Result 1 - 10 of total 73
2012
| Keywords | Text ; abstract_or_summary ; ddc:630 |
|---|---|
| Language | German |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Theoretical and applied genetics. 2020 Feb., v. 133, no. 2
2020
Abstract: KEY MESSAGE: About 10% of cultivars possessed superior resistance to four fungal diseases and association mapping for multiple disease resistance identified loci which are not detected by analyzing individual disease resistances. Multiple disease ... ...
| Abstract | KEY MESSAGE: About 10% of cultivars possessed superior resistance to four fungal diseases and association mapping for multiple disease resistance identified loci which are not detected by analyzing individual disease resistances. Multiple disease resistance (MDR) aims for cultivars that are resistant to more than one disease which is an important prerequisite for the registration of commercial cultivars. We analyzed a European winter wheat diversity panel of 158 old and new cultivars for four diseases by natural (powdery mildew) and artificial inoculation (yellow rust, stem rust, Fusarium head blight) observed on the same plot in a multilocation trial. Genotypic analyses were based on 21,543 genotype-by-sequencing markers. By association mapping, eight to 18 quantitative-trait loci (QTL) were detected for individual disease resistances, explaining in total 67–90% of the total genotypic variation. For MDR, nine QTL could be found explaining 62% of the total genotypic variation. Only three of them were also found as QTL for a single disease resistance illustrating that mapping of MDR-associated QTL can be regarded as a complementary approach. The high prediction ability obtained for MDR (> 0.9) implies that genomic prediction could be used in future, thereby eliminating the necessity to separately screen large numbers of lines in breeding programs for several diseases. |
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| Keywords | Fusarium head blight ; cultivars ; disease resistance ; fungi ; genetic variation ; genomics ; powdery mildew ; prediction ; stem rust ; stripe rust ; winter wheat |
| Language | English |
| Dates of publication | 2020-02 |
| Size | p. 419-431. |
| Publishing place | Springer Berlin Heidelberg |
| Document type | Article |
| Note | NAL-AP-2-clean |
| ZDB-ID | 2170-2 |
| ISSN | 1432-2242 ; 0040-5752 |
| ISSN (online) | 1432-2242 |
| ISSN | 0040-5752 |
| DOI | 10.1007/s00122-019-03472-4 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 584: Show issues |
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Food microbiology. 2020 May, v. 87 p.103376-
2020
Abstract: Dry dairy powder is a commonly used ingredient for ready-to-eat foods. It has been implicated in multiple foodborne outbreaks. Listeria monocytogenes can survive in low-moisture conditions for a long duration. However, there is no information on Listeria ...
| Abstract | Dry dairy powder is a commonly used ingredient for ready-to-eat foods. It has been implicated in multiple foodborne outbreaks. Listeria monocytogenes can survive in low-moisture conditions for a long duration. However, there is no information on Listeria survival in dry milk powder during storage and thermal treatments. The objectives of this study were to examine the stability of L. monocytogenes in non-fat dry milk (NFDM) during extended storage and further analyze thermal resistance of L. monocytogenes in NFDM under different water activities (aw) and its thermal stability after 1-year storage. We observed approximately 1.75 and 2.93 log CFU/g reduction of L. monocytogenes in aw 0.25 NFDM over 1-year storage at 4 and 22 °C, respectively. Thermal resistance of L. monocytogenes was inversely related to aw, and the inactivation kinetic curves of L. monocytogenes in NFDM at target aw showed a log-linear trend under all tested conditions. For aw 0.25, 0.30, and 0.45 NFDM, the ranges of D-values, were 66.2–21.3, 33.5–9.4, and 14.6–4.3 min at 70, 75 and 80 °C, respectively. The z-values for L. monocytogenes in NFDM at aw 0.25–0.45 were 14.6–16.0 C°. Furthermore, the thermal stability of L. monocytogenes in aw 0.25 NFDM post 6-month or 12-month storage under refrigerated or ambient temperature did not deviate much from that in NFDM prior to the storage. Data indicated that a 60-min heat treatment at 80 °C resulted in ~ 5-log reduction of L. monocytogenes in NFDM of aw 0.30. This provides a promising intervention strategy to enhance bactericidal efficacy of thermal treatment while maintaining the quality of milk powder. |
