigm.The results show a clear localization to the temporal lobe, in classical language areas.The P600 is probably not a unitary phenomenon in term of source localization, and the question whether it localizes within or outside the language system depends on the type of P600.
    MeSH term(s) Adult ; Brain Mapping/methods ; Comprehension/physiology ; Electroencephalography/methods ; Electromagnetic Phenomena ; Evoked Potentials/physiology ; Female ; Humans ; Language ; Male ; Photic Stimulation/methods ; Semantics ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/physiopathology ; Tomography/methods
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000023116
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  4. Article: Reducing Test Anxiety by Device-Guided Breathing: A Pilot Study.

    Ovadia-Blechman, Zehava / Tarrasch, Ricardo / Velicki, Maria / Chalutz Ben-Gal, Hila

    Frontiers in psychology

    2022  Volume 13, Page(s) 678098

    Abstract: Test anxiety remains a challenge for students and has considerable physiological and psychological impacts. The routine practice of slow, Device-Guided Breathing (DGB) is a major component of behavioral treatments for anxiety conditions. This paper ... ...

    Abstract Test anxiety remains a challenge for students and has considerable physiological and psychological impacts. The routine practice of slow, Device-Guided Breathing (DGB) is a major component of behavioral treatments for anxiety conditions. This paper addresses the effectiveness of using DGB as a self-treatment clinical tool for test anxiety reduction. This pilot study sample included 21 healthy men and women, all college students, between the ages of 20 and 30. Participants were randomly assigned to two groups: DGB practice (
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.678098
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  5. Article ; Online: Macro- and microstructural gray matter alterations in sexually assaulted women.

    Berman, Zohar / Assaf, Yaniv / Tarrasch, Ricardo / Joel, Daphna

    Journal of affective disorders

    2019  Volume 262, Page(s) 196–204

    Abstract: Background: Studies with trauma survivors documented structural alterations in brain regions involved in posttraumatic stress disorder (PTSD) neurocircuitry. Nonetheless, whether such alterations exist in women who were sexually assaulted in adulthood ... ...

    Abstract Background: Studies with trauma survivors documented structural alterations in brain regions involved in posttraumatic stress disorder (PTSD) neurocircuitry. Nonetheless, whether such alterations exist in women who were sexually assaulted in adulthood is not clear. We investigated the macro- and microstructure of key regions implicated in PTSD pathophysiology, namely the amygdala, hippocampus, anterior cingulate cortex (ACC), and insula, in this population.
    Methods: Thirty-eight sexually assaulted women (PTSD, n = 25; non-PTSD, n = 13) and 24 non-exposed controls (NEC) were studied with T1- and diffusion-weighted MRI. Gray matter volume, mean diffusivity (MD), and fractional anisotropy (FA) were calculated for each region. Between-group comparisons and correlations with PTSD symptom severity were performed.
    Results: Volumetric analyses revealed lower amygdala and insula volumes in the PTSD compared with the non-PTSD group. In contrast, altered microstructure was observed in both traumatized groups compared with NEC, including higher MD and lower FA in the right amygdala, and higher FA in the ACC bilaterally. Finally, the non-PTSD group had higher FA in the right insula compared with the PTSD group. PTSD symptom severity was correlated with amygdala and insula volumes, as well as with hippocampal FA and MD.
    Limitations: Sample size may have led to reduced statistical power.
    Conclusions: Sexual assault and the development of PTSD in women are linked with structural alterations in key regions implicated in PTSD following other trauma types (e.g., combat), though hippocampal and ACC volumes were preserved. Further studies are needed to disentangle the unique contribution of trauma type and of sex/gender to these observations.
    MeSH term(s) Adult ; Amygdala/pathology ; Brain/pathology ; Cerebral Cortex/pathology ; Female ; Gray Matter/pathology ; Gray Matter/ultrastructure ; Gyrus Cinguli/pathology ; Hippocampus/pathology ; Humans ; Magnetic Resonance Imaging ; Sexual Trauma/diagnostic imaging ; Sexual Trauma/pathology ; Stress Disorders, Post-Traumatic/pathology ; Young Adult
    Language English
    Publishing date 2019-10-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2019.10.024
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  6. Article ; Online: Peri-operative individually tailored psychological intervention in breast cancer patients improves psychological indices and molecular biomarkers of metastasis in excised tumors.

