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  1. AU="Tennakoon, Nipuna"
  2. AU="Jakob, Werner"
  3. AU="Ma, Penglei"
  4. AU="Monteleone, Pedro Augusto Araújo"
  5. AU="Sakuma, Ikki"
  6. AU="Cherniack, Andrew D."
  7. AU="Beitollahi, Hadi"
  8. AU="Hai-Tao Tang"
  9. AU=Rouse Benjamin AU=Rouse Benjamin
  10. AU="Rabensteiner, Toni"
  11. AU="Chowdhury, Forhad Uddin Hassan" AU="Chowdhury, Forhad Uddin Hassan"
  12. AU=Verdone Loredana AU=Verdone Loredana
  13. AU="Venegas, M"
  14. AU="Burtnick, Mary N"
  15. AU=Frisoni Giovanni B
  16. AU="Dhiraj Kumar"
  17. AU="Isaac S. Lee"
  18. AU="Bals, Julia"
  19. AU="Rovira-Clavé, Xavier"
  20. AU="Den Boer, Monique L"
  21. AU="Potts, T."
  22. AU="Cifuentes-Diaz, Carmen"
  23. AU="Alvim, Ricardo G"
  24. AU="Barron II, Joseph C"
  25. AU="Godin, Shea-Lee"
  26. AU="Leng, Chengcai"
  27. AU="Hyslop, Brian W"
  28. AU="Suzanne Fischer"
  29. AU="Aboelata, Noha"
  30. AU="Chiang, Sarah N"
  31. AU="Wessel, Kristin M"
  32. AU="Wilson, Jenna M"
  33. AU="Goines, Paula"
  34. AU=Ippolito Mariachiara AU=Ippolito Mariachiara
  35. AU="Jose Chauca"
  36. AU="Asih, Puji B S"
  37. AU="Dsane-Selby, Lydia"
  38. AU="Tolossa, Tadesse"
  39. AU="Erdal Bedir"

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  1. Artikel: Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis Virus

    Tennakoon, Nipuna / Ryu, Jihoon / Ujike, Makoto / Taguchi, Fumihiro / Shin, Hyun-Jin

    Viruses. 2022 Feb. 15, v. 14, no. 2

    2022  

    Abstract: Deletions in the spike gene of mouse hepatitis virus (MHV) produce several variants with diverse biological characteristics, highlighting the significance of the spike gene in viral pathogenesis. In this study, we characterized the JHM-X strain, which ... ...

    Abstract Deletions in the spike gene of mouse hepatitis virus (MHV) produce several variants with diverse biological characteristics, highlighting the significance of the spike gene in viral pathogenesis. In this study, we characterized the JHM-X strain, which has a deletion in the hypervariable region (HVR) of the spike gene, compared with the cl-2 strain, which has a full spike gene. Cytopathic effects (CPEs) induced by the two strains revealed that the size of the CPE produced by cl-2 is much greater than that produced by JHM-X in delayed brain tumor (DBT) cells. Thus, this finding explains the greater fusion activity of cl-2 than JHM-X in cultured cells, and we speculate that the deletion region of the spike protein is involved in the fusion activity differences. In contrast with the fusion activity, a comparison of the virus growth kinetics revealed that the titer of JHM-X was approximately 100 times higher than that of cl-2. We found that the deletion region of the spike protein was involved in fusion activity differences, whereas cl-2 produced significantly higher luciferase activity than JHM-X upon similar expression levels of the spike protein. However, the reason behind the growth difference is still unknown. Overall, we discovered that deletion in the HVR of the spike gene could be involved in the fusion activity differences between the two strains.
    Schlagwörter Murine hepatitis virus ; brain neoplasms ; cell fusion ; genes ; growth models ; luciferase ; pathogenesis ; viral growth
    Sprache Englisch
    Erscheinungsverlauf 2022-0215
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020398
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis Virus.

    Tennakoon, Nipuna / Ryu, Jihoon / Ujike, Makoto / Taguchi, Fumihiro / Shin, Hyun-Jin

    Viruses

    2022  Band 14, Heft 2

    Abstract: Deletions in the spike gene of mouse hepatitis virus (MHV) produce several variants with diverse biological characteristics, highlighting the significance of the spike gene in viral pathogenesis. In this study, we characterized the JHM-X strain, which ... ...

