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  1. Article ; Online: Post nirmatrelvir/ritonavir erythema multiforme in a patient with coronavirus disease infection.

    Tavares-Júnior, José Wagner Leonel / Pompeu Filho, José Carlos Jucá / Galvão, Luiz Eduardo Garcia

    Revista da Sociedade Brasileira de Medicina Tropical

    2023  Volume 56, Page(s) e0008

    Abstract: Erythema multiforme (EM), an immune-mediated skin condition, can occur after infection or following the use of medications. In this study, we describe a patient who developed EM after nirmatrelvir/ritonavir administration. An 81-year-old woman presented ... ...

    Abstract Erythema multiforme (EM), an immune-mediated skin condition, can occur after infection or following the use of medications. In this study, we describe a patient who developed EM after nirmatrelvir/ritonavir administration. An 81-year-old woman presented with fever and dyspnea. Laboratory investigations showed positive coronavirus disease (COVID-19) based on polymerase chain reaction assay, and she received a 5-day regimen of nirmatrelvir/ritonavir. We observed development of EM after this treatment and initiated prednisone (1 mg/kg) therapy, which led to rapid improvement. Our study is the first to report EM in a patient with COVID-19, who received nirmatrelvir/ritonavir and showed a favorable response.
    MeSH term(s) Female ; Humans ; Aged, 80 and over ; Ritonavir/adverse effects ; COVID-19 ; COVID-19 Drug Treatment ; Erythema Multiforme ; Antiviral Agents/therapeutic use
    Chemical Substances nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825) ; Antiviral Agents
    Language English
    Publishing date 2023-06-02
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0008-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cogan's sign in a patient with suspected post-COVID-19 vaccine-associated myasthenia gravis.

    Tavares-Júnior, José Wagner Leonel / Sobreira-Neto, Manoel Alves / Braga-Neto, Pedro

    Revista da Sociedade Brasileira de Medicina Tropical

    2023  Volume 56, Page(s) e0007

    Abstract: The Cogan's sign is indicative of myasthenia gravis. This is the first report of neurological signs in a patient with post-COVID-19 vaccine-associated myasthenia gravis in Brazil. In this case, a previously healthy 68-year-old woman presented with ... ...

    Abstract The Cogan's sign is indicative of myasthenia gravis. This is the first report of neurological signs in a patient with post-COVID-19 vaccine-associated myasthenia gravis in Brazil. In this case, a previously healthy 68-year-old woman presented with proximal limb weakness, left ptosis, and diplopia 1 month after receiving her fourth dose of the COVID-19 vaccine. Neurological examination revealed the presence of Cogan's sign, and she recovered rapidly after treatment. To our knowledge, this is the first reported case of myasthenia gravis associated with the COVID-19 vaccine in Brazil.
    MeSH term(s) Humans ; Female ; Aged ; COVID-19 Vaccines/adverse effects ; COVID-19/complications ; Myasthenia Gravis/chemically induced ; Myasthenia Gravis/diagnosis ; Myasthenia Gravis/complications ; Blepharoptosis/complications ; Blepharoptosis/diagnosis ; Blepharoptosis/drug therapy ; Diplopia/complications ; Diplopia/drug therapy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-06-02
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0007-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Isolated amoebic brain abscess with excellent therapeutic response

    Tavares-Junior José Wagner Leonel / Arnaldo Ribeiro de Arruda / Pablo Picasso de Araújo Coimbra

    Revista da Sociedade Brasileira de Medicina Tropical, Vol

    2022  Volume 55

    Keywords Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Medicina Tropical (SBMT)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Post Coronavirus Disease 2019 Vaccine-associated Acute Myeloradiculoneuropathy Responsive to Plasmapheresis.

    Tavares-Júnior, José Wagner Leonel / Coimbra, Pablo Picasso de Araújo / Braga-Neto, Pedro

    Revista da Sociedade Brasileira de Medicina Tropical

    2022  Volume 55, Page(s) e0015

    MeSH term(s) Acute Disease ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Humans ; Plasmapheresis
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-06-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0015-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Do

    Ciurleo, Gabriella C V / Tavares-Júnior, José Wagner Leonel / Vieira, Carlos Meton A G / Braga-Neto, Pedro / Oriá, Reinaldo B

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1229073

    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1229073
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  6. Article ; Online: Parinaud syndrome due to cofirmed neurotuberculosis in a lupus eritematosis systemic patient.

    Tavares-Júnior, José Wagner Leonel / Teles Júnior, José Newton / Magalhães, Samir Câmara / Cavalcante, Thiago Toscano / Coimbra, Pablo Picasso de Araújo / Luiz, Roberta Dos Santos Silva

    European journal of ophthalmology

    2022  Volume 33, Issue 4, Page(s) NP138–NP142

    Abstract: Introduction: This article aims to describe a patient with Parinaud syndrome due to neurotuberculosis confirmed by cerebrospinal fluid analysis.: Case report: Initially, patient sought medical care, performed a chest x-ray and later a chest CT scan, ... ...

