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Article ; Online: Growth Hormone and Premature Atherosclerosis in Childhood Obesity.

Smotkin-Tangorra, Margarita / Anhalt, Henry / Ten, Svetlana

Journal of pediatric endocrinology & metabolism : JPEM

2023 Volume 19, Issue 4, Page(s) 455–466

MeSH term(s)	Humans ; Atherosclerosis/etiology ; Child ; Pediatric Obesity/complications ; Human Growth Hormone
Language	English
Publishing date	2023-11-02
Publishing country	Germany
Document type	Editorial ; Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2006-190402
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Article: Statement 2: a growth hormone stimulation test should be done as part of the work-up for GHD.

Ten, Svetlana

Pediatric endocrinology reviews : PER

2008 Volume 5 Suppl 3, Page(s) 837–840

MeSH term(s)	Child ; Evidence-Based Medicine ; Growth Disorders/diagnosis ; Human Growth Hormone/blood ; Human Growth Hormone/deficiency ; Human Growth Hormone/secretion ; Humans ; Pituitary Function Tests
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2008-04
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	2434390-0
ISSN	1565-4753
ISSN	1565-4753
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Article ; Online: Response to Letter to the Editor: "Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood".

Panayiotopoulos, Aristotle / Bhangoo, Amrit / Khurana, Divya / Ten, Svetlana / Michl, Josef / Ghanny, Steven

Journal of the Endocrine Society

2020 Volume 5, Issue 2, Page(s) bvaa166

Language	English
Publishing date	2020-11-07
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvaa166
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Article ; Online: Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood.

Panayiotopoulos, Aristotle / Bhangoo, Amrit / Khurana, Divya / Ten, Svetlana / Michl, Josef / Ghanny, Steven

Journal of the Endocrine Society

2020 Volume 4, Issue 9, Page(s) bvaa111

Abstract: Context: We hypothesize that impaired glucocorticoid sensitivity (GC sensitivity) plays a role in the development of premature adrenarche (PA) and polycystic ovarian syndrome (PCOS) by increasing androgen synthesis.: Objective: To study ... ...

Abstract	Context: We hypothesize that impaired glucocorticoid sensitivity (GC sensitivity) plays a role in the development of premature adrenarche (PA) and polycystic ovarian syndrome (PCOS) by increasing androgen synthesis. Objective: To study glucocorticoid sensitivity in vitro in subjects with PA and PCOS. Patients and methods: Fourteen subjects (10 girls, 4 boys, 6.9 ± 0.6 years) with PA; 27 subjects with PCOS (17 ± 2.5 years) and 31 healthy controls were enrolled in the study. All subjects and controls underwent GC sensitivity analysis in vitro using a fluorescein labeled-dexamethasone (F-DEX) assay. A GC sensitivity index (GCSI) was calculated as area under the curve of the F-DEX assay results. Subjects were classified as GC resistant if the GCSI ≤ 264 and GC sensitive if the GCSI ≥ 386. Results: In the PA group, 8 of 14 subjects were resistant with GCSI of 179.7 ± 39.9, 4 were within the normal range with GCSI of 299.6 ± 27.9, and 2 had increased GC sensitivity with GCSI of 423.5 ± 47.9. In the PCOS group, 18 of 27 subjects were GC-resistant with GCSI of 180.9 ± 58.2, 8 were within the normal range with GCSI of 310.7 ± 26.4, and 1 had increased GCSI of 395.4. In the PCOS GC-resistant subgroup, cortisol was higher compared with PCOS with normal GCSI ( Conclusion: GC resistance was found in more than 50% of patients with PCOS and PA. The findings strongly suggest that GC resistance is associated with states of PA and PCOS.
Language	English
Publishing date	2020-08-04
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvaa111
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Article: Fasting Serum IGFBP-1 as a Marker of Insulin Resistance in Diverse School Age Groups.

Bhangoo, Amrit / Gupta, Rishi / Shelov, Steve P / Carey, Dennis E / Accacha, Siham / Fennoy, Ilene / Altshuler, Lisa / Lowell, Barbara / Rapaport, Robert / Rosenfeld, Warren / Speiser, Phyllis W / Ten, Svetlana / Rosenbaum, Michael

Frontiers in endocrinology

2022 Volume 13, Page(s) 840361

Abstract: Introduction: The known markers of insulin resistance in obese children are well studied. However, they require serial measurements and complicated calculations. The objective is to study IGFBP-1 and its relation with other known risk measures.: ... ...

