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Buch ; Online ; Dissertation / Habilitation: Evolution komplexer Algen und der Übergang von Grünalgen zu terrestrischen Pflanzen

Teich, René

molekulare und phylogenetische Charakterisierung der Gene des Primärstoffwechsels in Haptophyten und Streptophyten

2007

Verfasserangabe	von René Teich
Sprache	Deutsch
Umfang	Online-Ressource
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Dissertation / Habilitation	Techn. Univ., Diss--Braunschweig, 2007
Datenquelle	Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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Buch ; Online ; Dissertation / Habilitation: Evolution komplexer Algen und der Übergang von Grünalgen zu terrestrischen Pflanzen

Teich, René [Verfasser]

molekulare und phylogenetische Charakterisierung der Gene des Primärstoffwechsels in Haptophyten und Streptophyten

2007

Verfasserangabe	von René Teich
Schlagwörter	Biowissenschaften, Biologie ; Life Science, Biology
Thema/Rubrik (Code)	sg570
Sprache	Deutsch
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel ; Online: Cytotoxic CD8

Ciurkiewicz, Malgorzata / Herder, Vanessa / Khan, Muhammad Akram / Uhde, Ann-Kathrin / Teich, René / Floess, Stephan / Baumgärtner, Wolfgang / Huehn, Jochen / Beineke, Andreas

Brain pathology (Zurich, Switzerland)

2017 Band 28, Heft 3, Seite(n) 349–368

Abstract: Theiler's murine encephalomyelitis (TME) of susceptible mouse strains is a commonly used infectious animal model for multiple sclerosis. The study aim was to test the hypothesis whether cytotoxic T cell responses account for the limited impact of ... ...

Abstract	Theiler's murine encephalomyelitis (TME) of susceptible mouse strains is a commonly used infectious animal model for multiple sclerosis. The study aim was to test the hypothesis whether cytotoxic T cell responses account for the limited impact of regulatory T cells on antiviral immunity in TME virus-induced demyelinating disease (TMEV-IDD) resistant C57BL/6 mice. TME virus-infected C57BL/6 mice were treated with (i) interleukin-2/-anti-interleukin-2-antibody-complexes to expand regulatory T cells ("Treg-expansion"), (ii) anti-CD8-antibodies to deplete cytotoxic T cells ("CD8-depletion") or (iii) with a combination of Treg-expansion and CD8-depletion ("combined treatment") prior to infection. Results showed that "combined treatment", but neither sole "Treg-expansion" nor "CD8-depletion," leads to sustained hippocampal infection and virus spread to the spinal cord in C57BL/6 mice. Prolonged infection reduces myelin basic protein expression in the spinal cord together with increased accumulation of β-amyloid precursor protein in axons, characteristic of myelin loss and axonal damage, respectively. Chronic spinal cord infection upon "combined treatment" was also associated with increased T and B cell recruitment, accumulation of CD107b
Mesh-Begriff(e)	Animals ; Brain/immunology ; Brain/virology ; CD8-Positive T-Lymphocytes/immunology ; Cardiovirus Infections/immunology ; Demyelinating Diseases/immunology ; Demyelinating Diseases/virology ; Disease Models, Animal ; Female ; Mice, Inbred C57BL ; Spinal Cord/immunology ; Spinal Cord/virology ; T-Lymphocytes, Regulatory/immunology ; Theilovirus/immunology
Sprache	Englisch
Erscheinungsdatum	2017-05-12
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1051484-3
ISSN	1750-3639 ; 1015-6305
ISSN (online)	1750-3639
ISSN	1015-6305
DOI	10.1111/bpa.12518
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice.

Uhde, Ann-Kathrin / Ciurkiewicz, Malgorzata / Herder, Vanessa / Khan, Muhammad Akram / Hensel, Niko / Claus, Peter / Beckstette, Michael / Teich, René / Floess, Stefan / Baumgärtner, Wolfgang / Jung, Klaus / Huehn, Jochen / Beineke, Andreas

Scientific reports

2018 Band 8, Heft 1, Seite(n) 6106

Abstract: Theiler's murine encephalomyelitis virus (TMEV) infection represents an experimental mouse model to study hippocampal damage induced by neurotropic viruses. IL-10 is a pleiotropic cytokine with profound anti-inflammatory properties, which critically ... ...

