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Article ; Online: After nasopharyngeal infection, foot-and-mouth disease virus serotype A RNA is shed in bovine milk without associated mastitis.

Suchowski, Marcel / Eschbaumer, Michael / Teifke, Jens P / Ulrich, Reiner

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2021 Volume 33, Issue 5, Page(s) 997–1001

Abstract: Foot-and-mouth disease (FMD) is a highly contagious aphthoviral infection of cloven-hoofed animals, inducing vesiculopustular stomatitis, pododermatitis, and thelitis. Vesicular fluid represents a major pathway of virus excretion, but bovine milk is ... ...

Abstract	Foot-and-mouth disease (FMD) is a highly contagious aphthoviral infection of cloven-hoofed animals, inducing vesiculopustular stomatitis, pododermatitis, and thelitis. Vesicular fluid represents a major pathway of virus excretion, but bovine milk is another important source of virus shedding. We describe here the time course of FMD virus (FMDV) excretion in the milk and characterize associated lesions in the mammary gland. Three dairy cows were infected by nasopharyngeal instillation of FMDV and monitored over 12 d. Autopsy was performed at the end of the study, and specimens were collected for histopathology, IHC, and RT-qPCR. All 3 cows developed fever, drooling, vesiculopustular stomatitis, interdigital dermatitis, and thelitis. FMDV RNA was detectable in whole milk until the end of the trial, but only transiently in saliva, nasal secretions, and blood serum. Although histology confirmed vesiculopustular lesions in the oral and epidermal specimens, the mammary glands did not have unequivocal evidence of FMDV-induced inflammation. FMDV antigen was detectable in skin and oral mucosa, but not in the mammary gland, and FMDV RNA was detectable in 9 of 29 samples of squamous epithelia but only in 1 of 12 samples of mammary gland.
MeSH term(s)	Animals ; Cattle ; Cattle Diseases ; Female ; Foot-and-Mouth Disease ; Foot-and-Mouth Disease Virus/genetics ; Mastitis/veterinary ; Milk ; Nasopharynx/virology ; RNA ; Serogroup
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387211022467
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Article ; Online: Tropism of

Schlohsarczyk, Elfi K / Drewes, Stephan / Koteja, Paweł / Röhrs, Susanne / Ulrich, Rainer G / Teifke, Jens P / Herden, Christiane

Viruses

2023 Volume 15, Issue 3

Abstract: In Europe, most cases of human hantavirus disease are caused ... ...

Abstract	In Europe, most cases of human hantavirus disease are caused by
MeSH term(s)	Animals ; Humans ; Hemorrhagic Fever with Renal Syndrome ; Coinfection/veterinary ; Puumala virus/genetics ; Hantavirus Infections ; Arvicolinae ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15030612
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Article: After nasopharyngeal infection, foot-and-mouth disease virus serotype A RNA is shed in bovine milk without associated mastitis

Suchowski, Marcel / Eschbaumer, Michael / Teifke, Jens P. / Ulrich, Reiner

Journal of veterinary diagnostic investigation. 2021 Sept., v. 33, no. 5

2021

Abstract	Foot-and-mouth disease (FMD) is a highly contagious aphthoviral infection of cloven-hoofed animals, inducing vesiculopustular stomatitis, pododermatitis, and thelitis. Vesicular fluid represents a major pathway of virus excretion, but bovine milk is another important source of virus shedding. We describe here the time course of FMD virus (FMDV) excretion in the milk and characterize associated lesions in the mammary gland. Three dairy cows were infected by nasopharyngeal instillation of FMDV and monitored over 12 d. Autopsy was performed at the end of the study, and specimens were collected for histopathology, IHC, and RT-qPCR. All 3 cows developed fever, drooling, vesiculopustular stomatitis, interdigital dermatitis, and thelitis. FMDV RNA was detectable in whole milk until the end of the trial, but only transiently in saliva, nasal secretions, and blood serum. Although histology confirmed vesiculopustular lesions in the oral and epidermal specimens, the mammary glands did not have unequivocal evidence of FMDV-induced inflammation. FMDV antigen was detectable in skin and oral mucosa, but not in the mammary gland, and FMDV RNA was detectable in 9 of 29 samples of squamous epithelia but only in 1 of 12 samples of mammary gland.
Keywords	Foot-and-mouth disease virus ; RNA ; antigens ; blood serum ; dermatitis ; excretion ; fever ; foot-and-mouth disease ; histology ; histopathology ; inflammation ; mammary glands ; mucosa ; necropsy ; nose ; pododermatitis ; saliva ; serotypes ; viruses ; whole milk
Language	English
Dates of publication	2021-09
Size	p. 997-1001.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387211022467
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tropism of Puumala orthohantavirus and Endoparasite Coinfection in the Bank Vole Reservoir

Schlohsarczyk, Elfi K. / Drewes, Stephan / Koteja, Paweł / Röhrs, Susanne / Ulrich, Rainer G. / Teifke, Jens P. / Herden, Christiane

2023

Abstract: In Europe, most cases of human hantavirus disease are caused by Puumala orthohantavirus (PUUV) transmitted by bank voles (Clethrionomys glareolus, syn. Myodes glareolus), in which PUUV causes inconspicuous infection. Little is known about tropism and ... ...

