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Article ; Online: Marginally stable current sheets in collisionless magnetic reconnection.

Granier, C / Borgogno, D / Comisso, L / Grasso, D / Tassi, E / Numata, R

2022 Volume 106, Issue 4, Page(s) L043201

Abstract: Noncollisional current sheets that form during the nonlinear development of spontaneous magnetic reconnection are characterized by a small thickness, of the order of the electron skin depth. They can become unstable to the formation of plasmoids, which ... ...

Abstract	Noncollisional current sheets that form during the nonlinear development of spontaneous magnetic reconnection are characterized by a small thickness, of the order of the electron skin depth. They can become unstable to the formation of plasmoids, which allows the magnetic reconnection process to reach high reconnection rates. In this work, we investigate the marginal stability conditions for the development of plasmoids when the forming current sheet is purely collisionless and in the presence of a strong guide field. We analyze the geometry that characterizes the reconnecting current sheet, and what promotes its elongation. Once the reconnecting current sheet is formed, we identify the regimes for which it is plasmoid unstable. Our study shows that plasmoids can be obtained, in this context, from current sheets with an aspect ratio much smaller than in the collisional regime, and that the plasma flow channel of the marginally stable current layers maintains an inverse aspect ratio of 0.1.
Language	English
Publishing date	2022-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.106.L043201
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Book ; Online: Proceedings of the Sixteenth Workshop on Logical Frameworks and Meta-Languages

Pimentel, Elaine / Tassi, Enrico

Theory and Practice

2021

Abstract: Logical frameworks and meta-languages form a common substrate for representing, implementing and reasoning about a wide variety of deductive systems of interest in logic and computer science. Their design, implementation and their use in reasoning tasks, ...

Abstract	Logical frameworks and meta-languages form a common substrate for representing, implementing and reasoning about a wide variety of deductive systems of interest in logic and computer science. Their design, implementation and their use in reasoning tasks, ranging from the correctness of software to the properties of formal systems, have been the focus of considerable research over the last two decades. This workshop brings together designers, implementors and practitioners to discuss various aspects impinging on the structure and utility of logical frameworks, including the treatment of variable binding, inductive and co-inductive reasoning techniques and the expressiveness and lucidity of the reasoning process.
Keywords	Computer Science - Logic in Computer Science ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning ; Computer Science - Programming Languages
Publishing date	2021-07-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel spatiotemporal tool for the automatic classification of fMRI noise based on Independent Component Analysis.

Tassi, E / Maggioni, E / Cerutti, S / Brambilla, P / Bianchi, A M

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2020 Volume 2020, Page(s) 1718–1721

Abstract: In this study, a semi-automatic, easy-to-use classification method for the identification and removal of fMRI noise is proposed and tested. The method relies on subject-level spatial independent component analysis (ICA) of fMRI data. Starting from a ... ...

Abstract	In this study, a semi-automatic, easy-to-use classification method for the identification and removal of fMRI noise is proposed and tested. The method relies on subject-level spatial independent component analysis (ICA) of fMRI data. Starting from a reference set of labeled independent components (ICs), novel ICs are classified as physiological/artefactual by combining a spatial correlation (SC) analysis with the reference ICs and relative power spectral (PS) analysis. Here, ICs from a task-based fMRI dataset were used as reference. SC and SP thresholds were set using a test dataset (5 subjects, same fMRI protocol) based on Receiving Operating Characteristic curves. The tool performance and versatility were measured on a resting-state fMRI dataset (5 subjects). Our results show that the method can automatically identify noise-related ICs with accuracy, specificity and sensitivity higher than 80% across different fMRI protocols. These findings also suggest that the reference set provided in the present study might be used to mark ICs coming from independent taskrelated or resting-state fMRI datasets.Clinical relevance- The new method will be included in a userfriendly, open-source tool for removal of noisy contributions from fMRI datasets to be used in clinical and research practices.
MeSH term(s)	Algorithms ; Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Sensitivity and Specificity
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC44109.2020.9176117
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Article ; Online: Environmental effects on brain functional networks in a juvenile twin population.

Tassi, Emma / Maggioni, Eleonora / Mauri, Maddalena / Fagnani, Corrado / Agarwal, Nivedita / Bianchi, Anna Maria / Stazi, Maria A / Nobile, Maria / Brambilla, Paolo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3921

Abstract: The brain's intrinsic organization into large-scale functional networks, the resting state networks (RSN), shows complex inter-individual variability, consolidated during development. Nevertheless, the role of gene and environment on developmental brain ... ...

