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  1. AU="Tatar, Emel Cadalli"
  2. AU="Shcherbakova Tatyana"
  3. AU="Coats, Brittany"
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  5. AU="Sarma, D.K."
  6. AU=Deng Lisi AU=Deng Lisi
  7. AU=Deshmukh V
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  9. AU="Johnson, Sally"
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  14. AU="Jiang, Shimin"
  15. AU="Wu, Xue-Ying"
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  1. Artikel ; Online: Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers.

    Bayır, Ömer / Aşık, Mehmet Doğan / Saylam, Güleser / Pınarlı, Ferda Alpaslan / Tatar, Emel Çadallı / Han, Ünsal / Şimşek, Ender / Korkmaz, Mehmet Hakan

    Oncology letters

    2022  Band 24, Heft 5, Seite(n) 409

    Abstract: Understanding the molecular mechanisms and gene expression in laryngeal squamous cell carcinoma (LSCC) may explain its aggressive biological behavior and regional metastasis pathways. In the present study, patients with locally advanced LSCC tumors were ... ...

    Abstract Understanding the molecular mechanisms and gene expression in laryngeal squamous cell carcinoma (LSCC) may explain its aggressive biological behavior and regional metastasis pathways. In the present study, patients with locally advanced LSCC tumors were examined for differential gene expression in the normal mucosa (non-tumoral mucosa), tumors and lymph node tissues. The aim was to identify possible predictive genes for lymph node metastasis. A total of 16 patients who had undergone total laryngectomy with neck dissection for advanced LSCC were randomly selected from a hospital database: Eight of the patients had lymph node metastasis (Group 1) and the other eight patients did not have metastasis (Group 2). Overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) were analyzed. For each patient, paraffin-embedded tissue samples were collected from non-tumoral mucosa, tumoral lesions and lymph node tissues. RNA was extracted from the tissue samples and used for complementary DNA synthesis, and microarray analysis was subsequently performed on each sample. Gene expression levels were determined in each specimen, and Groups 1 and 2 were compared and statistically analyzed. The microarray results for lymph node metastasis-positive and -negative groups, indicated the differential expression of 312 genes in the lymph nodes, 691 genes in the normal mucosal tissue and 93 genes in the tumor tissue. Transgelin (TAGLN) and cofilin 1 (CFL1) were identified as possible target genes and validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The RT-qPCR results for TAGLN and CFL1 supported the microarray data. OS, DFS and DSS times were longer in Group 2 than in Group 1 (P=0.002, 0.015 and 0.009, respectively). In addition, TAGLN and CFL1 were associated with DFS and DSS. On the basis of these results, it is suggested that TAGLN and CFL1 expression may play an important role in the pathogenesis of regional metastasis and poor prognosis in advanced LSCC.
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2022.13529
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  2. Artikel ; Online: Management of deep neck infections in adults and importance of clinical and laboratory findings.

    Arslan, Hande / Bayır, Ömer / Aksoy, Şevket / Keseroğlu, Kemal / Saka, Cem / Tatar, Emel Çadallı / Saylam, Güleser / Korkmaz, Mehmet Hakan

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2022  Band 70, Heft 7, Seite(n) 1488–1493

    Abstract: This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38.2±14.5 years) were included in the study. Patients ... ...

