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  1. Article ; Online: The GLP-1 receptor agonist exenatide reduces serum TSH by its effect on body weight in people with type 2 diabetes.

    Tee, Su Ann / Tsatlidis, Vasileios / Razvi, Salman

    Clinical endocrinology

    2023  Volume 99, Issue 4, Page(s) 401–408

    Abstract: Objective: Glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy in patients with type 2 diabetes and obesity leads to a significant reduction in serum thyrotropin (TSH) levels but it is unclear whether this is related to weight loss and ... ...

    Abstract Objective: Glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy in patients with type 2 diabetes and obesity leads to a significant reduction in serum thyrotropin (TSH) levels but it is unclear whether this is related to weight loss and improvement in sensitivity to thyroid hormones (TH).
    Design, patients and measurements: We prospectively analysed clinical and biochemical data in patients with type 2 diabetes and obesity who were commenced on the GLP-1 RA exenatide and followed them for 12 months. We assessed the relationship between changes in body weight and serum TSH and resistance to TH indices.
    Results: In 112 patients (mean age: 53.5 years, 43.8% female, mean body mass index: 39.8 kg/m
    Conclusions: Exenatide therapy reduces serum TSH levels and improves central sensitivity to TH action over 12 months via its effect on weight loss. The effectiveness of weight loss strategies, rather than TH replacement, should be investigated in individuals with obesity and mildly raised serum TSH levels.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Exenatide/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Body Weight ; Obesity/drug therapy ; Thyroid Hormones ; Weight Loss ; Glucagon-Like Peptide 1 ; Thyrotropin
    Chemical Substances Exenatide (9P1872D4OL) ; Glucagon-Like Peptide-1 Receptor ; Thyroid Hormones ; Glucagon-Like Peptide 1 (89750-14-1) ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14901
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    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Value of cannulated prolactin testing in identifying true hyperprolactinaemia in females of reproductive age.

    Tee, Su Ann / Gad, Hady / Boot, Christopher / James, Andy / Mamoojee, Yaasir

    Clinical endocrinology

    2024  Volume 100, Issue 5, Page(s) 447–449

    MeSH term(s) Humans ; Female ; Hyperprolactinemia/diagnosis ; Prolactin ; Reproduction
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.15048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: McKittrick-Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease.

    Ahmad, Waqar / Hartley, Matthew / Singh, Shweta / Motohashi, Kenzo / Tee, Su Ann / Dallal, Helen / Kamali, Dariush / Matthews, Christopher / Kamaruddin, Shafie

    Endocrinology, diabetes & metabolism case reports

    2023  Volume 2023, Issue 2

    Abstract: Summary: Paraneoplastic syndromes (PS) are uncommon and are known to mimic other clinical entities, often carrying significant morbidity and mortality. The commonest cause of extra-ocular muscle enlargement (EOME) is thyroid eye disease (TED). Rarely, ... ...

    Abstract Summary: Paraneoplastic syndromes (PS) are uncommon and are known to mimic other clinical entities, often carrying significant morbidity and mortality. The commonest cause of extra-ocular muscle enlargement (EOME) is thyroid eye disease (TED). Rarely, PS can cause EOME and masquerade as TED. We describe a 52-year-old female who presented with diarrhoea, acute kidney injury and electrolyte imbalance. An ophthalmic review identified right upper lid retraction. MRI orbits showed increased thickness of the inferior and medial recti bilaterally, presumed as TED. Whilst investigating her diarrhoea, imaging revealed a large rectosigmoid tumour which required surgical excision. In the context of electrolyte disturbance and acute kidney injury, a diagnosis of McKittrick-Wheelock syndrome (MWS) was made. Following successful surgery, electrolyte imbalance, diarrhoea and eyelid retraction improved. Repeat MRI orbits displayed complete resolution of EOME. To our knowledge, this is the first case of MWS presenting with PS-EOME masquerading as TED.
    Learning points: McKittrick-Wheelock syndrome (MWS) is a rare disorder, although likely under-recognised, which is characterised by diarrhoea, dehydration and electrolyte depletion that results from a hypersecretory colorectal neoplasm. Definitive treatment of MWS involves the resection of the colorectal neoplasm. Bilateral ophthalmopathy that appears to be Graves' ophthalmopathy on imaging, though clinical and biochemical evidence fails to identify a thyroid pathology, has been associated with malignancy on rare occasions. Such patients should be investigated for potential malignant causes of their ophthalmopathy.
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-22-0386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Iatrogenic hypoglycaemia following glucose-insulin infusions for the treatment of hyperkalaemia.

