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  1. Article ; Online: Orofacial manifestations in Brazilian people living with HIV/AIDS under long-term antiretroviral therapy: a cross-sectional study.

    Bartholo, Maria Fernanda / Tenório, Jefferson R / Andrade, Natália Silva / Shibutani, Patrícia Pinheiro / Martins, Fabiana / Gallottini, Marina

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 136, Issue 4, Page(s) 436–441

    Abstract: Objective: The aim of this study was to assess the prevalence of orofacial manifestations in a Brazilian cohort of people living with HIV/AIDS (PLWHIV) using long-term combined antiretroviral therapy (cART) and to correlate the presence of these ... ...

    Abstract Objective: The aim of this study was to assess the prevalence of orofacial manifestations in a Brazilian cohort of people living with HIV/AIDS (PLWHIV) using long-term combined antiretroviral therapy (cART) and to correlate the presence of these manifestations with clinical and laboratory characteristics.
    Study design: A cross-sectional observational study evaluated 101 Brazilian PLWHIV. Demographic characteristics, medical history, and laboratory data were collected. Physical examination and measurement of stimulated salivary flow were performed.
    Results: The study included 101 participants who were mainly male (61%) and White (73%), with an average age of 48 years, using long-term cART. The most common oral manifestations were facial lipoatrophy (33%), xerostomia (30%), and salivary gland enlargement (12%). Facial lipoatrophy was linked to a longer duration of cART use (P = .002), whereas hairy leukoplakia was linked to a detectable viral load (P = .031). The salivary flow of <0.7 mL/min was associated with an HIV infection time >20 years (P = .023).
    Conclusions: People living with HIV/AIDS who use cART often experience facial lipoatrophy, xerostomia, and bilateral enlargement of the parotid glands. Although opportunistic infections and malignant neoplasms are not frequent occurrences, they can still arise.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Cross-Sectional Studies ; Brazil/epidemiology ; Leukoplakia, Hairy
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.05.001
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  2. Article ; Online: Oral manifestations of autoimmune polyglandular syndrome type 1.

    Tenório, Jefferson R / Tuma, Marina Maués / Andrade, Natália Silva / Santana, Thalita / Gallottini, Marina

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2022  Volume 42, Issue 5, Page(s) 531–535

    Abstract: Aims: Autoimmune polyglandular syndrome type I (APS-I) is a rare condition of autosomal recessive and monogenic inheritance, which is characterized clinically by at least two signs of the classic triad: mucocutaneous candidosis, hypoparathyroidism, and ... ...

    Abstract Aims: Autoimmune polyglandular syndrome type I (APS-I) is a rare condition of autosomal recessive and monogenic inheritance, which is characterized clinically by at least two signs of the classic triad: mucocutaneous candidosis, hypoparathyroidism, and Addison's disease. This study aims to report the oral manifestations of APS-I in a 42-year-old woman, who attended the Special Care Dentistry Center.
    Methods and results: The patient presented with hypoparathyroidism, diabetes mellitus, and autoimmune hepatitis. Chronic hyperplastic candidosis (CHC) was the main oral manifestation and it was diagnosed based on clinical and cytologic characteristics. Microstomia, angular cheilitis, xerostomia, enamel hypoplasia, and microdontia were also present.
    Conclusions: CHC was treated with topical nystatin and oral fluconazole, resulting in a significant improvement of the lesions.
    MeSH term(s) Addison Disease ; Adult ; Candidiasis, Chronic Mucocutaneous ; Dental Enamel Hypoplasia ; Female ; Humans ; Hypoparathyroidism ; Polyendocrinopathies, Autoimmune/complications ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/drug therapy
    Language English
    Publishing date 2022-02-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12703
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  3. Article ; Online: Nitrogenous compounds in the saliva and blood of cirrhotic patients: a cross-sectional study.

    Duarte, Nathália Tuany / Tenório, Jefferson R / Andrade, Natália Silva / Martins, Fabiana / Gallottini, Marina / Ortega, Karem L

    Clinical oral investigations

    2022  Volume 26, Issue 6, Page(s) 4587–4592

    Abstract: Objectives: Serum increase of nitrogenous compounds (NC) in cirrhotic patients has been associated with the development of hepatic encephalopathy (HE). However, the relation between NC in saliva and HE is unclear. The objective of this study is to ... ...

