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  1. Article ; Online: The LIV-1 Subfamily of Zinc Transporters: From Origins to Present Day Discoveries.

    Taylor, Kathryn M

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: This review explains the origin of the LIV-1 family of zinc transporters, paying attention to how this family of nine human proteins was originally discovered. Structural and functional differences between these nine human LIV-1 family members and the ... ...

    Abstract This review explains the origin of the LIV-1 family of zinc transporters, paying attention to how this family of nine human proteins was originally discovered. Structural and functional differences between these nine human LIV-1 family members and the five other ZIP transporters are examined. These differences are both related to aspects of the protein sequence, the conservation of important motifs and to the effect this may have on their overall function. The LIV-1 family are dependent on various post-translational modifications, such as phosphorylation and cleavage, which play an important role in their ability to transport zinc. These modifications and their implications are discussed in detail. Some of these proteins have been implicated in cancer which is examined. Furthermore, some additional areas of potential fruitful discovery are discussed and suggested as worthy of examination in the future.
    MeSH term(s) Humans ; Carrier Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Zinc/metabolism ; Amino Acid Sequence
    Chemical Substances zinc-binding protein ; Carrier Proteins ; Membrane Transport Proteins ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021255
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  2. Article: Enabling patients with learning disabilities to self-manage lower limb lymphoedema.

    Taylor, Kathryn

    British journal of nursing (Mark Allen Publishing)

    2021  Volume 30, Issue 13, Page(s) 820–821

    Abstract: ... Kathryn ... ...

    Abstract Kathryn Taylor
    MeSH term(s) Humans ; Learning Disabilities/nursing ; Lower Extremity ; Lymphedema/therapy ; Nurse-Patient Relations ; Self-Management
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2021.30.13.820
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3449: Show issues Location:
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  3. Article ; Online: Neuron-oligodendroglial interactions in health and malignant disease.

    Taylor, Kathryn R / Monje, Michelle

    Nature reviews. Neuroscience

    2023  Volume 24, Issue 12, Page(s) 733–746

    Abstract: Experience sculpts brain structure and function. Activity-dependent modulation of the myelinated infrastructure of the nervous system has emerged as a dimension of adaptive change during childhood development and in adulthood. Myelination is a richly ... ...

    Abstract Experience sculpts brain structure and function. Activity-dependent modulation of the myelinated infrastructure of the nervous system has emerged as a dimension of adaptive change during childhood development and in adulthood. Myelination is a richly dynamic process, with neuronal activity regulating oligodendrocyte precursor cell proliferation, oligodendrogenesis and myelin structural changes in some axonal subtypes and in some regions of the nervous system. This myelin plasticity and consequent changes to conduction velocity and circuit dynamics can powerfully influence neurological functions, including learning and memory. Conversely, disruption of the mechanisms mediating adaptive myelination can contribute to cognitive impairment. The robust effects of neuronal activity on normal oligodendroglial precursor cells, a putative cellular origin for many forms of glioma, indicates that dysregulated or 'hijacked' mechanisms of myelin plasticity could similarly promote growth in this devastating group of brain cancers. Indeed, neuronal activity promotes the pathogenesis of many forms of glioma in preclinical models through activity-regulated paracrine factors and direct neuron-to-glioma synapses. This synaptic integration of glioma into neural circuits is central to tumour growth and invasion. Thus, not only do neuron-oligodendroglial interactions modulate neural circuit structure and function in the healthy brain, but neuron-glioma interactions also have important roles in the pathogenesis of glial malignancies.
    MeSH term(s) Humans ; Neurons/physiology ; Oligodendroglia/physiology ; Myelin Sheath/physiology ; Neuroglia/physiology ; Glioma
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00744-3
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  4. Article ; Online: Al-Manshiyya

    Taylor Kathryn Miller

    Urban Transcripts, Vol 3, Iss

    Bordering and spatializations of difference on the vanishing Palestinian coastline

    2020  Volume 3

    Abstract: Walking north along the Homat HaYam Promenade in Jaffa, the entire Tel Aviv skyline comes into view with Mediterranean waves crashing against the old port’s walls. Families with young babies pause for pictures, bronzed 20-somethings play matkot (a ... ...