    Abstract This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38.2±14.5 years) were included in the study. Patients were divided into three groups according to the treatment strategy: group 1 received only antibiotic treatment, group 2 underwent abscess drainage with needle puncture in addition to antibiotic treatment, and group 3 underwent surgical drainage with antibiotic treatment. Laboratory outcomes, imaging methods, duration of hospital stay, treatment strategy, and clinical outcomes were analyzed.According to the laboratory results, complete blood count values did not vary among the three groups, but C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were higher in group 3 (p<0.01). Based on receiver operating characteristic (ROC) analysis, the cut-off levels for CRP and ESR associated with the need for surgical drainage were 133 mg/L and 42.5, respectively. According to radiological imaging results, the number of involved neck spaces was significantly different among the three groups (p=0.03), and group 3 had more spaces involved when compared with groups 1 and 2 (p=0.04). Gas formation in the neck tissues was noted in 10 patients in group 3 and 5 patients in groups 1 and 2 (p=0.02). ESR and CRP levels were higher in patients who underwent surgical drainage. In patients with deep neck space infections, the involvement of two or more neck spaces and gas formation on radiological images might indicate surgical drainage as a treatment strategy.
    Mesh-Begriff(e) Adult ; Anti-Bacterial Agents/therapeutic use ; Blood Sedimentation ; C-Reactive Protein ; Drainage ; Female ; Humans ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Young Adult
    Chemische Substanzen Anti-Bacterial Agents ; C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 2022-06-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2021-002271
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  3. Artikel ; Online: Oncological Outcomes of Transoral Laryngeal Microsurgery with Fiber-Optic Diode Laser for Early Glottic Cancer: A Single-Center Experience.

    Korkmaz, Mehmet Hakan / Bayır, Ömer / Hatipoğlu, Esra Bozkurt / Tatar, Emel Çadalli / Han, Ünsal / Öcal, Bülent / Keseroğlu, Kemal / Karahan, Sevilay / Saylam, Güleser

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

    2021  Band 63, Heft 3, Seite(n) 132–144

    Abstract: Backgroud/Objectives: Transoral laser laryngeal microsurgery (LTLM) has been widely used in the treatment of early-stage glottic laryngeal squamous cell carcinoma (LSCC) for the past few decades. Although T stage, tumor grade, anterior commissure ... ...

    Abstract Backgroud/Objectives: Transoral laser laryngeal microsurgery (LTLM) has been widely used in the treatment of early-stage glottic laryngeal squamous cell carcinoma (LSCC) for the past few decades. Although T stage, tumor grade, anterior commissure involvement, type of cordectomy, positive surgical margin, and postoperative additional therapies were accused as the prognostic factors for recurrence, there is still controversy about these data in the literature. The purpose of this study was to evaluate the oncological results of our patients with early glottic LSCC treated with LTLM as a single-modality therapy in a single-center study.
    Methods: Patients with early-stage (Tis-1-2/N0) glottic LSCC who underwent LTLM as a primary treatment from 2011 to 2019 were retrospectively reviewed. The clinicopathological factors and oncologic outcomes were analyzed.
    Results: One hundred and sixty-one patients were enrolled in this study. The 5-year overall (OS), disease-specific (DSS), disease-free (DFS), and laryngectomy-free survival rates were 84.5%, 97.9%, 79.2%, and 93.5%, respectively. The most common stage, histopathological type, and type of endoscopic cordectomy were T1 stage, well-differentiated cancer, and type 2 cordectomy, respectively. A positive surgical margin was defined in 20 (12.4%) patients. There was a significant relationship between histopathological grade and positive surgical margins (p = 0.038). OS and DSS rates of "wait and see" modality were lower, while DFS of radiotherapy was lower than that of other treatment modalities in patients with positive surgical margins, but the differences were not statistically significant. Nineteen (11.8%) patients had a recurrence. DSS was statistically significantly lower in patients with recurrence (p < 0.001).
    Conclusion: The results of our study showed that anterior commissure involvement, surgical margin positivity, and higher T stage statistically did not reduce survival rates in early-stage LSCC patients treated with LTLM. As the histopathological grade of the tumor worsens, the risk of surgical margin positivity increases. RT may have a negative effect on recurrence and organ preservation in the additional treatment of patient with positive surgical margins.
    Mesh-Begriff(e) Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/radiotherapy ; Laryngeal Neoplasms/surgery ; Lasers, Semiconductor ; Margins of Excision ; Microsurgery/methods ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-11-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000519718
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  4. Artikel: Coincidental Killian-Jamieson Diverticulum During Thyroid Surgery: A Rare Cause of Dysphagia.

