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Article ; Online: Ridostin induces transcription of a wide spectrum of interferon genes in human cells.

Sokolova, T M / Shuvalov, A N / Telkov, M V / Kolodyazhnaya, L V / Ershov, F I

Bulletin of experimental biology and medicine

2013 Volume 156, Issue 2, Page(s) 213–216

Abstract: The effects of Ridostin on the transcription of IFN family genes in human fibroblasts and lymphocytes were studied by quantitative real-time PCR. The degree of gene induction by Ridostin was most pronounced in fibroblasts, and was significantly higher ... ...

Abstract	The effects of Ridostin on the transcription of IFN family genes in human fibroblasts and lymphocytes were studied by quantitative real-time PCR. The degree of gene induction by Ridostin was most pronounced in fibroblasts, and was significantly higher than the induction by Kagocel: transcription of IFN-β, oligoadenylate synthetase, and double-stranded RNA-dependent protein kinase genes increased by about 2000, 100, and 20 times, respectively. In lymphocytes, Ridostin also activated a wide variety of IFN family genes, including genes of IFN-β, IFN-γ, and IFN-dependent enzymes, but this induction was less pronounced than in the fibroblasts. It was shown that gene response in lymphocyte from a child with cancer is reduced in comparison with that of adult healthy participant. Ridostin, and even more so Reaferon up-regulated activities of β-actin, glycerophosphate dehydrogenase, and β2-microglobulin genes, thus making impossible or limiting their use as constitutive stable reference genes (standards) in PCR-assays of IFN and their inductors.
MeSH term(s)	2',5'-Oligoadenylate Synthetase/biosynthesis ; 2',5'-Oligoadenylate Synthetase/genetics ; Actins/biosynthesis ; Actins/genetics ; Adult ; Antiviral Agents/pharmacology ; Cell Line ; Child ; Fibroblasts/metabolism ; Glycerolphosphate Dehydrogenase/biosynthesis ; Glycerolphosphate Dehydrogenase/genetics ; Gossypol/analogs & derivatives ; Gossypol/pharmacology ; Humans ; Interferon Inducers/pharmacology ; Interferon alpha-2 ; Interferon-alpha/pharmacology ; Interferon-beta/biosynthesis ; Interferon-beta/genetics ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interferons/biosynthesis ; Interferons/genetics ; Lymphocytes/metabolism ; Maus Elberfeld virus/drug effects ; RNA, Double-Stranded/pharmacology ; RNA, Fungal/pharmacology ; Recombinant Proteins/pharmacology ; Transcription, Genetic/drug effects ; Transcriptional Activation/drug effects ; beta 2-Microglobulin/biosynthesis ; beta 2-Microglobulin/genetics ; eIF-2 Kinase/biosynthesis ; eIF-2 Kinase/genetics
Chemical Substances	Actins ; Antiviral Agents ; Interferon Inducers ; Interferon alpha-2 ; Interferon-alpha ; RNA, Double-Stranded ; RNA, Fungal ; Recombinant Proteins ; beta 2-Microglobulin ; ridostin (112279-02-4) ; cagocel-1 (115774-57-7) ; Interferon-beta (77238-31-4) ; Interferon-gamma (82115-62-6) ; Interferons (9008-11-1) ; Glycerolphosphate Dehydrogenase (EC 1.1.-) ; eIF-2 Kinase (EC 2.7.11.1) ; 2',5'-Oligoadenylate Synthetase (EC 2.7.7.84) ; Gossypol (KAV15B369O)
Language	English
Publishing date	2013-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-013-2313-z
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Article: [Mutation scanning of short amplicons: optimization of DNA melting conditions].

Botezatu, I V / Zhordania, K I / Karseladze, A I / Stroganova, A M / Kondratova, B N / Shelepov, V P / Telkov, M V / Likhtenshtein, A V

Molekuliarnaia biologiia

2012 Volume 46, Issue 3, Page(s) 461–468

Abstract: High resolution melting analysis (HRMA) using special "saturating" fluorescent dyes is a new and very effective approach to genotyping and mutation scanning. HRMA, which is carried out usually just after PCR without any intermediate manipulations (the " ... ...