Abstract	The brain's intrinsic organization into large-scale functional networks, the resting state networks (RSN), shows complex inter-individual variability, consolidated during development. Nevertheless, the role of gene and environment on developmental brain functional connectivity (FC) remains largely unknown. Twin design represents an optimal platform to shed light on these effects acting on RSN characteristics. In this study, we applied statistical twin methods to resting-state functional magnetic resonance imaging (rs-fMRI) scans from 50 young twin pairs (aged 10-30 years) to preliminarily explore developmental determinants of brain FC. Multi-scale FC features were extracted and tested for applicability of classical ACE and ADE twin designs. Epistatic genetic effects were also assessed. In our sample, genetic and environmental effects on the brain functional connections largely varied between brain regions and FC features, showing good consistency at multiple spatial scales. Although we found selective contributions of common environment on temporo-occipital connections and of genetics on frontotemporal connections, the unique environment showed a predominant effect on FC link- and node-level features. Despite the lack of accurate genetic modeling, our preliminary results showed complex relationships between genes, environment, and functional brain connections during development. A predominant role of the unique environment on multi-scale RSN characteristics was suggested, which needs replications on independent samples. Future investigations should especially focus on nonadditive genetic effects, which remain largely unexplored.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain Mapping ; Twins/genetics ; Rest ; Nerve Net
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30672-2
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Article ; Online: Histone-Specific CD4

Ramirez, Giuseppe A / Tassi, Elena / Noviello, Maddalena / Mazzi, Benedetta A / Moroni, Luca / Citterio, Lorena / Zagato, Laura / Tombetti, Enrico / Doglio, Matteo / Baldissera, Elena M / Bozzolo, Enrica P / Bonini, Chiara / Dagna, Lorenzo / Manfredi, Angelo A

Arthritis & rheumatology (Hoboken, N.J.)

2024 Volume 76, Issue 5, Page(s) 739–750

Abstract: Objective: The aim of this study was to assess whether circulating histone-specific T cells represent tools for precision medicine in systemic lupus erythematosus (SLE).: Methods: Seroprevalence of autoantibodies and HLA-DR beta (DRB) 1 profile were ... ...

Abstract	Objective: The aim of this study was to assess whether circulating histone-specific T cells represent tools for precision medicine in systemic lupus erythematosus (SLE). Methods: Seroprevalence of autoantibodies and HLA-DR beta (DRB) 1 profile were assessed among 185 patients with SLE and combined with bioinformatics and literature evidence to identify HLA-peptide autoepitope couples for ex vivo detection of antigen-specific T cells through flow cytometry. T cell differentiation and polarization was investigated in patients with SLE, patients with Takayasu arteritis, and healthy controls carrying HLA-DRB103:01 and/or HLA-DRB111:01. SLE Disease Activity Index 2000 and Lupus Low Disease Activity State were used to estimate disease activity and remission. Results: Histone-specific CD4 Conclusion: Histone-specific T cells are selectively detected in patients with SLE, and their concentration in the blood varies with disease activity, suggesting that they represent innovative tools for patient stratification and therapy.
MeSH term(s)	Humans ; Lupus Erythematosus, Systemic/immunology ; Histones/immunology ; Histones/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Adult ; Male ; Female ; Middle Aged ; HLA-DRB1 Chains/genetics ; HLA-DRB1 Chains/immunology ; Autoantibodies/immunology ; Antibodies, Antinuclear/immunology ; Case-Control Studies ; Th1 Cells/immunology
Chemical Substances	Histones ; HLA-DRB1 Chains ; Autoantibodies ; Antibodies, Antinuclear
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42778
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Article ; Online: A scoping review of near infrared spectroscopy studies employing a verbal fluency task in bipolar disorder.

Tassi, Emma / Boscutti, Andrea / Mandolini, Gian Mario / Moltrasio, Chiara / Delvecchio, Giuseppe / Brambilla, Paolo

Journal of affective disorders

2021 Volume 298, Issue Pt A, Page(s) 604–617

Abstract: Background: Deficits in cognitive functioning, including attention, memory, and executive functions, along with impairments in language production, are present in patients with bipolar disorder (BD) patients during mood phases, but also during euthymia ... ...