Abstract	Theiler's murine encephalomyelitis virus (TMEV) infection represents an experimental mouse model to study hippocampal damage induced by neurotropic viruses. IL-10 is a pleiotropic cytokine with profound anti-inflammatory properties, which critically controls immune homeostasis. In order to analyze IL-10R signaling following virus-induced polioencephalitis, SJL mice were intracerebrally infected with TMEV. RNA-based next generation sequencing revealed an up-regulation of Il10, Il10rα and further genes involved in IL-10 downstream signaling, including Jak1, Socs3 and Stat3 in the brain upon infection. Subsequent antibody-mediated blockade of IL-10R signaling led to enhanced hippocampal damage with neuronal loss and increased recruitment of CD3
Mesh-Begriff(e)	Animals ; Cardiovirus Infections/genetics ; Cardiovirus Infections/immunology ; Cardiovirus Infections/pathology ; Cardiovirus Infections/virology ; Female ; Hippocampus/immunology ; Hippocampus/pathology ; Hippocampus/virology ; Mice, Inbred C57BL ; Receptors, Interleukin-10/genetics ; Receptors, Interleukin-10/immunology ; Signal Transduction ; Theilovirus/immunology ; Up-Regulation
Chemische Substanzen	Receptors, Interleukin-10
Sprache	Englisch
Erscheinungsdatum	2018-04-17
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-24378-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Intron distribution in Plantae: 500 million years of stasis during land plant evolution.

Teich, René / Grauvogel, Carina / Petersen, Jörn

Gene

2007 Band 394, Heft 1-2, Seite(n) 96–104

Abstract: Little is known about the evolution of the intron-exon organization in the more primitive groups of land plants, and the intron distribution among Plantae (glauco-, rhodo-, chloro- and streptophytes) has not been investigated so far. The present study is ...

Abstract	Little is known about the evolution of the intron-exon organization in the more primitive groups of land plants, and the intron distribution among Plantae (glauco-, rhodo-, chloro- and streptophytes) has not been investigated so far. The present study is focused on some key species such as the liverwort Marchantia polymorpha, representing the most ancient lineage of land plants, and the streptophycean green alga Mesostigma viride, branching prior to charophycean green algae and terrestrial plants. The intron distribution of six genes for sugar phosphate metabolism was analyzed including four different glyceraldehyde-3-phosphate dehydrogenases (GAPDH), the sedoheptulose-1,7-bisphosphatase (SBP) and the glucose-6-phosphate isomerase (GPI). We established 15 new sequences including three cDNA and twelve genomic clones with up to 24 introns per gene, which were identified in the GPI of Marchantia. The intron patterns of all six genes are completely conserved among seed plants, lycopods, mosses and even liverworts. This intron stasis without any gain of novel introns seem to last for nearly 500 million years and may be characteristic for land plants in general. Some unique intron positions in Mesostigma document that a uniform distribution is no common trait of all streptophytes, but it may correlate with the transition to terrestrial habitats. However, the respective genes of chlorophycean green algae display largely different patterns, thus indicating at least one phase of massive intron rearrangement in the green lineage. We moreover included rhodophyte and glaucophyte reference sequences in our analyses and, even if the well documented monophyly of Plantae is not reflected by a uniform intron distribution, at least one GPI intron is strictly conserved for 1.5 billion years.
Mesh-Begriff(e)	Base Sequence ; Chlorophyta/classification ; Chlorophyta/genetics ; Chlorophyta/metabolism ; Cyanophora/classification ; Cyanophora/genetics ; Cyanophora/metabolism ; DNA, Algal/genetics ; DNA, Plant/genetics ; Evolution, Molecular ; Gene Duplication ; Genes, Plant ; Introns ; Marchantia/classification ; Marchantia/genetics ; Marchantia/metabolism ; Phylogeny ; Plants/classification ; Plants/genetics ; Plants/metabolism ; Sugar Phosphates/genetics ; Sugar Phosphates/metabolism ; Time Factors
Chemische Substanzen	DNA, Algal ; DNA, Plant ; Sugar Phosphates
Sprache	Englisch
Erscheinungsdatum	2007-06-01
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2007.02.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Development and regulation of immune responses to food antigens in pre- and postnatal life.

