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Article ; Online: Perception of journal club seminars by medical doctoral students: results from five years of evaluation.

Taverna, Mara / Bucher, Julian Nicolaus / Weniger, Maximilian / Gropp, Roswitha / Lee, Serene M L / Mayer, Barbara / Werner, Jens / Bazhin, Alexandr V

GMS journal for medical education

2022 Volume 39, Issue 1, Page(s) Doc4

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Humans ; Perception ; Students, Medical ; Students, Pharmacy ; Surveys and Questionnaires
Language	English
Publishing date	2022-02-15
Publishing country	Germany
Document type	Journal Article
ISSN	2366-5017
ISSN (online)	2366-5017
DOI	10.3205/zma001525
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Survey on the Integration of Spiritual Care in Medical Schools from the German-Speaking Faculties.

Taverna, Mara / Berberat, Pascal O / Sattel, Heribert / Frick, Eckhard

Advances in medical education and practice

2019 Volume 10, Page(s) 1009–1019

Abstract: Objective: Teaching about spirituality and health is recommended by the American Association of Medical Colleges and partially implemented in some US medical schools as well as in some faculties of other countries. We systematically surveyed Medical ... ...

Abstract	Objective: Teaching about spirituality and health is recommended by the American Association of Medical Colleges and partially implemented in some US medical schools as well as in some faculties of other countries. We systematically surveyed Medical School Associate Deans for Student Affairs (ADSAs) in three German-speaking countries, assessing both projects on and attitudes towards Spiritual Care (SC) and the extent to which it is addressed in undergraduate (UME), graduate (GME), and continuing (CME) medical education (in this article, UME is understood as the complete basic medical education equivalent to college and Medical School. GME refers to the time of residency). Methods: We executed a cross-sectional qualitative complete online-survey, addressing ADSAs of all accredited 46 medical schools in these countries. Anonymized responses could be analyzed from 25 (54.3%). Results: No faculty provides a mandatory course exclusively dedicated to SC. Fourteen medical schools have UME courses or contents on SC, and 9 incorporate SC in mandatory classes addressing other topics. While most of the respondents indicate that spirituality is important for (a) the patients for coping and (b) for health care in general and thus, support the teaching of SC in UME, only half of them indicate a need for an SC curriculum in UME. Even if funding and training support were available, only a few of the respondents would agree to provide more of the sparse curricular time. Conclusion: A majority of the participating medical schools have curricular content on SC, predominantly in UME. However, most of the content is based on voluntary courses. Despite acknowledging its importance to patients, ADSAs and medical teachers are still reflecting on the divergences in patients' and doctors' spiritual orientations and its consequences for implementing spirituality into the medical education.
Language	English
Publishing date	2019-12-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2578539-4
ISSN	1179-7258
ISSN	1179-7258
DOI	10.2147/AMEP.S224679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Detection of the Alzheimer's disease soluble amyloid precursor protein and modulation of its proteolytic processing

Taverna, Mara / Lichtenthaler, Stefan

2014

Author's details	Mara Taverna. Betreuer: Stefan Lichtenthaler
Language	English
Size	Online-Ressource
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	München, Ludwig-Maximilians-Universität, Diss., 2014
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Perception of journal club seminars by medical doctoral students

Taverna, Mara / Bucher, Julian Nicolaus / Weniger, Maximilian / Gropp, Roswitha / Lee, Serene M. L. / Mayer, Barbara / Werner, Jens / Bazhin, Alexandr V.

GMS Journal for Medical Education, Vol 39, Iss 1, p Doc

results from five years of evaluation

2022 Volume 4

Abstract: Objectives: A journal club is one of the well-established and popular methods of post-graduate education. In this work, we were interested to understand how the participants perceive journal club as a whole and how they evaluate their personal process of ...