    Abstract Objectives: Serum increase of nitrogenous compounds (NC) in cirrhotic patients has been associated with the development of hepatic encephalopathy (HE). However, the relation between NC in saliva and HE is unclear. The objective of this study is to measure the levels of nitric oxide and urea in the blood and saliva in 38 cirrhotic patients and correlate them with clinical characteristics and presence and grades of HE.
    Material and methods: Automated enzymatic colourimetric assays were performed to determine the levels of NC. Diagnosis and severity of HE were determined based on the West Haven criteria and by using the inhibitory control test.
    Results: HE was diagnosed in 89.47% of the patients, with the majority (60.50%) presenting covert HE. With regard to the measurement of NC, although nitric oxide is moderately correlated with its amount in blood and saliva (r = 0.630; P < 0.001), only salivary levels were associated with the presence of ascites and ecchymosis (P = 0.013 and P = 0.030, respectively). In patients with HE, the serum levels of urea were higher (P = 0.013) than those in patients without HE or minimal HE.
    Conclusions: Nitrogenous compounds in the saliva were correlated with neither the presence nor grades of HE, whereas in the blood, only urea was positively correlated with the severity and presence of HE.
    Clinical relevance: Saliva is an excellent fluid for diagnosing several diseases, but it does not seem to be able to collaborate with the identification of HE.
    MeSH term(s) Cross-Sectional Studies ; Hepatic Encephalopathy/complications ; Hepatic Encephalopathy/diagnosis ; Humans ; Liver Cirrhosis/complications ; Nitric Oxide ; Nitrogen Compounds ; Saliva ; Urea
    Chemical Substances Nitrogen Compounds ; Nitric Oxide (31C4KY9ESH) ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-022-04426-9
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  4. Article ; Online: What are the main oral manifestations in heart transplant patients? A scoping review.

    Pimentel, Marianne Corrêa Dos Santos / Fernandes, Mariana Magalhães / Vogel, Jéssica de Oliveira / Freire, Clara Herrera / Pereira, Cláudia Maria / Andrade, Bruno Augusto Benevenuto de / Rech, Bruna de Oliveira / Tenório, Jefferson R

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2024  

    Abstract: Objective: The purpose of this scoping review is to evaluate the oral manifestations (OM) of heart transplant (HT) patients undergoing immunosuppressive therapy (IT).: Material and methods: A literature search was performed using keywords and MeSH ... ...

    Abstract Objective: The purpose of this scoping review is to evaluate the oral manifestations (OM) of heart transplant (HT) patients undergoing immunosuppressive therapy (IT).
    Material and methods: A literature search was performed using keywords and MeSH terms related to OM and HT in the Medline/PubMed, Web of Science, Cochrane Library, Scopus, LILACS/BBO databases and in gray literature without language or date restrictions until June 2023. Studies that evaluated HT individuals who used any IT and who reported the occurrence of OM were considered eligible. The results from the search were imported to EndNote Web, and duplicates were removed followed by title/abstract and full-text analysis.
    Results: A total of 402 nonduplicated studies were found and 13 fulfilled the criteria and were included in the present review: 10 cross-sectional, 2 cohorts, and 1 clinical trial. The most reported OM were periodontal diseases, including drug-induced gingival enlargement (DIGE), gingival bleeding, gingivitis, and periodontitis. Reported in a minority of studies are oral cancer, opportunistic infections (oral hairy leukoplakia and erythematous candidiasis), enamel defects, and burning mouth.
    Conclusion: Considering the methodological heterogeneity of the studies analyzed, DIGE is the most commonly observed oral manifestation in HT individuals.
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12999
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  5. Article ; Online: Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study.

    Bueno Marinho, Gabriella / Bertoldi Franco, Juliana / Tenório, Jefferson R / Silva Andrade, Natália / Zerbinati, Rodrigo Melim / Medina, Janaína B / Pérez-Sayáns, Mário / Braz-Silva, Paulo Henrique / Ortega, Karem L

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2024  

    Abstract: Aims: The objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic-cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross- ... ...

