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Article ; Online: SAPONIN RICH FRACTION OF BAUHINIA VARIEGATA LINN. AMELIORATES KIDNEY STONE FORMATION IN RATS

Anjali Patel / Hital Shah / Tejal Gandhi

Exploratory Animal and Medical Research, Vol 12, Iss 1, Pp 74-

2022 Volume 84

Abstract: The present study was planned to know the effect of saponin-rich extract of Bauhinia variegata Linn. (SREBV) in ethylene glycol induced urolithiasis model. The qualitative and quantitative analysis of SREBV revealed the presence of β-sitosterol, ... ...

Abstract	The present study was planned to know the effect of saponin-rich extract of Bauhinia variegata Linn. (SREBV) in ethylene glycol induced urolithiasis model. The qualitative and quantitative analysis of SREBV revealed the presence of β-sitosterol, stigmasterol, and lupeol. Administration of ethylene glycol (0.75% v/v in distilled water) to male Wistar rats for 28 days successfully induced urolithiasis with hyperoxaluria, hypercalciuria as well as increased renal excretion of uric acid and inorganic phosphate. Supplementation with SREBV significantly decreased these levels of stone promotors via diuresis and increased levels of stone inhibitors like magnesium. There was a significant reduction in creatinine, uric acid, and blood urea nitrogen in rats administered with SREBV. Moreover, the reno-protective effect is evident by decreased deposits of calcium-oxalate crystals in the kidney tissue of SREBV-treated rats. The antilithiatic activity of SREBV is also supported by its radical scavenging activity portrayed in DPPH assay in-vitro as well as alleviation in lipid peroxidation and improvement in antioxidant enzyme levels in-vivo. With this study, it was clinched that the SREBV supplementation safeguarded EG-induced urolithiasis as it abbreviated the growth of urinary stones. The mechanisms attributing to this effect might be due to its antioxidant, diuretic, nephroprotective, and curbing in stone-forming constituents.
Keywords	antiurolithiatic effect ; antioxidant ; bauhinia variegata ; calcium oxalate ; saponin ; Veterinary medicine ; SF600-1100
Subject code	500
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	West Bengal Veterinary Alumni Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modulation of Nrf2 by quercetin in doxorubicin-treated rats

Anish Sharma / Mihir Parikh / Hital Shah / Tejal Gandhi

Heliyon, Vol 6, Iss 4, Pp e03803- (2020)

2020

Abstract: Doxorubicin (DOXO), a potent and widely used chemotherapeutic agent, causes irreversible heart failure by increasing oxidative stress, which limits its clinical utility. Nuclear factor erythroid-derived 2 -like 2 (Nrf2) is a prominent central regulator ... ...

Abstract	Doxorubicin (DOXO), a potent and widely used chemotherapeutic agent, causes irreversible heart failure by increasing oxidative stress, which limits its clinical utility. Nuclear factor erythroid-derived 2 -like 2 (Nrf2) is a prominent central regulator of cellular impenetrable to oxidants. The purpose of the study is to assess the ameliorative outcome of quercetin in cardiomyopathic rats induced by doxorubicin. Cardiomyopathy was produced in rats by single intraperitoneal weekly with DOXO (2 mg/kg) for 4 weeks. The rats were divided into five groups: (I) control group; (II) DOXO (2 mg/kg, i.p.) group; (III–V) DOXO + quercetin (10 mg/kg, 25 mg/kg and 50 mg/kg, orally), and were treated for 7 weeks. At the end of the treatment duration, cardiac function and biochemical parameters were assessed. Quercetin (10 mg/kg, 25 mg/kg and 50 mg/kg, orally) treatment reduced the raised blood pressure (BP) and left ventricular dysfunction. Withal, it prevented the rise in CKMB and LDH, suggesting the effect of quercetin in the maintaining the integrity of the cell membrane Besides, it also prevented the alteration in electrolyte levels, the activity of ATPase, and antioxidant status. Quercetin increased Nrf2 mRNA expression and reduced histological abnormalities compared 11 Anish Sharma et al., MODULATION OF NRF2 BY QUERCETIN IN DOXORUBICIN TREATED RATS.to the DOXO control group. In conclusion, quercetin protected against DOXO- induced cardiomyopathy, by increasing expression of NRF2, and thereby increasing antioxidant defense and restoring biochemical and histological abnormalities.
Keywords	Doxorubicin ; Cardiomyopathy ; Quercetin ; NRF2 ; SD rats ; Antioxidant parameters ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	630
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Randomized Single Blind Parallel Group Study Comparing Monoherbal Formulation Containing Holarrhena antidysenterica Extract with Mesalamine in Chronic Ulcerative Colitis Patients

