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  1. AU="Tedim-Moreira, Joana"
  2. AU="Martínez-Moreno, Francisco Javier"
  3. AU=Cardoso Eduardo

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  1. Article ; Online: Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1

    Costa-Pinto, Sara / Gonçalves-Ribeiro, Joana / Tedim-Moreira, Joana / Socodato, Renato / Relvas, João B / Sebastião, Ana M / Vaz, Sandra H

    Neurobiology of disease

    2024  Volume 193, Page(s) 106435

    Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic function. Using the ALS SOD1
    MeSH term(s) Mice ; Animals ; Astrocytes/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism ; Mice, Transgenic ; Motor Cortex ; Neurodegenerative Diseases/metabolism ; Proteomics ; Disease Models, Animal ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
    Chemical Substances Superoxide Dismutase-1 (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2024.106435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: RhoA balances microglial reactivity and survival during neuroinflammation.

    Socodato, Renato / Rodrigues-Santos, Artur / Tedim-Moreira, Joana / Almeida, Tiago O / Canedo, Teresa / Portugal, Camila C / Relvas, João B

    Cell death & disease

    2023  Volume 14, Issue 10, Page(s) 690

    Abstract: Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily involved in restoring brain homeostasis. However, sustained or exacerbated microglia ... ...

    Abstract Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily involved in restoring brain homeostasis. However, sustained or exacerbated microglia inflammatory reactivity can lead to brain damage. Dynamic cytoskeleton reorganization correlates with alterations of microglial reactivity driven by external cues, and proteins controlling cytoskeletal reorganization, such as the Rho GTPase RhoA, are well positioned to refine or adjust the functional state of the microglia during injury, disease, or inflammation. Here, we use multi-biosensor-based live-cell imaging approaches and tissue-specific conditional gene ablation in mice to understand the role of RhoA in microglial response to inflammation. We found that a decrease in RhoA activity is an absolute requirement for microglial metabolic reprogramming and reactivity to inflammation. However, without RhoA, inflammation disrupts Ca
    MeSH term(s) Mice ; Animals ; Microglia/metabolism ; Neuroinflammatory Diseases ; Inflammation/metabolism ; Necrosis/metabolism ; Apoptosis
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06217-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: RhoA balances microglial reactivity and survival during neuroinflammation.

    Socodato, Renato / Rodrigues-Santos, Artur / Tedim-Moreira, Joana / Almeida, Tiago O / Canedo, Teresa / Portugal, Camila C / Relvas, João B

    Cell death & disease

    2023  Volume 14, Issue 12, Page(s) 808

    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06340-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance.

    Socodato, Renato / Almeida, Tiago O / Portugal, Camila C / Santos, Evelyn C S / Tedim-Moreira, Joana / Galvão-Ferreira, João / Canedo, Teresa / Baptista, Filipa I / Magalhães, Ana / Ambrósio, António F / Brakebusch, Cord / Rubinstein, Boris / Moreira, Irina S / Summavielle, Teresa / Pinto, Inês Mendes / Relvas, João B

    Cell reports

    2023  Volume 42, Issue 12, Page(s) 113447

    Abstract: Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the ... ...

    Abstract Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drives experience-dependent plasticity, a fundamental brain property impaired in several neuropsychiatric disorders. Phosphoproteomics profiling detects a large modulation of RhoGTPase signaling, predominantly of Rac1, in microglia of mice exposed to an environmental enrichment protocol known to induce experience-dependent brain plasticity and cognitive performance. Ablation of microglial Rac1 affects pathways involved in microglia-synapse communication, disrupts experience-dependent synaptic remodeling, and blocks the gains in learning, memory, and sociability induced by environmental enrichment. Our results reveal microglial Rac1 as a central regulator of pathways involved in the microglia-synapse crosstalk required for experience-dependent synaptic plasticity and cognitive performance.
    MeSH term(s) Microglia/metabolism ; Neuronal Plasticity ; Cognition/physiology ; Animals ; Mice ; Neuropeptides/genetics ; Neuropeptides/physiology ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/physiology ; Male ; Female ; Mice, Mutant Strains ; Synapses/physiology ; Brain/physiology ; Gene Knockdown Techniques
    Chemical Substances Rac1 protein, mouse ; Neuropeptides ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior.

    Socodato, Renato / Henriques, Joana F / Portugal, Camila C / Almeida, Tiago O / Tedim-Moreira, Joana / Alves, Renata L / Canedo, Teresa / Silva, Cátia / Magalhães, Ana / Summavielle, Teresa / Relvas, João B

    Science signaling

    2020  Volume 13, Issue 650

    Abstract: Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a ... ...

    Abstract Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a protocol simulating chronic binge drinking in male mice resulted in aberrant synaptic pruning and substantial loss of excitatory synapses in the prefrontal cortex, which resulted in increased anxiety-like behavior. Mechanistically, alcohol intake increased the engulfment capacity of microglia in a manner dependent on the kinase Src, the subsequent activation of the transcription factor NF-κB, and the consequent production of the proinflammatory cytokine TNF. Pharmacological blockade of Src activation or of TNF production in microglia, genetic ablation of
    MeSH term(s) Animals ; Anxiety/physiopathology ; Anxiety/psychology ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Cells, Cultured ; Central Nervous System Depressants/administration & dosage ; Ethanol/administration & dosage ; Ethanol/blood ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microglia/cytology ; Microglia/drug effects ; Microglia/metabolism ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Synapses/drug effects ; Synapses/physiology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Central Nervous System Depressants ; Tumor Necrosis Factor-alpha ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.aba5754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Multiplex Test Assessing

    Monteiro-Reis, Sara / Blanca, Ana / Tedim-Moreira, Joana / Carneiro, Isa / Montezuma, Diana / Monteiro, Paula / Oliveira, Jorge / Antunes, Luís / Henrique, Rui / Lopez-Beltran, António / Jerónimo, Carmen

    Journal of clinical medicine

    2020  Volume 9, Issue 2

    Abstract: Bladder cancer (BlCa) is a common malignancy with significant morbidity and mortality. Current diagnostic methods are invasive and costly, showing the need for newer biomarkers. Although several epigenetic-based biomarkers have been proposed, their ... ...

    Abstract Bladder cancer (BlCa) is a common malignancy with significant morbidity and mortality. Current diagnostic methods are invasive and costly, showing the need for newer biomarkers. Although several epigenetic-based biomarkers have been proposed, their ability to discriminate BlCa from common benign conditions of the urinary tract, especially inflammatory diseases, has not been adequately explored. Herein, we sought to determine whether VIM
    Language English
    Publishing date 2020-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9020605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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