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Article ; Online: We Grieve Too.

Taylor, Mallory R

2023 Volume 330, Issue 21, Page(s) 2055–2056

MeSH term(s)	Emotions ; Grief ; Guilt ; Shame
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2023.23193
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Article ; Online: Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.

Taylor, Mallory R / Garrison, Michelle M / Rosenberg, Abby R

PloS one

2021 Volume 16, Issue 11, Page(s) e0259385

Abstract: Background: Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer.: Methods: This was a secondary analysis of ... ...

Abstract	Background: Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer. Methods: This was a secondary analysis of baseline data from a randomized trial testing a resilience intervention in AYAs with cancer. Two widely used HRV metrics, the standard deviation of normal to normal beats (SDNN) and root mean square of successive differences (RMSSD), were derived from electrocardiograms. Patient-reported outcome (PRO) survey measures included quality of life, anxiety, depression, distress, and resilience. Linear regression models were used to test associations between HRV and PRO scores. The Wilcoxon rank sum test was used to test differences in median HRV values among participant subgroups. Results: Among the n = 76 patients with available electrocardiograms, the mean age was 16 years (SD 3y), 63% were white, and leukemia/lymphoma was the most common diagnosis. Compared to healthy adolescents, AYAs with cancer had lower median HRV (SDNN [Females: 31.9 (12.8-50.7) vs 66.4 (46.0-86.8), p<0.01; Males: 29.9 (11.5-47.9) vs 63.2 (48.4-84.6), p<0.01]; RMSSD [Females: 28.2 (11.1-45.5) vs 69.0 (49.1-99.6), p<0.01; Males: 27.9 (8.6-48.6) vs 58.7 (44.8-88.2), p<0.01]). There was no statistically significant association between PRO measures and SDNN or RMSSD in either an unadjusted or adjusted linear regression models. Conclusion: In this secondary analysis, we did not find an association between HRV and psychosocial PROs among AYAs with cancer. HRV measures were lower than for healthy adolescents. Larger prospective studies in AYA biopsychosocial research are needed.
MeSH term(s)	Adolescent ; Adult ; Anxiety/etiology ; Anxiety/physiopathology ; Cross-Sectional Studies ; Depression/etiology ; Depression/physiopathology ; Electrocardiography ; Female ; Heart Rate ; Humans ; Male ; Neoplasms/physiopathology ; Neoplasms/psychology ; Patient Reported Outcome Measures ; Prospective Studies ; Psychological Distress ; Quality of Life/psychology ; Randomized Controlled Trials as Topic ; Research Design ; Resilience, Psychological ; Young Adult
Language	English
Publishing date	2021-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259385
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Article ; Online: The biology of stress in cancer: Applying the biobehavioral framework to adolescent and young adult oncology research.

Taylor, Mallory R / Knight, Jennifer M / Rosenberg, Abby R

Brain, behavior, & immunity - health

2021 Volume 17, Page(s) 100321

Abstract: The stress response influences the development and trajectory of cancer through a host of complex neuroimmune mechanisms. Basic, translational, and clinical research has elucidated these biobehavioral connections and offers a new paradigm for scientific ... ...

Abstract	The stress response influences the development and trajectory of cancer through a host of complex neuroimmune mechanisms. Basic, translational, and clinical research has elucidated these biobehavioral connections and offers a new paradigm for scientific investigation and patient care. Using a biobehavioral approach could offer new diagnostic and therapeutic opportunities in oncology, and this approach will be particularly impactful for adolescent and young adult (AYA) patients with cancer. To date, nearly all biobehavioral oncology research has been done in the adult population. And yet, AYAs have traditionally poorer mental health and cancer-related outcomes, and thus represent a population that could benefit from parallel psychosocial and biomedical intervention. Future biobehavioral work in oncology should focus on the AYA population, integrating new cancer therapies and technology into the next generation of research.
Language	English
Publishing date	2021-08-17
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2021.100321
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Article ; Online: Objectifying the Subjective: The Use of Heart Rate Variability as a Psychosocial Symptom Biomarker in Hospice and Palliative Care Research.