    Saylam, Güleser / Keseroğlu, Kemal / Bayır, Ömer / Tatar, Emel Çadallı / Korkmaz, Mehmet Hakan

    Turkish archives of otorhinolaryngology

    2016  Band 54, Heft 4, Seite(n) 165–167

    Abstract: The aim of this case report is to demonstrate a very rare coincidental existence and management of the Killian-Jamieson diverticulum during thyroid surgery in a patient with dysphagia. An 18-year-old female patient with the complaints of progressive ... ...

    Abstract The aim of this case report is to demonstrate a very rare coincidental existence and management of the Killian-Jamieson diverticulum during thyroid surgery in a patient with dysphagia. An 18-year-old female patient with the complaints of progressive dysphagia and a rapidly growing mass at the anterior cervical region was undergone thyroid lobectomy. Coincidentally, a 2×2 cm Killian-Jamieson diverticulum was observed and simultaneously excised with the thyroid lobe, preserving the recurrent laryngeal nerve. Dysphagia is a frequent symptom, especially in patients with a rapidly growing thyroid mass. Thyroid surgeons should keep in mind that hypopharyngeal and upper esophageal pathologies can mimic the symptoms of a thyroid mass; therefore, detailed imaging techniques should be used for the differential diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2016-12-01
    Erscheinungsland Turkey
    Dokumenttyp Case Reports
    ISSN 2667-7466
    ISSN 2667-7466
    DOI 10.5152/tao.2016.1807
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  5. Artikel ; Online: Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity.

    Tatar, Emel Çadalli / Kupfer, Robbi A / Barry, Jonnae Y / Allen, Clint T / Merati, Albert L

    JAMA otolaryngology-- head & neck surgery

    2016  Band 143, Heft 1, Seite(n) 55–59

    Abstract: Importance: Management of recurrent respiratory papillomatosis (RRP) in adults has evolved to include office-based laser techniques.: Objective: To determine whether demographic or disease characteristics differ between patients undergoing office- ... ...

    Abstract Importance: Management of recurrent respiratory papillomatosis (RRP) in adults has evolved to include office-based laser techniques.
    Objective: To determine whether demographic or disease characteristics differ between patients undergoing office-based (office group) vs traditional operating room (OR group) surgical approaches for RRP.
    Design, setting, and participants: This study was a medical record review of adult patients with RRP treated between January 2011 and September 2013 at a tertiary care center. Patients were divided into 2 groups according to the setting in which the patient had the most procedures during the past 2 years.
    Main outcomes and measures: Demographic and disease characteristics were compared between patients receiving predominantly office-based vs predominantly OR management.
    Results: Of 57 patients (47 male and 10 female, with a mean [SD] age of 53.5 [16.4] years) treated during the 2-year period, 34 patients underwent predominantly office-based management and 23 patients underwent predominantly OR management. Sex, age, and weight were not statistically significantly different between the 2 groups. Patients in the OR group had a younger age at RRP diagnosis (mean [SD], 28.7 [22.0] years in the OR group and 45.5 [20.5] years in the office group), with a mean difference of 16.8 years (95% CI, -28.3 to -5.4 years). Patients in the OR group also had a significantly higher Derkay score (mean [SD], 15.1 [5.7] in the OR group and 10.7 [5.0] in the office group), with a mean difference of 4.4 (95% CI, 1.6-7.3). No statistically significant differences in comorbidities were observed between the 2 groups except for type 1 or 2 diabetes, which was more common in the OR group. There were 5 patients (22%) with diabetes in the OR group and 1 patient (3%) with diabetes in the office group, with a mean difference of 19% (95% CI, 2.7%-35%). In a subanalysis that excluded patients with juvenile-onset RRP, Derkay score (mean [SD], 13.9 [4.5] in the OR group and 10.8 [5.1] in the office group), with a mean difference of 3.1 (95% CI, 0.5-6.1), and the incidence of diabetes (25% [4 of 16] in the OR group and 3% [1 of 31] in the office group), with a mean difference of 22% (95% CI, 3%-40%), remained significantly higher in the OR group, while age at diagnosis of RRP was no longer statistically significant (mean [SD], 40.2 [15.6] years in the OR group and 49.6 [16.4] years in the office group), with a mean difference of 9.4 years (95% CI, -19.4 to -0.7 years).
    Conclusions and relevance: There were no sex or age differences between patients with RRP treated in the office compared with those treated in the OR. Patients with earlier age at diagnosis of RRP and greater disease severity were more likely to be managed in the OR.
    Mesh-Begriff(e) Adult ; Age Factors ; Ambulatory Surgical Procedures/statistics & numerical data ; Cohort Studies ; Confidence Intervals ; Disease Management ; Female ; Follow-Up Studies ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Odds Ratio ; Office Visits/statistics & numerical data ; Operating Rooms/utilization ; Outcome Assessment (Health Care) ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/pathology ; Papillomavirus Infections/surgery ; Patient Selection ; Postoperative Complications/epidemiology ; Postoperative Complications/physiopathology ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/pathology ; Respiratory Tract Infections/surgery ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors
    Sprache Englisch
    Erscheinungsdatum 2016-09-16
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2016.2724
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  6. Artikel: Complete nasopharyngeal stenosis: presentation of a rare case.