Abstract	Objectives: A journal club is one of the well-established and popular methods of post-graduate education. In this work, we were interested to understand how the participants perceive journal club as a whole and how they evaluate their personal process of acquiring new scientific knowledge and development of soft-skills as an indispensable prerequisite of the lifelong learning.Project description: This study is a survey analysis examining perception of journal club sessions by post-graduate medical students. A checklist for journal club preparation as well as a questionnaire for evaluation of the journal club session by participants has been developed to determine if the journal club had met its aims. Data were collected by summing up all answers to each question of the questionnaire for each session. Qualitative data from a five-year evaluation period were compiled and analyzed. Results: The journal club checklist served as a guideline for the preparation of a journal club session as well as an evaluation questionnaire containing 24 items. Our work presents evidence that journal club seminars are well perceived by participants. Furthermore, a high percentage of participants deemed the working atmosphere to be constructive and found it worthwhile to participate in the sessions. The topics of the presentations have been positively evaluated, however only a minority of participants found that the topics of the journal club was related to their own specific research topic. Concerning the distribution of the journal article, we could show that distributing the paper one week before the journal club event provided sufficient time for preparation. Our evaluation revealed that two-thirds of the participants found discussions during journal club sessions rich and productive. The motivation to think more critically increased during journal club sessions. From our work, it is evident that the participants perceived the speakers´ soft-skills to have improved with the practice. Finally, we show a clear trend of improved ...
Keywords	journal club ; research paper ; critical thinking ; post-graduate education ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	050
Language	German
Publishing date	2022-02-01T00:00:00Z
Publisher	German Medical Science GMS Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perception of journal club seminars by medical doctoral students: results from five years of evaluation

Taverna, Mara / Bucher, Julian Nicolaus / Weniger, Maximilian / Gropp, Roswitha / Lee, Serene M. L. / Mayer, Barbara / Werner, Jens / Bazhin, Alexandr V.

GMS Journal for Medical Education

2022 Volume 39, Issue 1, Page(s) 4

Abstract: Zielsetzung: Journal Clubs sind eine etablierte und weit verbreitete Methode der Postgraduiertenausbildung. Das Ziel dieser Arbeit war es zu untersuchen, wie die Teilnehmenden Journal Clubs insgesamt wahrnehmen und wie sie ihren persönlichen Prozess der ...

Title translation	Wahrnehmung von Journal-Club-Seminaren durch medizinische Promotionsstudierende: Ergebnisse aus fünf Jahren Evaluation
Abstract	Zielsetzung: Journal Clubs sind eine etablierte und weit verbreitete Methode der Postgraduiertenausbildung. Das Ziel dieser Arbeit war es zu untersuchen, wie die Teilnehmenden Journal Clubs insgesamt wahrnehmen und wie sie ihren persönlichen Prozess der Aneignung neuen wissenschaftlichen Wissens sowie die Entwicklung ihrer Soft Skills als unverzichtbare Voraussetzung für lebenslanges Lernen bewerten. Projektbeschreibung: Bei dieser Studie handelt es sich um eine Befragungsauswertung zur Untersuchung der Wahrnehmung von Journal-Club-Seminaren durch medizinische Promotionsstudierende. Dazu wurden eine Checkliste für die Vorbereitung von Journal Clubs sowie ein Fragebogen für die Evaluation der Journal-Club-Sitzung durch die Teilnehmenden erarbeitet, um zu ermitteln, ob die Ziele des Journal Clubs erreicht wurden. Die Daten wurden durch Zusammenfassung aller Antworten auf jede Frage des Fragebogens für jede Sitzung erhoben. Qualitative Daten aus einem fünfjährigen Evaluationszeitraum wurden zusammengeführt und ausgewertet. Ergebnisse: Die Journal-Club-Checkliste diente bei der Vorbereitung der Journal-Club-Sitzungen sowie des Evaluationsfragebogens mit 24 Items als Leitfaden. Diese Arbeit liefert Belege dafür, dass Journal-Club-Seminare von den Teilnehmenden positiv wahrgenommen werden. Darüber hinaus empfand ein hoher Prozentsatz der Teilnehmenden die Arbeitsatmosphäre als konstruktiv und die Teilnahme an den Sitzungen als wertvoll. Die Themen der Präsentationen wurden positiv bewertet, auch wenn nur wenige Teilnehmende angaben, dass die Themen des Journal Club Bezug zu ihrem eigenen spezifischen Forschungsthema hatten. Es konnte gezeigt werden, dass eine Verteilung des Zeitschriftenartikels eine Woche vor der Journal-Club-Sitzung ausreichend Zeit zur Vorbereitung bot. Die Auswertung ergab, dass zwei Drittel der Teilnehmenden die Diskussionen während der Sitzungen bereichernd und fruchtbar fanden. Die Motivation für kritischeres Denken stieg während der Journal-Club-Sitzungen. Gestützt auf diese Arbeit ist es evident, dass sich die Soft Skills der Vortragenden in der Wahrnehmung der Teilnehmenden mit zunehmender Übung verbesserten. Schließlich konnte ein eindeutiger positiver Trend bei der Wahrnehmung des Nutzens von Journal-Club-Sitzungen vom Beginn bis zum Ende des Evaluationszeitraums nachgewiesen werden. Schlussfolgerung: Auf Grundlage der ausgewerteten Evaluationen kann geschlussfolgert werden, dass Journal-Club-Seminare von den Teilnehmenden sehr geschätzt werden und eine sinnvolle Möglichkeit für die Entwicklung bestimmter Soft Skills sind. ; Objectives: A journal club is one of the well-established and popular methods of post-graduate education. In this work, we were interested to understand how the participants perceive journal club as a whole and how they evaluate their personal process of acquiring new scientific knowledge and development of soft-skills as an indispensable prerequisite of the lifelong learning. Project description: This study is a survey analysis examining perception of journal club sessions by post-graduate medical students. A checklist for journal club preparation as well as a questionnaire for evaluation of the journal club session by participants has been developed to determine if the journal club had met its aims. Data were collected by summing up all answers to each question of the questionnaire for each session. Qualitative data from a five-year evaluation period were compiled and analyzed. Results: The journal club checklist served as a guideline for the preparation of a journal club session as well as an evaluation questionnaire containing 24 items. Our work presents evidence that journal club seminars are well perceived by participants. Furthermore, a high percentage of participants deemed the working atmosphere to be constructive and found it worthwhile to participate in the sessions. The topics of the presentations have been positively evaluated, however only a minority of participants found that the topics of the journal club was related to their own specific research topic. Concerning the distribution of the journal article, we could show that distributing the paper one week before the journal club event provided sufficient time for preparation. Our evaluation revealed that two-thirds of the participants found discussions during journal club sessions rich and productive. The motivation to think more critically increased during journal club sessions. From our work, it is evident that the participants perceived the speakers´ soft-skills to have improved with the practice. Finally, we show a clear trend of improved perception of the value of journal club sessions from beginning to the end of the evaluation time. Conclusion: Based on the analyzed evaluations, we can conclude that journal club events are highly valued by participants and could be a good option for the development of certain soft-skills.
Keywords	Medizin, Gesundheit ; journal club ; research paper ; critical thinking ; post-graduate education ; Journal Club ; Forschungsarbeit ; kritisches Denken ; Postgraduiertenausbildung ; journal clubs ; Journal Clubs
Publishing date	2022-02-15
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Article ; Online
ISSN	2366-5017
ISSN (online)	2366-5017
DOI	10.3205/zma001525
Database	German Medical Science

