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Article ; Online: Stalking the link between reproduction and aging: After decades of research, it still remains a mystery whether and how reproduction drives the process of aging: After decades of research, it still remains a mystery whether and how reproduction drives the process of aging.

Tatar, Marc

2023 Volume 24, Issue 6, Page(s) e57374

Abstract: The hypothesis that aging and number of offspring are linked with each other has attracted much attention and research, but evidence for it remains elusive. ...

Abstract	The hypothesis that aging and number of offspring are linked with each other has attracted much attention and research, but evidence for it remains elusive.
MeSH term(s)	Reproduction ; Aging
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202357374
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.

Tatar, Marc

Frontiers in endocrinology

2021 Volume 12, Page(s) 649880

Abstract: Mutations of the insulin-like receptor ... ...

Abstract	Mutations of the insulin-like receptor in
MeSH term(s)	Aging ; Animals ; Binding Sites ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/metabolism ; Diapause ; Dimerization ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Female ; Insulin/metabolism ; Insulin Resistance ; Ligands ; Longevity ; Mutation ; Phenotype ; Phosphorylation ; Protein Binding ; Protein Domains ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction ; Substrate Specificity
Chemical Substances	Caenorhabditis elegans Proteins ; Drosophila Proteins ; Insulin ; Ligands ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.649880
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Article ; Online: Combinatorial interventions in aging.

Parkhitko, Andrey A / Filine, Elizabeth / Tatar, Marc

Nature aging

2023 Volume 3, Issue 10, Page(s) 1187–1200

Abstract: Insight on the underlying mechanisms of aging will advance our ability to extend healthspan, treat age-related pathology and improve quality of life. Multiple genetic and pharmacological manipulations extend longevity in different species, yet ... ...

Abstract	Insight on the underlying mechanisms of aging will advance our ability to extend healthspan, treat age-related pathology and improve quality of life. Multiple genetic and pharmacological manipulations extend longevity in different species, yet monotherapy may be relatively inefficient, and we have limited data on the effect of combined interventions. Here we summarize interactions between age-related pathways and discuss strategies to simultaneously retard these in different organisms. In some cases, combined manipulations additively increase their impact on common hallmarks of aging and lifespan, suggesting they quantitatively participate within the same pathway. In other cases, interactions affect different hallmarks, suggesting their joint manipulation may independently maximize their effects on lifespan and healthy aging. While most interaction studies have been conducted with invertebrates and show varying levels of translatability, the conservation of pro-longevity pathways offers an opportunity to identify 'druggable' targets relevant to multiple human age-associated pathologies.
MeSH term(s)	Humans ; Quality of Life ; Aging/genetics ; Longevity/genetics ; Healthy Aging/genetics
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-023-00489-9
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Article ; Online: Unraveling the Molecular Mechanism of Immunosenescence in

Min, Kyung-Jin / Tatar, Marc

International journal of molecular sciences

2018 Volume 19, Issue 9

Abstract: A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity contribute to aging and to provide evidence showing that changes in innate immunity have an ... ...

Abstract	A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity contribute to aging and to provide evidence showing that changes in innate immunity have an important role in the overall decline of net immune function.
MeSH term(s)	Aging/genetics ; Aging/immunology ; Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/immunology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/immunology ; Drosophila melanogaster/microbiology ; Ecdysterone/immunology ; Ecdysterone/metabolism ; Feedback, Physiological ; Gastrointestinal Microbiome/immunology ; Gene Expression Regulation ; Immunity, Innate ; Immunosenescence/genetics ; Insulin/genetics ; Insulin/immunology ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/immunology ; Juvenile Hormones/immunology ; Juvenile Hormones/metabolism ; Models, Biological ; Signal Transduction
Chemical Substances	Drosophila Proteins ; Insulin ; Juvenile Hormones ; Ecdysterone (5289-74-7) ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2018-08-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19092472
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Article ; Online: Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a

Zheng, Wenjing / Ocorr, Karen / Tatar, Marc

Disease models & mechanisms

2020 Volume 13, Issue 6

Abstract: Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its ... ...