    Korkmaz, Hakan / Selcuk, Omer Tarik / Tatar, Emel Cadalli / Saylam, Guleser / Ozdek, Ali

    The Eurasian journal of medicine

    2015  Band 44, Heft 3, Seite(n) 185–187

    Abstract: A sixty-eight years old female patient with complete nasopharyngeal stenosis without any determined etiology is presented. She had complete nasal obstruction as well as obstructive sleep apnea syndrome. She was operated and dense, thick, avascular ... ...

    Abstract A sixty-eight years old female patient with complete nasopharyngeal stenosis without any determined etiology is presented. She had complete nasal obstruction as well as obstructive sleep apnea syndrome. She was operated and dense, thick, avascular fibrotic tissues were excised and reconstructed with local flaps and skin graft. Only partial opening was achieved in the long term follow-up.
    Sprache Englisch
    Erscheinungsdatum 2015-01-06
    Erscheinungsland Turkey
    Dokumenttyp Case Reports
    ZDB-ID 2577670-8
    ISSN 1308-8742 ; 1308-8734
    ISSN (online) 1308-8742
    ISSN 1308-8734
    DOI 10.5152/eajm.2012.44
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  7. Artikel ; Online: The effects of the stem cell on ciliary regeneration of injured rabbit sinonasal epithelium.

    Kavuzlu, Ali / Tatar, Emel Çadallı / Karagöz, Tuğba / Pınarlı, Ferda Alpaslan / Tatar, İlkan / Bayır, Ömer / Korkmaz, Mehmet Hakan

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2017  Band 274, Heft 8, Seite(n) 3057–3064

    Abstract: Defects in mucosal healing after sinonasal surgery cause infection, scar formation causing obstruction, relapse of the disease within a shorter period and revision surgery. The present study aimed to create a functional ciliated epithelium using a stem ... ...

    Abstract Defects in mucosal healing after sinonasal surgery cause infection, scar formation causing obstruction, relapse of the disease within a shorter period and revision surgery. The present study aimed to create a functional ciliated epithelium using a stem cell and stem cell sheet of adipose tissue origin and to show such regeneration ultra-structurally on experimentally injured rabbit nasal epithelium. This was an experimental animal study and basic research. A total of 18 white New Zealand rabbits were divided into three groups. The medial wall of the maxillary sinus of the subjects was peeled off bilaterally. No additional procedure was applied to the subjects in Group 1. In Group 2, adipose tissue-derived mesenchymal stem cell was implanted on the wound edges of the subjects. In Group 3, a stem cell sheet of three layers was laid onto the defect area. All subjects were killed after 3 weeks. The presence of the stem cell stained with bromo-deoxyuridine was assessed with a light microscope, whereas cilia density, ciliated orientation and cilia structure were evaluated with a scanning electron microscope. Ciliary densities in Group 2 and Group 3 were statistically superior compared to the control group (p < 0.001, p = 0.007). Cilia morphology in Group 2 and Group 3 was also better than the control group (p < 0.01, p = 0.048). Ciliary orientation in Group 2 was scored highest (p < 0.01). The ratio of BrDu-stained cells was observed to be 27% in Group 3 and 8% in Group 2. Sub-epithelial recovery was observed to be better in Group 3. Adipose tissue-derived mesenchymal stem cell increased the healing of the injured maxillary sinus mucosa of the rabbits in terms of cilia presence, density and morphology regardless of the implementation technique. Level of evidence NA.
    Sprache Englisch
    Erscheinungsdatum 2017-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-017-4595-7
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  8. Artikel ; Online: Laryngeal electromyographic changes in postthyroidectomy patients with normal vocal cord mobility.