Renz, Harald / Pfefferle, Petra Ina / Teich, René / Garn, Holger

Nestle Nutrition workshop series. Paediatric programme

2009 Band 64, Seite(n) 139–51; discussion 151–5, 251–7

Abstract: Food antigens are harmless environmental components. The physiological response is the development of clinical and immunological tolerance. It is now well appreciated that tolerance development is the result of active immunoregulation and depends on a ... ...

Abstract	Food antigens are harmless environmental components. The physiological response is the development of clinical and immunological tolerance. It is now well appreciated that tolerance development is the result of active immunoregulation and depends on a close interaction between the innate and adaptive immune system resulting in the development of tolerance-mediating T-cell responses. Programming of the immune system, particularly with regard to tolerance development, already starts before birth and stays under close control of the maternal immune system. Therefore, the pre-and postnatal period represents an important 'window of opportunity' for immunoprogramming. Underlying mechanisms include maternal cell transmission, antibody transfer, transfer of mediates/cytokines, and transmission of antigens and allergens. Immunoprogramming is fostered and augmented in the context of microbial components. Recently, several microbes have been identified which possess the capacity of immunoprogramming early in life. Epigenetic regulation represents an important novel mechanism in this regard. This concept opens new avenues for the development of preventive strategies to avoid inappropriate immune responses against food antigens.
Mesh-Begriff(e)	Aging/immunology ; Allergens/physiology ; Antibodies/physiology ; Dietary Proteins/immunology ; Epigenesis, Genetic ; Female ; Food Hypersensitivity/embryology ; Food Hypersensitivity/immunology ; Food Hypersensitivity/prevention & control ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/growth & development ; Gastrointestinal Tract/microbiology ; Humans ; Immune Tolerance/physiology ; Immunity ; Immunity, Innate ; Immunity, Maternally-Acquired ; Immunologic Factors/physiology ; Male ; Maternal-Fetal Exchange/immunology ; Pregnancy ; T-Lymphocytes/immunology
Chemische Substanzen	Allergens ; Antibodies ; Dietary Proteins ; Immunologic Factors
Sprache	Englisch
Erscheinungsdatum	2009
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1661-6677
ISSN	1661-6677
DOI	10.1159/000235788
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A "green" phosphoribulokinase in complex algae with red plastids: evidence for a single secondary endosymbiosis leading to haptophytes, cryptophytes, heterokonts, and dinoflagellates.

Petersen, Jörn / Teich, René / Brinkmann, Henner / Cerff, Rüdiger

Journal of molecular evolution

2006 Band 62, Heft 2, Seite(n) 143–157

Abstract: Phosphoribulokinase (PRK) is an essential enzyme of photosynthetic eukaryotes which is active in the plastid-located Calvin cycle and regenerates the substrate for ribulose-bisphosphate carboxylase/oxygenase (Rubisco). Rhodophytes and chlorophytes (red ... ...

Abstract	Phosphoribulokinase (PRK) is an essential enzyme of photosynthetic eukaryotes which is active in the plastid-located Calvin cycle and regenerates the substrate for ribulose-bisphosphate carboxylase/oxygenase (Rubisco). Rhodophytes and chlorophytes (red and green algae) recruited their nuclear-encoded PRK from the cyanobacterial ancestor of plastids. The plastids of these organisms can be traced back to a single primary endosymbiosis, whereas, for example, haptophytes, dinoflagellates, and euglenophytes obtained their "complex" plastids through secondary endosymbioses, comprising the engulfment of a unicellular red or green alga by a eukaryotic host cell. We have cloned eight new PRK sequences from complex algae as well as a rhodophyte in order to investigate their evolutionary origin. All available PRK sequences were used for phylogenetic analyses and the significance of alternative topologies was estimated by the approximately unbiased test. Our analyses led to several astonishing findings. First, the close relationship of PRK genes of haptophytes, heterokontophytes, cryptophytes, and dinophytes (complex red lineage) supports a monophyletic origin of their sequences and hence their plastids. Second, based on PRK genes the complex red lineage forms a highly supported assemblage together with chlorophytes and land plants, to the exclusion of the rhodophytes. This green affinity is in striking contrast to the expected red algal origin and our analyses suggest that the PRK gene was acquired once via lateral transfer from a green alga. Third, surprisingly the complex green lineages leading to Bigelowiella and Euglena probably also obtained their PRK genes via lateral gene transfers from a red alga and a complex alga with red plastids, respectively.
Mesh-Begriff(e)	Animals ; Base Sequence ; Biological Evolution ; Cryptophyta/genetics ; Dinoflagellida/genetics ; Molecular Sequence Data ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/isolation & purification ; Phylogeny ; Plastids/genetics ; Rhodophyta/genetics ; Symbiosis
Chemische Substanzen	Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; phosphoribulokinase (EC 2.7.1.19)
Sprache	Englisch
Erscheinungsdatum	2006-02
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120148-7
ISSN	1432-1432 ; 0022-2844
ISSN (online)	1432-1432
ISSN	0022-2844
DOI	10.1007/s00239-004-0305-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.