    Abstract Aims: The objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic-cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross-sectional study.
    Methods and results: Specimens of plasma and saliva from 72 cirrhotic individuals were analyzed by means of polymerase chain reaction. The patient population had a mean age of 54.84 years old (SD ± 10) and was 70% males (51/72). Approximately 47% (n = 34) of the patients had leukopenia and HHV was not identified in the plasma specimens. The main species of HHV identified in the saliva were HHV-7 (n = 42, 62%) and Epstein-Barr virus (EBV) (n = 30, 41%). Moreover, there was a significant decrease in the total number of leukocytes and lymphocytes in saliva containing EBV (P = .038 and P = .047, respectively).
    Conclusion: The results show that the presence of EBV in the saliva of cirrhotic patients was correlated with their circulating immune status. It may be possible that the immune dysfunction displayed by the cirrhotic patients plays a role in the shedding of EBV into saliva.
    Language English
    Publishing date 2024-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.13016
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  6. Article ; Online: Supernumerary teeth in a patient with Turner syndrome: An unusual finding.

    Andrade, Natália Silva / Tenório, Jefferson R / Gallottini, Marina

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2019  Volume 39, Issue 5, Page(s) 538–542

    Abstract: Aims: Turner syndrome (TS) is a genetic disorder associated with abnormalities of the X-chromosome, occurring in about 1 in 2000 to 1 in 3000 live-born girls. We present a case of a 14-year-old girl with TS, who was referred to our outpatient clinic in ... ...

    Abstract Aims: Turner syndrome (TS) is a genetic disorder associated with abnormalities of the X-chromosome, occurring in about 1 in 2000 to 1 in 3000 live-born girls. We present a case of a 14-year-old girl with TS, who was referred to our outpatient clinic in 2016 because of an ectopic eruption.
    Methods and results: Dental clinical examination and radiographic investigation revealed eight supernumerary teeth, short roots, enamel hypoplasia, increased overjet, rotation and displacement of teeth, moderate gingivitis and morphological alteration of the upper right central incisor. Dental treatment included extraction of erupted supernumerary teeth, composite resin restoration, supragingival scaling and oral hygiene for plaque control.
    Conclusions: The unpublished finding of supernumerary teeth in our patient has led us to suggest the investigation of this dental developmental anomaly in other patients with Turner syndrome.
    MeSH term(s) Adolescent ; Dental Enamel Hypoplasia ; Female ; Humans ; Incisor ; Mouth Abnormalities ; Tooth, Supernumerary ; Turner Syndrome
    Language English
    Publishing date 2019-07-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12412
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  7. Article ; Online: Recurrent chronic suppurative osteomyelitis in the maxilla of a patient with diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency.

    de Mello, Carlos Henrique / Barbosa, Joyce / Cortezzi, Ellen Brilhante de Albuquerque / Janini, Maria Elisa Rangel / Tenório, Jefferson R

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2022  Volume 43, Issue 1, Page(s) 83–86

    Abstract: Aims: To report the case of chronic osteomyelitis of a maxilla in a woman with uncontrolled diabetes mellitus (DM), glucose-6-phosphate dehydrogenase (G6PD) deficiency and mental illness, in an attempt to clarify its pathogenesis and treatment.: ... ...

    Abstract Aims: To report the case of chronic osteomyelitis of a maxilla in a woman with uncontrolled diabetes mellitus (DM), glucose-6-phosphate dehydrogenase (G6PD) deficiency and mental illness, in an attempt to clarify its pathogenesis and treatment.
    Methods and results: A case of a woman with moderate G6PD deficiency (Class III) who developed bilateral and asynchronous chronic suppurative osteomyelitis (CSO) of her maxilla with extensive bone sequestra, fistulae and whose management was performed by local surgery for bony sequestra and fistulae removal; closure communication under 4 weeks antibiotic cover.
    Conclusions: CSO of the jaw may be a complication of the G6PD deficiency and DM and its severity depends on patient's medical status.
    MeSH term(s) Female ; Humans ; Glucosephosphate Dehydrogenase Deficiency ; Maxilla ; Osteomyelitis/complications ; Osteomyelitis/surgery ; Diabetes Mellitus ; Bone Diseases
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12729
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  8. Article: Oral lichen planus and HCV infection.

