Article ; Online: Sodium channel endocytosis drives axon initial segment plasticity.
2023 Volume 9, Issue 37, Page(s) eadf3885
Abstract: Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated ... ...
| Abstract | Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated sodium channels, but the molecular mechanisms regulating their plasticity remain largely unknown. Here, we developed genetic tools to label endogenous sodium channels and their scaffolding protein, to reveal their nanoscale organization and longitudinally image AIS plasticity in hippocampal neurons in slices and primary cultures. We find that |
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| MeSH term(s) | Axon Initial Segment ; Sodium Channels ; Action Potentials ; Cluster Analysis ; Endocytosis |
| Chemical Substances | Sodium Channels |
| Language | English |
| Publishing date | 2023-09-15 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2810933-8 |
| ISSN | 2375-2548 ; 2375-2548 |
| ISSN (online) | 2375-2548 |
| ISSN | 2375-2548 |
| DOI | 10.1126/sciadv.adf3885 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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