Pasztoi, Maria / Bonifacius, Agnes / Pezoldt, Joern / Kulkarni, Devesha / Niemz, Jana / Yang, Juhao / Teich, René / Hajek, Janina / Pisano, Fabio / Rohde, Manfred / Dersch, Petra / Huehn, Jochen

Cellular and molecular life sciences : CMLS

2017 Band 74, Heft 15, Seite(n) 2839–2850

Abstract: Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of ... ...

Abstract	Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4
Mesh-Begriff(e)	Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/microbiology ; Cell Differentiation ; Female ; Forkhead Transcription Factors/immunology ; Host-Pathogen Interactions ; Intestines/immunology ; Intestines/microbiology ; Mice, Inbred BALB C ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/microbiology ; Th17 Cells/immunology ; Th17 Cells/microbiology ; Yersinia pseudotuberculosis/immunology ; Yersinia pseudotuberculosis/physiology ; Yersinia pseudotuberculosis Infections/immunology
Chemische Substanzen	Forkhead Transcription Factors ; Foxp3 protein, mouse ; Receptors, Antigen, T-Cell
Sprache	Englisch
Erscheinungsdatum	2017-08
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2516-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Origin and distribution of Calvin cycle fructose and sedoheptulose bisphosphatases in plantae and complex algae: a single secondary origin of complex red plastids and subsequent propagation via tertiary endosymbioses.

Teich, René / Zauner, Stefan / Baurain, Denis / Brinkmann, Henner / Petersen, Jörn

Protist

2007 Band 158, Heft 3, Seite(n) 263–276

Abstract: Sedoheptulose-1,7-bisphosphatase (SBPase) and fructose-1,6-bisphosphatase (FBPase) are essential nuclear-encoded enzymes involved in land plant Calvin cycle and gluconeogenesis. In this study, we cloned seven SBP and seven FBP cDNAs/genes and established ...

Abstract	Sedoheptulose-1,7-bisphosphatase (SBPase) and fructose-1,6-bisphosphatase (FBPase) are essential nuclear-encoded enzymes involved in land plant Calvin cycle and gluconeogenesis. In this study, we cloned seven SBP and seven FBP cDNAs/genes and established sequences from all lineages of photosynthetic eukaryotes, in order to investigate their origin and evolution. Our data are best explained by a single recruitment of plastid-targeted SBP in Plantae after primary endosymbiosis and a further distribution to algae with complex plastids. While SBP is universally found in photosynthetic lineages, its presence in apicomplexa, ciliates, trypanosomes, and ascomycetes is surprising given that no metabolic function beyond the one in the plastid Calvin cycle is described so far. Sequences of haptophytes, cryptophytes, diatoms, and peridinin-containing dinoflagellates (complex red lineage) strongly group together in the SBP tree and the same assemblage is recovered for plastid-targeted FBP sequences, although this is less supported. Both SBP and plastid-targeted FBP are most likely of red algal origin. Including phosphoribulokinase, fructose bisphosphate aldolase, and glyceraldehyde-3-phosphate dehydrogenase, a total of five independent plastid-related nuclear-encoded markers support a common origin of all complex rhodoplasts via a single secondary endosymbiosis event. However, plastid phylogenies are incongruent with those of the host cell, as illustrated by the cytosolic FBP isoenzyme. These results are discussed in the context of Cavalier-Smith's far-reaching chromalveolate hypothesis. In our opinion, a more plausible evolutionary scenario would be the establishment of a unique secondary rhodoplast and its subsequent spread via tertiary endosymbioses.
Mesh-Begriff(e)	Algal Proteins/genetics ; Animals ; Apicomplexa/genetics ; Ascomycota/genetics ; Ciliophora/genetics ; DNA, Algal/genetics ; DNA, Plant/genetics ; Diatoms/genetics ; Dinoflagellida/genetics ; Emigration and Immigration ; Eukaryota/enzymology ; Eukaryota/genetics ; Eukaryota/physiology ; Evolution, Molecular ; Fructose-Bisphosphatase/genetics ; Gene Transfer, Horizontal ; Molecular Sequence Data ; Phosphoric Monoester Hydrolases/genetics ; Phylogeny ; Plant Physiological Phenomena ; Plant Proteins/genetics ; Plants/enzymology ; Plants/genetics ; Plastids/genetics ; Sequence Analysis, DNA ; Sequence Homology ; Symbiosis ; Trypanosoma/genetics
Chemische Substanzen	Algal Proteins ; DNA, Algal ; DNA, Plant ; Plant Proteins ; Fructose-Bisphosphatase (EC 3.1.3.11) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; sedoheptulose-bisphosphatase (EC 3.1.3.37)
Sprache	Englisch
Erscheinungsdatum	2007-07
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036014-9
ISSN	1618-0941 ; 1434-4610
ISSN (online)	1618-0941
ISSN	1434-4610
DOI	10.1016/j.protis.2006.12.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