Abstract	Introduction: The known markers of insulin resistance in obese children are well studied. However, they require serial measurements and complicated calculations. The objective is to study IGFBP-1 and its relation with other known risk measures. Materials and methods: The study included 98 New York City school students of diverse ethnic/racial backgrounds (57 males and 41 females), 11-15 years of age. Subjects were enrolled in a cross-sectional study, and anthropometric measures were collected. They underwent fasting intravenous glucose tolerance tests (IVGTT), and glucose, insulin, lipids, IGFBP-1, adiponectin and inflammatory markers were collected. Results: The subjects were stratified into 3 groups based upon the BMI Z-score. Out of all the subjects, 65.3% were in the group with a BMI Z-score <1 SDS, 16.3% subjects were in the group with a BMI Z-score of 1 to 2 SDS, and 18.4% of the subjects were in the group with a BMI Z-score of more than 2 SDS. The group with a BMI Z-score of more than 2 SDS had increased waist circumference (WC), body fat, increased fasting insulin, and triglycerides (TG). This group had decreased levels of adiponectin and HDL and low IGFBP-1 as compared to the group with BMI <1 SDS. The group with a BMI Z-score of 1 to 2 SDS had a decreased level of IGFBP-1 as compared to the group with a BMI Z-score less than 1 SDS. IGFBP-1 inversely correlated with age, WC, BMI, body fat, TG, and insulin levels. IGFBP-1 positively correlated with adiponectin and HDL levels. Conclusion: IGFBP-1 in children can identify the presence of insulin resistance in the group with BMI 1 to 2 SDS, even before the known markers of insulin resistance such as elevated triglycerides and even before decreased HDL and adiponectin levels are identified.
MeSH term(s)	Adiponectin ; Adolescent ; Biomarkers/blood ; Body Mass Index ; Child ; Cross-Sectional Studies ; Fasting/blood ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Insulin-Like Growth Factor Binding Protein 1/blood ; Male ; Pediatric Obesity/blood ; Triglycerides/blood
Chemical Substances	Adiponectin ; Biomarkers ; IGFBP1 protein, human ; Insulin ; Insulin-Like Growth Factor Binding Protein 1 ; Triglycerides
Language	English
Publishing date	2022-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.840361
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Article: Baseline IGFBP - 3 as the Key Element to Predict Growth Response to Growth Hormone and IGF - 1 Therapy in Subjects with Non - GH Deficient Short Stature and IGF - 1 Deficiency.

Perez-Colon, Sheila / Lazareva, Oksana / Purushothaman, Radhika / Malik, Shahid / Ten, Svetlana / Bhangoo, Amrit

International journal of endocrinology and metabolism

2018 Volume 16, Issue 3, Page(s) e58928

Abstract: Background: Short stature in children represents a heterogeneous group with different etiologies. Primary Insulin like growth factor 1 (IGF - 1) deficiency in short stature can present with normal or elevated growth hormone (GH) production. Currently ... ...

