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  1. Book ; Online ; Thesis: Analyse des Gleichgewichts zwischen pro- und antiinflammatorischen Zytokinen bei Frühgeborenen

    Temming, Petra

    2005  

    Author's details vorgelegt von Petra Temming
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Lübeck, 2005
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: The Interdisciplinary Diagnosis and Treatment of Intraocular Tumors.

    Bornfeld, Norbert / Biewald, Eva / Bauer, Sebastian / Temming, Petra / Lohmann, Dietmar / Zeschnigk, Michael

    Deutsches Arzteblatt international

    2018  Volume 115, Issue 7, Page(s) 106–111

    Abstract: Background: Recent years have seen major changes in the diagnosis and treatment of solid intraocular tumors, mainly owing to an improved molecular biological understanding of their pathogenesis, new therapeutic approaches for the local treatment of ... ...

    Abstract Background: Recent years have seen major changes in the diagnosis and treatment of solid intraocular tumors, mainly owing to an improved molecular biological understanding of their pathogenesis, new therapeutic approaches for the local treatment of tumors in children, and long-term follow-up observations in clinical trials.
    Methods: This review is based on pertinent publications retrieved by a selective search in PubMed.
    Results: Retinoblastoma is the most common type of primary intraocular tumor, with approximately 8000 new cases per year around the world, while malignant melanoma of the uvea is the most common primary intraocular tumor in adults, with approximately 7000 new cases per year around the world. Intraocular metastases of malignant tumors are ten times more common, in terms of incidence, than primary intraocular tumors and are therefore the most common intraocular tumors overall. Improved methods of intraocular biopsy, diagnostic imaging, and molecular genetic investigation have led to steady improvement in clinical and predictive diagnostic assessment. In the treatment of retinoblastoma, local techniques including brachytherapy and intra-arterial and intravitreal chemotherapy play a prominent role. Prognostic molecular-genetic testing now enables the highly selective identification of uveal melanomas that have a high potential to metastasize. Cutaneous and uveal melanomas differ both in their clinical behavior and in their basic biological features; to date, effective systemic treatment has been established for melanoma of the skin, but not for metastatic melanoma of the uvea. Intraocular metastases are common and often the initial manifestation of an extraocular tumor, particularly lung cancer.
    Conclusion: Modern diagnostic and therapeutic concepts for intraocular tumors can only be implemented through the close interdisciplinary collaboration of ophthal - mologists, oncologists, radiologists, radiotherapists, pathologists, and human geneticists.
    MeSH term(s) Adult ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Biopsy ; Brachytherapy/methods ; Child, Preschool ; Humans ; Incidence ; Infant ; Intravitreal Injections/methods ; Lung Neoplasms/pathology ; Melanoma/epidemiology ; Melanoma/genetics ; Melanoma/pathology ; Melanoma/therapy ; Molecular Biology/methods ; Neoplasm Metastasis/pathology ; Patient Care Team/standards ; Prognosis ; Retinoblastoma/epidemiology ; Retinoblastoma/genetics ; Retinoblastoma/pathology ; Retinoblastoma/therapy ; Treatment Outcome ; Uveal Neoplasms/epidemiology ; Uveal Neoplasms/genetics ; Uveal Neoplasms/pathology ; Uveal Neoplasms/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2018-03-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2018.0106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ectopic intracranial retinoblastoma in a 3.5-month-old infant without eye involvement and without evidence of heritability.

    Römer, Tristan / Temming, Petra / Lohmann, Dietmar R / Sturm, Dominik / von Deimling, Andreas / Sellhaus, Bernd / Mull, Michael / Kontny, Udo / Moser, Olga

    Pediatric blood & cancer

    2019  Volume 66, Issue 5, Page(s) e27599

    Abstract: Heritable retinoblastoma can rarely be associated with a midline intracranial neuroblastic tumor, referred to as trilateral retinoblastoma. We present an unusual midline brain tumor in an infant that was identified as ectopic retinoblastoma by ... ...

    Abstract Heritable retinoblastoma can rarely be associated with a midline intracranial neuroblastic tumor, referred to as trilateral retinoblastoma. We present an unusual midline brain tumor in an infant that was identified as ectopic retinoblastoma by histopathology, DNA methylation analysis, and molecular genetic detection of biallelic somatic inactivation of the RB1 gene. There was no ocular involvement, and germline mutation was excluded. In this nonresectable tumor, treatment with systemic chemotherapy including high-dose therapy with autologous stem cell transplantation, but without definite local therapy, resulted in long-lasting tumor control.
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Genetic Predisposition to Disease ; Humans ; Infant ; Male ; Mutation ; Prognosis ; Retinal Neoplasms/genetics ; Retinal Neoplasms/pathology ; Retinal Neoplasms/therapy ; Retinoblastoma/genetics ; Retinoblastoma/pathology ; Retinoblastoma/therapy ; Retinoblastoma Binding Proteins/genetics ; Stem Cell Transplantation ; Transplantation, Autologous ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances RB1 protein, human ; Retinoblastoma Binding Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.27599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1131: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Retinoblastoma tumorigenesis: genetic and epigenetic changes walk hand in hand.

