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  1. Book ; Online: The Role of Complement in Cancer Immunotherapy

    Taylor, Ronald P.

    2022  

    Keywords Medicine ; complement ; therapeutic monoclonal antibodies (mAbs) ; Ca2+ ; fluorescence microscopy ; gC1qR ; breast cancer ; xenotransplant model ; complement system ; cancer ; immune infiltrate ; tumor microenvironment ; tumor growth ; anaphylatoxins ; antibody dependent cellular cytotoxicity ; phagocytosis ; complement receptors ; CD46 ; membrane cofactor protein (MCP) ; cancer therapeutics ; measles virus ; adenovirus ; antibody-drug conjugates ; immunity ; myeloid cells ; therapeutics ; antibody therapy ; cluster of differentiation 19 (CD19) ; CD19 ; Fc fragment crystallizable (Fc) ; Fc engineering ; complement-dependent cytotoxicity (CDC) ; antibody-dependent cell-mediated cytotoxicity (ADCC) ; angiogenesis ; ocular pathology ; cytotoxicity ; monoclonal antibody ; B-cell lymphoma ; chronic lymphocytic leukemia (CLL) ; complement C5a ; complement C3a ; mammary carcinoma ; immunoregulation ; tumor infiltrating leukocytes ; n/a
    Size 1 electronic resource (184 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291220
    ISBN 9783036529387 ; 3036529381
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: T cells reinforce NK cell-mediated ADCC.

    Taylor, Ronald P

    Blood

    2024  Volume 143, Issue 18, Page(s) 1786–1787

    MeSH term(s) Humans ; Killer Cells, Natural/immunology ; Antibody-Dependent Cell Cytotoxicity/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2024024444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  3. Article ; Online: Antibody drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms.

    Taylor, Ronald P / Lindorfer, Margaret A

    Blood

    2024  

    Abstract: Numerous antibody-drug conjugates (ADC) are being developed for cancer immunotherapy. Although several of these agents have demonstrated considerable clinical efficacy and have won FDA approval, in many instances they have been characterized by adverse ... ...

    Abstract Numerous antibody-drug conjugates (ADC) are being developed for cancer immunotherapy. Although several of these agents have demonstrated considerable clinical efficacy and have won FDA approval, in many instances they have been characterized by adverse side effects (ASE) which can be quite severe in a fraction of treated patients. The key hypothesis in this perspective is that many of the most serious ASE associated with the use of ADC in the treatment of cancer can be most readily explained and understood due to the inappropriate processing of these ADC via pathways normally followed for immune complex clearance, which include phagocytosis and trogocytosis. We review the key published basic science experiments and clinical observations that support this idea. We propose that it is the interaction of the ADC with Fc receptors expressed on off-target cells and tissues that can most readily explain ADC-mediated pathologies which therefore provides a rationale for the design of protocols to minimize ASE. We describe measurements that should help to identify those patients most likely to experience ASE due to ADC and we propose readily available treatments as well as therapies under development for other indications that should substantially reduce ASE associated with ADC. Our focus will be on the following FDA-approved ADC for which there are substantial literatures: gemtuzumab ozogamicin (Mylotarg) and inotuzumab ozogamicin; and trastuzumab emtansine (T-DM1), and trastuzumab deruxtecan (T-DXd).
    Language English
    Publishing date 2024-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2024024442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Special Issue: The Role of Complement in Cancer Immunotherapy.

    Taylor, Ronald P

    Antibodies (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: The complement system plays an important role in critical aspects of immune defense and in the maintenance of homeostasis in the bloodstream, as well as in essentially all tissues and organs [ ... ]. ...

    Abstract The complement system plays an important role in critical aspects of immune defense and in the maintenance of homeostasis in the bloodstream, as well as in essentially all tissues and organs [...].
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Editorial
    ISSN 2073-4468
    ISSN (online) 2073-4468
    DOI 10.3390/antib10030029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Measurement of Trogocytosis: Quantitative Analyses Validated with Rigorous Controls.

    Taylor, Ronald P / Lindorfer, Margaret A

    Current protocols

    2023  Volume 3, Issue 10, Page(s) e897

    Abstract: Trogocytosis is a process in which receptors on acceptor cells remove and internalize cognate ligands from donor cells. Trogocytosis has a profound and negative impact on mAb-based cancer immunotherapy, as seen in the treatment of chronic lymphocytic ... ...

