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  1. Article ; Online: Trained Innate Immunity in Animal Models of Cardiovascular Diseases.

    Kleimann, Patricia / Irschfeld, Lisa-Marie / Grandoch, Maria / Flögel, Ulrich / Temme, Sebastian

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Acquisition of immunological memory is an important evolutionary strategy that evolved to protect the host from repetitive challenges from infectious agents. It was believed for a long time that memory formation exclusively occurs in the adaptive part of ...

    Abstract Acquisition of immunological memory is an important evolutionary strategy that evolved to protect the host from repetitive challenges from infectious agents. It was believed for a long time that memory formation exclusively occurs in the adaptive part of the immune system with the formation of highly specific memory T cells and B cells. In the past 10-15 years, it has become clear that innate immune cells, such as monocytes, natural killer cells, or neutrophil granulocytes, also have the ability to generate some kind of memory. After the exposure of innate immune cells to certain stimuli, these cells develop an enhanced secondary response with increased cytokine secretion even after an encounter with an unrelated stimulus. This phenomenon has been termed trained innate immunity (TI) and is associated with epigenetic modifications (histone methylation, acetylation) and metabolic alterations (elevated glycolysis, lactate production). TI has been observed in tissue-resident or circulating immune cells but also in bone marrow progenitors. Risk-factors for cardiovascular diseases (CVDs) which are associated with low-grade inflammation, such as hyperglycemia, obesity, or high salt, can also induce TI with a profound impact on the development and progression of CVDs. In this review, we briefly describe basic mechanisms of TI and summarize animal studies which specifically focus on TI in the context of CVDs.
    MeSH term(s) Animals ; Immunity, Innate ; Adaptive Immunity ; Trained Immunity ; Cardiovascular Diseases ; Monocytes ; Models, Animal
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042312
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  2. Article ; Online: Noninvasive assessment of metabolic turnover during inflammation by

    Flocke, Vera / Temme, Sebastian / Bouvain, Pascal / Grandoch, Maria / Flögel, Ulrich

    Frontiers in immunology

    2023  Volume 14, Page(s) 1258027

    Abstract: Background: Inflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinflammatory ... ...

    Abstract Background: Inflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinflammatory immune cells mainly utilize glycolysis to meet their energy needs. Noninvasive approaches to monitor both processes would help elucidate this interwoven relationship to identify new therapeutic targets and diagnostic opportunities.
    Methods: For induction of defined inflammatory hotspots, LPS-doped Matrigel plugs were implanted into the neck of C57BL/6J mice. Subsequently,
    Results: After plug implantation and intravenous administration of the
    Conclusion: 1
    MeSH term(s) Humans ; Mice ; Animals ; Deuterium ; Lipopolysaccharides ; Mice, Inbred C57BL ; Magnetic Resonance Spectroscopy/methods ; Inflammation ; Glucose/metabolism
    Chemical Substances Deuterium (AR09D82C7G) ; Lipopolysaccharides ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1258027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Rolle des Mas-Rezeptors auf die Angiotensin-II-induzierte Druckantwort in Nieren von Apolipoprotein-E-defizienten Mäusen

    Ishak, Bassam [Verfasser] / Stegbauer, Johannes [Gutachter] / Temme, Sebastian [Gutachter]

    2023  

    Author's details Bassam Ishak ; Gutachter: Johannes Stegbauer, Sebastian Temme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  4. Book ; Online ; Thesis: Purinabhängige Aktivierung des Inflammasoms in epikardialen Progenitorzellen nach Myokardinfarkt

    Leberling, Stella [Verfasser] / Schrader, Jürgen [Gutachter] / Temme, Sebastian [Gutachter]

    2023  

    Author's details Stella Leberling ; Gutachter: Jürgen Schrader, Sebastian Temme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Standardisierung eines perfusionsbasierten Präparationsprotokolls des CLARITY-Verfahrens zur Darstellung kardialer Strukturen im Mausmodell durch Lichtblattmikroskopie

    Schmitz, Lukas [Verfasser] / Temme, Sebastian [Gutachter]

    2021  

    Author's details Lukas Schmitz ; Gutachter: Sebastian Temme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Hot spot

    Bouvain, Pascal / Temme, Sebastian / Flögel, Ulrich

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2020  Volume 12, Issue 6, Page(s) e1639

    Abstract: Among the preclinical molecular imaging approaches, lately fluorine ( ...

    Abstract Among the preclinical molecular imaging approaches, lately fluorine (
    MeSH term(s) Fluorine ; Fluorocarbons ; Humans ; Inflammation/diagnostic imaging ; Magnetic Resonance Imaging
    Chemical Substances Fluorocarbons ; Fluorine (284SYP0193)
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1639
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6781: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; Thesis: Einfluss des Glykoprotein B aus Herpes Simplex Virus Typ 1 auf die intrazelluläre Verteilung und Exozytose von HLA Klasse IIMolekülen

    Temme, Sebastian

    2010  

    Author's details vorgelegt von: Sebastian Temme
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2009
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Assembly, Intracellular Transport, and Release of MHC Class II Peptide Receptors.

