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  1. Article ; Online: Donating blood on a regular basis reduces blood pressure (in hypertensives): appearances are not deceiving.

    Kamhieh-Milz, Julian / Tauchmann, Yvonne / Kamhieh-Milz, Sundrela / Pruss, Axel / Doerffel, Yvonne / Michalsen, Andreas

    Transfusion

    2019  Volume 59, Issue 4, Page(s) 1405–1406

    MeSH term(s) Blood Donors ; Blood Pressure ; Humans ; Hypertension
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Blutspende – Behandlungsoption bei Hypertonie?

    Kamhieh-Milz, Julian / Tauchmann, Yvonne / Pruß, Axel / Dörffel, Yvonne / Michalsen, Andreas

    Zeitschrift für Komplementärmedizin

    2018  Volume 10, Issue 05, Page(s) 56–61

    Abstract: Der Aderlass zählt zu den wichtigsten traditionellen Behandlungsverfahren der traditionellen Medizin in den unterschiedlichsten Kulturen. Das zwischenzeitlich durch missbräuchliche Anwendung in Ungnade gefallene Verfahren hat sich heute z.B. zur ... ...

    Abstract Der Aderlass zählt zu den wichtigsten traditionellen Behandlungsverfahren der traditionellen Medizin in den unterschiedlichsten Kulturen. Das zwischenzeitlich durch missbräuchliche Anwendung in Ungnade gefallene Verfahren hat sich heute z.B. zur Behandlung von Patienten mit Hämochromatose und Polycythaemiaverawieder etabliert. In den letzten Jahren konnten positive Ergebnisse bei therapierefraktärem Hypertonus gezeigt werden. So konnte im Rahmen von Studien bei Patienten nach Nierentransplantation und bei Patienten mit metabolischem Syndrom der Blutdruck durch Aderlass erfolgreich gesenkt werden. Weitere Forschungsarbeit zu den vielversprechenden Ergebnissen ist allerdings notwendig, um die Ergebnisse zu untermauern. Perspektiven ergeben sich zudem in Anbetracht der zunehmenden Blutknappheit. Allerdings steht die Klärung ethischer Fragestellungen noch aus.
    Keywords Hypertonie ; Aderlass ; Blutspende
    Language German
    Publishing date 2018-10-01
    Publisher © Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2495975-3
    ISSN 1867-6103 ; 1867-6081
    ISSN (online) 1867-6103
    ISSN 1867-6081
    DOI 10.1055/s-0038-1675318
    Database Thieme publisher's database

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  3. Article ; Online: Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors.

    Kamhieh-Milz, Sundrela / Kamhieh-Milz, Julian / Tauchmann, Yvonne / Ostermann, Thomas / Shah, Yatin / Kalus, Ulrich / Salama, Abdulgabar / Michalsen, Andreas

    Transfusion

    2015  Volume 56, Issue 3, Page(s) 637–644

    Abstract: Background: Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.: Study design and methods: Unselected blood donors were included in this ... ...

    Abstract Background: Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.
    Study design and methods: Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1-year study period.
    Results: In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (> 140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p < 0.001). There was a clear dose effect with decreasing BP by the increasing number of blood donations. After at least four blood donations, donors with Stage II hypertensive baseline values (≥ 160 mmHg SBP and/or ≥ 100 mmHg DBP) were found to have the most marked reduction in BP, with 17.1 mmHg (95% confidence interval [CI], -23.2 to -11.0; p < 0.0001) and 11.7 mmHg (95% CI, -17.1 to -6.1; p = 0.0006) for SBP and DBP, respectively. The decrease in BP was not significantly associated with changes of blood count or variables of iron metabolism.
    Conclusions: Regular blood donation is associated with pronounced decreases of BP in hypertensives. This beneficial effect of blood donation may open a new door regarding community health care and cost reduction in the treatment of hypertension.
    MeSH term(s) Adult ; Aged ; Blood Donors/statistics & numerical data ; Blood Pressure/physiology ; Female ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Young Adult
    Language English
    Publishing date 2015-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.13428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High Prevalence of Infectious Adeno-associated Virus (AAV) in Human Peripheral Blood Mononuclear Cells Indicative of T Lymphocytes as Sites of AAV Persistence.

    Hüser, Daniela / Khalid, Dina / Lutter, Timo / Hammer, Eva-Maria / Weger, Stefan / Heßler, Melanie / Kalus, Ulrich / Tauchmann, Yvonne / Hensel-Wiegel, Karin / Lassner, Dirk / Heilbronn, Regine

    Journal of virology

    2017  Volume 91, Issue 4

    Abstract: Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from humans or nonhuman primates have so far not been proven to be causes of human disease. In view of the increasing success of ... ...

