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Article: The Role of 4-Phenylbutyric Acid in Gut Microbial Dysbiosis in a Mouse Model of Simulated Microgravity.

Shama, Shama / Qaisar, Rizwan / Khan, Naveed Ahmed / Tauseef, Isfahan / Siddiqui, Ruqaiyyah

2022 Volume 12, Issue 9

Abstract: The altered gut microbes of astronauts during space travel may contribute to health issues after their return to Earth. Previously, an association between the elevated endoplasmic reticulum (ER) stress and gut microbial dysbiosis has been described. ... ...

Abstract	The altered gut microbes of astronauts during space travel may contribute to health issues after their return to Earth. Previously, an association between the elevated endoplasmic reticulum (ER) stress and gut microbial dysbiosis has been described. Herein, we induced gut microbial changes in mice under a simulated microgravity environment in an established model of hindlimb unloaded (HU) mice. The intestinal metabolomic profiles under microgravity conditions using the HU model were examined, along with the potential role of 4-phenylbutyric acid (4-PBA), a potent ER stress inhibitor. For a microgravity environment, the mice were suspended in special cages individually for three weeks. Mice were sacrificed, and gut dissections were performed, followed by amplicon sequencing analysis of bacterial species via DNA extraction and 16S rRNA analysis. The results indicate that the gut bacterial communities of mice differed under gravity and microgravity conditions. Principal component analyses revealed differences in the bacterial community structure in all groups. Around 434 operational taxonomic units (OTUs) were specific to mice seen in controls, while 620 OTUs were specific to HU mice. Additionally, 321 bacterial OTUs were specific to HU mice treated with 4-PBA. When the relative abundance of taxa was analyzed, Bacteroidetes dominated the gut of control and HU mice treated with 4-PBA.. In contrast, the untreated HU mice were dominated by Firmicutes. At the genus level, a reduction in beneficial species of
Language	English
Publishing date	2022-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12091301
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Article ; Online: Fish collagen peptides' modulating effect on human skin microbiota against pathogenic

Bayan, Rasol / Tauseef, Isfahan / Hussain, Mubashir / Ahmed, Muhammad S / Haider, Adnan / Khalil, Atif Ak / Islam, Salman U / Subhan, Fazli

Future microbiology

2023 Volume 18, Page(s) 795–807

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Animals ; Humans ; Staphylococcus aureus ; Skin/microbiology ; Staphylococcal Infections/microbiology ; Peptides/pharmacology ; Bacteria ; Collagen/pharmacology ; Microbiota ; Staphylococcus epidermidis
Chemical Substances	Peptides ; Collagen (9007-34-5)
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2022-0208
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Article ; Online: Enhancing microbial diversity as well as multi-organ health in hind-limb unloaded mice.

Shama, Shama / Ranade, Anu V / Qaisar, Rizwan / Khan, Naveed Ahmed / Tauseef, Isfahan / Elmoselhi, Adel / Siddiqui, Ruqaiyyah

Life sciences in space research

2023 Volume 40, Page(s) 62–71

Abstract: During space travel, the gut microbiota is changed which can lead to health-related issues. Previously, we utilized the hind-limb unloaded (HU) mouse, which is an established ground-based in-vivo model of microgravity and observed altered gut microbiota. ...

Abstract	During space travel, the gut microbiota is changed which can lead to health-related issues. Previously, we utilized the hind-limb unloaded (HU) mouse, which is an established ground-based in-vivo model of microgravity and observed altered gut microbiota. In this study, we evaluated the beneficial effects of novel bacterial conditioned media in HU mice to understand if they can offset the effects of unloading in the HU mouse model. We aimed to explore the influence of bacterial conditioned media on diversity and quantity of intestinal microbes in HU mice, and investigated the microarchitecture of mice retinas and kidneys to evaluate the potential systemic effects of bacterial conditioned media in HU mice. Four-month-old, male C57/Bl6 mice were separated into groups: including the ground-based control group, the HU group mice fed with vehicle as placebo (HU-placebo mice), and the HU group fed with bacterial conditioned media (HU-CP mice) and kept under controlled environmental conditions for three weeks. Next, mice were sacrificed; gut dissections were conducted, and metagenomic analysis of bacterial species was performed via DNA extraction and 16S rRNA analysis. The results revealed an HU-induced reduction in intestinal microbial diversity, and an increase in pathogenic bacteria dominated by Firmicutes (45%). In contrast, supplementation with bacterial conditioned media for three weeks led to a significant increase in gut microbial diversity with noticeable changes in the OTUs abundance in the HU mice. Additionally, HU-induced muscle weakness and structural abnormalities in the retina and kidney were partially prevented with bacterial conditioned media. Moreover, a greater diversity of several bacteria in the HU-CP was observed including, Bacteriodota, Firmicutes, Proteobacteria, Actionobacteriota, Verrucomicorbiota, Cyanobacteria, Gemmatimonadota, Acidobacteriota, Chloroflexi, Myxococcota, and others. Prospective research involving molecular mechanistic studies are needed to comprehend the systemic effects of bacterial metabolites conditioned media on experimental animal models under chronic stress.
MeSH term(s)	Mice ; Male ; Animals ; RNA, Ribosomal, 16S/genetics ; Culture Media, Conditioned ; Prospective Studies ; Gastrointestinal Microbiome/genetics ; Cyanobacteria
Chemical Substances	RNA, Ribosomal, 16S ; Culture Media, Conditioned
Language	English
Publishing date	2023-09-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-5532
ISSN (online)	2214-5532
DOI	10.1016/j.lssr.2023.08.006
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Article ; Online: A review on recent advances and applications of fish collagen.