Abstract	In Europe, most cases of human hantavirus disease are caused by Puumala orthohantavirus (PUUV) transmitted by bank voles (Clethrionomys glareolus, syn. Myodes glareolus), in which PUUV causes inconspicuous infection. Little is known about tropism and endoparasite coinfections in PUUV-infected reservoir and spillover-infected rodents. Here, we characterized PUUV tropism, pathological changes and endoparasite coinfections. The voles and some non-reservoir rodents were examined histologically, immunohistochemically, by in situ hybridization, indirect IgG enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. PUUV RNA and anti-PUUV antibodies were detected simultaneously in a large proportion of the bank voles, indicating persistent infection. Although PUUV RNA was not detected in non-reservoir rodents, the detection of PUUV-reactive antibodies suggests virus contact. No specific gross and histological findings were detected in the infected bank voles. A broad organ tropism of PUUV was observed: kidney and stomach were most frequently infected. Remarkably, PUUV was detected in cells lacking the typical secretory capacity, which may contribute to the maintenance of virus persistence. PUUV-infected wild bank voles were found to be frequently coinfected with Hepatozoon spp. and Sarcocystis (Frenkelia) spp., possibly causing immune modulation that may influence susceptibility to PUUV infection or vice versa. The results are a prerequisite for a deeper understanding of virus–host interactions in natural hantavirus reservoirs.
Keywords	Text ; ddc:570 ; Puumala orthohantavirus -- hantavirus infection -- zoonoses -- rodents -- bank vole -- immunohistochemistry -- in situ hybridization -- endoparasite coinfection
Subject code	616
Language	English
Publishing date	2023-02-23
Publisher	MDPI AG
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An improved animal model for herpesvirus encephalitis in humans.

Sehl, Julia / Hölper, Julia E / Klupp, Barbara G / Baumbach, Christina / Teifke, Jens P / Mettenleiter, Thomas C

PLoS pathogens

2020 Volume 16, Issue 3, Page(s) e1008445

Abstract: Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most devastating diseases in humans. Patients present with fever, mental status changes or seizures and when untreated, sequelae can be fatal. Herpes Simplex Encephalitis ( ... ...

Abstract	Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most devastating diseases in humans. Patients present with fever, mental status changes or seizures and when untreated, sequelae can be fatal. Herpes Simplex Encephalitis (HSE) is characterized by mainly unilateral necrotizing inflammation effacing the frontal and mesiotemporal lobes with rare involvement of the brainstem. HSV-1 is hypothesized to invade the CNS via the trigeminal or olfactory nerve, but viral tropism and the exact route of infection remain unclear. Several mouse models for HSE have been developed, but they mimic natural infection only inadequately. The porcine alphaherpesvirus Pseudorabies virus (PrV) is closely related to HSV-1 and Varicella Zoster Virus (VZV). While pigs can control productive infection, it is lethal in other susceptible animals associated with severe pruritus leading to automutilation. Here, we describe the first mutant PrV establishing productive infection in mice that the animals are able to control. After intranasal inoculation with a PrV mutant lacking tegument protein pUL21 and pUS3 kinase activity (PrV-ΔUL21/US3Δkin), nearly all mice survived despite extensive infection of the central nervous system. Neuroinvasion mainly occurred along the trigeminal pathway. Whereas trigeminal first and second order neurons and autonomic ganglia were positive early after intranasal infection, PrV-specific antigen was mainly detectable in the frontal, mesiotemporal and parietal lobes at later times, accompanied by a long lasting lymphohistiocytic meningoencephalitis. Despite this extensive infection, mice showed only mild to moderate clinical signs, developed alopecic skin lesions, or remained asymptomatic. Interestingly, most mice exhibited abnormalities in behavior and activity levels including slow movements, akinesia and stargazing. In summary, clinical signs, distribution of viral antigen and inflammatory pattern show striking analogies to human encephalitis caused by HSV-1 or VZV not observed in other animal models of disease.
MeSH term(s)	Animals ; Disease Models, Animal ; Encephalitis, Varicella Zoster/genetics ; Encephalitis, Varicella Zoster/metabolism ; Female ; Ganglia, Autonomic/metabolism ; Ganglia, Autonomic/pathology ; Ganglia, Autonomic/virology ; Herpes Simplex/genetics ; Herpes Simplex/metabolism ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/metabolism ; Herpesvirus 1, Suid/genetics ; Herpesvirus 1, Suid/metabolism ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/metabolism ; Humans ; Mice ; Neurons/metabolism ; Neurons/pathology ; Neurons/virology ; Pseudorabies/genetics ; Pseudorabies/metabolism ; Pseudorabies/pathology ; Swine
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1008445
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Article ; Online: Field survey and molecular characterization of apicomplexan parasites in small mammals from military camps in Afghanistan.