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| Keywords | Listeria monocytogenes ; ambient temperature ; dried skim milk ; heat tolerance ; heat treatment ; ingredients ; milk quality ; ready-to-eat foods ; refrigeration ; shelf life ; storage temperature ; thermal stability ; water activity ; Nonfat dry milk ; Thermal resistance ; Storage |
| Language | English |
| Dates of publication | 2020-05 |
| Publishing place | Elsevier Ltd |
| Document type | Article ; Online |
| ZDB-ID | 50892-5 |
| ISSN | 1095-9998 ; 0740-0020 |
| ISSN (online) | 1095-9998 |
| ISSN | 0740-0020 |
| DOI | 10.1016/j.fm.2019.103376 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 4306: Show issues |
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2018 Volume 253, Page(s) 55–59
Abstract: Anthelmintic treatments to ewes around lambing time, often with long acting products, have become common practice on UK sheep farms, but these treatments have also been shown to be highly selective for anthelmintic resistance in New Zealand and Australia, ...
| Abstract | Anthelmintic treatments to ewes around lambing time, often with long acting products, have become common practice on UK sheep farms, but these treatments have also been shown to be highly selective for anthelmintic resistance in New Zealand and Australia, with field data supported by modelling results. The purpose of this study was to determine (1) the effect of treating or withholding anthelmintic treatments and (2) the effect of treatment of ewes with a persistent or non-persistent anthelmintic, on early infection in lambs in the UK. Faecal egg count data for 10-16 weeks old lambs collected over a three year period (2012-2014) was analysed. Samples were grouped according to whether the ewes on the farm had or had not been treated with an anthelmintic at lambing. For both analyses, data for early infection were analysed by generalised linear mixed model. There was no effect of withholding or treating ewes on subsequent early infection in lambs. In addition, there was no effect of region, farm type or management type on the faecal egg counts. There was, however an effect of year, with lambs having lower counts in 2014 than in 2012 and an interaction between year and ewe treatment, with data suggesting lower infection levels over time for those farms withholding anthelmintic treatments altogether. There was no effect of drug type on early infection in lambs nor region, farm type or treatment on the lamb faecal egg counts. However, there was an effect of year and an interaction between year and drug type with lower egg count over time with the short acting drugs. Our study supports data generated by other researchers suggesting that the practice of treating ewes at lambing to reduce contamination on pasture and minimise subsequent disease may not in fact always result in lower levels of infection in lambs. The study also demonstrated no significant benefit in early infection in lambs when ewes were treated with long acting compared to short acting anthelmintics. This provides further evidence to support the potential benefits of a more targeted approach to anthelmintic treatment on sheep farms. |
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| MeSH term(s) | Animals ; Anthelmintics/therapeutic use ; Farms ; Feces/parasitology ; Female ; Helminthiasis, Animal/drug therapy ; Helminthiasis, Animal/parasitology ; Helminthiasis, Animal/prevention & control ; Parasite Egg Count/veterinary ; Sheep ; Sheep Diseases/drug therapy ; Sheep Diseases/parasitology ; Sheep Diseases/prevention & control ; United Kingdom |
| Chemical Substances | Anthelmintics |
| Language | English |
| Publishing date | 2018-02-12 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 196831-2 |
| ISSN | 1873-2550 ; 0304-4017 |
| ISSN (online) | 1873-2550 |
| ISSN | 0304-4017 |
| DOI | 10.1016/j.vetpar.2018.02.026 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4380: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2018 Volume 254, Page(s) 64–71
Abstract: UK guidelines for the sustainable control of parasites in sheep (SCOPS) were formulated with the primary aim of delaying development of anthelmintic resistance (AR) on UK sheep farms. Promoting their use requires the engagement and commitment of ... ...