    Hanalis-Miller, Tsipi / Ricon-Becker, Itay / Sakis, Nahida / Trachtenberg, Estherina / Ohayon, Frida / Wadhawker, Sonya / Birnboim, Yehudit / Magen, Ada / Sharon, Eran / Tarrasch, Ricardo / Goldzweig, Gil / Cole, Steve W / Jacoby, Rebecca / Ben-Eliyahu, Shamgar

    Brain, behavior, and immunity

    2024  Volume 117, Page(s) 529–540

    Abstract: Perioperative stress and inflammatory signaling can invigorate pro-metastatic molecular processes in patients' tumors, potentially worsening long-term survival. Yet, it is unknown whether pre-operative psychotherapeutic interventions can attenuate such ... ...

    Abstract Perioperative stress and inflammatory signaling can invigorate pro-metastatic molecular processes in patients' tumors, potentially worsening long-term survival. Yet, it is unknown whether pre-operative psychotherapeutic interventions can attenuate such effects. Herein, three weeks before surgery, forty women diagnosed with stage I-III invasive ductal/lobular breast carcinoma were randomized to a 6-week one-on-one psychological intervention (6 meetings with a medical psychologist and bi-weekly phone calls) versus standard nursing-staff-attention. The intervention protocol was individually tailored based on evaluation of patients' emotional, cognitive, physiological, and behavioral stress response-patterns, and also included psychoeducation regarding medical treatments and recruitment of social support. Resected primary tumors were subjected to whole-genome RNA sequencing and bioinformatic analyses, assessing a priori hypothesized cancer-relevant molecular signatures. Self-report questionnaires (BSI-18, Hope-18, MSPSS, and a stress-scale) were collected three (T1) and one (T2) week before surgery, a day before (T3) and after (T4) surgery, and three weeks (T5) and 3-months (T6) following surgery. The intervention reduced distress (GSI), depression, and somatization scores (BSI-18: p < 0.01, p < 0.05, p < 0.05; T5 vs. T1). Additionally, tumors from treated patients (vs. controls) showed: (i) decreased activity of transcription control pathways involved in adrenergic and glucocorticoid signaling (CREB, GR) (p < 0.001), pro-inflammatory signaling (NFkB) (p < 0.01), and pro-malignant signaling (ETS1, STAT and GATA families) (p < 0.001, p < 0.01, p < 0.005); (ii) increased M1 macrophage polarization (p < 0.05), and CD4
    MeSH term(s) Humans ; Female ; Breast Neoplasms/surgery ; Psychosocial Intervention ; Biomarkers ; Adrenergic Agents ; Cognition
    Chemical Substances Biomarkers ; Adrenergic Agents
    Language English
    Publishing date 2024-02-10
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.02.009
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  7. Article ; Online: The influence of mindfulness meditation on inattention and physiological markers of stress on students with learning disabilities and/or attention deficit hyperactivity disorder.

    Gabriely, Ranit / Tarrasch, Ricardo / Velicki, Maria / Ovadia-Blechman, Zehava

    Research in developmental disabilities

    2020  Volume 100, Page(s) 103630

    Abstract: Background: Over recent decades, the number of students diagnosed with learning disabilities and/or attention deficit hyperactivity disorders has substantially increased. These students face various challenges and experience stress when receiving higher ...