Sarika Johari / Tejal Gandhi

Ancient Science of Life, Vol 36, Iss 1, Pp 19-

2016 Volume 27

Abstract: Background: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. Aims and Objectives: This study aims to compare the treatment with monoherbal formulation of Holarrhena ... ...

Abstract	Background: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. Aims and Objectives: This study aims to compare the treatment with monoherbal formulation of Holarrhena antidysenterica with Mesalamine in chronic ulcerative colitis patients with special emphasis to side effects and relapse. Settings and Design: Patients were enrolled from an Ayurveda Hospital and a private Hospital, Gujarat. The study was randomized, parallel group and single blind design. Materials and Methods: The protocol was approved by Institutional Human Research Ethics Committee of Anand Pharmacy College on 23rd Jan 2013. Three groups (n = 10) were treated with drug Mesalamine (Group I), monoherbal tablet (Group II) and combination of both (Group III) respectively. Baseline characteristics, factors affecting quality of life, chronicity of disease, signs and symptoms, body weight and laboratory investigations were recorded. Side effects and complications developed, if any were recorded during and after the study. Statistical Analysis Used: Results were expressed as mean ± SEM. Data was statistically evaluated using t-test, Wilcoxon test, Mann Whitney U test, Kruskal Wallis test and ANOVA, wherever applicable, using GraphPad Prism 6. Results: All the groups responded positively to the treatments. All the patients were positive for occult blood in stool which reversed significantly after treatment along with rise in hemoglobin. Patients treated with herbal tablets alone showed maximal reduction in abdominal pain, diarrhea, and bowel frequency and stool consistency scores than Mesalamine treated patients. Treatment with herbal tablet alone and in combination with Mesalamine significantly reduced the stool infection. Patients treated with herbal drug alone and in combination did not report any side effects, relapse or complications while 50% patients treated with Mesalamine exhibited the relapse with diarrhea and flatulence after drug withdrawal. Conclusion: Thus, monoherbal formulation alone and with Mesalamine was efficacious than Mesalamine alone in UC.
Keywords	Clinical study ; Holarrhena antidysenterica ; mesalamine ; ulcerative colitis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development and validation of an HPTLC method for the simultaneous estimation of Clonazepam and Paroxetine hydrochloride using a DOE approach

Purvi Shah / Jalpa Patel / Kalpana Patel / Tejal Gandhi

Journal of Taibah University for Science, Vol 11, Iss 1, Pp 121-

2017 Volume 132

Abstract: The present study examines simultaneous multiple response optimization using Derringer's desirability function for the development of an HPTLC method to detect Clonazepam and Paroxetine hydrochloride in pharmaceutical dosage form. Central composite ... ...