| Abstract | UK guidelines for the sustainable control of parasites in sheep (SCOPS) were formulated with the primary aim of delaying development of anthelmintic resistance (AR) on UK sheep farms. Promoting their use requires the engagement and commitment of stakeholders. An important driver for behavioural change in sheep farmers is evidence of economic benefits. A recent evaluation of SCOPS guidance in practice demonstrated a significant reduction in anthelmintic use, suggesting economic benefits through a direct reduction in product and labour costs. However, in order to maintain production, a range of alternative control strategies are advised, resulting in additional costs to farmers and so a full cost benefit analysis of best practice management was undertaken. We allocated financial values to the management recommendations described in the SCOPS technical manual. Benefits were calculated using data for production variables and anthelmintic use measured during studies to evaluate the effect of SCOPS recommendations on 16 UK sheep farms and from other published work. As SCOPS control is not prescriptive and a range of different diagnostics are available, best and worst case scenarios were presented, comparing the cheapest methods (e.g. egg counts without larval culture) and management situations (e.g closed flocks not requiring quarantine treatments) with the most laborious and expensive. Simulations were run for farms with a small, medium or large flock (300; 1000; 1900 ewes) as well as comparing scenarios with and without potential production benefits from using effective wormers. Analysis demonstrated a moderate cost for all farms under both scenarios when production benefits were not included. A cost benefit was demonstrated for medium and large farms when production benefits were included and the benefit could be perceived as significant in the case of the large farms for the best case scenario (>£5000 per annum). Despite a significant potential reduction in anthelmintic use by farmers employing SCOPS guidance, the very low price of the older anthelmintic classes meant that the benefit did not always outweigh the additional management/diagnostic costs unless an increase in production was also achieved. This is an important finding. Focussing research on key innovations that will improve the cost effectiveness of diagnostic assays in a diagnostic driven control strategy, as well as designing treatment options that can improve production outcomes, and presenting them in a clear and transparent way, must be high priority goals. Coupling targeted research with improvements in the delivery of messages to the end user is important in the light of increasing global concerns over drug resistance. |
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| MeSH term(s) | Animal Husbandry/economics ; Animals ; Anthelmintics/pharmacology ; Communicable Disease Control/economics ; Communicable Disease Control/methods ; Cost-Benefit Analysis ; Drug Resistance ; Farms ; Female ; Helminths/drug effects ; Male ; Sheep ; Sheep Diseases/economics ; Sheep Diseases/prevention & control ; United Kingdom |
| Chemical Substances | Anthelmintics |
| Language | English |
| Publishing date | 2018-02-21 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 196831-2 |
| ISSN | 1873-2550 ; 0304-4017 |
| ISSN (online) | 1873-2550 |
| ISSN | 0304-4017 |
| DOI | 10.1016/j.vetpar.2018.02.033 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4380: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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In practice. 2009 Nov-Dec, v. 31, no. 10
2009
| Keywords | sheep ; ectoparasites ; endoparasites ; disease prevalence ; United Kingdom |
|---|---|
| Language | English |
| Dates of publication | 2009-11 |
| Size | p. 474-483. |
| Document type | Article |
| ZDB-ID | 439810-5 |
| ISSN | 2042-7689 ; 0263-841X |
| ISSN (online) | 2042-7689 |
| ISSN | 0263-841X |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 3145 a: Show issues |
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developing tools for a more science-and risk-based approach
2003
| Author's details | by Michael R. Taylor ... [et al.] |
|---|---|
| MeSH term(s) | Food Contamination/prevention & control ; Risk Management/methods ; Bioterrorism/prevention & control ; Food Industry/organization & administration |
| Keywords | United States |