Abstract	High resolution melting analysis (HRMA) using special "saturating" fluorescent dyes is a new and very effective approach to genotyping and mutation scanning. HRMA, which is carried out usually just after PCR without any intermediate manipulations (the "closed tube" format), is simple and high-throughput method excluding sample cross-contaminations. The "closed tube" format makes, however, HRMA dependent on PCR mixes and, as such, limits its capability. The "open tube" format (post-PCR amplicon shortening and optimization of the ionic medium) proposed by us earlier, although somewhat more laborious, significantly increases sensitivity of the method and makes it possible to scan mutations in the short amplicons using conventional SYBR Green I dye and a standard (not adapted specifically for HRMA) real-time PCR instrument. Detection of mutant K-RAS in DNA of clinical specimens (tumor tissues, formalin-fixed paraffin-embedded samples) reveals equal, at least, sensitivity of this method as compared with the HRMA and much higher as compared with Sanger sequencing. The problem of false-negative results in mutation scanning of K-RAS, which is highly important in some forms of cancer, is discussed.
MeSH term(s)	Colonic Neoplasms/diagnosis ; Colonic Neoplasms/genetics ; DNA/genetics ; DNA Fingerprinting/methods ; DNA Mutational Analysis/methods ; False Negative Reactions ; Female ; Fluorescent Dyes ; Formaldehyde ; Humans ; Mutation ; Nucleic Acid Denaturation ; Organic Chemicals ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Paraffin Embedding ; Polymorphism, Restriction Fragment Length ; Proto-Oncogene Proteins p21(ras)/genetics ; Real-Time Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Tissue Fixation ; Transition Temperature
Chemical Substances	Fluorescent Dyes ; Organic Chemicals ; SYBR Green I (163795-75-3) ; Formaldehyde (1HG84L3525) ; DNA (9007-49-2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	Russian
Publishing date	2012-05
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	213542-5
ISSN	0026-8984
ISSN	0026-8984
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Article: Kharakteristika transkriptov genov sup1 i sup2 drozhzheĭ-sakharomitsetov.

Telkov, M V / Surguchev, A P

Doklady Akademii nauk SSSR

1986 Volume 290, Issue 4, Page(s) 988–990

Title translation	Characteristics of transcripts of sup1 and sup2 genes in Saccharomyces yeasts.
MeSH term(s)	Cloning, Molecular ; Plasmids ; Saccharomyces cerevisiae/genetics ; Suppression, Genetic ; Transcription, Genetic
Language	Russian
Publishing date	1986
Publishing country	Russia (Federation)
Document type	Journal Article
ISSN	0002-3264
ISSN	0002-3264
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Article: Obrazovanie "nekul'tiviruemykh" kletok Mycobacterium tuberculosis i ikh ozhivlenie.

Shleeva, M O / Mukamolova, G V / Telkov, M V / Berezinskaia, T L / Syroeshkin, A V / Biketov, S F / Kaprel'iants, A S

Mikrobiologiia

2003 Volume 72, Issue 1, Page(s) 76–83

Abstract: Nonculturable cells were found to occur in populations of Mycobacterium tuberculosis cells during the long post-stationary phase. These cells were small (0.6-0.8 micron) ovoid and coccoid forms with intact cell walls and negligible respiratory activity, ... ...

Title translation	Formation of nonculturable Mycobacterium tuberculosis and their regeneration.
Abstract	Nonculturable cells were found to occur in populations of Mycobacterium tuberculosis cells during the long post-stationary phase. These cells were small (0.6-0.8 micron) ovoid and coccoid forms with intact cell walls and negligible respiratory activity, which allows them to be regarded as dormant cells. Nonculturable cells were characterized by low viability after plating onto solid medium; a minor part of the population of these cells could be cultivated in liquid medium. Cell-free culture liquid of an exponential-phase Mycobacterium tuberculosis culture or the bacterial growth factor Rpf exerted a resuscitating effect, increasing substantially the growth capacity of the nonculturable cells in liquid medium. During resuscitation of nonculturable cells, a transition from ovoid to rodlike cell shape occurred. At early stages of resuscitation, ovoid cells formed small aggregates. The recovery of culturability was associated with the formation of rod-shaped cells in the culture. The data obtained demonstrate the in vitro formation of dormant cells of Mycobacterium tuberculosis, which do not grow on solid media but can be resuscitated in liquid medium under the effect of substance(s) secreted by actively growing cells.
MeSH term(s)	Bacterial Physiological Phenomena ; Bacterial Proteins/metabolism ; Culture Media ; Cytokines/metabolism ; Mycobacterium tuberculosis/cytology ; Mycobacterium tuberculosis/physiology
Chemical Substances	Bacterial Proteins ; Culture Media ; Cytokines ; resuscitation-promoting factor, bacteria
Language	Russian
Publishing date	2003-01
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	209707-2
ISSN	0026-3656
ISSN	0026-3656
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Article: Absence of structural homology between sup1 and sup2 genes of yeast Saccharomyces cerevisiae and identification of their transcripts.