    Abstract Walking north along the Homat HaYam Promenade in Jaffa, the entire Tel Aviv skyline comes into view with Mediterranean waves crashing against the old port’s walls. Families with young babies pause for pictures, bronzed 20-somethings play matkot (a popular paddle ball game similar to beach tennis) on the sand, and the occasional vendor hawking ice cream or drinks passes by. To the uncritical tourist eye, this is a veritable paradise; perfect weather, warm sand and cosmopolitan pleasures abound. But what these seaside vignettes of leisure and decadence omit is the historicity of the al-Manshiyya neighborhood upon which these spaces are built, as well as the ongoing dispossession of Palestinians in greater Tel Aviv. Consecutive eras of Zionist colonialism since the late 19th and early 20th century in this coastal city are generative of physical and psychic bordering through present day. The Hassan Bek mosque, Charles Clore Park and the Etzel Museum, all situated in what was historically al-Manshiyya, serve as sites to anchor this understanding of negation and erasure.
    Keywords jaffa ; palestine ; israel ; al-manshiyya ; tel aviv ; zionism ; dispossession ; occupation ; borders ; practice-based research ; land ; Cities. Urban geography ; GF125
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Urban Transcripts
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Interval forecasts of weekly incident and cumulative COVID-19 mortality in the United States: A comparison of combining methods.

    Taylor, Kathryn S / Taylor, James W

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0266096

    Abstract: Background: A combined forecast from multiple models is typically more accurate than an individual forecast, but there are few examples of studies of combining in infectious disease forecasting. We investigated the accuracy of different ways of ... ...

    Abstract Background: A combined forecast from multiple models is typically more accurate than an individual forecast, but there are few examples of studies of combining in infectious disease forecasting. We investigated the accuracy of different ways of combining interval forecasts of weekly incident and cumulative coronavirus disease-2019 (COVID-19) mortality.
    Methods: We considered weekly interval forecasts, for 1- to 4-week prediction horizons, with out-of-sample periods of approximately 18 months ending on 8 January 2022, for multiple locations in the United States, using data from the COVID-19 Forecast Hub. Our comparison involved simple and more complex combining methods, including methods that involve trimming outliers or performance-based weights. Prediction accuracy was evaluated using interval scores, weighted interval scores, skill scores, ranks, and reliability diagrams.
    Results: The weighted inverse score and median combining methods performed best for forecasts of incident deaths. Overall, the leading inverse score method was 12% better than the mean benchmark method in forecasting the 95% interval and, considering all interval forecasts, the median was 7% better than the mean. Overall, the median was the most accurate method for forecasts of cumulative deaths. Compared to the mean, the median's accuracy was 65% better in forecasting the 95% interval, and 43% better considering all interval forecasts. For all combining methods except the median, combining forecasts from only compartmental models produced better forecasts than combining forecasts from all models.
    Conclusions: Combining forecasts can improve the contribution of probabilistic forecasting to health policy decision making during epidemics. The relative performance of combining methods depends on the extent of outliers and the type of models in the combination. The median combination has the advantage of being robust to outlying forecasts. Our results support the Hub's use of the median and we recommend further investigation into the use of weighted methods.
    MeSH term(s) COVID-19/epidemiology ; Forecasting ; Humans ; Reproducibility of Results ; United States/epidemiology
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0266096
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  6. Article ; Online: Invasive glioma cells: The malignant pioneers that follow the current.

    Taylor, Kathryn R / Monje, Michelle

    Cell

    2022  Volume 185, Issue 16, Page(s) 2846–2848

    Abstract: Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of ... ...

    Abstract Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of glioblastoma interactions with neural circuits, demonstrating that conduction of electrochemical signals via neuron-to-glioma synapses drives glioma invasion.
    MeSH term(s) Brain Neoplasms/pathology ; Cell Line, Tumor ; Glioblastoma/pathology ; Glioma/pathology ; Humans ; Neoplasm Invasiveness/pathology ; Neurons/pathology
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
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  7. Article ; Online: Transition to Medicare Does Not Contribute to Rise in Outpatient Visits for Nonmelanoma Skin Cancer, Actinic Keratosis, or Actinic Cheilitis in the US Population.

    Taylor, Kathryn M E / Woodie, Brad / Neltner, Scott A / Fleischer, Alan B

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2024  

    Abstract: Background: Outpatient visits for nonmelanoma skin cancer (NMSC) and actinic keratoses (AK) have risen steadily in the United States, notably among Medicare beneficiaries. Individuals may delay seeking care for minimally symptomatic conditions until ... ...