Schotte, Ulrich / Binder, Alfred / Goller, Katja V / Faulde, Michael / Ruhl, Silke / Sauer, Sabine / Schlegel, Mathias / Teifke, Jens P / Ulrich, Rainer G / Wylezich, Claudia

Parasitology research

2023 Volume 122, Issue 5, Page(s) 1199–1211

Abstract: Small mammals are an important reservoir for causative agents of numerous infectious diseases, including zoonotic and vector-borne diseases. The occurrence of these pathogens represents a regional but permanent threat for humans and animals in general ... ...

Abstract	Small mammals are an important reservoir for causative agents of numerous infectious diseases, including zoonotic and vector-borne diseases. The occurrence of these pathogens represents a regional but permanent threat for humans and animals in general and might especially weaken military personnel and companion animals in abroad missions. In our study, small mammals collected in military camps in Afghanistan (Feyzabad, Mazar-e Sharif, and Kunduz) were investigated for the presence of apicomplexans using histopathology and molecular methods. For this purpose, well-established and newly developed real-time PCR assays were applied. A high prevalence was detected not only in house mice (Mus musculus), but also in shrews (Crocidura cf. suaveolens) and grey dwarf hamsters (Cricetulus migratorius). The molecular characterization based on the 18S rRNA gene revealed a close relationship to a cluster of Hepatozoon sp. detected in voles of the genus Microtus. Hepatozoon canis DNA was detected in one house mouse as well as in two Rhipicephalus ticks from a dog puppy. In addition, around 5% of the house mice were found to be infected with far related adeleorinids showing the highest sequence identity of 91.5% to Klossiella equi, the only published Klossiella sequence at present. For their better phylogenetic characterization, we conducted metagenomics by sequencing of two selected samples. The resulting 18S rRNA gene sequences have a length of about 2400 base pairs including an insertion of about 500 base pairs and are 100% identical to each other. Histopathology together with organ tropism and detection rates verified this sequence as of Klossiella muris. In conclusion, we documented naturally occurring protozoan stages and the additional taxonomic characterization of a well-known commensal in mice by applying a combination of different approaches. The study is of medical, social, and biological importance for ensuring human and animal health in military camps and also stresses the required awareness for the potential risk of zoonoses.
MeSH term(s)	Humans ; Animals ; Dogs ; Mice ; Parasites ; Afghanistan ; Phylogeny ; Military Personnel ; Eucoccidiida ; Shrews
Language	English
Publishing date	2023-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-023-07820-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uh II Zs.124: Show issues

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Article ; Online: Airborne Disinfection by Dry Fogging Efficiently Inactivates Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Mycobacteria, and Bacterial Spores and Shows Limitations of Commercial Spore Carriers.

Schinköthe, Jan / Scheinemann, Hendrik A / Diederich, Sandra / Freese, Holger / Eschbaumer, Michael / Teifke, Jens P / Reiche, Sven

Applied and environmental microbiology

2021 Volume 87, Issue 3

Abstract: Airborne disinfection of high-containment facilities before maintenance or between animal studies is crucial. Commercial spore carriers (CSC) coated with ... ...

Abstract	Airborne disinfection of high-containment facilities before maintenance or between animal studies is crucial. Commercial spore carriers (CSC) coated with 10
MeSH term(s)	Aerosols ; COVID-19/prevention & control ; Cell Line ; Decontamination/methods ; Disinfectants/pharmacology ; Disinfection/methods ; Geobacillus stearothermophilus/drug effects ; Hydrogen Peroxide ; Mycobacterium/drug effects ; Particle Size ; Peracetic Acid ; SARS-CoV-2/drug effects ; Spores, Bacterial/drug effects ; Steam
Chemical Substances	Aerosols ; Disinfectants ; Steam ; Hydrogen Peroxide (BBX060AN9V) ; Peracetic Acid (I6KPI2E1HD)
Keywords	covid19
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/AEM.02019-20
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Article ; Online: Clinical, neuropathological, and immunological short- and long-term feature of a mouse model mimicking human herpes virus encephalitis.