Subhan, Fazli / Hussain, Zohaib / Tauseef, Isfahan / Shehzad, Adeeb / Wahid, Fazli

Critical reviews in food science and nutrition

2020 Volume 61, Issue 6, Page(s) 1027–1037

Abstract: During the processing of the fishery resources, the significant portion is either discarded or used to produce low-value fish meal and oil. However, the discarded portion is the rich source of valuable proteins such as collagen, vitamins, minerals, and ... ...

Abstract	During the processing of the fishery resources, the significant portion is either discarded or used to produce low-value fish meal and oil. However, the discarded portion is the rich source of valuable proteins such as collagen, vitamins, minerals, and other bioactive compounds. Collagen is a vital protein in the living body as a component of a fibrous structural protein in the extracellular matrix, connective tissue and building block of bones, tendons, skin, hair, nails, cartilage and joints. In recent years, the use of fish collagen as an increasingly valuable biomaterial has drawn considerable attention from biomedical researchers, owing to its enhanced physicochemical properties, stability and mechanical strength, biocompatibility and biodegradability. This review focuses on summarizing the growing role of fish collagen for biomedical applications. Similarly, the recent advances in various biomedical applications of fish collagen, including wound healing, tissue engineering and regeneration, drug delivery, cell culture and other therapeutic applications, are discussed in detail. These applications signify the commercial importance of fish collagen for the fishing industry, food processors and biomedical sector.
MeSH term(s)	Animals ; Biocompatible Materials ; Collagen ; Extracellular Matrix ; Tissue Engineering ; Wound Healing
Chemical Substances	Biocompatible Materials ; Collagen (9007-34-5)
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2020.1751585
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Article ; Online: In-vivo toxicity and therapeutic efficacy of Paeonia emodi-mediated zinc oxide nanoparticles: In-vitro study.

Shah, Amreen / Tauseef, Isfahan / Yameen, Muhammad Arfat / Haleem, Syed Kashif / Haq, Sirajul / Shoukat, Sabeena

Microscopy research and technique

2021 Volume 85, Issue 1, Page(s) 181–192

Abstract: This study was planned to explore the in-vitro and in-vivo therapeutic significance of Paeonia emodi-mediated zinc oxide nanoparticles (ZnO NPs) against the Staphylococcus aureus and Escherichia coli. The texture parameters were derived from nitrogen ... ...

Abstract	This study was planned to explore the in-vitro and in-vivo therapeutic significance of Paeonia emodi-mediated zinc oxide nanoparticles (ZnO NPs) against the Staphylococcus aureus and Escherichia coli. The texture parameters were derived from nitrogen adsorption-desorption data using Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) methods, and the surface area (S
MeSH term(s)	Animals ; Anti-Bacterial Agents ; Metal Nanoparticles/toxicity ; Mice ; Nanoparticles/toxicity ; Paeonia ; X-Ray Diffraction ; Zinc Oxide/toxicity
Chemical Substances	Anti-Bacterial Agents ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2021-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.23894
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Article ; Online: Quantitative Estimation of Aflatoxin Level in Poultry Feed in Selected Poultry Farms.