Abstract	Background: Short stature in children represents a heterogeneous group with different etiologies. Primary Insulin like growth factor 1 (IGF - 1) deficiency in short stature can present with normal or elevated growth hormone (GH) production. Currently there is no model that can reliably predict response to recombinant (r)GH therapy and/or rIGF - 1 therapy in children with non - GH deficient short stature. Hypothesis: Baseline Insulin like growth factor binding protein 3 (IGFBP - 3) along with ∆ IGF - 1 in the first 3 months of GH therapy level can be a marker of growth response to the rGH and/or rIGF - 1 therapy in children with non - growth hormone deficiency short stature. Objectives: To study the relationship between baseline IGFBP - 3 and IGF - 1 levels and the response to rGH and rIGF - 1 therapy in children with short stature, normal GH secretion and low IGF - 1 SDS. Methods: 43 children, age 9.07 ± 2.75 years with height -2.72 ± 0.7 SD and baseline IGF - 1 of -2.76 ± 0.58 SD, who passed the growth hormone releasing hormone (GHRH) stimulation test were included in a retrospective chart review. They were treated with rGH therapy with a mean dose of 0.46 ± 0.1 mg/kg/week. Growth velocity (GV), IGF - 1 and IGFBP - 3 levels were done at 3 and 6 months of therapy. Subjects with poor response to rGH after 6 months of therapy were switched to rIGF - 1 therapy at 0.24 mg/kg/day for the next 6 months. Subjects were divided according to their growth rate into responders to rGH (N = 23); non - responders to rGH, responders to rIGF - 1 (N = 14) and non - responders to rGH and rIGF-1 (N = 6). Results: There was no correlation between GV and peak GH level at GHRH test. Growth velocity positively correlated with ΔIGF - 1 SD among subjects treated with rGH therapy. Height SD positively correlated with IGFBP - 3 SD. Baseline IGFBP - 3 also inversely correlated with GH peak during GHRH test. Conclusions: In subjects with short stature and low IGF - 1 level, baseline IGFBP - 3 levels can predict the growth response to rGH and/or rIGF - 1 therapy.
Language	English
Publishing date	2018-05-21
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2744447-8
ISSN	1726-9148 ; 1726-913X
ISSN (online)	1726-9148
ISSN	1726-913X
DOI	10.5812/ijem.58928
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Article: Evidence That the Etiology of Congenital Hypopituitarism Has a Major Genetic Component but Is Infrequently Monogenic.

Jee, Youn Hee / Gangat, Mariam / Yeliosof, Olga / Temnycky, Adrian G / Vanapruks, Selena / Whalen, Philip / Gourgari, Evgenia / Bleach, Cortney / Yu, Christine H / Marshall, Ian / Yanovski, Jack A / Link, Kathleen / Ten, Svetlana / Baron, Jeffrey / Radovick, Sally

Frontiers in genetics

2021 Volume 12, Page(s) 697549

Abstract: Purpose: Congenital hypopituitarism usually occurs sporadically. In most patients, the etiology remains unknown.: Methods: We studied 13 children with sporadic congenital hypopituitarism. Children with non-endocrine, non-familial idiopathic short ... ...

Abstract	Purpose: Congenital hypopituitarism usually occurs sporadically. In most patients, the etiology remains unknown. Methods: We studied 13 children with sporadic congenital hypopituitarism. Children with non-endocrine, non-familial idiopathic short stature (NFSS) ( Results: First, we assessed the frequency of rare, predicted-pathogenic variants in 42 genes previously reported to be associated with pituitary gland development. The average number of variants per individual was greater in probands with congenital hypopituitarism than those with NFSS (1.1 vs. 0.21, mean variants/proband, Conclusion: Our findings provide evidence that the etiology of sporadic congenital hypopituitarism has a major genetic component but may be infrequently monogenic with full penetrance, suggesting a more complex etiology.
Language	English
Publishing date	2021-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.697549
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Article ; Online: Insulin resistance, lipodystrophy and cardiometabolic syndrome in HIV/AIDS.

Galescu, Ovidiu / Bhangoo, Amrit / Ten, Svetlana

Reviews in endocrine & metabolic disorders

2013 Volume 14, Issue 2, Page(s) 133–140

Abstract: HIV associated insulin resistance, lipodistrophy and cardiometabolic syndrome have been extensively studied and continue to be the scope of much research. There is compelling evidence that both the HIV itself and the therapeutical regimes are major ... ...

Abstract	HIV associated insulin resistance, lipodistrophy and cardiometabolic syndrome have been extensively studied and continue to be the scope of much research. There is compelling evidence that both the HIV itself and the therapeutical regimes are major contributors to all of these associated comorbidities. HIV has increasingly been recognized as a disease of accelerated aging, manifested by increased progression of vascular disease and cellular markers of aging. The antiretroviral medication can increase insulin resistance and cause lipotoxocity and HIV-associated lipodystrophy leading to cardiovascular pathology. In this article we review the pathogenesis, management, and prevention of the long-term complications of HIV and its therapies, including cardiovascular disease, lipodystrophy, and insulin resistance along with the growing focus on biomarkers to predict development of end-organ disease. Through a focused literature search we review the established evidence, the developing research about the treatment strategies in treated HIV infection as well as identify potential areas for future research.
MeSH term(s)	Acquired Immunodeficiency Syndrome/metabolism ; Acquired Immunodeficiency Syndrome/physiopathology ; Animals ; HIV Infections/metabolism ; HIV Infections/physiopathology ; Humans ; Insulin Resistance/physiology ; Lipodystrophy/metabolism
Language	English
Publishing date	2013-05-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-013-9247-7
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Article: Complications of obesity in childhood.