    Tenório, Jefferson R / de Camargo, Alessandra Rodrigues / Lemos, Celso / Ortega, Karem L

    Autopsy & case reports

    2020  Volume 10, Issue 4, Page(s) e2020210

    Abstract: Chronic infection by hepatitis C virus (HCV) can lead not only to the development of hepatic cirrhosis, but also to the emergence of extra-hepatic manifestations (EHMs), such as oral lichen planus (OLP). Here, we describe a clinical presentation of ... ...

    Abstract Chronic infection by hepatitis C virus (HCV) can lead not only to the development of hepatic cirrhosis, but also to the emergence of extra-hepatic manifestations (EHMs), such as oral lichen planus (OLP). Here, we describe a clinical presentation of massive, erosive OLP in an HCV-positive patient whose clinical management was difficult. Full remission was achieved after sustained virological response by using direct-acting anti-retrovirals. This case report demonstrates not only the importance of diagnosing EHMs for identification of HCV infection, but also the importance of controlling it for management of OLP and EHMs.
    Language English
    Publishing date 2020-11-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2020.210
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  9. Article ; Online: Diagnosis and management of oral ulcerations associated with mycophenolate mofetil in kidney transplantation.

    Tenório, Jefferson R / Tuma, Marina / Martins, Fabiana / Ortega, Karem L / Cristelli, Marina / Gallottini, Marina

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2020  Volume 40, Issue 6, Page(s) 605–610

    Abstract: Aims: The final diagnosis of oral mucosal ulcerations in solid organ transplant recipients represents a challenge. We describe a unique case of oral ulceration related to mycophenolate mofetil (MMF) toxicity, 11 years after kidney transplantation, whose ...

    Abstract Aims: The final diagnosis of oral mucosal ulcerations in solid organ transplant recipients represents a challenge. We describe a unique case of oral ulceration related to mycophenolate mofetil (MMF) toxicity, 11 years after kidney transplantation, whose dose reduction was sufficient to resolve it.
    Methods and results: A 54-year-old female patient, who underwent kidney transplantation 11 years ago, presents multiple ulcers on the buccal mucosa bilaterally, soft palate and tongue dorsum, for 8 months, with moderate pain. The diagnosis of oral ulcerations associated with MMF therapy was assumed by excluding infection and malignancy diagnosis. After MMF dose reduction, the oral ulcers healed utterly.
    Conclusions: MMF toxicity manifested as oral ulcers. Reduction or discontinuation of MMF therapy should be considered in a patient with refractory oral ulcers and a negative workup for other causes.
    MeSH term(s) Female ; Graft Rejection ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Middle Aged ; Mycophenolic Acid/adverse effects ; Oral Ulcer/chemically induced ; Oral Ulcer/diagnosis
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12522
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  10. Article ; Online: Orofacial Manifestations in a Middle-Aged Woman with Cowden Syndrome: A Case Image.

    de Arruda, José Alcides Almeida / Freire, Clara Herrera / Leite, Taísa Domingues Boehmer / Noce, César Werneck / Cavalcante, Israel Leal / Vogel, Jéssica de Oliveira / Mesquita, Ricardo Alves / Tenório, Jefferson R / de Andrade, Bruno Augusto Benevenuto

    Head and neck pathology

    2023  Volume 17, Issue 4, Page(s) 1071–1074

    Abstract: A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish ...

    Abstract A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish papules were also observed on the face, neck, and limbs. Incisional biopsies of these lesions were performed. Microscopically, the skin lesion revealed epithelial clear cells and intraepithelial keratinization with areas of orthokeratosis, while the gingival lesions showed a parakeratinized stratified squamous epithelium with collagenous connective tissue. These features were consistent with those of a trichilemmoma and fibroepithelial hyperplasia, respectively. This article illustrates a case of Cowden syndrome (CS), a rare multisystem genetic condition in which both cutaneous and mucosal tissues were affected. Fewer than 40 cases of CS with oral involvement affecting middle-aged adults have been documented hitherto.
    MeSH term(s) Adult ; Middle Aged ; Female ; Humans ; Hamartoma Syndrome, Multiple/complications ; Hamartoma Syndrome, Multiple/pathology ; Skin Neoplasms/pathology ; Skin Diseases ; Papilloma ; Gingiva/pathology ; PTEN Phosphohydrolase/genetics
    Chemical Substances PTEN Phosphohydrolase (EC 3.1.3.67)
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-023-01586-2
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