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Book ; Online ; Thesis: Detection of the Alzheimer's disease soluble amyloid precursor protein and modulation of its proteolytic processing

Taverna, Mara [Verfasser] / Lichtenthaler, Stefan [Akademischer Betreuer]

2014

Author's details	Mara Taverna. Betreuer: Stefan Lichtenthaler
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Gesund durch die Erkältungssaison.

Offenbächer, Martin / Weber, Annemarie / van Dyck, Marcus / Taverna, Mara / Stahler, Arndt / Kohls, Niko / Schelling, Jörg

MMW Fortschritte der Medizin

2017 Volume 159, Issue 1, Page(s) 43–47

Title translation	Protection against common cold.
MeSH term(s)	Common Cold/prevention & control ; Humans
Language	German
Publishing date	2017-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478211-x
ISSN	1438-3276
ISSN	1438-3276
DOI	10.1007/s15006-017-9159-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A new sandwich immunoassay for detection of the α-secretase cleaved, soluble amyloid-β protein precursor in cerebrospinal fluid and serum.

Taverna, Mara / Straub, Tobias / Hampel, Harald / Rujescu, Dan / Lichtenthaler, Stefan F

Journal of Alzheimer's disease : JAD

2013 Volume 37, Issue 4, Page(s) 667–678

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Frequently used diagnostic biomarkers are amyloid-β42 (Aβ42), tau, and phospho-tau, which are measured in cerebrospinal fluid (CSF), and allow a reasonable, but not full, separation ... ...