Taylor, Mallory R / Scott, Samantha R / Steineck, Angela / Rosenberg, Abby R

Journal of pain and symptom management

2021 Volume 62, Issue 3, Page(s) e315–e321

Abstract: Measuring psychosocial symptoms in hospice and palliative care research is critical to understanding the patient and caregiver experience. Subjective patient-reported outcome tools have been the primary method for collecting these data in palliative care, ...

Abstract	Measuring psychosocial symptoms in hospice and palliative care research is critical to understanding the patient and caregiver experience. Subjective patient-reported outcome tools have been the primary method for collecting these data in palliative care, and the growing field of biobehavioral research offers new tools that could deepen our understanding of psychosocial symptomatology. Here we describe one psychosocial biomarker, heart rate variability (HRV), and simple techniques for measurement in an adolescent and young adult cancer population that are applicable to palliative care studies. Complementing self-reported measures with objective biomarkers like HRV could facilitate a more nuanced understanding of physiologic and perceived well-being in patients with serious or life-limiting illness and inform future "precision supportive care" in hospice and palliative medicine.
MeSH term(s)	Adolescent ; Biomarkers ; Heart Rate ; Hospice Care ; Hospices ; Humans ; Palliative Care ; Young Adult
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2021.04.015
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Article: Correction to: Congenital pleuropulmonary blastoma in a newborn with a variant of uncertain significance in DICER1 evaluated by RNA-sequencing.

Lyle, Allison N J / Ohlsen, Timothy J D / Miller, Danny E / Brown, Gabrielle / Waligorski, Natalie / Stark, Rebecca / Taylor, Mallory R / Puia-Dumitrescu, Mihai

Maternal health, neonatology and perinatology

2023 Volume 9, Issue 1, Page(s) 7

Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Published Erratum
ZDB-ID	2809925-4
ISSN	2054-958X
ISSN	2054-958X
DOI	10.1186/s40748-023-00161-5
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Article: Congenital pleuropulmonary blastoma in a newborn with a variant of uncertain significance in DICER1 evaluated by RNA-sequencing.

Lyle, Allison N J / Ohlsen, Timothy J D / Miller, Danny E / Brown, Gabrielle / Waligorski, Natalie / Stark, Rebecca / Taylor, Mallory R / Puia-Dumitrescu, Mihai

Maternal health, neonatology and perinatology

2023 Volume 9, Issue 1, Page(s) 4

Abstract: Background: Pleuropulmonary blastoma (PPB) is a rare mesenchymal malignancy of the lung and is the most common pulmonary malignancy in infants and children. Cystic PPB, the earliest form of PPB occurring from birth to approximately two years of age, is ... ...

Abstract	Background: Pleuropulmonary blastoma (PPB) is a rare mesenchymal malignancy of the lung and is the most common pulmonary malignancy in infants and children. Cystic PPB, the earliest form of PPB occurring from birth to approximately two years of age, is often mistaken for a congenital pulmonary airway malformation, as the two entities can be difficult to distinguish on imaging and pathology. Diagnosis of PPB should prompt workup for DICER1 syndrome, an autosomal dominant tumor predisposition syndrome. We report a newborn with a congenital PPB presenting with tachypnea and hypoxia, who was found to have variant of uncertain clinical significance (VUS) in DICER1. Case presentation: A term female infant developed respiratory distress shortly after birth. Initial imaging was concerning for a congenital pulmonary airway malformation versus congenital diaphragmatic hernia, and she was transferred to a quaternary neonatal intensive care unit for management and workup. Chest CT angiography demonstrated a macrocytic multicystic lesion within the right lower lobe without systemic arterial supply. The pediatric surgery team was consulted, and the neonate underwent right lower lobectomy. Pathology revealed a type I PPB. Oncology and genetics consultants recommended observation without chemotherapy and single gene sequencing of DICER1, which identified a germline VUS in DICER1 predicted to alter splicing. RNA-sequencing from blood demonstrated that the variant resulted in an in-frame deletion of 29 amino acids in a majority of transcripts from the affected allele. Due to the patient's young age at presentation and high clinical suspicion for DICER1 syndrome, tumor surveillance was initiated. Renal and pelvic ultrasonography were unremarkable. Conclusion: We present the case of a term neonate with respiratory distress and cystic lung mass, found to have a type I PPB with a germline VUS in DICER1 that likely increased her risk of DICER1-related tumors. Nearly 70% of patients with PPB demonstrate germline mutations in DICER1. Review of RNA sequencing data demonstrates the difficulty in classifying splice variants such as this. Penetrance is low, and many patients with pathogenic DICER1 variants do not develop a malignancy. Best practice surgical and oncologic recommendations include an individualized approach and tumor board discussion. This case highlights the importance of a multidisciplinary team approach and the utility of international registries for patients with rare diagnoses.
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2809925-4
ISSN	2054-958X
ISSN	2054-958X
DOI	10.1186/s40748-023-00148-2
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Article ; Online: Little patients, big impacts: a narrative review of palliative and emergent radiotherapy for pediatric cancers.

