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  1. Book ; Thesis: Validierung der deutschen Fassung der Skala „Pain Attitudes Questionnaire (revised)" von Yong, H.-H., Bell, R., Workman, B. und Gibson, S. J

    Temme, Christian

    2014  

    Author's details vorgelegt von Christian Temme
    Language German
    Size 82 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 2014
    HBZ-ID HT018733333
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 D 727 order for loan Magazin

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  2. Article ; Online: Impact of the COVID-19 outbreak on blood supply in two large university hospitals.

    Brieske, Christian M / Temme, Christian / Hiller, Jens / Goebel, Meike / Peine, Sven / Horn, Peter A

    Transfusion medicine (Oxford, England)

    2024  Volume 34, Issue 1, Page(s) 11–19

    Abstract: Objective: This study aimed to examine the relationship between the decrease in elective procedures and the need for blood donation during the novel coronavirus disease (COVID-19) pandemic at university hospitals.: Background: The COVID-19 pandemic ... ...

    Abstract Objective: This study aimed to examine the relationship between the decrease in elective procedures and the need for blood donation during the novel coronavirus disease (COVID-19) pandemic at university hospitals.
    Background: The COVID-19 pandemic has immensely impacted transfusion medicine. By cancelling elective surgery, the German government hoped to increase the available resources for patients infected with COVID-19, especially in intensive care units, and prevent the shortage of blood products.
    Methods/materials: Over 26 weeks, from the 3rd of February 2020 to the 2nd of August 2020, during the first phase of the pandemic, we assessed the number of crossmatches, blood group typing, use of donated blood, and case mix indices by retrospectively analysing data from two major university hospitals' information systems in Essen and Hamburg, Germany. Data were pooled, analysed, and compared with that of the same period in the previous year.
    Results: Following the cessation of elective procedures, the number of requests for crossmatches and blood group typing significantly decreased in 2020 compared to that in 2019. However, the number of blood transfusions required was reduced to a lesser extent. The number of outpatient and inpatient cases significantly decreased, whereas the cases requiring transfusion decreased only.
    Conclusion: During the initial phase of the pandemic, transfusion medicine, especially in large institutions, faced an almost unchanged high demand for donated blood. This should be considered regarding personnel and blood donation allocations. Therefore, we developed a monitoring system to display the availability of blood products in real-time. The quick and easy display of in-stock and expiring blood products can optimise the use of this valuable resource.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Hospitals, University ; Pandemics ; Retrospective Studies ; Blood Group Antigens
    Chemical Substances Blood Group Antigens
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.13031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Book ; Online ; Thesis: Reaktionen des Quecksilbers und seiner Spezies in bodennahen Luftschichten der Antarktis

    Temme, Christian

    2003  

    Abstract: Den Gegenstand der vorliegenden Arbeit bilden Untersuchungen zum Verhalten atmosphärischer Quecksilberspezies in bodennahen Luftschichten der Antarktis. Dabei wurden die ersten zeitlich hochaufgelösten Langzeitmessungen atmosphärischer Quecksilberspezies ...

    Author's details von Christian Temme
    Abstract Den Gegenstand der vorliegenden Arbeit bilden Untersuchungen zum Verhalten atmosphärischer Quecksilberspezies in bodennahen Luftschichten der Antarktis. Dabei wurden die ersten zeitlich hochaufgelösten Langzeitmessungen atmosphärischer Quecksilberspezies an der Neumayer-Station in der Antarktis durchgeführt. Das mehr als einjährige Messprogramm konnte zeigen, dass es zu Beginn des antarktischen Frühlings an der Neumayer-Station zu starken Rückgängen der atmosphärischen Quecksilber-Konzentrationen kommt. Hg0 wird in einer Gasphasenreaktion zu Hg(II)-Spezies oxidiert. Dieses führt zu einem erhöhten Eintrag von Quecksilber in das Ökosystem der Antarktis. Mit Hilfe von Langzeitdatensätzen des atmosphärischen Quecksilbers aus der Nordhemisphäre und Messungen an Bord der "Polarstern" konnte gezeigt werden, dass es sich um ein Phänomen der Polarregionen handelt.
    Language German
    Size Online-Ressource (PDF-Datei: 144 S., 11,0 MB)
    Publisher Thüringer Universitäts- und Landesbibliothek
    Publishing place Jena
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Jena, 2003
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Thesis: Reaktionen des Quecksilbers und seiner Spezies in bodennahen Luftschichten der Antarktis

    Temme, Christian

    (GKSS ; 2003,19)

    2003  

    Author's details Autor: C. Temme
    Series title GKSS ; 2003,19
    Language German
    Size 116, IX S., Ill., graph. Darst., Kt.
    Edition Als Ms. vervielfältigt
    Publisher GKSS-Forschungszentrum
    Publishing place Geesthacht
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Jena, 2003
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Thesis: Reaktionen des Quecksilbers und seiner Spezies in bodennahen Luftschichten der Antarktis

