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  1. Article ; Online: Developing dietary interventions as therapy for cancer.

    Taylor, Samuel R / Falcone, John N / Cantley, Lewis C / Goncalves, Marcus D

    Nature reviews. Cancer

    2022  Volume 22, Issue 8, Page(s) 452–466

    Abstract: Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic alterations and degree of interaction with systemic hormones and metabolites. These adaptations support the increased nutrient demand required for increased ... ...

    Abstract Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic alterations and degree of interaction with systemic hormones and metabolites. These adaptations support the increased nutrient demand required for increased growth and proliferation. Diet is the major source of nutrients for tumours, yet dietary interventions lack robust evidence and are rarely prescribed by clinicians for the treatment of cancer. Well-controlled diet studies in patients with cancer are rare, and existing studies have been limited by nonspecific enrolment criteria that inappropriately grouped together subjects with disparate tumour and host metabolic profiles. This imprecision may have masked the efficacy of the intervention for appropriate candidates. Here, we review the metabolic alterations and key vulnerabilities that occur across multiple types of cancer. We describe how these vulnerabilities could potentially be targeted using dietary therapies including energy or macronutrient restriction and intermittent fasting regimens. We also discuss recent trials that highlight how dietary strategies may be combined with pharmacological therapies to treat some cancers, potentially ushering a path towards precision nutrition for cancer.
    MeSH term(s) Diet ; Fasting ; Humans ; Neoplasms/pathology ; Nutrients
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-022-00485-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5563: Show issues Location:
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  2. Article ; Online: The proteasome regulates body weight and systemic nutrient metabolism during fasting.

    Langer, Henning Tim / Taylor, Samuel R / Ahmed, Mujmmail / Perrier, Tiffany / Ahmed, Tanvir / Goncalves, Marcus D

    American journal of physiology. Endocrinology and metabolism

    2023  Volume 325, Issue 5, Page(s) E500–E512

    Abstract: The ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway are the primary means of degradation in mammalian tissues. We sought to determine the individual contribution of the UPS and autophagy to tissue catabolism during fasting. Mice were ...

    Abstract The ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway are the primary means of degradation in mammalian tissues. We sought to determine the individual contribution of the UPS and autophagy to tissue catabolism during fasting. Mice were overnight fasted for 15 h before regaining food access ("Fed" group,
    MeSH term(s) Mice ; Animals ; Proteasome Endopeptidase Complex/metabolism ; Bortezomib/pharmacology ; Proteolysis ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ubiquitin/metabolism ; Ubiquitin/pharmacology ; Fasting/metabolism ; Nutrients ; Weight Loss ; Body Weight ; Autophagy ; Mammals/metabolism
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Bortezomib (69G8BD63PP) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ubiquitin
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00069.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia.

    Gurbatri, Candice R / Radford, Georgette A / Vrbanac, Laura / Im, Jongwon / Thomas, Elaine M / Coker, Courtney / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin R M / Wang, Tongtong / Wright, Josephine A / Kobayashi, Hiroki / Ng, Jia Q /
    Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Stavropoulos, Alexandra M / Gouskos, Dion A / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 646

    Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) ...

    Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) to a genetically-engineered murine model of CRC predisposition and orthotopic models of CRC. We next undertake an interventional, double-blind, dual-centre, prospective clinical trial, in which CRC patients take either placebo or EcN for two weeks prior to resection of neoplastic and adjacent normal colorectal tissue (ACTRN12619000210178). We detect enrichment of EcN in tumor samples over normal tissue from probiotic-treated patients (primary outcome of the trial). Next, we develop early CRC intervention strategies. To detect lesions, we engineer EcN to produce a small molecule, salicylate. Oral delivery of this strain results in increased levels of salicylate in the urine of adenoma-bearing mice, in comparison to healthy controls. To assess therapeutic potential, we engineer EcN to locally release a cytokine, GM-CSF, and blocking nanobodies against PD-L1 and CTLA-4 at the neoplastic site, and demonstrate that oral delivery of this strain reduces adenoma burden by ~50%. Together, these results support the use of EcN as an orally-deliverable platform to detect disease and treat CRC through the production of screening and therapeutic molecules.
    MeSH term(s) Animals ; Humans ; Mice ; Adenoma/diagnosis ; Adenoma/therapy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Escherichia coli/genetics ; Prospective Studies ; Salicylates ; Double-Blind Method
    Chemical Substances Salicylates
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44776-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Colorectal cancer detection and treatment with engineered probiotics.

    Gurbatri, Candice R / Radford, Georgette / Vrbanac, Laura / Coker, Courtney / Im, Jong-Won / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin Rm / Wang, Tongtong / Wright, Josephine A / Thomas, Elaine / Kobayashi, Hiroki / Ng, Jia Q /
    Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of ... ...

    Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of probiotic
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.03.535370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dietary fructose improves intestinal cell survival and nutrient absorption.

    Taylor, Samuel R / Ramsamooj, Shakti / Liang, Roger J / Katti, Alyna / Pozovskiy, Rita / Vasan, Neil / Hwang, Seo-Kyoung / Nahiyaan, Navid / Francoeur, Nancy J / Schatoff, Emma M / Johnson, Jared L / Shah, Manish A / Dannenberg, Andrew J / Sebra, Robert P / Dow, Lukas E / Cantley, Lewis C / Rhee, Kyu Y / Goncalves, Marcus D

    Nature

    2021  Volume 597, Issue 7875, Page(s) 263–267

    Abstract: Fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality ... ...

    Abstract Fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality globally
    MeSH term(s) Animals ; Cell Survival/drug effects ; Enzyme Activation ; Female ; Fructokinases/metabolism ; Fructose/metabolism ; Fructose/pharmacology ; High Fructose Corn Syrup/metabolism ; High Fructose Corn Syrup/pharmacology ; Hypoxia/diet therapy ; Hypoxia/pathology ; Intestinal Absorption/drug effects ; Intestinal Mucosa/cytology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Lipid Metabolism/drug effects ; Male ; Mice ; Nutrients/metabolism ; Pyruvate Kinase/metabolism
    Chemical Substances High Fructose Corn Syrup ; Fructose (30237-26-4) ; Fructokinases (EC 2.7.1.-) ; ketohexokinase (EC 2.7.1.3) ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2021-08-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03827-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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