    Temming, Petra / Corson, Timothy W / Lohmann, Dietmar R

    Future oncology (London, England)

    2012  Volume 8, Issue 5, Page(s) 525–528

    Abstract: The rate-limiting step in retinoblastoma tumorigenesis is inactivation of both RB1 alleles, but it has remained unclear how this tumor acquires the additional changes that constitute a malignant phenotype. Zhang et al. characterized the genetic and ... ...

    Abstract The rate-limiting step in retinoblastoma tumorigenesis is inactivation of both RB1 alleles, but it has remained unclear how this tumor acquires the additional changes that constitute a malignant phenotype. Zhang et al. characterized the genetic and epigenetic alterations in four retinoblastomas using whole-genome analysis techniques. In these samples, the retinoblastoma genome was found to be remarkably stable genetically, although recurrent mutations in BCOR were identified in 13% of patients. However, an approach that integrated the results of ChIP, methylation and expression analysis identified multiple, more frequent alterations of the epigenetic landscape. One of the leading genes on the list the authors obtained was SYK, a kinase epigenetically upregulated. Knockdown of this gene and exposure to small molecules inhibiting the kinase function stopped tumor growth in vitro and in vivo, thus offering a new therapeutic target for the treatment of retinoblastoma.
    Language English
    Publishing date 2012-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2184533-5
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon.12.41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Analyse des Gleichgewichts zwischen pro- und antiinflammatorischen Zytokinen bei Frühgeborenen

    Temming, Petra [Verfasser]

    2005  

    Author's details vorgelegt von Petra Temming
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Sporadic unilateral retinoblastoma or first sign of bilateral disease?

    Temming, Petra / Viehmann, Anja / Biewald, Eva / Lohmann, Dietmar R

    The British journal of ophthalmology

    2013  Volume 97, Issue 4, Page(s) 475–480

    Abstract: Background: A small number of children with unilateral retinoblastoma later develop retinoblastoma in the contralateral eye (metachronous bilateral retinoblastoma).: Methods: We analysed the clinical and genetic characteristics of children with ... ...

    Abstract Background: A small number of children with unilateral retinoblastoma later develop retinoblastoma in the contralateral eye (metachronous bilateral retinoblastoma).
    Methods: We analysed the clinical and genetic characteristics of children with sporadic unilateral retinoblastoma to identify risk factors for the development of metachronous bilateral disease.
    Results: Fifteen (3.1%) of 480 children with unilateral retinoblastoma later developed metachronous bilateral retinoblastoma (latency period  >30 days). The maximum latency period was 2.3 years after initial diagnosis. Nine (22.5%) of 40 children with a RB1 mutation detectable in blood developed metachronous bilateral disease while all 155 children proved to be without a germline RB1 mutation remained unilaterally affected. Clinically, the risk of developing metachronous bilateral retinoblastoma was higher for age at diagnosis ≤0.5 years compared with >0.5 years (19.6% vs 1.2%), and for multifocal compared with unifocal unilateral retinoblastoma (17.1% vs 2.2%).
    Conclusions: This study shows that an oncogenic RB1 mutation in the blood is a risk factor for metachronous bilateral retinoblastoma. Additional clinical risk factors for metachronous bilateral disease are diagnosis at young age (≤0.5 years) and multifocal unilateral retinoblastoma. Early genetic analysis may identify children at high risk of developing metachronous bilateral disease and may help to preserve vision using risk-adapted follow-up and early treatment.
    MeSH term(s) Age Distribution ; Child ; Child, Preschool ; DNA Mutational Analysis ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/genetics ; Real-Time Polymerase Chain Reaction ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/genetics ; Retinoblastoma/diagnosis ; Retinoblastoma/genetics ; Retinoblastoma Protein/genetics ; Retrospective Studies ; Risk Factors
    Chemical Substances Retinoblastoma Protein
    Language English
    Publishing date 2013-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2012-302666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.83: Show issues Location:
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  7. Article: Interdisziplinäre Diagnostik und Therapie von intraokularen Tumoren. The Interdisciplinary Diagnosis and Treatment of Intraocular Tumors