    Temme, Christian

    (GKSS ; 2003,19)

    2003  

    Author's details Autor: C. Temme
    Series title GKSS ; 2003,19
    Language German
    Size 116, IX S., Ill., graph. Darst., Kt.
    Edition Als Ms. vervielfältigt
    Publisher GKSS-Forschungszentrum
    Publishing place Geesthacht
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Jena, 2003
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Reaktionen des Quecksilbers und seiner Spezies in bodennahen Luftschichten der Antarktis

    Temme, Christian

    2003  Volume 2003/19, Page(s) 116, IX S.

    Abstract: Den Gegenstand der vorliegenden Arbeit bilden Untersuchungen zum Verhalten atmosphaerischer Quecksilberspezies in bodennahen Luftschichten der Antarktis. Dabei wurden die ersten zeitlich hochaufgeloesten Langzeitmessungen atmosphaerischer ... ...

    Abstract Den Gegenstand der vorliegenden Arbeit bilden Untersuchungen zum Verhalten atmosphaerischer Quecksilberspezies in bodennahen Luftschichten der Antarktis. Dabei wurden die ersten zeitlich hochaufgeloesten Langzeitmessungen atmosphaerischer Quecksilberspezies an der Neumayerstation in der Antarktis durchgefuehrt. Das mehr als einjaehrige Messprogramm konnte zeigen, dass es zu Beginn des antarktischen Fruehlings an der Neumayer-Station zu starken Rueckgaengen der atmosphaerischen Quecksilberkonzentrationen kommt. Hg(0) wird in einer Gasphasenreaktion zu Hg(II)-Spezies oxidiert. Dieses fuehrt zu einem erhoehten Eintrag von Quecksilber in das Oekosystem der Antarktis. Mit Hilfe von Langzeitdatensaetzen des atmosphaerischen Quecksilbers aus der Nordhemisphaere und Messungen an Bord der Polarstern konnte gezeigt werden, dass es sich um ein Phaenomen der Polarregionen handelt.
    Keywords Messprogramm ; Fruehling ; Quecksilber ; Langzeitversuch ; Oxidation ; Antarktisches Oekosystem ; Atmosphaere ; Schwermetallgehalt ; Arktisches Oekosystem ; Klimatologie ; Analysenverfahren ; Quantitative Analyse ; Bestimmungsmethode ; Schiff ; Forschungseinrichtung ; Flugzeug ; Ozean ; Quecksilbergehalt ; Ozon ; Summenparameter ; Globale Aspekte ; Troposphaere ; Spurenstoff ; Jahreszeitabhaengigkeit ; Schadstoffverhalten ; Polargebiet ; Weitraeumiger Transport ; Zeitreihenanalyse
    Language German
    Document type Book
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  7. Article ; Online: Invasive Mold Infection of the Central Nervous System in Immunocompromised Children.

    Porto, Luciana / You, Se-Jong / Attarbaschi, Andishe / Cario, Gunnar / Döring, Michaela / Moser, Olga / Mücke, Urs / Poyer, Fiona / Temme, Christian / Voigt, Sebastian / Groll, Andreas H / Lauten, Melchior / Hattingen, Elke / Lehrnbecher, Thomas

    Journal of fungi (Basel, Switzerland)

    2020  Volume 6, Issue 4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof6040226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG.

    Schwarzkopf, Sina / Krawczyk, Adalbert / Knop, Dietmar / Klump, Hannes / Heinold, Andreas / Heinemann, Falko M / Thümmler, Laura / Temme, Christian / Breyer, Marianne / Witzke, Oliver / Dittmer, Ulf / Lenz, Veronika / Horn, Peter A / Lindemann, Monika

    Emerging infectious diseases

    2020  Volume 27, Issue 1

    Abstract: We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 ( ... ...

    Abstract We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2. We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using interferon-γ ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; Antibody Specificity ; Blood Donors ; COVID-19/immunology ; COVID-19/virology ; Enzyme-Linked Immunospot Assay/methods ; Female ; Humans ; Immunity, Cellular/physiology ; Immunoglobulin G/blood ; Interferon-gamma ; Male ; Middle Aged ; Polymerase Chain Reaction ; SARS-CoV-2 ; T-Lymphocytes/physiology
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Interferon-gamma (82115-62-6)
    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/2701.203772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Pregnancies and Neonatal Outcomes in Patients with Sickle Cell Disease (SCD): Still a (High-)Risk Constellation?

