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  1. Book ; Online: Cancer Care Delivery and Womens Health

    Temkin, Sarah M.

    2017  

    Abstract: Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include ... ...

    Abstract Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women's health care has its own unique challenges, the intersection between cancer care delivery and women's health is to be examined in this Frontiers in Oncology issue. The unique opportunities and challenges of improving the health care system for women with breast and gynecologic cancers are to be explored in depth. We will visit many topics of cancer care delivery with the unique perspective geared towards the care of women's malignancies
    Keywords Medicine (General) ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    Size 1 electronic resource (153 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020097447
    ISBN 9782889453092 ; 288945309X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Frontiers in Oncology Breast Cancer Awareness Month. Special Edition

    Pohlman, Paula R. / Temkin, Sarah M.

    2019  

    Keywords Medicine ; Oncology ; breast cancer ; BCA ; Mastectomy ; BRCA1 ; BRCA2 ; Breast Cancer National Screening Programs ; diagnostics ; targeted therapy ; chemotherapy ; Risk factors
    Size 1 electronic resource (117 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229913
    ISBN 9782889631643 ; 2889631648
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

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  3. Article ; Online: "Bless Your Heart".

    Temkin, Sarah M

    Narrative inquiry in bioethics

    2022  Volume 11, Issue 3, Page(s) 249–251

    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2632728-4
    ISSN 2157-1740 ; 2157-1732
    ISSN (online) 2157-1740
    ISSN 2157-1732
    DOI 10.1353/nib.2021.0096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Levels of Gynecologic Care: A Task Force Consensus Statement.

    Temkin, Sarah M / Terplan, Mishka

    Obstetrics and gynecology

    2023  Volume 142, Issue 4, Page(s) 993–994

    MeSH term(s) Female ; Humans ; Advisory Committees ; Gynecology ; Delivery of Health Care
    Language English
    Publishing date 2023-09-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000005363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.230: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: On Vulnerability.

    Temkin, Sarah M

    Narrative inquiry in bioethics

    2020  Volume 9, Issue 3, Page(s) 184–186

    MeSH term(s) Cancer Care Facilities/organization & administration ; Cancer Care Facilities/standards ; Dissent and Disputes ; Female ; Gynecology ; Humans ; Physicians, Women/psychology ; Problem Behavior/psychology ; Surgical Oncology/organization & administration ; Surgical Oncology/standards ; Vulnerable Populations/psychology
    Language English
    Publishing date 2020-01-16
    Publishing country United States
    Document type Personal Narrative
    ZDB-ID 2632728-4
    ISSN 2157-1740 ; 2157-1732
    ISSN (online) 2157-1740
    ISSN 2157-1732
    DOI 10.1353/nib.2019.0063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Reply.

    Temkin, Sarah M

    Obstetrics and gynecology

    2019  Volume 134, Issue 3, Page(s) 650–651

    MeSH term(s) Female ; Genital Neoplasms, Female/therapy ; Gynecology ; Humans ; Medical Oncology
    Language English
    Publishing date 2019-09-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000003444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Personal Reflections on Gynecologic Oncology and Its Future.

    Temkin, Sarah M

    Obstetrics and gynecology

    2019  Volume 133, Issue 6, Page(s) 1255–1258

    MeSH term(s) Gynecology/trends ; Humans ; Medical Oncology/trends
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000003277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Contributions, Aspirations, and Challenges of Academic Specialist Divisions in Obstetrics and Gynecology.

    Temkin, Sarah M / Terplan, Mishka

    Obstetrics and gynecology

    2021  Volume 137, Issue 2, Page(s) 374–375

    MeSH term(s) Faculty, Medical ; Female ; Gynecology ; Humans ; Obstetrics ; Pregnancy ; Specialization
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Editorial: Cancer Care Delivery and Women's Health: Beyond the Patient and Provider Relationship.

    Temkin, Sarah M

    Frontiers in oncology

    2017  Volume 7, Page(s) 213

    Language English
    Publishing date 2017-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2017.00213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: PARP inhibitors in the treatment of ARID1A mutant ovarian clear cell cancer: PI3K/Akt1-dependent mechanism of synthetic lethality.

    Yakovlev, Vasily A / Sullivan, Stephanie A / Fields, Emma C / Temkin, Sarah M

    Frontiers in oncology

    2023  Volume 13, Page(s) 1124147

    Abstract: Introduction: Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme involved in the repair of DNA single-strand breaks (SSB). The recent development of poly(ADP-ribose) polymerase inhibitors (PARPi) results from over 45 years of studies. When the ... ...

    Abstract Introduction: Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme involved in the repair of DNA single-strand breaks (SSB). The recent development of poly(ADP-ribose) polymerase inhibitors (PARPi) results from over 45 years of studies. When the activity of PARP1 or PARP2 is compromised, DNA SSB lesions are unresolved and can be converted to DNA double-strand breaks (DSBs) by the cellular transcription mechanisms. ARID1A (also called BAF250a) is an important component of the mammalian Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex. ARID1A gene demonstrates >50% of mutation rate in ovarian clear-cell carcinomas (OCCC). Mutated or downregulated ARID1A significantly compromises the Homologous Recombination Repair (HRR) of DNA DSB.
    Results: The present study demonstrated that downregulated or mutated ARID1A attenuates DNA HRR through stimulation of the PI3K/Akt1 pathway and makes tumor cells highly sensitive to PARPi and PARPi/ionizing radiation (IR) combination. We showed that PI3K/Akt1 pathway plays an important role in the sensitization of cancer cell lines with compromised function of ARID1A to PARPi treatment.
    Discussion: We believe that using of PARPi monotherapy or in combination with radiation therapy is an appealing strategy for treating ARID1A-mutated cancers, as well as many other types of PI3K/Akt1-driven cancers.
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1124147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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