    Abstract Background: Outpatient visits for nonmelanoma skin cancer (NMSC) and actinic keratoses (AK) have risen steadily in the United States, notably among Medicare beneficiaries. Individuals may delay seeking care for minimally symptomatic conditions until they qualify for Medicare coverage, indicating potential delay of nonurgent screening interventions for uninsured or underinsured patients younger than 65 years.
    Objective: This study investigates whether an atypical increase in outpatient visits for NMSC, AK, or actinic cheilitis (AC) occurs at the age of Medicare transition by utilizing the National Ambulatory Care Survey from 1993 to 2019.
    Materials and methods: The National Ambulatory Care Survey data were analyzed for patients aged within 5 years of 65 years. Diagnoses were identified using International Classification of Diseases codes. Linear regression and outlier detection were used to identify a relationship between Medicare eligibility and outpatient visits for NMSC and AK/AC.
    Results: Predicted visits for AK/AC and NMSC increased with age. However, there was no evidence of a disproportionate increase in outpatient visits for NMSC and AK/AC at the age of Medicare eligibility.
    Conclusion: Outside evidence indicates health care utilization increases after Medicare transition. This study's data do not support a corresponding rise in outpatient visits for NMSC and AK/AC at the age of Medicare eligibility.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000004217
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    Zs.A 1212: Show issues Location:
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  8. Article ; Online: Invasive glioma cells: The malignant pioneers that follow the current

    Taylor, Kathryn R. / Monje, Michelle

    Cell. 2022 Aug., v. 185, no. 16 p.2846-2848

    2022  

    Abstract: Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of ... ...

    Abstract Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of glioblastoma interactions with neural circuits, demonstrating that conduction of electrochemical signals via neuron-to-glioma synapses drives glioma invasion.
    Keywords brain ; brain neoplasms ; electrochemistry ; glioblastoma
    Language English
    Dates of publication 2022-08
    Size p. 2846-2848.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.033
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Methods to visualise zinc transporter proteins of the SLC39A family in cells.

    Farr, Georgia / Jones, Samuel / Taylor, Kathryn M

    Methods in enzymology

    2023  Volume 687, Page(s) 67–85

    Abstract: Zinc is essential to many important biological processes and the SLC39A family of zinc transporters which help to control zinc levels in cells, are increasingly being implicated in disease states. In order to determine their exact roles in these ... ...

    Abstract Zinc is essential to many important biological processes and the SLC39A family of zinc transporters which help to control zinc levels in cells, are increasingly being implicated in disease states. In order to determine their exact roles in these processes, reliable methods for their successful production are now required. Unfortunately, extensive post-translational modification and temporally specific activation makes visualisation of ZIP family transporters difficult. As such, modifications of common molecular cell biology techniques are necessary to maximise success when studying these proteins. These include zinc stimulation and nocodazole synchronisation to enhance the activation of ZIP7 and ZIP6/ZIP10, respectively. Maximal ZIP6/ZIP10 retention can also be achieved through careful handling of loosely adhered mitotic fractions when harvesting cell cultures for lysis. Transfection can also be used to enhance ZIP visualisation, however consideration of transfection periods and inclusion of sodium butyrate are recommended to enhance transfection efficiency. When probing for ZIP family transporters, we recommend that epitope choice considers post-translational cleavage and phosphorylated protein isoforms. Finally, where expression of a particular ZIP transporter is manipulated, researchers should consider parallel evaluation of related ZIP transporter expression, to account for transporter compensation.
    MeSH term(s) Cation Transport Proteins/genetics ; Endoplasmic Reticulum ; Zinc ; Butyric Acid
    Chemical Substances zinc-binding protein ; Cation Transport Proteins ; Zinc (J41CSQ7QDS) ; Butyric Acid (107-92-6)
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Toward Antiracist Reimbursement Policy in End-Stage Kidney Disease: From Equality to Equity.

    Taylor, Kathryn / Crews, Deidra C

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 10, Page(s) 2422–2424

    MeSH term(s) Black or African American/statistics & numerical data ; Ambulatory Care Facilities/economics ; Humans ; Insurance, Health, Reimbursement ; Kidney Failure, Chronic/economics ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/therapy ; Medicaid ; Medicare ; Neighborhood Characteristics/statistics & numerical data ; Racism ; Renal Dialysis/economics ; United States ; Value-Based Health Insurance ; White People/statistics & numerical data
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021020189
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