Abstract	The present study examines simultaneous multiple response optimization using Derringer's desirability function for the development of an HPTLC method to detect Clonazepam and Paroxetine hydrochloride in pharmaceutical dosage form. Central composite design (CCD) was used to optimize the chromatographic conditions for HPTLC. The independent variables used for the optimization were the n-butanol content in the mobile phase, the chamber saturation time and the distance travelled. HPTLC separation was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase using n-butanol:glacial acetic acid:water (9:2:0.5% v/v/v) as the mobile phase. Quantification was achieved based on a densitometric analysis of Clonazepam and Paroxetine hydrochloride over the concentration range of 40–240 ng/band and 300–1800 ng/band, respectively, at 288 nm. The method yielded compact and well-resolved bands at Rf of 0.77 ± 0.02 and 0.34 ± 0.02 for Clonazepam and Paroxetine hydrochloride, respectively. The linear regression analysis for the calibration plots produced r2 = 0.9958 and r2 = 0.9989 for Clonazepam and Paroxetine hydrochloride, respectively. The precision, accuracy, robustness, specificity, limit of detection and limit of quantitation of the method were validated according to the ICH guidelines. The factors evaluated in the robustness test were determined to have an insignificant effect on the selected responses. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.
Keywords	Clonazepam ; Paroxetine hydrochloride ; Central composite design ; High performance thin layer chromatography ; Validation ; Science (General) ; Q1-390
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Cyperus Rotundus on Cytokine Gene Expression in Experimental Inflammatory Bowel Disease

Sarika Johari / Chaitanya Joshi / Tejal Gandhi

Iranian Journal of Medical Sciences, Vol 41, Iss 5, Pp 391-

2016 Volume 398

Abstract: Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of ... ...

Abstract	Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to unravel the molecular mechanism through cytokine regulation in rats in experimental IBD. Methods: Sprague Dawley rats were randomly allocated to 5 groups (n=6). Group I served as the normal control. Group II served as the vehicle control and received 50% ethanol intracolonically on day 11 of the study. Group III served as the model control. Group IV and Group V were given standard drug 5-aminosalicylic acid (100 mg/kg) and CHCR (800 mg/kg), respectively, for 18 days once a day orally. Colitis was induced with dinitrobenzene sulfonic acid (180 mg/kg in 50% ethanol) intracolonically in groups III–V on day 11 of the study. On day 18, the rats were euthanized and colon tissues were removed for IL-4, IL-6, IL-12, and IFN-gamma gene expression studies using quantitative RT-PCR. Results: The expression levels of proinflammatory cytokines IL-4, IL-6, IL-12, and IFN-gamma were upregulated in the model control rats. Pretreatment with 5-aminosalicylic acid (100 mg/kg) and CHCR (800 mg/kg) significantly decreased the fold of the expression of the above cytokines. Conclusion: CHCR acts as a molecular brake and downregulates the expression of proinflammatory cytokine genes; this is beneficial for reducing the severity of the experimental IBD. Thus, Cyperus rotundus is a safe, economical, and effective alternative for the treatment of patients with IBD.
Keywords	Inflammatory bowel diseases ; Cyperus rotundus ; Interleukin-4 ; Interleukin-6 ; Interleukin-12 ; Interleukin-18 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Development and validation of an HPTLC method for the simultaneous estimation of Clonazepam and Paroxetine hydrochloride using a DOE approach