Schaub, Stephanie K / Oh, Justin / Menghini, Anthony M / Taylor, Mallory R / Blau, Molly H / Murphy, Blair / Lo, Andrea / Chapple, Alayne / Rosenberg, Abby R / Ermoian, Ralph P / Tsang, Derek S

Annals of palliative medicine

2024 Volume 13, Issue 2, Page(s) 355–372

Abstract: Background and objective: The use of radiotherapy (RT) in the palliative and emergent settings for pediatric cancers is an under-utilized resource. Our objective was to provide an evidence-based review of the data to increase awareness of the benefit ... ...

Abstract	Background and objective: The use of radiotherapy (RT) in the palliative and emergent settings for pediatric cancers is an under-utilized resource. Our objective was to provide an evidence-based review of the data to increase awareness of the benefit for this population along with providing guidance on pediatric specific treatment considerations for palliative care physicians, pediatric oncologists, and radiation oncologists. Methods: A narrative review was performed querying PubMed, MEDLINE, ClinicalTrials.gov databases, and supplemented with review articles, survey studies, current and recent clinical trials. When limited data existed, well-designed retrospective and prospective studies in the adult setting were evaluated and expert opinion was provided from pediatric oncologists. Key content and findings: Pediatric specific treatment considerations include the use of anesthesia, impact of treatment on the developing child, and logistical challenges of RT. Treatment modality and dose selection are driven by histology and symptomatic site of pain, where we discuss detailed recommendations for hematologic, central nervous system, and solid tumors. For palliative RT, an underlying principle of searching for the lowest effective dose to balance response rate with minimal acute and late treatment related morbidity and logistical hardships is of paramount importance when caring for a pediatric patient. Lastly, we outline how to effectively communicate this option to patients and their caregivers. Conclusions: Palliative RT can be of valuable benefit in most settings for patients with pediatric cancer. There is an unmet need for prospective data to inform on dose-fractionation along with patient and caregiver reported outcomes.
MeSH term(s)	Adult ; Humans ; Child ; Prospective Studies ; Retrospective Studies ; Neoplasms/radiotherapy ; Neoplasms/pathology ; Palliative Care ; Radiation Oncology
Language	English
Publishing date	2024-01-15
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-23-505
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Article ; Online: Biobehavioral Implications of Chimeric Antigen Receptor T-cell Therapy: Current State and Future Directions.

Taylor, Mallory R / Steineck, Angela / Lahijani, Sheila / Hall, Anurekha G / Jim, Heather S L / Phelan, Rachel / Knight, Jennifer M

Transplantation and cellular therapy

2022 Volume 29, Issue 1, Page(s) 19–26

Abstract: Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable clinical responses in hematologic malignancies. Recent advances in CAR T-cell therapy have expanded its application into other populations including older patients and those with ... ...