    Bornfeld, Norbert / Biewald, Eva / Bauer, Sebastian / Temming, Petra / Lohmann, Dietmar / Zeschnigk, Michael

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2018  Volume 115, Issue 7, Page(s) 106

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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    Ua VI Zs.103/2: Show issues Location:
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  8. Article: Erhaltend heilen. Interdisziplinäre Ansätze zur augenerhaltenden Therapie des einseitigen Retinoblastoms

    Temming, Petra / Bornfeld, Norbert / Lohmann, Dietmar

    Wtz-Journal

    2014  Volume -, Issue 2, Page(s) 4

    Language German
    Document type Article
    ZDB-ID 2530214-0
    ISSN 1869-5892
    Database Current Contents Medicine

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    Zs.A 6879: Show issues Location:
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  9. Article ; Online: Feasibility of intra-arterial chemotherapy for retinoblastoma: experiences in a large single center cohort study.

    Stenzel, Elena / Göricke, Sophia / Temming, Petra / Biewald, Eva / Zülow, Stefan / Göbel, Juliane / Wanke, Isabel / Umutlu, Lale / Kleinschnitz, Christoph / Bornfeld, Norbert / Forsting, Michael / Radbruch, Alexander / Mönninghoff, Christoph

    Neuroradiology

    2019  Volume 61, Issue 3, Page(s) 351–357

    Abstract: Purpose: In the last 10 years, intra-arterial chemotherapy (IAC) has been increasingly used in the clinical management of retinoblastoma. It is reported to provide tumor control even in advanced stage disease that might have previously required ... ...

    Abstract Purpose: In the last 10 years, intra-arterial chemotherapy (IAC) has been increasingly used in the clinical management of retinoblastoma. It is reported to provide tumor control even in advanced stage disease that might have previously required enucleation. In our clinical experience, there are three conditions that may impair the use of IAC: (1) significant collaterals to meningeal arteries, (2) technical failure of ophthalmic artery catheterization, or (3) retina blood supply from collaterals different to the ophthalmic artery. In the current study, we assessed the rate of IACs that could not be carried out in our institution due to these three reasons.
    Methods: All patients admitted for IAC in our hospital were retrospectively assessed by chart review. Non-application rate of IAC was assessed and classified according to the three abovementioned criteria. Complication rate of both finalized and interrupted interventions was recorded.
    Results: Ninety-eight patients (median age 21.4 months, range 5.3 months-10.5 years) were identified. IAC was performed in 69 (70.4%) patients and interrupted in 12 (12.2%) cases because of meningeal collaterals, in 8 (8.2%) because of technical failure to cannulate the ophthalmic artery, and in 9 (9.2%) because of alternative blood supply of the retina.
    Conclusion: The rather defensive approach that is pursued in our center resulted in an overall non-application rate of IAC around 30%. The relatively high probability of conditions that impair the use of IAC needs to be addressed adequately in the patient conversation prior to the procedure. Our rate of 8% of abstention from IAC due to technical limitations might be reduced by the application of more rigorous therapeutic approaches such as balloon occlusion of the distal internal carotid artery. More research is finally needed to determine if IAC can be safely performed in the presence of meningeal collaterals and via branches of the external carotid artery.
    MeSH term(s) Antineoplastic Agents, Alkylating/administration & dosage ; Cerebral Angiography ; Child ; Child, Preschool ; Collateral Circulation ; Contrast Media/administration & dosage ; Feasibility Studies ; Female ; Humans ; Infant ; Infusions, Intra-Arterial ; Male ; Melphalan/administration & dosage ; Meningeal Arteries/diagnostic imaging ; Neoplasm Staging ; Ophthalmic Artery/diagnostic imaging ; Retinoblastoma/drug therapy ; Retinoblastoma/pathology ; Retrospective Studies ; Treatment Outcome ; Ultrasonography, Interventional
    Chemical Substances Antineoplastic Agents, Alkylating ; Contrast Media ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2019-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-019-02153-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 658: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Retinoblastoma with late metastatic spread-a case report.

    Hofer, Silvia / Diebold, Joachim / Temming, Petra / Lohmann, Dietmar / Howell, Jeremy / Moulin, Alexandre / Beck-Popovic, Maja / Sahm, Felix / Milde, Till / Ecker, Jonas

    Pediatric blood & cancer

    2019  Volume 66, Issue 6, Page(s) e27656

    MeSH term(s) Adult ; Female ; Humans ; Prognosis ; Retinal Neoplasms/pathology ; Retinal Neoplasms/therapy ; Retinoblastoma/pathology ; Retinoblastoma/therapy ; Sarcoma/secondary ; Sarcoma/therapy ; Young Adult
    Language English
    Publishing date 2019-02-05
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.27656
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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