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  1. Article ; Online: The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis.

    Cordeiro, Patrícia Azevedo Soares / Assone, Tatiane / Prates, Gabriela / Tedeschi, Marcia Regina Martinez / Fonseca, Luiz Augusto Marcondes / Casseb, Jorge

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2022  Volume 64, Page(s) e64

    Abstract: Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The ... ...

    Abstract Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
    MeSH term(s) Cytokines ; HIV Infections ; Human T-lymphotropic virus 1 ; Humans ; Inflammation ; Interferon-gamma
    Chemical Substances Cytokines ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2022-09-30
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/S1678-9946202264064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: PHYSICAL ACTIVITY PROGRAM FOR ELDERLY AND ECONOMY FOR THE HEALTH SYSTEM.

    Daher, Samir Salim / Nogueira, Monica Paschoal / Ferreira, Mauro / Tedeschi, Marcia Regina Martinez / Martinez, Lilton Rodolfo Castellan / Shirassu, Mirian Matsura

    Acta ortopedica brasileira

    2018  Volume 26, Issue 4, Page(s) 271–274

    Abstract: Objective: To evaluate the impact of physical activity on the use of the health system and the quality of life in sedentary elderly.: Methods: A prospective interventional study was carried out between March 2010 and February 2011 with 100 subjects ( ... ...

    Abstract Objective: To evaluate the impact of physical activity on the use of the health system and the quality of life in sedentary elderly.
    Methods: A prospective interventional study was carried out between March 2010 and February 2011 with 100 subjects (60-90 years of age,) divided into active group (AG) and control group (CG). During this period, AG performed physical exercise twice a week in 60-minute sessions and the CG remained sedentary with observation of their activities. Before and after the study, all subjects were clinically evaluated and completed a quality of life questionnaire.
    Results: Eighty-nine subjects (AG = 44; CG = 45) were analyzed. AG had fewer visits to emergency room (p = 0.0056), hospitalizations (p = 0.0011), length of hospital stay (p = 0.0012) and fewer subsidiary tests (p = 0.0236) compared to the CG. The quality of life score analyzed before and after physical activity increased in AG compared to CG (p < 0.0001) and among subjects in AG (p < 0.0001), with no change in the CG.
    Conclusion: The intervention of a physical activity program for sedentary elderly can contribute to reduce the use of the health system and improve the quality of life.
    Language English
    Publishing date 2018-08-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105206-2
    ISSN 1809-4406 ; 1413-7852
    ISSN (online) 1809-4406
    ISSN 1413-7852
    DOI 10.1590/1413-785220182604194374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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