    Keseroglu, Kemal / Bayir, Omer / Umay, Ebru Karaca / Saylam, Guleser / Tatar, Emel Cadalli / Ozdek, Ali / Korkmaz, Mehmet Hakan

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2017  Band 274, Heft 4, Seite(n) 1925–1931

    Abstract: Thyroidectomy has been used for the treatment of thyroid disease for more than 100 years. In spite of the advancement of surgical techniques, there is still a risk of laryngeal nerve injury. The risk of partial or complete injury still depends on some ... ...

    Abstract Thyroidectomy has been used for the treatment of thyroid disease for more than 100 years. In spite of the advancement of surgical techniques, there is still a risk of laryngeal nerve injury. The risk of partial or complete injury still depends on some surgical and disease-related factors. The aim of this study is to show the partial injury and to establish these risk factors via laryngeal electromyographic analysis (LEMG) in postthyroidectomy patients with normal vocal cord motion and mucosal anatomy. Patients who had undergone thyroid surgery were enrolled in this prospective study. LEMG analysis was performed to all patients with normal vocal cord mobility preoperatively and was repeated after the first and the third months of surgery. Thyroarytenoid (TA) and cricothyroid (CT) muscles were used to evaluate recurrent and external branch of superior laryngeal nerves, respectively. Four of the 32 patients had mild-to-moderate degrees of partial LEMG changes during preoperative LEMG analysis of TA and CT muscles on each side. After 3 months of surgery, there was a statistically significant worsening of LEMG findings in the right and left external branches of superior and left recurrent laryngeal nerves. Disease and surgery-related risk factors were analyzed. However, there was no significant relationship on the progression of LEMG findings according to these parameters. This is the first prospective study which supports the risk of progression of LEMG changes in patients with normal laryngoscopic examination after thyroid surgery. No reliable significant risk factor was found influencing the LEMG progression.
    Mesh-Begriff(e) Adult ; Aged ; Electromyography/methods ; Female ; Follow-Up Studies ; Humans ; Laryngeal Muscles/innervation ; Laryngeal Muscles/physiopathology ; Laryngeal Nerve Injuries/diagnosis ; Laryngeal Nerve Injuries/etiology ; Laryngeal Nerve Injuries/physiopathology ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Postoperative Complications/diagnosis ; Postoperative Complications/physiopathology ; Prospective Studies ; Risk Factors ; Thyroidectomy/adverse effects ; Vocal Cords/physiology
    Sprache Englisch
    Erscheinungsdatum 2017-04
    Erscheinungsland Germany
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-016-4442-2
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  9. Artikel ; Online: Stentless endoscopic repair of congenital choanal atresia: is it enough for maintaining choanal patency?

    Tatar, Emel Çadallı / Öcal, Bülent / Doğan, Esra / Bayır, Ömer / Saka, Cem / Özdek, Ali / Korkmaz, Mehmet Hakan

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2017  Band 274, Heft 10, Seite(n) 3673–3678

    Abstract: The aim of choanal atresia (CA) surgery is to achieve bilateral nasal patency. Among the different methods of CA repair, the endoscopic transnasal approach has gained recent popularity with the advent of endoscopic instruments and techniques. This ... ...

