Article ; Online: The rs2165241 polymorphism of the
Climacteric : the journal of the International Menopause Society
2022 Volume 25, Issue 4, Page(s) 407–412
Abstract: Objective: This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (: Methods: The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP ( ... ...
Abstract | Objective: This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 ( Methods: The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with Results: A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42). Conclusion: No association was detected between rs2165241 of the |
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MeSH term(s) | Amino Acid Oxidoreductases/genetics ; Female ; Humans ; Infant, Newborn ; Pelvic Organ Prolapse/genetics ; Polymorphism, Genetic ; Postmenopause/genetics ; Pregnancy ; Vagina |
Chemical Substances | Amino Acid Oxidoreductases (EC 1.4.-) ; LOXL1 protein, human (EC 1.4.3.-) |
Language | English |
Publishing date | 2022-04-20 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1469153-x |
ISSN | 1473-0804 ; 1369-7137 |
ISSN (online) | 1473-0804 |
ISSN | 1369-7137 |
DOI | 10.1080/13697137.2022.2058392 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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