| Language | English |
| Size | vii, 41 p. |
| Publisher | Resources for the Future |
| Publishing place | New York, NY |
| Document type | Book |
| ISBN | 9781887748544 ; 1887748547 |
| Database | Catalogue of the US National Library of Medicine (NLM) |
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2013 Volume 172, Issue 3, Page(s) 82
| MeSH term(s) | Animals ; Cattle ; Fasciola hepatica/growth & development ; Fascioliasis/epidemiology ; Fascioliasis/transmission ; Fascioliasis/veterinary ; Humans ; Parasite Egg Count/veterinary ; Seasons ; Sheep |
|---|---|
| Language | English |
| Publishing date | 2013-01-19 |
| Publishing country | England |
| Document type | Letter |
| ZDB-ID | 390015-0 |
| ISSN | 2042-7670 ; 0042-4900 |
| ISSN (online) | 2042-7670 |
| ISSN | 0042-4900 |
| DOI | 10.1136/vr.f334 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 645: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2016 Volume 178, Issue 15, Page(s) 377–378
| MeSH term(s) | Animals ; Anthelmintics/administration & dosage ; Female ; Helminthiasis, Animal/prevention & control ; Pregnancy ; Sheep ; Sheep Diseases/prevention & control |
|---|---|
| Chemical Substances | Anthelmintics |
| Language | English |
| Publishing date | 2016-04-09 |
| Publishing country | England |
| Document type | Letter |
| ZDB-ID | 390015-0 |
| ISSN | 2042-7670 ; 0042-4900 |
| ISSN (online) | 2042-7670 |
| ISSN | 0042-4900 |
| DOI | 10.1136/vr.i1978 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 645: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of the American Heart Association
2024 Volume 13, Issue 4, Page(s) e030749
Abstract: Background: The objective of the PERSONAL-CovidBP (Personalised Electronic Record Supported Optimisation When Alone for Patients With Hypertension: Pilot Study for Remote Medical Management of Hypertension During the COVID-19 Pandemic) trial was to ... ...
| Abstract | Background: The objective of the PERSONAL-CovidBP (Personalised Electronic Record Supported Optimisation When Alone for Patients With Hypertension: Pilot Study for Remote Medical Management of Hypertension During the COVID-19 Pandemic) trial was to assess the efficacy and safety of smartphone-enabled remote precision dosing of amlodipine to control blood pressure (BP) in participants with primary hypertension during the COVID-19 pandemic. Methods and results: This was an open-label, remote, dose titration trial using daily home self-monitoring of BP, drug dose, and side effects with linked smartphone app and telemonitoring. Participants aged ≥18 years with uncontrolled hypertension (5-7 day baseline mean ≥135 mm Hg systolic BP or ≥85 mm Hg diastolic BP) received personalized amlodipine dose titration using novel (1, 2, 3, 4, 6, 7, 8, 9 mg) and standard (5 and 10 mg) doses daily over 14 weeks. The primary outcome of the trial was mean change in systolic BP from baseline to end of treatment. A total of 205 participants were enrolled and mean BP fell from 142/87 (systolic BP/diastolic BP) to 131/81 mm Hg (a reduction of 11 (95% CI, 10-12)/7 (95% CI, 6-7) mm Hg, Conclusions: Personalized dose titration with amlodipine was safe, well tolerated, and efficacious in treating primary hypertension. The majority of participants achieved BP control on novel doses, and with personalization of dose there were no trial discontinuations due to drug intolerance. App-assisted remote clinician dose titration may better balance BP control and adverse effects and help optimize long-term care. Registration: URL: clinicaltrials.gov. Identifier: NCT04559074. |
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| MeSH term(s) | Adolescent ; Adult ; Humans ; Amlodipine/therapeutic use ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; COVID-19 ; Essential Hypertension/drug therapy ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/chemically induced ; Pandemics ; Pilot Projects ; Smartphone ; Treatment Outcome |
| Chemical Substances | Amlodipine (1J444QC288) ; Antihypertensive Agents |
| Language | English |
| Publishing date | 2024-02-07 |
| Publishing country | England |
| Document type | Clinical Trial ; Journal Article |
| ZDB-ID | 2653953-6 |
| ISSN | 2047-9980 ; 2047-9980 |
| ISSN (online) | 2047-9980 |
| ISSN | 2047-9980 |
| DOI | 10.1161/JAHA.123.030749 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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