Surguchov, A P / Telkov, M V / Smirnov, V N

FEBS letters

1986 Volume 206, Issue 1, Page(s) 147–150

Abstract: The results of Southern blotting demonstrate that sup2 is a unique gene in Saccharomyces cerevisiae that does not possess homologous sequences in the yeast genome. The direct hybridization of DNA fragments, containing cloned sup1 and sup2 genes, did not ... ...

Abstract	The results of Southern blotting demonstrate that sup2 is a unique gene in Saccharomyces cerevisiae that does not possess homologous sequences in the yeast genome. The direct hybridization of DNA fragments, containing cloned sup1 and sup2 genes, did not reveal any structural homology between these two genes. By Northern blotting analysis the sizes of the transcripts were determined to be 1.6 kb for sup1 gene and 2.5 and 1.4kb for sup2 gene. Experiments with RNA isolated from yeast mutant with impaired splicing demonstrated that sup1 and sup2 genes do not contain introns.
MeSH term(s)	Base Sequence ; DNA Restriction Enzymes ; DNA, Fungal/genetics ; Genes, Fungal ; Nucleic Acid Hybridization ; RNA, Fungal/genetics ; Saccharomyces cerevisiae/genetics ; Transcription, Genetic
Chemical Substances	DNA, Fungal ; RNA, Fungal ; DNA Restriction Enzymes (EC 3.1.21.-)
Language	English
Publishing date	1986-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1016/0014-5793(86)81357-6
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Article: Formation and resuscitation of "non-culturable" cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase.

Shleeva, M O / Bagramyan, K / Telkov, M V / Mukamolova, G V / Young, M / Kell, D B / Kaprelyants, A S

Microbiology (Reading, England)

2001 Volume 148, Issue Pt 5, Page(s) 1581–1591

Abstract: After growth of Rhodococcus rhodochrous in Sauton's medium, and further incubation for about 60 h in stationary phase, there was a transient (up to 5 log) decrease in the c.f.u. count, whereas the total count remained similar to its initial value. At the ...

Abstract	After growth of Rhodococcus rhodochrous in Sauton's medium, and further incubation for about 60 h in stationary phase, there was a transient (up to 5 log) decrease in the c.f.u. count, whereas the total count remained similar to its initial value. At the point of minimal viability, the most probable number (MPN) count was 10 times greater than the c.f.u. count. This difference was further magnified by 3-4 logs (giving values close to the total count) by incorporating supernatant taken from growing cultures. A small protein similar to Rpf (resuscitation-promoting factor of Micrococcus luteus) appeared to be responsible for some of the activity in the culture supernatant. The formation of "non-culturable" cells of the "Academia" strain of Mycobacterium tuberculosis was similarly observed following growth in Sauton's medium containing Tween 80 in sealed culture vessels, and further incubation for an extended stationary phase. This resulted in the formation, 4-5 months post-inoculation, of a homogeneous population of ostensibly "non-culturable" cells (zero c.f.u.). Remarkably, the MPN count for these cultures was 10(5) organisms ml(-1), and this value was further increased by one log using supernatant from an actively growing culture. Populations of "non-culturable" cells of Mycobacterium tuberculosis were also obtained by the filtration of "clumpy" cultures, which were grown in the absence of Tween 80. These small cells could only be grown in liquid medium (MPN) and their viability was enhanced by the addition of culture supernatant or Rpf. The "non-culturable" cells that accumulated during prolonged stationary phase in both the R. rhodochrous and the Mycobacterium tuberculosis cultures were small ovoid and coccoid forms with an intact permeability barrier, but with undetectable respiratory activity. The authors consider these non-culturable bacteria to be dormant. The observed activity of culture supernatants and Rpf with "non-culturable" bacterial suspensions invites the speculation that one, or more, of the cognate Mycobacterium tuberculosis Rpf-like molecule(s) could be involved in mechanisms of latency and reactivation of tuberculosis in vivo.
MeSH term(s)	Bacterial Proteins ; Cell Division/drug effects ; Colony Count, Microbial ; Culture Media, Conditioned/pharmacology ; Cytokines/immunology ; Cytokines/metabolism ; Hot Temperature ; Interphase/drug effects ; Micrococcus luteus ; Microscopy, Electron, Scanning ; Models, Biological ; Mycobacterium tuberculosis/cytology ; Mycobacterium tuberculosis/growth & development ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/ultrastructure ; Oxidation-Reduction ; Rhodococcus/cytology ; Rhodococcus/growth & development ; Rhodococcus/metabolism ; Rhodococcus/ultrastructure
Chemical Substances	Bacterial Proteins ; Culture Media, Conditioned ; Cytokines ; resuscitation-promoting factor, bacteria
Language	English
Publishing date	2001-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/00221287-148-5-1581
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Article: Proteins of the Rpf (resuscitation promoting factor) family are peptidoglycan hydrolases.