Abstract	Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable clinical responses in hematologic malignancies. Recent advances in CAR T-cell therapy have expanded its application into other populations including older patients and those with central nervous system and solid tumors. Although its clinical efficacy has been excellent for some malignancies, CAR T-cell therapy is associated with severe and even life-threatening immune-mediated toxicities, including cytokine release syndrome and neurotoxicity. There is a strong body of scientific evidence highlighting the connection between immune activation and neurocognitive and psychological phenomena. To date, there has been limited investigation into this relationship in the context of immunotherapy. In this review, we present a biobehavioral framework to inform current and future cellular therapy research and contribute to improving the multidimensional outcomes of patients receiving CAR T-cell therapy.
MeSH term(s)	Humans ; Immunotherapy, Adoptive/adverse effects ; Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes ; Neoplasms/therapy ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2022.09.029
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Article: Defining a "Good Death" in Pediatric Oncology: A Mixed Methods Study of Healthcare Providers.

Taylor, Mallory R / Barton, Krysta S / Kingsley, Jenny M / Heunis, Julia / Rosenberg, Abby R

Children (Basel, Switzerland)

2020 Volume 7, Issue 8

Abstract: Delivering optimal end-of-life (EOL) care to children and adolescents is a healthcare priority, yet relatively little is known about what patients, families, and healthcare providers (HCPs) consider "best" practices. The objective of this study was to ... ...

Abstract	Delivering optimal end-of-life (EOL) care to children and adolescents is a healthcare priority, yet relatively little is known about what patients, families, and healthcare providers (HCPs) consider "best" practices. The objective of this study was to identify factors that pediatric oncology HCPs consider important for EOL care. This was a cross-sectional mixed methods study. Participants were multidisciplinary pediatric oncology staff who completed surveys and participated in semi-structured qualitative interviews. Interviews were analyzed using a modified grounded theory approach. Provider statements were compared based on years of experience (≤10 or >10 years) and discipline (non-physician or physician). A total of
Language	English
Publishing date	2020-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children7080086
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Article ; Online: CD43-positive, EWSR1::FLI1 -rearranged Soft Tissue Sarcoma in a Pediatric Patient With History of B-Cell Acute Lymphoblastic Leukemia.

Ohlsen, Timothy J D / Rudzinski, Erin R / Bohling, Sandra D / Liu, Yajuan J / Maloney, Ezekiel J / Lindberg, Antoinette W / Albert, Catherine M / Lamble, Adam J / Taylor, Mallory R

Journal of pediatric hematology/oncology

2023 Volume 45, Issue 5, Page(s) e635–e638

Abstract: Ewing sarcoma is a small round blue cell tumor typically characterized by an EWSR1 rearrangement and expression of CD99 and NKX2.2, without expression of hematopoietic markers such as CD45. CD43 is an alternative hematopoietic immunohistochemical marker ... ...

Abstract	Ewing sarcoma is a small round blue cell tumor typically characterized by an EWSR1 rearrangement and expression of CD99 and NKX2.2, without expression of hematopoietic markers such as CD45. CD43 is an alternative hematopoietic immunohistochemical marker often utilized in the workup of these tumors and its expression typically argues against Ewing sarcoma. We report a 10-year-old with history of B-cell acute lymphoblastic leukemia presenting with an unusual malignant shoulder mass with variable CD43 positivity, but with an EWSR1::FLI1 fusion detected by RNA sequencing. Her challenging workup highlights the utility of next-generation DNA-based and RNA-based sequencing methods in cases with unclear or conflicting immunohistochemical results.
MeSH term(s)	Female ; Humans ; Child ; Sarcoma, Ewing/pathology ; Immunohistochemistry ; RNA-Binding Protein EWS/genetics ; Sarcoma ; Soft Tissue Neoplasms ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Biomarkers, Tumor/genetics
Chemical Substances	RNA-Binding Protein EWS ; Oncogene Proteins, Fusion ; Biomarkers, Tumor ; EWSR1 protein, human
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002673
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