    Abstract The aim of choanal atresia (CA) surgery is to achieve bilateral nasal patency. Among the different methods of CA repair, the endoscopic transnasal approach has gained recent popularity with the advent of endoscopic instruments and techniques. This article describes our experience regarding CA repair that was done either using or not using a stent in different periods of time in our department. Between February 2006 and February 2016, a total of 29 patients aged 2 days-53 years underwent endoscopic transnasal CA repair. While in early years stents were used to maintain nasal patency, since 2010, all cases were repaired endoscopically without stenting. Of the 29 patients, 8 were excluded because of inadequate follow-up data. The mean follow-up time for the remaining 21 patients after surgery averaged 53 months (range 12-111 months). Intranasal stents were used in 5 of 21 patients for 8 out of 32 operative sides. Of the 8 stented neochoanae, 6 (75%), restenosed at a mean time of 15.2 weeks (5-24). The restenosis rate was 25% (6/24 nasal sides) in 16 patients who underwent stentless repair. In unilateral CA, 2 of 10 (20%) patients underwent atresia repair using stents and only these cases restenosed after surgery in this group. Of the 11 patients with bilateral disease, 5 (45.4%) underwent revision surgeries. In the bilateral group, 2 of 3 (66.6%) stented patients required revision surgeries, whereas 3 of 8 (37.5%) patients who underwent stentless repair relapsed. In one patient, we have experienced an alar cartilage injury intraoperatively caused by drilling. The transnasal endoscopic repair has proved to be effective and yielded long-term satisfactory results. The use of stent seems to have no advantage over a stentless repair regarding maintenance of a patent nasal airway. Patients experienced restenosis more frequently with stenting.
    Sprache Englisch
    Erscheinungsdatum 2017-10
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-017-4702-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The need of prophylactic central lymph node dissection is controversial in terms of postoperative thyroglobulin follow-up of patients with cN0 papillary thyroid cancer.

    Korkmaz, Mehmet Hakan / Öcal, Bülent / Saylam, Güleser / Çakal, Erman / Bayır, Ömer / Tutal, Esra / Tatar, Emel Çadallı

    Langenbeck's archives of surgery

    2017  Band 402, Heft 2, Seite(n) 235–242

    Abstract: Purpose: The objective of this study was to investigate whether prophylactic central lymph node dissection (pCLND) facilitates postoperative thyroglobulin (Tg) follow-up in the patients with papillary thyroid carcinoma (PTC). We also questioned whether ... ...

    Abstract Purpose: The objective of this study was to investigate whether prophylactic central lymph node dissection (pCLND) facilitates postoperative thyroglobulin (Tg) follow-up in the patients with papillary thyroid carcinoma (PTC). We also questioned whether radioactive iodine (RAI) remnant ablation provides any further advantage in this regard.
    Methods: The records of patients with low-intermediate risk PTC who underwent either only total thyroidectomy (TT) or TT in conjunction with pCLND were reviewed. Adjuvant RAI ablation was performed depending on tumor diameter, multifocality, the presence of positive lymph nodes and adverse histopathologic features. Pre-ablative and post-ablative Tg levels, post-operative complications and clinico-pathological characteristics were compared between the two groups (TT alone and TT with pCLND).
    Results: Among the 302 patients, TT was performed in 140 (46.4%) and TT with pCLND in 162 (53.6%). More than half of all patients in both groups had papillary microcarcinoma (58.0% and 53,1%, respectively). Postoperatively, the median preablative Tg level was higher in the TT only group than that of the TT with pCLND group (0.96 vs 0.27 ng/ml, respectively). The post-ablative Tg levels were undetectable in both groups at the last follow-up visit. Also, a subgroup of patients (19.5%) who did not receive RAI ablation all became athyroglobulinemic at one year after surgery.
    Conclusions: Although performing pCLND with TT seems to have an advantage over TT alone as to achieve lower Tg levels in the early post-operative period, Tg levels become comparable following RAI ablation. On the other hand, the patients who have not been treated with adjuvant RAI ablation, also became athyroglobulinemic regardless of the surgical method.
    Mesh-Begriff(e) Ablation Techniques ; Adult ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Neck Dissection ; Retrospective Studies ; Thyroglobulin/blood ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Treatment Outcome
    Chemische Substanzen Thyroglobulin (9010-34-8)
    Sprache Englisch
    Erscheinungsdatum 2017-02-21
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-017-1556-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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