Naveed, Muhammad / Haleem, Kashif Syed / Ghazanfar, Shakira / Tauseef, Isfahan / Bano, Naseem / Adetunji, Charles Oluwaseun / Saleem, Muhammad Hamzah / Alshaya, Huda / Paray, Bilal Ahamad

BioMed research international

2022 Volume 2022, Page(s) 5397561

Abstract: Statement of ... ...

Abstract	Statement of Novelty
MeSH term(s)	Aflatoxins/analysis ; Animal Feed/analysis ; Animals ; Food Contamination/analysis ; Pakistan ; Poultry
Chemical Substances	Aflatoxins
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/5397561
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Article ; Online: In-Vitro and In-Vivo Tolerance and Therapeutic Investigations of Phyto-Fabricated Iron Oxide Nanoparticles against Selected Pathogens.

Shah, Amreen / Tauseef, Isfahan / Ali, Manel Ben / Yameen, Muhammad Arfat / Mezni, Amine / Hedfi, Amor / Haleem, Syed Kashif / Haq, Sirajul

Toxics

2021 Volume 9, Issue 5

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2021-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics9050105
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Article ; Online: Biological and biochemical characteristics of male reproductive system, serum metabolites and carcass quality of Japanese quails by the supplementation of Pinus ponderosa leaves and α-tocopherol acetate.

Shah, Assar Ali / Khan, Irfan Ullah / Sahibzada, Fayaz Ahmed / Tauseef, Isfahan / Kalsoom, Umm-E- / Sultana, Nighat

Reproduction in domestic animals = Zuchthygiene

2019 Volume 54, Issue 10, Page(s) 1348–1356

Abstract: The aim of the current study was to evaluate the effect of dietary supplementation of Pinus ponderosa leaves (pine leaves) and α-tocopherol acetate (vitamin E) powder on male reproductive system, serum metabolites and carcass characteristics of Japanese ... ...

Abstract	The aim of the current study was to evaluate the effect of dietary supplementation of Pinus ponderosa leaves (pine leaves) and α-tocopherol acetate (vitamin E) powder on male reproductive system, serum metabolites and carcass characteristics of Japanese quails. A total of 360-day-old male quails were purchased from the open market and kept at poultry shed for ninety-four days. After ten days of adaptation, all quails were randomly assigned into 4 groups, control (IC); supplemented with α-tocopherol acetate (IE) at the rate of 150 mg/L; Pinus ponderosa leaves (IP) at the rate of 150 mg/L; and 70 mg α-tocopherol acetate and 70 mg Pinus ponderosa leaves (IEP). Pinus ponderosa leaves and α-tocopherol acetate supplementation had not significantly (p > .05) effected on final body weight gain, feed intake and feed conversion ratio of quails. The high-density lipoprotein cholesterol (HDLC) and total cholesterol (TC) were significantly (p > .05) affected by IE and IP groups as compared to IC and IEP groups. Triglyceride (TG), glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly (p < .05) increased in all treatment groups except for the IC group. Aspartate transaminase (AST) significantly (p > .05) decreased in treatment groups as compared to control group. Overall, the mineral levels significantly (p < .05) increased in treatment groups as compared to control. Cloacal gland index values, the quantity of foam production and testis weight were significantly (p < .05) increased in treatment groups. It was concluded that the supplementation of Pinus ponderosa leaves and α-tocopherol acetate improved the testis weight, foam production, serum antioxidant enzymes and mineral level especially zinc in Japanese quail considered an indicative characteristic of higher sperm production rate and improved sexual activity. Further, higher gametogenesis rate, sperm production or reproductive behaviour including different hormonal level will be analysed in future study.
MeSH term(s)	Animal Feed/analysis ; Animals ; Antioxidants/analysis ; Cholesterol/blood ; Coturnix/physiology ; Diet/veterinary ; Genitalia, Male/drug effects ; Male ; Minerals/analysis ; Organ Size/drug effects ; Pinus ponderosa ; Plant Leaves ; Testis/drug effects ; alpha-Tocopherol/administration & dosage
Chemical Substances	Antioxidants ; Minerals ; Cholesterol (97C5T2UQ7J) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2019-09-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.13521
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Article: Characterization of cross-linked amyloglucosidase aggregates from Aspergillus fumigatus KIBGE-IB33 for continuous production of glucose

Pervez, Sidra / Nawaz, Muhammad Asif / Shahid, Faiza / Aman, Afsheen / Tauseef, Isfahan / Qader, Shah Ali Ul

International journal of biological macromolecules. 2019 Aug. 15, v. 135

2019

Abstract: Current research deals with immobilization of amyloglucosidase through carrier-free approach using cross-linking strategy. Cross-linked amyloglucosidase aggregates (CLAAs) with aggregation yield of 94% were prepared in 04 h by incorporating 40% ammonium ... ...