Abstract	Background: Deficits in cognitive functioning, including attention, memory, and executive functions, along with impairments in language production, are present in patients with bipolar disorder (BD) patients during mood phases, but also during euthymia.Verbal fluency tasks (VFTs), being able to evaluate integrity of a wide range of cognitive domains and represent, can be used to screen for these disturbances. Neuroimaging studies, including Near-InfraRed Spectroscopy (NIRS), have repeatedly showed widespread alterations in the prefrontal and temporal cortex during the performance of VFTs in BD patients. This review aims to summarize the results of NIRS studies that evaluated hemodynamic responses associated with the VFTs in prefrontal and temporal regions in BD patients. Methods: We performed a scoping review of studies evaluating VFT-induced activation in prefrontal and temporal regions in BD patients, and the relationship between NIRS data and various clinical variables. Results: 15 studies met the inclusion criteria. In BD patients, compared to healthy controls, NIRS studies showed hypoactivation of the dorsolateral prefrontal cortex, ventrolateral prefrontal cortex and anterior temporal regions. Moreover, clinical variables, such as depressive and social adaptation scores, were negatively correlated with hemodynamic responses in prefrontal and temporal regions, while a positive correlation were reported for measures of manic symptoms and impulsivity. Limitations: The heterogeneity of the studies in terms of methodology, study design and clinical characteristics of the samples limited the comparability of the findings. Conclusions: Given its non-invasiveness, good time-resolution and no need of posturalconstraint, NIRS technique could represent a useful tool for the evaluation of prefrontal and temporal haemodynamic correlates of cognitive performances in BD patients.
MeSH term(s)	Bipolar Disorder/diagnostic imaging ; Dorsolateral Prefrontal Cortex ; Humans ; Neuropsychological Tests ; Prefrontal Cortex/diagnostic imaging ; Spectroscopy, Near-Infrared
Language	English
Publishing date	2021-11-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2021.11.019
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Article ; Online: The non-small cell lung cancer immune landscape: emerging complexity, prognostic relevance and prospective significance in the context of immunotherapy.

Anichini, Andrea / Tassi, Elena / Grazia, Giulia / Mortarini, Roberta

Cancer immunology, immunotherapy : CII

2018 Volume 67, Issue 6, Page(s) 1011–1022

Abstract: Immunotherapy of non-small cell lung cancer (NSCLC), by immune checkpoint inhibitors, has profoundly improved the clinical management of advanced disease. However, only a fraction of patients respond and no effective predictive factors have been defined. ...

Abstract	Immunotherapy of non-small cell lung cancer (NSCLC), by immune checkpoint inhibitors, has profoundly improved the clinical management of advanced disease. However, only a fraction of patients respond and no effective predictive factors have been defined. Here, we discuss the prospects for identification of such predictors of response to immunotherapy, by fostering an in-depth analysis of the immune landscape of NSCLC. The emerging picture, from several recent studies, is that the immune contexture of NSCLC lesions is a complex and heterogeneous feature, as documented by analysis for frequency, phenotype and spatial distribution of innate and adaptive immune cells, and by characterization of functional status of inhibitory receptor
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Immunotherapy/methods ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Prognosis ; Prospective Studies
Language	English
Publishing date	2018-03-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-018-2147-7
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Article ; Online: Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L.

Bellani, Lorenza / Muccifora, Simonetta / Barbieri, Francesco / Tassi, Eliana / Ruffini Castiglione, Monica / Giorgetti, Lucia

Mutation research

2020 Volume 849, Page(s) 503142

Abstract: E171 (titanium dioxide, ... ...

Abstract	E171 (titanium dioxide, TiO
MeSH term(s)	Animals ; Chromosome Aberrations/drug effects ; Endocytosis/drug effects ; Food Additives/toxicity ; Germination/drug effects ; Humans ; Lens Plant/drug effects ; Lens Plant/metabolism ; Lens Plant/ultrastructure ; Micronuclei, Chromosome-Defective ; Microscopy, Electron ; Mitotic Index/statistics & numerical data ; Mutagens/toxicity ; Nanoparticles/toxicity ; Onions/drug effects ; Onions/metabolism ; Onions/ultrastructure ; Plant Roots/drug effects ; Plant Roots/metabolism ; Plant Roots/ultrastructure ; Titanium/toxicity
Chemical Substances	Food Additives ; Mutagens ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2020-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	206607-5
ISSN	1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrgentox.2020.503142
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Article: Physiological and biochemical responses of sunflower (Helianthus annuus L.) exposed to nano-CeO2 and excess boron: Modulation of boron phytotoxicity

Tassi, E / Barbafieri, M / Gardea-Torresdey, J.L / Giorgetti, L / Morelli, E / Peralta-Videa, J.R

Plant physiology and biochemistry. 2017 Jan., v. 110

2017

Abstract: Little is known about the interaction of nanoparticles (NPs) with soil constituents and their effects in plants. Boron (B), an essential micronutrient that reduces crop production at both deficiency and excess, has not been investigated with respect to ... ...