    Abstract Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from humans or nonhuman primates have so far not been proven to be causes of human disease. In view of the increasing success of AAV-derived vectors in human gene therapy, definition of the in vivo sites of wild-type AAV persistence and the clinical consequences of its reactivation is becoming increasingly urgent. Here, we identify the presumed cell type for AAV persistence in the human host by highly sensitive AAV PCRs developed for the full spectrum of human AAV serotypes. In genomic-DNA samples from leukocytes of 243 healthy blood donors, 34% were found to be AAV positive, predominantly AAV type 2 (AAV2) (77%), AAV5 (19%), and additional serotypes. Roughly 11% of the blood donors had mixed AAV infections. AAV prevalence was dramatically increased in immunosuppressed patients, 76% of whom were AAV positive. Of these, at least 45% displayed mixed infections. Follow-up of single blood donors over 2 years allowed repeated detection of the initial and/or additional AAV serotypes, suggestive of fluctuating, persistent infection. Leukocyte separation revealed that AAV resided in CD3
    Importance: Adeno-associated virus is viewed as apathogenic and replication defective, requiring coinfection with adenovirus or herpesvirus for productive infection. In vivo persistence of a defective virus requires latency in specialized cell types to escape the host immune response until viral spread becomes possible. Reactivation from latency can be induced by diverse stimuli, including infections, typically induced upon host immunosuppression. We show for the first time that infectious AAV is highly prevalent in human leukocytes, specifically T lymphocytes, and that AAV is strongly amplified upon immunosuppression, along with reactivation of latent human herpesviruses. In the absence of an animal model to study the AAV life cycle, our findings in the human host will advance the understanding of AAV latency, reactivation, and in vivo pathogenesis.
    MeSH term(s) DNA, Viral ; Dependovirus/classification ; Dependovirus/physiology ; Humans ; Immunocompromised Host ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/virology ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/virology ; Polymerase Chain Reaction ; Prevalence ; Seroepidemiologic Studies ; T-Lymphocytes/immunology ; T-Lymphocytes/virology ; Virus Activation ; Virus Latency
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2017-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.02137-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epigenomic Profiling of Human CD4

    Durek, Pawel / Nordström, Karl / Gasparoni, Gilles / Salhab, Abdulrahman / Kressler, Christopher / de Almeida, Melanie / Bassler, Kevin / Ulas, Thomas / Schmidt, Florian / Xiong, Jieyi / Glažar, Petar / Klironomos, Filippos / Sinha, Anupam / Kinkley, Sarah / Yang, Xinyi / Arrigoni, Laura / Amirabad, Azim Dehghani / Ardakani, Fatemeh Behjati / Feuerbach, Lars /
    Gorka, Oliver / Ebert, Peter / Müller, Fabian / Li, Na / Frischbutter, Stefan / Schlickeiser, Stephan / Cendon, Carla / Fröhler, Sebastian / Felder, Bärbel / Gasparoni, Nina / Imbusch, Charles D / Hutter, Barbara / Zipprich, Gideon / Tauchmann, Yvonne / Reinke, Simon / Wassilew, Georgi / Hoffmann, Ute / Richter, Andreas S / Sieverling, Lina / Chang, Hyun-Dong / Syrbe, Uta / Kalus, Ulrich / Eils, Jürgen / Brors, Benedikt / Manke, Thomas / Ruland, Jürgen / Lengauer, Thomas / Rajewsky, Nikolaus / Chen, Wei / Dong, Jun / Sawitzki, Birgit / Chung, Ho-Ryun / Rosenstiel, Philip / Schulz, Marcel H / Schultze, Joachim L / Radbruch, Andreas / Walter, Jörn / Hamann, Alf / Polansky, Julia K

    Immunity

    2016  Volume 45, Issue 5, Page(s) 1148–1161

    Abstract: The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We generated deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA ... ...

    Abstract The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We generated deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated CD45RA
    MeSH term(s) CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Epigenesis, Genetic/immunology ; Epigenomics/methods ; Female ; Flow Cytometry ; Gene Expression Profiling/methods ; Humans ; Immunologic Memory/immunology ; Machine Learning ; Polymerase Chain Reaction ; Transcriptome
    Language English
    Publishing date 2016-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2016.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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