    Abstract Background: Over recent decades, the number of students diagnosed with learning disabilities and/or attention deficit hyperactivity disorders has substantially increased. These students face various challenges and experience stress when receiving higher education.
    Aims: The purpose of this study was to compare two non-pharmacological interventions: mindfulness and device-guided slow breathing, with a control group.
    Methods: Seventy-three students (age = 25.76, std. dev = 3.10) with attention problems and/or learning disabilities were randomly assigned to three groups: mindfulness meditation, device guided breathing practice and waiting-list control. Before and after the intervention physiological and psychological measures were collected.
    Results: Our results show that only mindfulness practice improved awareness of the present moment and decreased hyperactivity and inattention. Furthermore, both mindfulness and practice with device-guided breathing were associated with stress reduction, as shown by an increase in the galvanic skin response only in the control group.
    Conclusions: Implementation of the study results may lead to an advance in treating attention deficit disorders and learning disabilities, especially among higher education students.
    MeSH term(s) Adult ; Attention ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/rehabilitation ; Breathing Exercises/methods ; Female ; Galvanic Skin Response ; Humans ; Learning Disabilities/psychology ; Learning Disabilities/rehabilitation ; Male ; Meditation/psychology ; Mindfulness/methods ; Stress, Psychological/physiopathology ; Stress, Psychological/psychology ; Stress, Psychological/rehabilitation ; Students/psychology ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639175-8
    ISSN 1873-3379 ; 0891-4222
    ISSN (online) 1873-3379
    ISSN 0891-4222
    DOI 10.1016/j.ridd.2020.103630
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  8. Article ; Online: Assault-related self-blame and its association with PTSD in sexually assaulted women: an MRI inquiry.

    Berman, Zohar / Assaf, Yaniv / Tarrasch, Ricardo / Joel, Daphna

    Social cognitive and affective neuroscience

    2018  Volume 13, Issue 7, Page(s) 775–784

    Abstract: Sexual assault is a frequent interpersonal trauma, which often leads to post-traumatic stress disorder (PTSD). Among other postassault characteristics, self-blame attributions were suggested to play an important role in sexually assaulted individuals' ... ...

    Abstract Sexual assault is a frequent interpersonal trauma, which often leads to post-traumatic stress disorder (PTSD). Among other postassault characteristics, self-blame attributions were suggested to play an important role in sexually assaulted individuals' coping and were consistently associated with PTSD in this population. The present study aimed to elucidate the neural underpinnings that may associate self-blame and PTSD in women who experienced sexual assault at adulthood, using structural and resting-state functional MRI. Thirty-eight sexually assaulted women and 24 non-exposed matched controls were studied (mean age: 25 years). Among the sexually assaulted participants, assault-related self-blame was negatively correlated with gray matter volume (GMV) bilaterally in the lingual gyrus and adjacent intracalcarine cortex. GMV in this cluster was also predicted by intrusion symptoms and negative social reactions. Resting-state functional connectivity (rs-FC) of this cluster with the left anterior temporal fusiform cortex significantly differed between PTSD and non-PTSD sexually assaulted participants, and was inversely correlated with intrusion symptoms and with peritraumatic dissociation. Finally, lingual cluster's GMV and rs-FC with the anterior fusiform mediated the association between self-blame and intrusion symptoms across sexually assaulted participants. These findings link assault-related self-blame, disrupted postassault recovery and the neural circuitry involved in the processing of traumatic memories.
    MeSH term(s) Adult ; Cerebral Cortex/diagnostic imaging ; Child ; Child Abuse, Sexual/psychology ; Crime Victims ; Female ; Gray Matter/growth & development ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neuropsychological Tests ; Rape/psychology ; Self Concept ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Stress Disorders, Post-Traumatic/psychology ; Temporal Lobe/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2018-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsy044
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  9. Article ; Online: On behalf of tradition: An analysis of medical student and physician beliefs on how anatomy should be taught.

    Marom, Assaf / Tarrasch, Ricardo

    Clinical anatomy (New York, N.Y.)

    2015  Volume 28, Issue 8, Page(s) 980–984

    Abstract: Human anatomy, one of the basic medical sciences, is a time-honored discipline. As such, it is taught using traditional methods, cadaveric dissection chief among them. Medical imaging has recently gained popularity as a teaching method in anatomy courses. ...

