Article ; Online: Web interface for 3D visualization and analysis of SARS-CoV-2-human mimicry and interactions.
Bioinformatics (Oxford, England)
2021
Abstract: Summary: We present a web-based server for navigating and visualizing possible interactions between SARS-CoV-2 and human host proteins. The interactions are obtained from HMI_Pred which relies on the rationale that virus proteins mimic host proteins. ... ...
| Abstract | Summary: We present a web-based server for navigating and visualizing possible interactions between SARS-CoV-2 and human host proteins. The interactions are obtained from HMI_Pred which relies on the rationale that virus proteins mimic host proteins. The structural alignment of the viral protein with one side of the human protein-protein interface determines the mimicry. The mimicked human proteins and predicted interactions, and the binding sites are presented. The user can choose one of the 18 SARS-CoV-2 protein structures and visualize the potential 3D complexes it forms with human proteins. The mimicked interface is also provided. The user can superimpose two interacting human proteins in order to see whether they bind to the same site or different sites on the viral protein. The server also tabulates all available mimicked interactions together with their match scores and number of aligned residues. This is the first server listing and cataloging all interactions between SARS-CoV-2 and human protein structures, enabled by our innovative interface mimicry strategy. Availability: The server is available at https://interactome.ku.edu.tr/sars/. |
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| Language | English | |||||
| Publishing date | 2021-12-02 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1422668-6 | |||||
| ISSN | 1367-4811 ; 1367-4803 | |||||
| ISSN (online) | 1367-4811 | |||||
| ISSN | 1367-4803 | |||||
| DOI | 10.1093/bioinformatics/btab799 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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