Abstract	Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its canonical mineralocorticoid receptor. Here, we present a
MeSH term(s)	Age Factors ; Aldosterone ; Animals ; Animals, Genetically Modified ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Disease Models, Animal ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Ecdysone ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fibrosis ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Receptors, Invertebrate Peptide/genetics ; Receptors, Invertebrate Peptide/metabolism ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Signal Transduction
Chemical Substances	Collagen Type IV ; Drosophila Proteins ; Prc protein, Drosophila ; Receptors, Invertebrate Peptide ; Receptors, Steroid ; ecdysone receptor ; Ecdysone (3604-87-3) ; Aldosterone (4964P6T9RB) ; Egfr protein, Drosophila (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2020-06-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.041301
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Article ; Online: The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster.

Tatar, Marc

Experimental gerontology

2010 Volume 46, Issue 5, Page(s) 363–368

Abstract: It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific ... ...

Abstract	It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific nutrient. The problem is complex because is it difficult to measure what a fly actually consumes. A powerful solution uses the geometric framework of nutrition where diets in many combinations can be tested for their effects on lifespan and reproduction while measuring intake. Applied to Drosophila, it is now clear that specific nutrients, not calories, mediate longevity. The geometric framework also reveals a nutritional basis for the trade-off between reproduction and lifespan. This complements a stable-isotope analysis that tracked the allocation of nitrogen, carbon and essential amino acids into eggs versus reproduction. Together, these studies show that it is not possible to explain how DR extends lifespan through a mechanism were resources are simply reallocated to somatic maintenance away from reproduction. Although promising in principle, genetic analysis of DR mechanisms has had limited success. To be productive, studies must include enough diets at appropriate concentrations. In reviewing the best data, there is little evidence to date for any gene to be required for DR to increase Drosophila lifespan, including insulin signaling or 4eBP. Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework.
MeSH term(s)	Aging/physiology ; Animals ; Caloric Restriction ; Drosophila melanogaster/physiology ; Food Deprivation/physiology ; Models, Animal
Language	English
Publishing date	2010-12-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2010.12.002
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Zs.A 579: Show issues

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Article ; Online: Reproductive aging in invertebrate genetic models.

Tatar, Marc

Annals of the New York Academy of Sciences

2010 Volume 1204, Page(s) 149–155

Abstract: The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive ...

Abstract	The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive decline in egg production beginning at early middle age, caused in part by reduction in germline stem cell proliferation as well as in survival of developing eggs. Molecular genetic analysis reveals that insulin and TGF-beta signaling are regulators of germline stem cell maintenance and proliferation during aging. Furthermore, the lifespan of both C. elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging.
MeSH term(s)	Aging/genetics ; Aging/physiology ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology ; Insulin/metabolism ; Invertebrates/genetics ; Invertebrates/physiology ; Models, Animal ; Reproduction/genetics ; Reproduction/physiology ; Transforming Growth Factor beta/metabolism
Chemical Substances	Insulin ; Transforming Growth Factor beta
Language	English
Publishing date	2010-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/j.1749-6632.2010.05522.x
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Article ; Online: Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?

Tatar, Marc

The journals of gerontology. Series A, Biological sciences and medical sciences

2009 Volume 64, Issue 2, Page(s) 161–163

Abstract: Understanding healthspan is arguably the most relevant clinical, social, and economic feature of aging research. The model systems of worm, fly, and mouse are potentially powerful tools to achieve this aim. These models provide two unique approaches. The ...