    Tee, Su Ann / Devine, Kerri / Potts, Adam / Javaid, Usman / Razvi, Salman / Quinton, Richard / Roberts, Graham / Leech, Nicola J

    Clinical endocrinology

    2020  Volume 94, Issue 2, Page(s) 176–182

    Abstract: Objectives: To study the incidence of, and risk factors for, iatrogenic hypoglycaemia following GwI infusion in our institution.: Context: Hyperkalaemia is a life-threatening biochemical abnormality. Glucose-with-insulin (GwI) infusions form standard ...

    Abstract Objectives: To study the incidence of, and risk factors for, iatrogenic hypoglycaemia following GwI infusion in our institution.
    Context: Hyperkalaemia is a life-threatening biochemical abnormality. Glucose-with-insulin (GwI) infusions form standard management, but risk iatrogenic hypoglycaemia (glucose ≤ 3.9 mmol/L). Recently updated UK guidelines include an additional glucose infusion in patients with pretreatment capillary blood glucose (CBG) < 7.0 mmol/L.
    Design: Retrospective analysis of outcomes for GwI infusions prescribed for hyperkalaemia from 1 January to 28 February 2019, extracted from the Newcastle upon Tyne Hospitals NHS Foundation Trust electronic platform (eRecord).
    Participants: 132 patients received 228 GwI infusions for hyperkalaemia.
    Main outcome measures: Incidence, severity and time to onset of hypoglycaemia.
    Results: Hypoglycaemia incidence was 11.8%. At least 1 hypoglycaemic episode occurred in 18.2% of patients with 6.8% having at least 1 episode of severe hypoglycaemia (< 3.0 mmol/L). Most episodes (77.8%) occurred within 3 h of treatment. Lower pretreatment CBG (5.9 mmol/L [4.1 mmol/L-11.2 mmol/L], versus 7.6 mmol/L [3.7 mmol/L-31.3 mmol/L], P = .000) was associated with hypoglycaemia risk. A diagnosis of type 2 diabetes and treatment for hyperkalaemia within the previous 24 h were negatively associated.
    Conclusions: Within our inpatient population, around 1 in 8 GwI infusions delivered as treatment for hyperkalaemia resulted in iatrogenic hypoglycaemia. Higher pretreatment CBG and a diagnosis of type 2 diabetes were protective, irrespective of renal function. Our findings support the immediate change to current management, either with additional glucose infusions or by using glucose-only infusions in patients without diabetes. These approaches should be compared via a prospective randomized study.
    MeSH term(s) Blood Glucose ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Humans ; Hyperkalemia/chemically induced ; Hyperkalemia/drug therapy ; Hypoglycemia/chemically induced ; Hypoglycemia/drug therapy ; Hypoglycemic Agents/adverse effects ; Iatrogenic Disease ; Insulin/adverse effects ; Prospective Studies ; Retrospective Studies
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: An unusual cause of adrenal insufficiency and bilateral adrenal masses.

    Tee, Su Ann / Gan, Earn Hui / Kanaan, Mohamad Zaher / Price, David Ashley / Hoare, Tim / Pearce, Simon H S

    Endocrinology, diabetes & metabolism case reports

    2018  Volume 2018

    Abstract: Primary adrenal insufficiency secondary to syphilis is extremely rare, with only five cases being reported in the literature. We report a case of adrenal insufficiency as a manifestation of : Learning points: Infectious causes, including syphilis, ... ...