Shah, Purvi / Jalpa Patel / Kalpana Patel / Tejal Gandhi

Journal of Taibah University for Science. 2017 Jan., v. 11

2017

Abstract	The present study examines simultaneous multiple response optimization using Derringer's desirability function for the development of an HPTLC method to detect Clonazepam and Paroxetine hydrochloride in pharmaceutical dosage form. Central composite design (CCD) was used to optimize the chromatographic conditions for HPTLC. The independent variables used for the optimization were the n-butanol content in the mobile phase, the chamber saturation time and the distance travelled. HPTLC separation was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase using n-butanol:glacial acetic acid:water (9:2:0.5% v/v/v) as the mobile phase. Quantification was achieved based on a densitometric analysis of Clonazepam and Paroxetine hydrochloride over the concentration range of 40–240ng/band and 300–1800ng/band, respectively, at 288nm. The method yielded compact and well-resolved bands at Rf of 0.77±0.02 and 0.34±0.02 for Clonazepam and Paroxetine hydrochloride, respectively. The linear regression analysis for the calibration plots produced r2=0.9958 and r2=0.9989 for Clonazepam and Paroxetine hydrochloride, respectively. The precision, accuracy, robustness, specificity, limit of detection and limit of quantitation of the method were validated according to the ICH guidelines. The factors evaluated in the robustness test were determined to have an insignificant effect on the selected responses. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.
Keywords	aluminum ; butanol ; chromatography ; densitometry ; detection limit ; drug formulations ; guidelines ; quality control ; regression analysis ; silica gel
Language	English
Dates of publication	2017-01
Size	p. 121-132.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834710-9
ISSN	1658-3655
ISSN	1658-3655
DOI	10.1016/j.jtusci.2015.11.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Jenee Christian / Purvi Shah / Margi Patel / Kalpana Patel / Tejal Gandhi

Journal of Taibah University for Science, Vol 11, Iss 5, Pp 729-

2017 Volume 740

Abstract: Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the ... ...

Abstract	Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the simultaneous estimation of artemether and lumefantrine in a fixed dose combination tablet. The first step in development of the method was to derivatize artemether. As artemether does not show absorption in the UV region, it was derivatized using hydrochloric acid as the derivatizing agent. The derivatizing conditions were further optimized by full factorial multivariate approach, where the independent variables were volume of concentrated hydrochloric acid and time taken for artemether derivatization at room temperature. Furthermore, based on the statistical analysis, derivatizing conditions were optimized i.e. 1.3 ml of conc. HCl at room temperature for 30 min. At this condition, the artemether was found to absorb in the UV region satisfactorily, and the absorbance of lumefantrine was found to remain unaffected. The developed method showed good calibration data in the range of 5–30 μg/ml for artemether and 2–12 μg/ml for lumefantrine. The mean % recovery values were found to be 99.96–100.49% and 99.48–100.31% for artemether and lumefantrine, respectively. Additionally, the developed method was effectively applied in the estimation of artemether and lumefantrine in a commercial tablet (ARH-L DS tablets), suggesting that it can be practically applied for quality control of routinely examined drugs in combined dosage forms with the reduced expenditure of time.
Keywords	Artemether ; Lumefantrine ; Ratio first derivative spectroscopic method ; Factorial design derivatization ; Science (General) ; Q1-390
Subject code	540
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Two novel spectrophotometric methods for determinat ion of ternary mixture used as antihypertensive therapy in combined tablet dosage formulation

Trupti Solanki / Jenee Christian / Kalpana Patel / Purvi Shah / Tejal Gandhi

International Journal of Drug Development & Research, Vol 7, Iss 1, Pp 240-

2015 Volume 249

Abstract: Aim: To develop and validate two novel spectrophotometric methods for the simultaneous determination of ternary mixture of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide. Methods: The proposed methods, successive ratio derivative ... ...

Abstract	Aim: To develop and validate two novel spectrophotometric methods for the simultaneous determination of ternary mixture of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide. Methods: The proposed methods, successive ratio derivative method and double divisor method involved treatment of normal absorption spectra of ternary mixture in UV probe software for the simultaneous determination of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide in bulk and tablet dosage formulation without prior separation. Results: All the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The method was validated according to ICH guidelines for evaluation of accuracy, repeatability, reproducibility, sensitivity showing acceptable percent relative standard deviation of less than 2.Conclusion: The proposed methods demonstrated that these are simple, rapid, accurate and precise methods and can be used for routine analysis of bulk and tablet dosage formulation in quality control laboratories eliminating the need of prior separation of the pharmaceutical mixtures.
Keywords	successive ratio derivative method ; double divisor method ; Olmesartan medoxomil ; Amlodipine besylate ; Hydrochlorothiazide ; UV spectrophotometry. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
Subject code	518
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	Chauhan Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Two novel spectrophotometric methods for determinat ion of ternary mixture used as antihypertensive therapy in combined tablet dosage formulation