Gunturu, Sreenivas Dutt / Ten, Svetlana

Pediatric annals

2007 Volume 36, Issue 2, Page(s) 96–101

MeSH term(s)	Abdominal Fat ; Acanthosis Nigricans/etiology ; Adolescent ; Atherosclerosis/etiology ; Bone Diseases, Endocrine/etiology ; Child ; Fatty Liver/etiology ; Ghrelin ; Humans ; Hyperandrogenism/etiology ; Hypertension/etiology ; Insulin/metabolism ; Insulin Resistance ; Leptin/metabolism ; Obesity/complications ; Obesity/metabolism ; Peptide Hormones/metabolism ; Phenotype ; Satiation ; Sleep Apnea Syndromes/etiology
Chemical Substances	Ghrelin ; Insulin ; Leptin ; Peptide Hormones
Language	English
Publishing date	2007-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	195430-1
ISSN	0090-4481
ISSN	0090-4481
DOI	10.3928/0090-4481-20070201-08
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Article ; Online: Real-life utilization of real-time continuous glucose monitoring: the complete picture.

Ramchandani, Neesha / Arya, Sandeep / Ten, Svetlana / Bhandari, Sonal

Journal of diabetes science and technology

2011 Volume 5, Issue 4, Page(s) 860–870

Abstract: Background: Very few studies to date have analyzed the reasons why some people do not use real-time continuous glucose monitoring (RT-CGM) continuously, especially given its positive glycemic outcomes, or choose not to wear it at all, even after ... ...

Abstract	Background: Very few studies to date have analyzed the reasons why some people do not use real-time continuous glucose monitoring (RT-CGM) continuously, especially given its positive glycemic outcomes, or choose not to wear it at all, even after learning about its benefits. Methods: A questionnaire was designed to assess real-life use of and issues surrounding RT-CGM. Hemoglobin A1c (HbA1c) and duration of sensor use were also obtained from the patients' charts. Results: Fifty-eight subjects with type 1 diabetes (T1DM), average age 15.0 ± 4.8 years, T1DM duration 5.7 ± 3.8 years, HbA1c 8.8 ± 2.1%, 50% with RT-CGM, were included in the analysis. Hemoglobin A1c was lower with increased RT-CGM use. Real-time continuous glucose monitoring was ordered to improve control. Users liked the continuous data. The most disliked part was pain and discomfort. Occasional users described RT-CGM as annoying, a hassle, and interfering with their lives. Reasons for discontinuing RT-CGM included problematic equipment and inaccuracy (64%), intrusion in life (36%), and insurance issues (29%). Twenty-one percent of nonusers reported RT-CGM to be inconvenient or a hassle or just did not want it. Fifty-two percent of subjects continue to use RT-CGM despite reported problems. Conclusion: Real-time continuous glucose monitoring is a beneficial tool for improving glycemic control, and many use it despite reported problems and hassles with current devices. However, this technology has not been wholeheartedly embraced by many individuals with T1DM, especially in youngsters, because of issues mentioned here. Based on the findings of this study, it is hoped that improvements will be made to RT-CGM technology so that more people with diabetes will embrace this beneficial tool.
MeSH term(s)	Activities of Daily Living ; Adolescent ; Adult ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Blood Glucose Self-Monitoring/instrumentation ; Blood Glucose Self-Monitoring/methods ; Blood Glucose Self-Monitoring/statistics & numerical data ; Child ; Child, Preschool ; Computer Systems/standards ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/therapy ; Female ; Humans ; Infant ; Life ; Male ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2011-07-01
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/193229681100500407
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