    Abstract Primary adrenal insufficiency secondary to syphilis is extremely rare, with only five cases being reported in the literature. We report a case of adrenal insufficiency as a manifestation of
    Learning points: Infectious causes, including syphilis, should be excluded before considering adrenalectomy or biopsy for any patient presenting with an adrenal mass.It is important to perform a full infection screen including tests for human immunodeficiency virus, other blood-borne viruses and concurrent sexually transmitted diseases in patients presenting with bilateral adrenal hyperplasia with primary adrenal insufficiency.Awareness of syphilis as a potential differential diagnosis is important, as it not only has a wide range of clinical presentations, but its prevalence has been increasing in recent times.
    Language English
    Publishing date 2018-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-18-0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham / Quinton, Richard

    Clinical endocrinology

    2020  Volume 93, Issue 4, Page(s) 508–511

    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/pathology ; Critical Care ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Severity of Illness Index ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Letter
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Original publication: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham P / Quinton, Richard

    Clinical endocrinology

    2020  Volume 93, Issue 5, Page(s) 629–630

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vitamin D/analogs & derivatives
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice.

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S. / Stock, Nadia / Macfarlane, Jim / Martineau, Adrian R. / Burns, Graham Paul / Quinton, Richard

    medRxiv

    Abstract: Objectives: To audit implementation of a local protocol for the treatment of vitamin D deficiency (VDD) among patients hospitalized for Coronavirus Disease 2019 (COVID-19), including an assessment of the prevalence of VDD in these patients, and of ... ...

    Abstract Objectives: To audit implementation of a local protocol for the treatment of vitamin D deficiency (VDD) among patients hospitalized for Coronavirus Disease 2019 (COVID-19), including an assessment of the prevalence of VDD in these patients, and of potential associations with disease severity and fatality. Design: This was not a study or clinical trial, but rather a retrospective interim audit (Newcastle-upon-Tyne Hospitals Registration No. 10075) of a local clinical care pathway for hospitalized patients with COVID-19-related illness. The Information (Caldicott) Guardian permitted these data to be shared beyond the confines of our institution. Setting: A large tertiary academic NHS Foundation Trust in the North East of England, UK, providing care to COVID-19 patients. Participants: One hundred thirty-four hospitalized patients with documented COVID-19 infection. Main outcome measures: Adherence to local investigation and treatment protocol; prevalence of VDD, and relationship of baseline serum 25(OH)D with markers of COVID-19 severity and inpatient fatality versus recovery. Results: 55.8% of eligible patients received Colecalciferol replacement, albeit not always loaded as rapidly as our protocol suggested, and no cases of new hypercalcaemia occurred following treatment. Patients admitted to ITU were younger than those managed on medical wards (61.1 years +/- 11.8 vs. 76.4 years +/- 14.9, p<0.001), with greater prevalence of hypertension, and higher baseline respiratory rate, National Early Warning Score-2 and C-reactive protein level. While mean serum 25(OH)D levels were comparable [i.e. ITU: 33.5 nmol/L +/- 16.8 vs. Non-ITU: 48.1 nmol/L +/- 38.2, mean difference for Ln-transformed-25(OH)D: 0.14, 95% Confidence Interval (CI) (-0.15, 0.41), p=0.3], only 19% of ITU patients had 25(OH)D levels greater than 50 nmol/L vs. 60.9% of non-ITU patients (p=0.02). However, we found no association with fatality, potentially due to small sample size, limitations of no-trial data and, potentially, the prompt diagnosis and treatment of VDD. Conclusions: Subject to the inherent limitations of observational (non-trial) audit data, analysed retrospectively, we found that patients requiring ITU admission were more frequently vitamin D deficient than those managed on medical wards, despite being significantly younger. Larger prospective studies and/or clinical trials are needed to elucidate the role of vitamin D as a preventive and/or therapeutic strategy for mitigating the effects of COVID-19 infection in patients with VDD.
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.21.20136903
    Database COVID19

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  9. Article: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham / Quinton, Richard

    Clin. endocrinol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648988
    Database COVID19

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  10. Article: Original publication: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity

    Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham P / Quinton, Richard

    Clin Endocrinol (Oxf)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #767198
    Database COVID19

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