Sehl-Ewert, Julia / Schwaiger, Theresa / Schäfer, Alexander / Hölper, Julia E / Klupp, Barbara G / Teifke, Jens P / Blohm, Ulrike / Mettenleiter, Thomas C

Brain pathology (Zurich, Switzerland)

2021 Volume 32, Issue 3, Page(s) e13031

Abstract: Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV-1) infections ... ...

Abstract	Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV-1) infections mimic different crucial aspects of HSE, central questions remain unanswered. They comprise the specific temporofrontal tropism, viral spread within the central nervous system (CNS), as well as potential molecular and immunological barriers that drive virus into latency while only rarely resulting in severe HSE. We have recently proposed an alternative mouse model by using a pseudorabies virus (PrV) mutant that more faithfully represents the striking features of human HSE: temporofrontal meningoencephalitis with few severely, but generally only moderately to subclinically affected mice as well as characteristic behavioral abnormalities. Here, we characterized this animal model using 6- to 8-week-old female CD-1 mice in more detail. Long-term investigation over 6 months consistently revealed a biphasic course of infection accompanied by recurring clinical signs including behavioral alterations and mainly mild meningoencephalitis restricted to the temporal and frontal lobes. By histopathological and immunological analyses, we followed the kinetics and spatial distribution of inflammatory lesions as well as the underlying cytokine expression in the CNS over 21 days within the acute phase of infection. Affecting the temporal lobes, the inflammatory infiltrate was composed of lymphocytes and macrophages showing a predominantly lymphocytic shift 15 days after infection. A strong increase was observed in cytokines CXCL10, CCL2, CCL5, and CXCL1 recruiting inflammatory cells to the CNS. Unlike the majority of infected mice, strongly affected animals demonstrated extensive temporal lobe edema, which is typically present in severe human HSE cases. In summary, these results support the validity of our animal model for in-depth investigation of HSE pathogenesis.
MeSH term(s)	Animals ; Central Nervous System/pathology ; Cytokines ; Disease Models, Animal ; Encephalitis, Herpes Simplex/diagnosis ; Encephalitis, Herpes Simplex/pathology ; Female ; Humans ; Meningoencephalitis ; Mice ; Neuropathology
Chemical Substances	Cytokines
Language	English
Publishing date	2021-10-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1051484-3
ISSN	1750-3639 ; 1015-6305
ISSN (online)	1750-3639
ISSN	1015-6305
DOI	10.1111/bpa.13031
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Zs.A 3585: Show issues

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Book: Untersuchung zur Pathogenese des hämorrhagischen Syndroms und zum Organtropismus von hochvirulenten H5N1 Isolaten in unterschiedlichen Spezies (Priorität 2)

Breithaupt, Angele / Teifke, Jens P

Abschlussbericht FSI Projekt 2-4.2 ; Laufzeit: 01.01.2007 - 30.06.2010

2010

Title variant	Abschlussbericht FSI Projekt 2-4.2
Institution	Friedrich-Loeffler-Institut
Author's details	[Friedrich-Loeffler-Institut - FLI]. Bearb. von: Jens P. Teifke; Angele Breithaupt
Language	German
Size	Ohne Zählung, [ca. 80] Bl., graph. Darst.
Publishing place	Greifswald - Insel Riems
Document type	Book
Note	Auch als elektronische Ressource vorh. ; Förderkennzeichen BMBF 2813101206 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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Book ; Online: Untersuchung zur Pathogenese des hämorrhagischen Syndroms und zum Organtropismus von hochvirulenten H5N1 Isolaten in unterschiedlichen Spezies (Priorität 2)

Breithaupt, Angele / Teifke, Jens P

Abschlussbericht FSI Projekt 2-4.2 ; Laufzeit: 01.01.2007 - 30.06.2010

2010

Title variant	Abschlussbericht FSI Projekt 2-4.2
Institution	Friedrich-Loeffler-Institut
Author's details	[Friedrich-Loeffler-Institut - FLI]. Bearb. von: Jens P. Teifke; Angele Breithaupt
Language	German
Size	Online-Ressource (57 S., 395 KB), graph. Darst.
Publisher	Technische Informationsbibliothek u. Universitätsbibliothek
Publishing place	Hannover ; Greifswald - Insel Riems
Document type	Book ; Online
Note	Auch als gedr. Ausg. vorhanden ; Förderkennzeichen BMBF 2813101206 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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