    Proske, Pia / Distelmaier, Laura / Aramayo-Singelmann, Carmen / Koliastas, Nikolaos / Iannaccone, Antonella / Papathanasiou, Maria / Temme, Christian / Klump, Hannes / Lenz, Veronika / Koldehoff, Michael / Carpinteiro, Alexander / Reinhardt, Hans Christian / Köninger, Angela / Röth, Alexander / Yamamoto, Raina / Dührsen, Ulrich / Alashkar, Ferras

    Journal of personalized medicine

    2021  Volume 11, Issue 9

    Abstract: Background: This monocentric study conducted at the University Hospital of Essen aims to describe maternal and fetal/neonatal outcomes in sickle cell disease (SCD) documented between 1996 to 2021 (N = 53), reflecting the largest monocentric analysis ... ...

    Abstract Background: This monocentric study conducted at the University Hospital of Essen aims to describe maternal and fetal/neonatal outcomes in sickle cell disease (SCD) documented between 1996 to 2021 (N = 53), reflecting the largest monocentric analysis carried out in Germany.
    Methods/results: 46 pregnancies in 22 patients were followed. None of the patients died. In total, 35% (11/31) of pregnancies were preterm. 15 pregnancies in eight patients were conceived on hydroxycarbamide (HC), of which nine had a successful outcome and three were terminated prematurely. There was no difference regarding the rate of spontaneous abortions in patients receiving HC compared to HC-naive patients prior to conception. In patients other than HbS/C disease, pregnancies were complicated by vaso-occlusive crises (VOCs)/acute pain crises (APCs) (96%, 23/24); acute chest syndrome (ACS) (13%, 3/24), transfusion demand (79%, 19/24), urinary tract infections (UTIs) (42%, 10/24) and thromboembolic events (8%, 2/24). In HbS/C patients complications included: VOCs/APCs (43%, 3/7; ACS: 14%, 1/7), transfusion demand (14%, 1/7), and UTIs (14%, 1/7). Independent of preterm deliveries, a significant difference with respect to neonatal growth in favor of neonates from HbS/C mothers was observed.
    Conclusion: Our data support the results of previous studies, highlighting the high rate of maternal and fetal/neonatal complications in pregnant SCD patients.
    Language English
    Publishing date 2021-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11090870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2-specific humoral and cellular immunity in two renal transplants and two hemodialysis patients treated with convalescent plasma.

    Lindemann, Monika / Krawczyk, Adalbert / Dolff, Sebastian / Konik, Margarethe / Rohn, Hana / Platte, Maximillian / Thümmler, Laura / Schwarzkopf, Sina / Schipper, Leonie / Bormann, Maren / van de Sand, Lukas / Breyer, Marianne / Klump, Hannes / Knop, Dietmar / Lenz, Veronika / Temme, Christian / Dittmer, Ulf / Horn, Peter A / Witzke, Oliver

    Journal of medical virology

    2021  Volume 93, Issue 5, Page(s) 3047–3054

    Abstract: When patients with chronic kidney disease are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) they can face two specific problems: virus-specific immune responses may be impaired and remdesivir, an antiviral drug described to ... ...

    Abstract When patients with chronic kidney disease are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) they can face two specific problems: virus-specific immune responses may be impaired and remdesivir, an antiviral drug described to shorten recovery, is contraindicated. Antiviral treatment with convalescent plasma (CP) could be an alternative treatment option. In this case report, we present two kidney transplant recipients and two hemodialysis patients who were infected with SARS-CoV-2 and received CP. Antibodies against the receptor-binding domain in the S1 subunit of the SARS-CoV-2 spike protein were determined sequentially by immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) and neutralization assay and specific cellular responses by interferon-gamma ELISpot. Before treatment, in both kidney transplant recipients and one hemodialysis patient antibodies were undetectable by ELISA (ratio < 1.1), corresponding to low neutralizing antibody titers (≤1:40). ELISpot responses in the four patients were either weak or absent. After CP treatment, we observed an increase of SARS-CoV-2-specific antibodies (IgG ratio and neutralization titer) and of specific cellular responses. After intermittent clinical improvement, one kidney transplant recipient again developed typical symptoms on Day 12 after treatment and received a second cycle of CP treatment. Altogether, three patients clinically improved and could be discharged from the hospital. However, one 83-year-old multimorbid patient deceased. Our data suggest that the success of CP therapy may only be temporary in patients with chronic kidney disease; which requires close monitoring of viral load and antiviral immunity and possibly an adaptation of the treatment regimen.
    MeSH term(s) Aged ; Aged, 80 and over ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Antiviral Agents/therapeutic use ; C-Reactive Protein ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/therapy ; Enzyme-Linked Immunospot Assay/methods ; Female ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Immunization, Passive/methods ; Immunoglobulin G/blood ; Kidney Transplantation ; Middle Aged ; Renal Dialysis ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Antiviral Agents ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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