Telkov, M V / Demina, G R / Voloshin, S A / Salina, E G / Dudik, T V / Stekhanova, T N / Mukamolova, G V / Kazaryan, K A / Goncharenko, A V / Young, M / Kaprelyants, A S

Biochemistry. Biokhimiia

2006 Volume 71, Issue 4, Page(s) 414–422

Abstract: The secreted Micrococcus luteus protein, Rpf, is required for successful resuscitation of dormant "non-culturable" M. luteus cells and for growth stimulation in poor media. The biochemical mechanism of Rpf action remained unknown. Theoretical predictions ...

Abstract	The secreted Micrococcus luteus protein, Rpf, is required for successful resuscitation of dormant "non-culturable" M. luteus cells and for growth stimulation in poor media. The biochemical mechanism of Rpf action remained unknown. Theoretical predictions of Rpf domain architecture and organization, together with a recent NMR analysis of the protein structure, indicate that the conserved Rpf domain has a lysozyme-like fold. In the present study, we found that both the secreted native protein and the recombinant protein lyse crude preparations of M. luteus cell walls. They also hydrolyze 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotrioside, a synthetic substrate for peptidoglycan muramidases, with optimum activity at pH 6. The Rpf protein also has weak proteolytic activity against N-CBZ-Gly-Gly-Arg-beta-naphthylamide, a substrate for trypsin-like enzymes. Rpf activity towards 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotrioside was reduced when the glutamate residue at position 54, invariant for all Rpf family proteins and presumably involved in catalysis, was altered. The same amino acid substitution resulted in impaired resuscitation activity of Rpf. The data indicate that Rpf is a peptidoglycan-hydrolyzing enzyme, and strongly suggest that this specific activity is responsible for its growth promotion and resuscitation activity. A possible mechanism of Rpf-mediated resuscitation is discussed.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Culture Media ; Cytokines/chemistry ; Cytokines/genetics ; Cytokines/metabolism ; Micrococcus luteus/cytology ; Micrococcus luteus/enzymology ; Micrococcus luteus/metabolism ; Mutagenesis, Site-Directed ; N-Acetylmuramoyl-L-alanine Amidase/chemistry ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Time Factors
Chemical Substances	Bacterial Proteins ; Culture Media ; Cytokines ; Recombinant Proteins ; resuscitation-promoting factor, bacteria ; Peptide Hydrolases (EC 3.4.-) ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
Language	English
Publishing date	2006-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/s0006297906040092
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Article: Predvaritel'nyĭ rezul'tat v pol'zu binemnoĭ struktury khromosom cheloveka.

Luchnik, A N / Slezinger, M / Telkov, M V / Kustikova, O / Kutueva, A B

Doklady Akademii nauk

1993 Volume 328, Issue 5, Page(s) 622–624

Title translation	Preliminary results in the use of the binemic structure of human chromosomes.
MeSH term(s)	Apolipoproteins B/genetics ; Base Sequence ; Chromosomes, Human ; DNA ; Exons ; Gene Amplification ; Humans ; Male ; Molecular Sequence Data ; Spermatozoa/metabolism
Chemical Substances	Apolipoproteins B ; DNA (9007-49-2)
Language	Russian
Publishing date	1993-02
Publishing country	Russia (Federation)
Document type	Journal Article
ISSN	0869-5652
ISSN	0869-5652
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Article: Nukleotidnaia posledovatel'nost' mutantnoĭ alleli i alleli dikogo tipa SUP1 i sravnenie transkriptov genov SUP1 i SUP2.