    Abstract Trogocytosis is a process in which receptors on acceptor cells remove and internalize cognate ligands from donor cells. Trogocytosis has a profound and negative impact on mAb-based cancer immunotherapy, as seen in the treatment of chronic lymphocytic leukemia (CLL) with CD20 mAbs, such as rituximab (RTX) and ofatumumab (OFA). Our clinical observations of RTX/OFA-mediated loss of the CD20 target from circulating CLL cells have been replicated in our in vitro studies. Here we describe flow cytometry and fluorescence microscopy experiments, which demonstrate that acceptor cells, such as monocytes/macrophages that express FcγR, remove and internalize both antigen and donor cell-bound cognate IgG mAbs for several different mAb-donor cell pairs. Fluorescent mAbs and portions of the plasma cell membrane are transferred from donor cells to acceptor cells, which include the THP-1 monocytic cell line as well as freshly isolated monocytes. We describe rigorous controls to validate the reactions and eliminate dissociation or internalization as alternative mechanisms. Trogocytosis is likely to contribute to neutropenia, thrombocytopenia, and liver damage associated with use of antibody-drug conjugates. The methods we have described should allow for examination of strategies focused on blocking trogocytosis and its adverse effects. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Trogocytosis of mAb-opsonized donor cells mediated by adherent THP-1 cells Alternate Protocol: Application of fluorescence microscopy to examine THP-1 cell-mediated trogocytosis Support Protocol 1: Alexa labeling of mAbs and determination of F/P ratios Support Protocol 2: Standard washing procedure Support Protocol 3: Labeling and opsonization of cells Basic Protocol 2: Trogocytosis mediated by human monocytes as acceptor cells Support Protocol 4: Isolation of human monocytes Basic Protocol 3: Trogocytosis mediated by THP-1 cells in solution Support Protocol 5: Retinoic acid treatment of THP-1 cells Support Protocol 6: Culturing of SCC-25, BT-474, MOLT-4 and THP-1 cell lines.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Trogocytosis ; Antigens, CD20/therapeutic use ; Rituximab/pharmacology ; Rituximab/therapeutic use
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: FcγR-Mediated Trogocytosis 2.0: Revisiting History Gives Rise to a Unifying Hypothesis.

    Lindorfer, Margaret A / Taylor, Ronald P

    Antibodies (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: There is increasing interest in the clinical implications and immunology of trogocytosis, a process in which the receptors on acceptor cells remove and internalize cognate ligands from donor cells. We have reported that this phenomenon occurs in cancer ... ...

    Abstract There is increasing interest in the clinical implications and immunology of trogocytosis, a process in which the receptors on acceptor cells remove and internalize cognate ligands from donor cells. We have reported that this phenomenon occurs in cancer immunotherapy, in which cells that express FcγR remove and internalize CD20 and bound mAbs from malignant B cells. This process can be generalized to include other reactions including the immune adherence phenomenon and antibody-induced immunosuppression. We discuss in detail FcγR-mediated trogocytosis and the evidence supporting a proposed predominant role for liver sinusoidal endothelial cells via the action of the inhibitory receptor FcγRIIb2. We describe experiments to test the validity of this hypothesis. The elucidation of the details of FcγR-mediated trogocytosis has the potential to allow for the development of novel therapies that can potentially block or enhance this reaction, depending upon whether the process leads to unfavorable or positive biological effects.
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661514-9
    ISSN 2073-4468 ; 2073-4468
    ISSN (online) 2073-4468
    ISSN 2073-4468
    DOI 10.3390/antib11030045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Null donors favor prepared immunologists.

    Taylor, Ronald P

    Blood

    2019  Volume 133, Issue 13, Page(s) 1389–1390

    MeSH term(s) Humans ; Neutrophils ; Tissue Donors
    Language English
    Publishing date 2019-03-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2019-01-898775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Assessment of individuals with mental retardation

    Taylor, Ronald L.

    1997  

    Author's details Ronald L. Taylor
    Keywords Mental Retardation / diagnosis ; Psychological Tests
    Language English
    Size X, 244 S. : Ill.
    Publisher Singular Publ
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008888708
    ISBN 1-56593-708-2 ; 978-1-56593-708-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 A 3328 order for loan Magazin

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  9. Article ; Online: Neutrophils: positive or negative?

    Taylor, Ronald P

    Blood

    2017  Volume 129, Issue 19, Page(s) 2596–2597

    MeSH term(s) Humans ; Neutrophils
    Language English
    Publishing date 2017-05-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-03-774695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Perceived effectiveness of messages promoting hand hygiene.

    Taylor, Ronald E

    American journal of infection control

    2017  Volume 45, Issue 3, Page(s) 314–316

    Abstract: Eighty-six infection control specialists evaluated 24 messages promoting hand hygiene (HH). Brief, simple messages using appeals to social situations and to ego (self-efficacy) were rated as most likely to increase HH compliance. ...

    Abstract Eighty-six infection control specialists evaluated 24 messages promoting hand hygiene (HH). Brief, simple messages using appeals to social situations and to ego (self-efficacy) were rated as most likely to increase HH compliance.
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2016.10.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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