    Abstract Human anatomy, one of the basic medical sciences, is a time-honored discipline. As such, it is taught using traditional methods, cadaveric dissection chief among them. Medical imaging has recently gained popularity as a teaching method in anatomy courses. In light of a general tendency to reduce course hours, this has resulted in a decrease of dissection time and intense debates between traditional and modern approaches to anatomy teaching. In an attempt to explore trends in the attitudes of medical professionals toward the various methods of anatomy teaching, medical imaging in particular, the authors constructed a questionnaire and conducted a nationwide survey among medical students (in all stages at medical school), residents, and specialists in all fields of medicine. The survey results demonstrated indisputable appreciation of traditional methods of anatomy teaching, particularly cadaveric dissection, and showed that specialists believe significantly more strongly than clinical or preclinical students that anatomy and medical imaging should be taught separately. Strong correlations among the components of the traditional approach to anatomy instruction were also found. In light of the results, it was recommended that imaging should be incorporated into anatomy courses with caution, and, as far as possible, not at the expense of dissection time. It was advised that medical imaging has to be taught as a separate course, parallel to a traditional anatomy course. This will allow anatomical principles to be appreciated, which in turn will serve the students when they study radiology. "And we proceed in the following order: in front walks Nikolai with the slides or atlases, I come after him, and after me, his head humbly lowered, strides the cart horse; or else, if necessary, a cadaver is carried in first, after the cadaver walks Nikolai, and so on. At my appearance, the students rise, then sit down, and the murmur of the sea suddenly grows still. Calm ensues." -From "A Boring Story: From the Notebook of an Old Man" by Anton Chekhov.
    MeSH term(s) Anatomy/education ; Attitude of Health Personnel ; Cadaver ; Diagnostic Imaging ; Dissection ; Education, Medical/methods ; Humans ; Internship and Residency/statistics & numerical data ; Physicians/psychology ; Physicians/statistics & numerical data ; Specialization/statistics & numerical data ; Students, Medical/psychology ; Students, Medical/statistics & numerical data ; Surveys and Questionnaires ; Teaching/methods
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.22621
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  10. Article: Relation between contemplative exercises and an enriched psychology students' experience in a neuroscience course.

    Levit Binnun, Nava / Tarrasch, Ricardo

    Frontiers in psychology

    2014  Volume 5, Page(s) 1296

    Abstract: This article examines the relation of contemplative exercises with enhancement of students' experience during neuroscience studies. Short contemplative exercises inspired by the Buddhist tradition of self-inquiry were introduced in an undergraduate ... ...

    Abstract This article examines the relation of contemplative exercises with enhancement of students' experience during neuroscience studies. Short contemplative exercises inspired by the Buddhist tradition of self-inquiry were introduced in an undergraduate neuroscience course for psychology students. At the start of the class, all students were asked to participate in short "personal brain investigations" relevant to the topic presented. These investigations were aimed at bringing stable awareness to a specific perceptual, emotional, attentional, or cognitive process and observing it in a non-judgmental, non-personal way. In addition, students could choose to participate, for bonus credit, in a longer exercise designed to expand upon the weekly class activity. In the exercise, students continued their "personal brain investigations" for 10 min a day, 4 days a week. They wrote "lab reports" on their daily observations, obtained feedback from the teacher, and at the end of the year reviewed their reports and reflected upon their experiences during the semester. Out of 265 students, 102 students completed the bonus track and their final reflections were analyzed using qualitative methodology. In addition, 91 of the students answered a survey at the end of the course, 43 students participated in a quiz 1 year after course graduation, and the final grades of all students were collected and analyzed. Overall, students reported satisfaction from the exercises and felt they contributed to their learning experience. In the 1-year follow-up, the bonus-track students were significantly more likely than their peers to remember class material. The qualitative analysis of bonus-track students' reports revealed that the bonus-track process elicited positive feelings, helped students connect with class material and provided them with personal insights. In addition, students acquired contemplative skills, such as increased awareness and attention, non-judgmental attitudes, and better stress-management abilities. We provide examples of "personal brain investigations" and discuss limitations of introducing a contemplative approach.
    Language English
    Publishing date 2014-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2014.01296
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