    Abstract Introduction: This article aims to describe a patient with Parinaud syndrome due to neurotuberculosis confirmed by cerebrospinal fluid analysis.
    Case report: Initially, patient sought medical care, performed a chest x-ray and later a chest CT scan, with a probable diagnosis of miliary tuberculosis. In addition, she presented binocular diplopia worse at right lateral gaze, paresis of vertical gaze, light near-dissociation and convergent retraction nystagmus and presence of mycobacterium tuberculosis on PCR Xpert MTB/RIF. The treatment of miliary tuberculosis was interrupted due to pharmacodermia, but after diagnosis of neurotuberculosis, it was restarted with isoniazid, pyrazinamide and ethambutol with partial visual symptoms improvement.
    Discussion: This case demonstrates the importance of pursuing diagnosis through more accurate techniques, especially in a patient with previous treatment pharmacoderma, whose absence of proper diagnosis and treatment would be extremely deleterious.
    MeSH term(s) Female ; Humans ; Tuberculosis, Miliary ; Mycobacterium tuberculosis ; Isoniazid/therapeutic use ; Ethambutol/therapeutic use ; Ocular Motility Disorders ; Sensitivity and Specificity
    Chemical Substances Isoniazid (V83O1VOZ8L) ; Ethambutol (8G167061QZ)
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221098284
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    Zs.A 3342: Show issues Location:
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  7. Article: Diagnostic approach in a patient with Creutzfeldt-Jakob disease.

    Tavares-Júnior, José Wagner Leonel / Carvalho, Renata de Oliveira / Feitosa, Raul Raposo Pereira / Rolim, Flávia de Paiva Santos / Rocha, Felipe Araújo / Pitombeira, Milena Sales / Malveira, George Linard Silva / de Carvalho, João José Freitas / Frota, Norberto Anizio Ferreira / Dias, Daniel Aguiar

    Dementia & neuropsychologia

    2022  Volume 16, Issue 3, Page(s) 361–364

    Abstract: Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.: Objective: To describe the ... ...

    Abstract Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.
    Objective: To describe the diagnostic approach of a patient with Creutzfeldt-Jakob disease.
    Methods: The diagnosis is established through the clinical picture associated with characteristic changes in the brain magnetic resonance imaging, the electroencephalogram, and analysis of specific changes in the cerebrospinal fluid.
    Results: The present report describes the case of a 53-year-old patient in the city of Fortaleza-CE. The diagnosis was made based on the clinical condition and through diagnostic tests, including 14-3-3 protein and RT QUIC analysis. Differential diagnosis was performed with other rapidly progressive causes, such as infectious and immune-mediated diseases.
    Conclusions: The diagnosis of probable sporadic CJD was established.
    Language English
    Publishing date 2022-05-23
    Publishing country Brazil
    Document type Case Reports
    ISSN 1980-5764
    ISSN 1980-5764
    DOI 10.1590/1980-5764-DN-2021-0110
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  8. Article ; Online: Central hypersomnia and chronic insomnia: expanding the spectrum of sleep disorders in long COVID syndrome - a prospective cohort study.

    Moura, Alissa Elen Formiga / Oliveira, Danilo Nunes / Torres, Danielle Mesquista / Tavares-Júnior, José Wagner Leonel / Nóbrega, Paulo Ribeiro / Braga-Neto, Pedro / Sobreira-Neto, Manoel Alves

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 417

    Abstract: Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. ... ...

    Abstract Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. This syndrome can affect up to 32% of affected individuals, with symptoms of fatigue, dyspnea, chest pain, cognitive disorders, insomnia, and psychiatric disorders. The present study aimed to characterize and evaluate the prevalence of sleep symptoms in patients with long COVID syndrome.
    Methodology: A total of 207 patients with post-COVID symptoms were evaluated through clinical evaluation with a neurologist and specific exams in the subgroup complaining of excessive sleepiness.
    Results: Among 189 patients included in the long COVID sample, 48 (25.3%) had sleep-related symptoms. Insomnia was reported by 42 patients (22.2%), and excessive sleepiness (ES) was reported by 6 patients (3.17%). Four patients with ES were evaluated with polysomnography and test, multiple sleep latencies test, and actigraphic data. Two patients had a diagnosis of central hypersomnia, and one had narcolepsy. A history of steroid use was related to sleep complaints (insomnia and excessive sleepiness), whereas depression was related to excessive sleepiness. We observed a high prevalence of cognitive complaints in these patients.
    Conclusion: Complaints related to sleep, such as insomnia and excessive sleepiness, seem to be part of the clinical post-acute syndrome (long COVID syndrome), composing part of its clinical spectrum, relating to some clinical data.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Prospective Studies ; Sleepiness ; Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/epidemiology ; Sleep Wake Disorders/epidemiology ; Syndrome
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02940-7
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  9. Article ; Online: Hemorrhagic PRES: an unusual neurologic manifestation in two COVID-19 patients.

    Dias, Daniel Aguiar / de Brito, Lara Albuquerque / Neves, Luciana de Oliveira / Paiva, Roberto Guido Santos / Barbosa Júnior, Octávio Alencar / Tavares-Júnior, José Wagner Leonel

    Arquivos de neuro-psiquiatria

    2020  Volume 78, Issue 11, Page(s) 739–740

    MeSH term(s) COVID-19 ; Hemorrhage/etiology ; Humans ; Posterior Leukoencephalopathy Syndrome ; SARS-CoV-2
    Language English
    Publishing date 2020-12-16
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X20200184
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  10. Article: Cognitive Assessment Tools for Screening Older Adults With Low Levels of Education: A Critical Review.

    Tavares-Júnior, José Wagner Leonel / de Souza, Ana Célia Caetano / Alves, Gilberto Sousa / Bonfadini, Janine de Carvalho / Siqueira-Neto, José Ibiapina / Braga-Neto, Pedro

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 878

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2019-12-13
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00878
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