Abstract	Current research deals with immobilization of amyloglucosidase through carrier-free approach using cross-linking strategy. Cross-linked amyloglucosidase aggregates (CLAAs) with aggregation yield of 94% were prepared in 04 h by incorporating 40% ammonium sulfate and 1.5% glutaraldehyde in enzyme solution. CLAAs were characterized by optimizing various conditions including reaction time, pH, temperature and substrate concentration. It was noticed that after cross-linking no change in optimum reaction time and substrate concentration was observed however, a 5-degree shift in optimum temperature from 60 °C to 65 °C was obtained as compared to soluble amyloglucosidase. Activation energy (Ea) of amyloglucosidase as calculated from Arrhenius plot was 5.5 kcal mol−1 and 5.2 kcal mol−1 for soluble and cross-linked aggregates, respectively. Stability studies revealed that CLAAs can be used at higher temperatures for longer time period than soluble amyloglucosidase. Furthermore, data of recycling studies showed that CLAAs can be efficiently reused for 20 cycles with the retention of 63% of its initial activity. Due to the continuous reusability of CLAAs, the product formation is also increased 8 times from 5.71 mg ml−1 (soluble enzyme) to 46.548 mg ml−1 (CLAAs). Findings of this research show that carrier-free strategy is more effective for continuous hydrolysis of starch and production of glucose.
Keywords	Aspergillus fumigatus ; activation energy ; ammonium sulfate ; crosslinking ; enzymes ; glucose ; glutaraldehyde ; hydrolysis ; pH ; starch ; temperature
Language	English
Dates of publication	2019-0815
Size	p. 1252-1260.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2018.11.097
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Article: Mycoremediation: a treatment for heavy metal-polluted soil using indigenous metallotolerant fungi

Khan, Ibrar / Aftab, Maryam / Ali, Madiha / Haleem, Kashif Syed / Qayyum, Sadia / Shakir, SajidUllah / Tauseef, Isfahan

Environmental monitoring and assessment. 2019 Oct., v. 191, no. 10

2019

Abstract: Bioleaching of heavy metals from industrial contaminated soil using metallotolerant fungi is the most efficient, cost-effective, and eco-friendly technique. In the current study, the contaminated soil samples from Hattar Industrial Estate revealed a ... ...

Abstract	Bioleaching of heavy metals from industrial contaminated soil using metallotolerant fungi is the most efficient, cost-effective, and eco-friendly technique. In the current study, the contaminated soil samples from Hattar Industrial Estate revealed a total lead (Pb) and mercury (Hg) concentration of 170.90 mg L−1 and 26.66 mg L−1, respectively. Indigenous metallotolerant fungal strains including Aspergillus niger M1, Aspergillus fumigatus M3, Aspergillus terreus M6, and Aspergillus flavus M7 were isolated and identified by pheno- and genotyping. A. fumigatus and A. flavus of soil sample S1 showed higher efficiency for Pb removal (99.20% and 99.30%, respectively), in SDB medium. Likewise, A. niger and A. terreus of soil sample S2 showed higher efficiency for Hg removal (96% and 95.50%, respectively), in YPG medium. Furthermore, the maximum uptake efficiency for Pb removal (8.52 mg g−1) from soil sample S1 was noticed for A. fumigatus in YPG medium, while the highest uptake efficiency (4.23 mg g−1) of A. flavus M2 strain was observed with CYE medium. Similarly, the maximum uptake efficiency of 0.41 mg g−1 and 0.44 mg g−1 for Hg removal from soil sample S2 was found for A. niger and A. terreus strains, respectively, in CYE medium. Thus, in order to address the major issue of industrial waste pollution, indigenous fungal strains A. fumigatus (M1) and A. terreus (M7), isolated in this study, could be used (ex situ or in situ) to remediate soils contaminated with Pb and Hg.
Keywords	Aspergillus flavus ; Aspergillus fumigatus ; Aspergillus niger ; Aspergillus terreus ; bioleaching ; cost effectiveness ; fungi ; genotyping ; heavy metals ; industrial wastes ; lead ; mercury ; polluted soils ; pollution ; soil sampling ; sustainable technology
Language	English
Dates of publication	2019-10
Size	p. 622.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-019-7781-9
Database	NAL-Catalogue (AGRICOLA)

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