    Abstract Deletions in the spike gene of mouse hepatitis virus (MHV) produce several variants with diverse biological characteristics, highlighting the significance of the spike gene in viral pathogenesis. In this study, we characterized the JHM-X strain, which has a deletion in the hypervariable region (HVR) of the spike gene, compared with the cl-2 strain, which has a full spike gene. Cytopathic effects (CPEs) induced by the two strains revealed that the size of the CPE produced by cl-2 is much greater than that produced by JHM-X in delayed brain tumor (DBT) cells. Thus, this finding explains the greater fusion activity of cl-2 than JHM-X in cultured cells, and we speculate that the deletion region of the spike protein is involved in the fusion activity differences. In contrast with the fusion activity, a comparison of the virus growth kinetics revealed that the titer of JHM-X was approximately 100 times higher than that of cl-2. We found that the deletion region of the spike protein was involved in fusion activity differences, whereas cl-2 produced significantly higher luciferase activity than JHM-X upon similar expression levels of the spike protein. However, the reason behind the growth difference is still unknown. Overall, we discovered that deletion in the HVR of the spike gene could be involved in the fusion activity differences between the two strains.
    Mesh-Begriff(e) Animals ; Cell Fusion ; Cell Line ; Mice ; Murine hepatitis virus/genetics ; Murine hepatitis virus/pathogenicity ; Murine hepatitis virus/physiology ; Sequence Deletion ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/physiology
    Chemische Substanzen Spike Glycoprotein, Coronavirus
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020398
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Complete genome sequence analysis and phylogenetic classification of the novel Aeromonas phage AHP-1, a potential member of the genus Tequatrovirus

    Nikapitiya, Chamilani / Senevirathne, Amal / Dananjaya, S. H. S. / Tennakoon, Nipuna / Shin, Hyun-Jin / Lee, Jehee / De Zoysa, Mahanama

    Archives of virology. 2022 Apr., v. 167, no. 4

    2022  

    Abstract: Aeromonas phage AHP-1 was originally isolated from crucian carp (Carassius carassius) tissue. It was able to infect Aeromonas hydrophila and A. salmonicida. Genome sequence analysis revealed a 218,317-bp-long linear genome with an overall G + C content ... ...

    Abstract Aeromonas phage AHP-1 was originally isolated from crucian carp (Carassius carassius) tissue. It was able to infect Aeromonas hydrophila and A. salmonicida. Genome sequence analysis revealed a 218,317-bp-long linear genome with an overall G + C content of 47.9%, 315 open reading frames (ORFs), and 25 tRNA sequences. Its genome was found to contain 67 unique ORFs (21.26%) that did not show any homology to previously characterized proteins. A comparative genome analysis suggested that its closest neighbors are unclassified phages belonging to the genus Tequatrovirus of the subfamily Tevenvirinae.
    Schlagwörter Aeromonas hydrophila ; Carassius carassius ; bacteriophages ; genome ; phylogeny ; sequence analysis ; virology
    Sprache Englisch
    Erscheinungsverlauf 2022-04
    Umfang p. 1225-1230.
    Erscheinungsort Springer Vienna
    Dokumenttyp Artikel
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-022-05418-6
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Complete genome sequence analysis and phylogenetic classification of the novel Aeromonas phage AHP-1, a potential member of the genus Tequatrovirus.

    Nikapitiya, Chamilani / Senevirathne, Amal / Dananjaya, S H S / Tennakoon, Nipuna / Shin, Hyun-Jin / Lee, Jehee / De Zoysa, Mahanama

    Archives of virology

    2022  Band 167, Heft 4, Seite(n) 1225–1230

    Abstract: Aeromonas phage AHP-1 was originally isolated from crucian carp (Carassius carassius) tissue. It was able to infect Aeromonas hydrophila and A. salmonicida. Genome sequence analysis revealed a 218,317-bp-long linear genome with an overall G + C content ... ...

    Abstract Aeromonas phage AHP-1 was originally isolated from crucian carp (Carassius carassius) tissue. It was able to infect Aeromonas hydrophila and A. salmonicida. Genome sequence analysis revealed a 218,317-bp-long linear genome with an overall G + C content of 47.9%, 315 open reading frames (ORFs), and 25 tRNA sequences. Its genome was found to contain 67 unique ORFs (21.26%) that did not show any homology to previously characterized proteins. A comparative genome analysis suggested that its closest neighbors are unclassified phages belonging to the genus Tequatrovirus of the subfamily Tevenvirinae.
    Mesh-Begriff(e) Aeromonas ; Genome, Viral ; Myoviridae/genetics ; Phylogeny ; Sequence Analysis
    Sprache Englisch
    Erscheinungsdatum 2022-03-16
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-022-05418-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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