Abstract	Little is known about the interaction of nanoparticles (NPs) with soil constituents and their effects in plants. Boron (B), an essential micronutrient that reduces crop production at both deficiency and excess, has not been investigated with respect to its interaction with cerium oxide NPs (nano-CeO2). Considering conflicting results on the nano-CeO2 toxicity and protective role as antioxidant, their possible modulation on B toxicity in sunflower (Helianthus annuus L.) was investigated. Sunflower was cultivated for 30 days in garden pots containing original or B-spiked soil amended with nano-CeO2 at 0–800 mg kg−1. At harvest, Ce and B concentrations in tissues, biomass, and activities of stress enzymes in leaves were determined. Results showed that in the original soil, Ce accumulated mainly in roots, with little translocation to stems and leaves, while reduced root Ce was observed in plants from B-spiked soil. In the original soil, higher levels of nano-CeO2 reduced plant B concentration. Although morphological effects were not visible, changes in biomass and oxidative stress response were observed. Sunflower leaves from B-spiked soil showed visible symptoms of B toxicity, such as necrosis and chlorosis in old leaves, as well as an increase of superoxide dismutase (SOD) activity. However, at high nano-CeO2 level, SOD activity decreased reaching values similar to that of the control. This study has shown that nano-CeO2 reduced both the B nutritional status of sunflower in original soil and the B phytotoxicity in B-spiked soil.
Keywords	antioxidants ; biomass ; boron ; ceric oxide ; chlorosis ; crop production ; gardens ; Helianthus annuus ; leaves ; nanoparticles ; necrosis ; nutritional status ; oxidative stress ; phytotoxicity ; protective effect ; roots ; soil ; stems ; stress response ; superoxide dismutase ; tissues
Language	English
Dates of publication	2017-01
Size	p. 50-58.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2016.09.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Strategies to use phytoextraction in very acidic soil contaminated by heavy metals.

Pedron, F / Petruzzelli, G / Barbafieri, M / Tassi, E

Chemosphere

2009 Volume 75, Issue 6, Page(s) 808–814

Abstract: In microcosm experiments, the use of inorganic and organic amendments has been studied as potential agents to reduce heavy metal bioavailability in an acidic soil highly contaminated by Cu, Zn and Ni, that has to be remediated by phytoremediation. The ... ...

Abstract	In microcosm experiments, the use of inorganic and organic amendments has been studied as potential agents to reduce heavy metal bioavailability in an acidic soil highly contaminated by Cu, Zn and Ni, that has to be remediated by phytoremediation. The concentrations of heavy metals in the original soil (O-Soil) produced phytotoxic effects with a strong reduction in biomass yield that hinder the utilization of this technology. To overcome phytotoxicity the use of three immobilizing agents was evaluated. The results obtained showed that all the strategies decreased the mobile fractions of heavy metals in soil and increased the metal removal efficiency. In the case of Brassica juncea the best results for Zn and Ni were obtained after zeolites addition (Z-Soil) with an increase of about 6 times with respect to the value found in the O-Soil. In the case of Cu, the more efficient treatment was Ca(OH)(2) addition (Ca-Soil). The B. juncea plants accumulated Cu amounts 8 times greater than in the O-Soil. For this metal, relevant results were obtained also with compost, that increased the amount of Cu in the plants of 7 times with respect to the O-Soil. Similar results were obtained with Helianthus annuus the highest Zn and Ni accumulation was detected in the Z-Soil and compost-treated soils (C-Soil), with an increase of nearly 11 times with respect to the accumulation in the O-Soil. In the case of Cu the highest increase of total uptake was found in the C-Soil: 28 times higher than in the O-Soil. Total accumulation in Poa annua plants showed the highest removal efficiency in the Z-Soil for all metals. The values obtained increased of 4, 11 and 12 times for Cu, Zn and Ni, respectively.
MeSH term(s)	Biodegradation, Environmental ; Copper/metabolism ; Helianthus/metabolism ; Metals, Heavy/metabolism ; Mustard Plant/metabolism ; Nickel/metabolism ; Poa/metabolism ; Soil Pollutants/metabolism ; Zinc/metabolism
Chemical Substances	Metals, Heavy ; Soil Pollutants ; Copper (789U1901C5) ; Nickel (7OV03QG267) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2009-05
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2009.01.044
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