Trupti Solanki / Jenee Christian / Kalpana Patel / Purvi Shah / Tejal Gandhi

International Journal of Drug Development & Research, Vol 7, Iss 1, Pp 201-

2015 Volume 209

Abstract	Aim: To develop and validate two novel spectrophotometric methods for the simultaneous determination of ternary mixture of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide. Methods: The proposed methods, successive ratio derivative method and double divisor method involved treatment of normal absorption spectra of ternary mixture in UV probe software for the simultaneous determination of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide in bulk and tablet dosage formulation without prior separation. Results: All the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The method was validated according to ICH guidelines for evaluation of accuracy, repeatability, reproducibility, sensitivity showing acceptable percent relative standard deviation of less than 2. Conclusion: The proposed methods demonstrated that these are simple, rapid, accurate and precise methods and can be used for routine analysis of bulk and tablet dosage formulation in quality control laboratories eliminating the need of prior separation of the pharmaceutical mixtures.
Keywords	successive ratio derivative method ; double divisor method ; Olmesartan medoxomil ; Amlodipine besylate ; Hydrochlorothiazide ; UV spectrophotometry ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
Subject code	518
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	Chauhan Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Variation in COVID-19 characteristics, treatment and outcomes in Michigan

Vineet Chopra / Megan O'Malley / Elizabeth McLaughlin / Tejal Gandhi / Scott A Flanders / Tae Kim / Valerie Vaughn / Lindsay Petty / Jakob Israel McSparron / Anurag Malani

BMJ Open, Vol 11, Iss

an observational study in 32 hospitals

2021 Volume 7

Abstract: Objective To describe patient characteristics, symptoms, patterns of care and outcomes for patients hospitalised with COVID-19 in Michigan.Design Multicentre retrospective cohort study.Setting 32 acute care hospitals in the state of Michigan.Participants ...

Abstract	Objective To describe patient characteristics, symptoms, patterns of care and outcomes for patients hospitalised with COVID-19 in Michigan.Design Multicentre retrospective cohort study.Setting 32 acute care hospitals in the state of Michigan.Participants Patients discharged (16 March–11 May 2020) with suspected or confirmed COVID-19 were identified. Trained abstractors collected demographic information on all patients and detailed clinical data on a subset of COVID-19-positive patients.Primary outcome measurements Patient characteristics, treatment and outcomes including cardiopulmonary resuscitation, mortality and venous thromboembolism within and across hospitals.Results Demographic-only data from 1593 COVID-19-positive and 1259 persons under investigation discharges were collected. Among 1024 cases with detailed data, the median age was 63 years; median body mass index was 30.6; and 51.4% were black. Cough, fever and shortness of breath were the top symptoms. 37.2% reported a known COVID-19 contact; 7.0% were healthcare workers; and 16.1% presented from congregated living facilities.During hospitalisation, 232 (22.7%) patients were treated in an intensive care unit (ICU); 558 (54.9%) in a ‘cohorted’ unit; 161 (15.7%) received mechanical ventilation; and 90 (8.8%) received high-flow nasal cannula. ICU patients more often received hydroxychloroquine (66% vs 46%), corticosteroids (34% vs 18%) and antibiotic therapy (92% vs 71%) than general ward patients (p<0.05 for all). Overall, 219 (21.4%) patients died, with in-hospital mortality ranging from 7.9% to 45.7% across hospitals. 73% received at least one COVID-19-specific treatment, ranging from 32% to 96% across sites.Across 14 hospitals, the proportion of patients admitted directly to an ICU ranged from 0% to 43.8%; mechanical ventilation on admission from 0% to 12.8%; mortality from 7.9% to 45.7%. Use of at least one COVID-19-specific therapy varied from 32% to 96.3% across sites.Conclusions During the early days of the Michigan outbreak of COVID-19, ...
Keywords	Medicine ; R
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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