Uhde, Ann-Kathrin / Herder, Vanessa / Akram Khan, Muhammad / Ciurkiewicz, Malgorzata / Schaudien, Dirk / Teich, René / Floess, Stefan / Baumgärtner, Wolfgang / Huehn, Jochen / Beineke, Andreas

PloS one

2016 Band 11, Heft 9, Seite(n) e0161883

Abstract: Theiler´s murine encephalomyelitis virus (TMEV)-infection is a widely used animal model for studying demyelinating disorders, including multiple sclerosis (MS). The immunosuppressive cytokine Interleukin (IL)-10 counteracts hyperactive immune responses ... ...

Abstract	Theiler´s murine encephalomyelitis virus (TMEV)-infection is a widely used animal model for studying demyelinating disorders, including multiple sclerosis (MS). The immunosuppressive cytokine Interleukin (IL)-10 counteracts hyperactive immune responses and critically controls immune homeostasis in infectious and autoimmune disorders. In order to investigate the effect of signaling via Interleukin-10 receptor (IL-10R) in infectious neurological diseases, TMEV-infected SJL mice were treated with IL-10R blocking antibody (Ab) in the acute and chronic phase of the disease. The findings demonstrate that (i) Ab-mediated IL-10 neutralization leads to progressive colitis with a reduction in Foxp3+ regulatory T cells and increased numbers of CD8+CD44+ memory T cells as well as activated CD4+CD69+ and CD8+CD69+ T cells in uninfected mice. (ii) Concurrent acute TMEV-infection worsened enteric disease-mediated by IL-10R neutralization. Virus-triggered effects were associated with an enhanced activation of CD4+ T helper cells and CD8+ cytotoxic T lymphocytes and augmented cytokine expression. By contrast, (iii) IL-10R neutralization during chronic TMEV-infection was not associated with enhanced peripheral immunopathology but an increased CD3+ T cell influx in the spinal cord. IL-10R neutralization causes a breakdown in peripheral immune tolerance in genetically predisposed mice, which leads to immune-mediated colitis, resembling inflammatory bowel disease. Hyperactive immune state following IL-10R blockade is enhanced by central nervous system-restricted viral infection in a disease phase-dependent manner.
Mesh-Begriff(e)	Animals ; Antibodies/pharmacology ; Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD3 Complex/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Central Nervous System/metabolism ; Central Nervous System/virology ; Colitis/metabolism ; Colitis/pathology ; Colitis/virology ; Female ; Forkhead Transcription Factors/metabolism ; Hyaluronan Receptors/metabolism ; Lectins, C-Type ; Mice ; Receptors, Interleukin-10/antagonists & inhibitors ; Receptors, Interleukin-10/deficiency ; Receptors, Interleukin-10/metabolism ; T-Lymphocytes/metabolism ; Theilovirus/physiology
Chemische Substanzen	Antibodies ; Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD3 Complex ; CD69 antigen ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Hyaluronan Receptors ; Lectins, C-Type ; Receptors, Interleukin-10
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2016-09-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0161883
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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