Abstract	Alzheimer's disease (AD) is the most common neurodegenerative disorder. Frequently used diagnostic biomarkers are amyloid-β42 (Aβ42), tau, and phospho-tau, which are measured in cerebrospinal fluid (CSF), and allow a reasonable, but not full, separation of AD patients and controls. Besides Aβ42, additional proteolytic cleavage products of the amyloid-β protein precursor (AβPP) have been investigated as potential biomarkers. This includes the α-secretase cleaved soluble AβPP ectodomain (sAβPPα). However, some studies found a reduction of sAβPPα, whereas other studies reported an increase of sAβPPα in the CSF of AD patients. The divergent findings may result from the detection of sAβPPα with antibodies, such as 6E10, which do not exclusively detect sAβPPα, but also the alternative β-secretase cleavage product sAβPPβ'. Here, we used the sAβPPα-specific antibody 14D6 and developed an ELISA-like sandwich immunoassay. The assay specifically detected sAβPPα in cell culture supernatants, in human CSF and even in serum, which is more readily accessible than CSF. The assay was used to analyze sAβPPα levels in CSF and serum of AD patients and controls. The assay detected a mild, but significant increase in sAβPPα in the CSF of AD patients compared to non-demented controls, while a mild reduction was observed in serum. The 14D6 assay in CSF allowed a better separation of AD patients from controls compared to the 6E10 antibody. Taken together, the new assay is widely applicable for specific sAβPPα measurement in culture media, CSF, and serum.
MeSH term(s)	Amino Acid Sequence ; Amyloid Precursor Protein Secretases/blood ; Amyloid Precursor Protein Secretases/cerebrospinal fluid ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/blood ; Amyloid beta-Protein Precursor/cerebrospinal fluid ; Amyloid beta-Protein Precursor/genetics ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Cell Line, Tumor ; Enzyme-Linked Immunosorbent Assay/trends ; Female ; Humans ; Male ; Molecular Sequence Data ; Registries
Chemical Substances	Amyloid beta-Protein Precursor ; Biomarkers ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2013
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-130509
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Conference proceedings: Entwicklung, Implementierung und Evaluation eines Blended-Learning-Szenarios im Sinne der Inverted-Classroom-Methode

Vogel, Barbara / Bischoff, Thomas / Tolks, Daniel / Taverna, Mara / Schelling, Jörg / Oberprieler, Günter / Fischer, Martin R.

2016 , Page(s) P13–560

Event/congress	Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA); Bern; 2016
Keywords	Medizin, Gesundheit
Publishing date	2016-09-05
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/16gma204
Database	German Medical Science

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Article ; Online: ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

Moss, Marcia L / Powell, Gary / Miller, Miles A / Edwards, Lori / Qi, Bin / Sang, Qing-Xiang Amy / De Strooper, Bart / Tesseur, Ina / Lichtenthaler, Stefan F / Taverna, Mara / Zhong, Julia Li / Dingwall, Colin / Ferdous, Taheera / Schlomann, Uwe / Zhou, Pei / Griffith, Linda G / Lauffenburger, Douglas A / Petrovich, Robert / Bartsch, Jörg W

The Journal of biological chemistry

2011 Volume 286, Issue 47, Page(s) 40443–40451

Abstract: Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24-204), expressed and characterized from ...

Abstract	Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24-204), expressed and characterized from Escherichia coli, is a competitive inhibitor of human ADAM9 catalytic/disintegrin domain with an overall inhibition constant of 280 ± 34 nM and high specificity toward ADAM9. In SY5Y neuroblastoma cells overexpressing amyloid precursor protein, proA9 treatment reduces the amount of endogenous ADAM10 enzyme in the medium while increasing membrane-bound ADAM10, as shown both by Western and activity assays with selective fluorescent peptide substrates using proteolytic activity matrix analysis. An increase in membrane-bound ADAM10 generates higher levels of soluble amyloid precursor protein α in the medium, whereas soluble amyloid precursor protein β levels are decreased, demonstrating that inhibition of ADAM9 increases α-secretase activity on the cell membrane. Quantification of physiological ADAM10 substrates by a proteomic approach revealed that substrates, such as epidermal growth factor (EGF), HER2, osteoactivin, and CD40-ligand, are increased in the medium of BT474 breast tumor cells that were incubated with proA9, demonstrating that the regulation of ADAM10 by ADAM9 applies for many ADAM10 substrates. Taken together, our results demonstrate that ADAM10 activity is regulated by inhibition of ADAM9, and this regulation may be used to control shedding of amyloid precursor protein by enhancing α-secretase activity, a key regulatory step in the etiology of Alzheimer disease.
MeSH term(s)	ADAM Proteins/antagonists & inhibitors ; ADAM Proteins/chemistry ; ADAM Proteins/metabolism ; ADAM10 Protein ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Biocatalysis/drug effects ; Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/enzymology ; Cell Membrane/metabolism ; Humans ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Peptide Fragments/pharmacology ; Protease Inhibitors/pharmacology ; Protein Array Analysis ; Protein Structure, Tertiary
Chemical Substances	Amyloid beta-Protein Precursor ; Membrane Proteins ; Peptide Fragments ; Protease Inhibitors ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM Proteins (EC 3.4.24.-) ; ADAM9 protein, human (EC 3.4.24.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81)
Language	English
Publishing date	2011-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M111.280495
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