Surguchev, A P / Telkov, M V / Smirnov, V N / Breining, P / Piepersberg, W

Molekuliarnaia biologiia

1987 Volume 21, Issue 2, Page(s) 347–358

Abstract: Nucleotide sequences of the yeast recessive suppressor gene SUP1 and one of its mutant alleles (supl-ts36) are compared. One open reading frame is found in the gene able to code 438 amino acid residues. The reading frame is not interrupted by introns. ... ...

Title translation	Nucleotide sequence of a mutant allele and wild type allele SUP1 and comparison of transcripts of SUP1 and SUP2 genes.
Abstract	Nucleotide sequences of the yeast recessive suppressor gene SUP1 and one of its mutant alleles (supl-ts36) are compared. One open reading frame is found in the gene able to code 438 amino acid residues. The reading frame is not interrupted by introns. Mutant allele supl-ts36 contains one nucleotide change at position + 101 (T----C) inducing the exchange of leucine on serine in N-terminal part of the polypeptide product. The homology between the structure of SUP1 gene and two groups of proteins is found (1.tRNA-binding or nucleotide-binding proteins; 2. mitochondrial proteins coded by mitochondrial genome). The size of transcript for SUP1 gene is 1600 nucleotides corresponding to the coding region of the gene. For SUP2 gene two stable transcripts are found corresponding to approximately 2500 and approximately 1400 nucleotides. The homology between SUP1 and SUP2 genes is not found. The absence of splicing for both SUP1 and SUP2 genes transcripts is demonstrated in the experiments with RNA2 conditional mutants with impaired splicing.
MeSH term(s)	Alleles ; Amino Acid Sequence ; Base Sequence ; DNA Restriction Enzymes ; DNA, Fungal/genetics ; Saccharomyces cerevisiae/genetics ; Suppression, Genetic ; Transcription, Genetic
Chemical Substances	DNA, Fungal ; DNA Restriction Enzymes (EC 3.1.21.-)
Language	Russian
Publishing date	1987-03
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	213542-5
ISSN	0026-8984
ISSN	0026-8984
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Article: Issledovanie restriktsionnogo polimorfizma genov apoB u bol'nykh s narusheniiami lipidnogo obmena i ishemicheskoĭ bolezn'iu serdtsa.

Poliakov, A P / Telkov, M V / Nikiforov, A N / Solov'eva, N P / Koshechkin, V A / Zhukova, I M / Surguchev, A P

Molekuliarnaia genetika, mikrobiologiia i virusologiia

1990 , Issue 10, Page(s) 15–18

Abstract: Using the RELP analysis we studied the frequency of X2 allele of apoB gene in three groups of patients: 1) men at the age of 20-59 with lipid metabolism disorders revealed in population inspection of Oktyabrsky district in Moscow; 2) men with ischaemic ... ...

Title translation	Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease.
Abstract	Using the RELP analysis we studied the frequency of X2 allele of apoB gene in three groups of patients: 1) men at the age of 20-59 with lipid metabolism disorders revealed in population inspection of Oktyabrsky district in Moscow; 2) men with ischaemic heart disease and 3) healthy men. It was established that in individuals suffering from type IIa hyperlipidemia the frequency of X2 allele was significantly higher than in healthy donors from Moscow population. Homozygotes for X2 allele of XbaI RELP had 7-9% higher serum cholesterol levels, than homozygotes for X1 allele. The study suggests the X2 allele of the apoB gene to be associated with the development of high plasma cholesterol level. No significant difference in X2 allele frequencies was found between patients with ischaemic heart disease and healthy donors. There was also no association found between cholesterol and triglyceride levels and the presence of X2 allele in this group of patients.
MeSH term(s)	Adult ; Alleles ; Apolipoproteins B/genetics ; Cholesterol/blood ; Cholesterol, LDL/blood ; Coronary Disease/blood ; Coronary Disease/etiology ; Coronary Disease/genetics ; Gene Frequency ; Humans ; Hyperlipoproteinemia Type II/blood ; Hyperlipoproteinemia Type II/complications ; Hyperlipoproteinemia Type II/genetics ; Male ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Triglycerides/blood
Chemical Substances	Apolipoproteins B ; Cholesterol, LDL ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	Russian
Publishing date	1990-10
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	989858-x
ISSN	0208-0613
ISSN	0208-0613
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