    Temme, Sebastian / Temme, Nadine / Koch, Norbert

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1988, Page(s) 297–314

    Abstract: MHC class II molecules play a pivotal role for the induction and maintenance of immune responses against pathogens, but are also implicated in pathological conditions like autoimmune diseases or rejection of transplanted organs. Human antigen-presenting ... ...

    Abstract MHC class II molecules play a pivotal role for the induction and maintenance of immune responses against pathogens, but are also implicated in pathological conditions like autoimmune diseases or rejection of transplanted organs. Human antigen-presenting cells express three human leukocyte antigen (HLA) class II isotypes (DR, DP, and DQ), which are, with the exception of DRα, composed of highly polymorphic α and β subunits. The combination of α- and β-chains results in a multitude of MHC-II αβ-heterodimers of the same isotype, but also isotype-mixed MHC class II molecules have been identified. Invariant chain chaperones the assembly of MHC-II molecules within the endoplasmatic reticulum and also facilitates the intracellular transport to MHC class II loading compartments (MIICs). MHC-II molecules are loaded with antigenic peptides and shuttled to the cell surface for inspection by CD4 T-cells. Alternatively, class-II molecules enriched on intraluminal vesicles can be released via exosomes into the extracellular space. Since some of the αβ-combinations may yield mismatched nonfunctional heterodimers, it is not entirely clear which type of HLA class II peptide receptors are transported to MIICs and found on the cell surface of antigen-presenting cells. We present techniques to inspect assembly, intracellular transport, cell surface expression, and exosomal release of MHC class II heterodimers.
    MeSH term(s) Animals ; Antigens, Differentiation, B-Lymphocyte/metabolism ; COS Cells ; Carbohydrates/chemistry ; Cell Membrane/metabolism ; Chlorocebus aethiops ; Endosomes/metabolism ; Exosomes/metabolism ; Glycoside Hydrolases/metabolism ; Histocompatibility Antigens Class II/metabolism ; Intracellular Space/metabolism ; Peptides/metabolism ; Protein Subunits/metabolism ; Protein Transport ; Receptors, Peptide/metabolism ; Sodium Dodecyl Sulfate/metabolism
    Chemical Substances Antigens, Differentiation, B-Lymphocyte ; Carbohydrates ; Histocompatibility Antigens Class II ; Peptides ; Protein Subunits ; Receptors, Peptide ; invariant chain ; Sodium Dodecyl Sulfate (368GB5141J) ; Glycoside Hydrolases (EC 3.2.1.-)
    Language English
    Publishing date 2019-05-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9450-2_22
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  9. Article: Beyond Vessel Diameters: Non-invasive Monitoring of Flow Patterns and Immune Cell Recruitment in Murine Abdominal Aortic Disorders by Multiparametric MRI.

    Temme, Sebastian / Yakoub, Mina / Bouvain, Pascal / Yang, Guang / Schrader, Jürgen / Stegbauer, Johannes / Flögel, Ulrich

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 750251

    Abstract: The pathophysiology of the initiation and progression of abdominal aortic aneurysms (AAAs) and aortic dissections (AADs) is still unclear. However, there is strong evidence that monocytes and macrophages are of crucial importance in these processes. Here, ...

    Abstract The pathophysiology of the initiation and progression of abdominal aortic aneurysms (AAAs) and aortic dissections (AADs) is still unclear. However, there is strong evidence that monocytes and macrophages are of crucial importance in these processes. Here, we utilized a molecular imaging approach based on background-free
    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.750251
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  10. Article ; Online: CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice.

    Massold, Timo / Ibrahim, Fady / Niemann, Viola / Steckel, Bodo / Becker, Katrin / Schrader, Jürgen / Stegbauer, Johannes / Temme, Sebastian / Grandoch, Maria / Flögel, Ulrich / Bouvain, Pascal

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17125

    Abstract: Vascular inflammation plays a key role in the development of aortic diseases. A potential novel target for treatment might be CD73, an ecto-5'-nucleotidase that generates anti-inflammatory adenosine in the extracellular space. Here, we investigated ... ...

    Abstract Vascular inflammation plays a key role in the development of aortic diseases. A potential novel target for treatment might be CD73, an ecto-5'-nucleotidase that generates anti-inflammatory adenosine in the extracellular space. Here, we investigated whether a lack of CD73 results in enhanced aortic inflammation. To this end, angiotensin II was infused into wildtype and CD73
    MeSH term(s) Animals ; Female ; Male ; Mice ; 5'-Nucleotidase/genetics ; Adenosine/metabolism ; Angiotensin II ; Inflammation/genetics ; Mice, Knockout
    Chemical Substances 5'-Nucleotidase (EC 3.1.3.5) ; Adenosine (K72T3FS567) ; Angiotensin II (11128-99-7) ; Nt5e protein, mouse (EC 3.1.3.5)
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44361-7
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