Abstract	Understanding healthspan is arguably the most relevant clinical, social, and economic feature of aging research. The model systems of worm, fly, and mouse are potentially powerful tools to achieve this aim. These models provide two unique approaches. The first is based on genetic screening for gain or loss of function mutations that ameliorate senescence. Genetic factors discovered by this process permit us to recognize causal and regulatory mechanisms of aging. A related screen looks for compounds that slow aging or act upon proteins that were initially identified from genetic analysis. The second research strategy uses manipulations of targeted genetic factors to test causal explanations for aging. These studies include transgenic organisms and genetic epistasis analysis. Overall, genetically driven research with model organisms is largely responsible for the breakthrough of aging biology in the past 15 years. Aging in these contexts, however, has been measured almost exclusively from cohort survival statistics such as life expectancy and age-specific mortality. This is for a good reason. Manipulated factors that extend life span are thought to unambiguously slow senescence and thus to reflect underlying causes of the aging process. But this approach is also common for a practical reason--healthspan is a poorly defined commodity in humans, let alone for genetic animal model systems. It was the consensus of the working session that making healthspan an operational metric would be an innovation needed for the genetic power of model systems to address this aspect of human aging.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/genetics ; Aging/physiology ; Animals ; Cellular Senescence/genetics ; Cellular Senescence/physiology ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Forecasting ; Health Status ; Humans ; Life Expectancy ; Longevity/genetics ; Models, Animal ; Models, Genetic ; Research Design ; Species Specificity ; United States
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2009-02-18
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/gln067
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Article ; Online: Metabolism by remote control.

Tatar, Marc

Cell metabolism

2009 Volume 10, Issue 3, Page(s) 164–166

Abstract: Drosophila melanogaster produce insulin-like peptides in specialized neuroendocrine cells to regulate growth, metabolism, aging, and reproduction. In this issue of Cell Metabolism, Géminard et al. (2009) describe how secretion of insulin-like peptides is ...

Abstract	Drosophila melanogaster produce insulin-like peptides in specialized neuroendocrine cells to regulate growth, metabolism, aging, and reproduction. In this issue of Cell Metabolism, Géminard et al. (2009) describe how secretion of insulin-like peptides is remotely controlled by the fat body (an adipose, liver-like tissue) in response to dietary amino acids.
MeSH term(s)	Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Insulin-Secreting Cells/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Neuropeptides/metabolism
Chemical Substances	Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; raptor protein, Drosophila
Language	English
Publishing date	2009-09-02
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2009.08.007
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Article ; Online: Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster.

Post, Stephanie / Tatar, Marc

PloS one

2016 Volume 11, Issue 5, Page(s) e0155628

Abstract: Insulin/IGF signaling (IIS) in Drosophila melanogaster is propagated by eight Drosophila insulin-like peptides (dilps) and is regulated by nutrition. To understand how dietary protein and sugar affect dilp expression, we followed the analytical concepts ... ...

Abstract	Insulin/IGF signaling (IIS) in Drosophila melanogaster is propagated by eight Drosophila insulin-like peptides (dilps) and is regulated by nutrition. To understand how dietary protein and sugar affect dilp expression, we followed the analytical concepts of the Nutritional Geometric Framework, feeding Drosophila adults media comprised of seven protein-to-carbohydrate ratios at four caloric concentrations. Transcript levels of all dilps and three IIS-regulated genes were measured. Each dilp presented a unique pattern upon a bivariate plot of sugar and protein. Dilp2 expression was greatest upon diets with low protein-to-carbohydrate ratio regardless of total caloric value. Dilp5 expression was highly expressed at approximately a 1:2 protein-to-carbohydrate ratio and its level increased with diet caloric content. Regression analysis revealed that protein-to-carbohydrate ratio and the interaction between this ratio and caloric content significantly affects dilp expression. The IIS-regulated transcripts 4eBP and InR showed strikingly different responses to diet composition: 4eBP was minimally expressed except when elevated at low caloric diets. InR expression increased with protein level, independent of caloric content. Values of published life history traits measured on similar diets revealed correlations between egg production and the expression of dilp8 4eBP, while low protein-to-carbohydrate ratio diets associated with long lifespan correlated with elevated dilp2. Analyzing how nutient composition associates with dilp expression and IIS reveals that nutritional status is modulated by different combinations of insulin-like peptides, and these features variously correlate to IIS-regulated life history traits.
MeSH term(s)	Animal Nutritional Physiological Phenomena ; Animals ; Carbohydrates/analysis ; Diet ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Fertility ; Gene Expression Regulation ; Insulin/metabolism ; Longevity ; Models, Biological ; Somatomedins/metabolism ; Transcription, Genetic
Chemical Substances	Carbohydrates ; Drosophila Proteins ; Insulin ; Somatomedins
Language	English
Publishing date	2016-05-12
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0155628
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