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Article ; Online: Iron overload disorders: Growth and gonadal dysfunction in childhood and adolescence.

Tenuta, Marta / Cangiano, Biagio / Rastrelli, Giulia / Carlomagno, Francesco / Sciarra, Francesca / Sansone, Andrea / Isidori, Andrea M / Gianfrilli, Daniele / Krausz, Csilla

Pediatric blood & cancer

2024 , Page(s) e30995

Abstract: Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can ... ...

Abstract	Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can adversely affect linear growth or pubertal development, with significant repercussions on quality of life even into adulthood. Therefore, a timely and accurate diagnosis of these disorders is mandatory, but sometimes complex for hematologists without endocrinological support. This is a narrative review focused on puberty and growth disorders during infancy and adolescence aiming to offer guidance for diagnosis, treatment, and proper follow-up. Additionally, it aims to highlight gaps in the existing literature and emphasizes the importance of collaboration among specialists, which is essential in the era of precision medicine.
Language	English
Publishing date	2024-04-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30995
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Article: Multiparametric Ultrasound for Diagnosing Testicular Lesions: Everything You Need to Know in Daily Clinical Practice.

Pozza, Carlotta / Tenuta, Marta / Sesti, Franz / Bertolotto, Michele / Huang, Dean Y / Sidhu, Paul S / Maggi, Mario / Isidori, Andrea M / Lotti, Francesco

Cancers

2023 Volume 15, Issue 22

Abstract: Background: Ultrasonography (US) represents the gold standard imaging method for the assessment of testicular lesions (TL). The gray-scale (GSUS) and color-Doppler (CDUS) ultrasound examination allow sonographers to investigate the size, margins, ... ...

Abstract	Background: Ultrasonography (US) represents the gold standard imaging method for the assessment of testicular lesions (TL). The gray-scale (GSUS) and color-Doppler (CDUS) ultrasound examination allow sonographers to investigate the size, margins, echotexture, and vascular features of TLs with the aim to differentiate benign from malignant lesions. Recently, the use of contrast-enhanced US (CEUS) and sonoelastography (SE) has led to further improvements in the differential diagnosis of TL. Although GSUS and CDUS are often sufficient to suggest the benign or malignant nature of the TL, CEUS can be decisive in the differential diagnosis of unclear findings, while SE can help to strengthen the diagnosis. The contemporary combination of GSUS, CDUS, CEUS, and SE has led to a new diagnostic paradigm named multiparametric US (mp-US), which is able to provide a more detailed characterization of TLs than single techniques alone. This narrative and pictorial review aimed to describe the mp-US appearance of several TLs. Methods: An extensive Medline search was performed to identify studies in the English language focusing on the mp-US evaluation of TLs. Results: A practical mp-US "identity card" and iconographic characterization of several benign and malignant TLs is provided herein. Conclusions: The mp-US characterization of TL reported herein can be useful in daily clinical practice.
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15225332
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Article ; Online: Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.

Tenuta, Marta / Sesti, Franz / Bonaventura, Ilaria / Mazzotta, Paola / Pofi, Riccardo / Gianfrilli, Daniele / Pozza, Carlotta

Andrology

2021 Volume 9, Issue 5, Page(s) 1369–1382

Abstract: Background: Contrast-enhanced ultrasound (CEUS) is a sonographic technique that increases the diagnostic accuracy of ultrasound and color Doppler ultrasound (CDUS) when studying testicular abnormalities. However, its role in clinical practice is still ... ...

Abstract	Background: Contrast-enhanced ultrasound (CEUS) is a sonographic technique that increases the diagnostic accuracy of ultrasound and color Doppler ultrasound (CDUS) when studying testicular abnormalities. However, its role in clinical practice is still debatable because there are no accepted standards regarding how and when this technique should be used for patients with testicular disease. Objectives: To perform a nonsystematic review of the current literature to highlight the strength and flaws of performing CEUS and to provide a critical overview of current research evidence on this topic. Materials and methods: A thorough search of published peer-reviewed studies in PubMed was performed using proper keywords. Results: Strong enhancement of neoplastic lesions (both benign and malignant) during CEUS aids in differential diagnosis with non-neoplastic lesions, which usually appears either nonenhanced or enhanced in a manner similar to that of the surrounding parenchyma. CEUS enhancement has a high predictive value in the identification of neoplastic lesions, whereas a similar or complete absence of enhancement may be interpreted as strong evidence of benignity, although there are exceptions. Literature on quantitative analysis is still scarce, though promising, particularly in distinguishing benign from malignant neoplasms. Furthermore, CEUS may be useful in many emergency situations, such as acute scrotum, blunt scrotal trauma, and focal infarction of the testis. Finally, CEUS can help increase the probability of sperm recovery in azoospermic males. Discussion and conclusion: CEUS is a safe, easy-to-perform, and cost-effective diagnostic tool that can provide a more accurate diagnosis in testicular lesions and acute scrotal disease. However, further studies with larger cohorts are required to refine the differential diagnosis between benign and malignant neoplasms. Finally, these preliminary results can instigate the development of innovative research on pre-testicular sperm extraction to increase the chances of sperm recovery.
MeSH term(s)	Contrast Media ; Diagnosis, Differential ; Humans ; Male ; Testicular Diseases/diagnostic imaging ; Testis/diagnostic imaging ; Ultrasonography/methods ; Ultrasonography, Doppler, Color/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2021-06-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13057
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Article ; Online: Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.

Campolo, Federica / Sesti, Franz / Feola, Tiziana / Puliani, Giulia / Faggiano, Antongiulio / Tarsitano, Maria Grazia / Tenuta, Marta / Hasenmajer, Valeria / Ferretti, Elisabetta / Verrico, Monica / Gianfrilli, Daniele / Venneri, Mary Anna / Isidori, Andrea M / Giannetta, Elisa

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 548

Abstract: Background: Neuroendocrine tumors (NETs) early diagnosis is a clinical challenge that require a deep understanding of molecular and genetic features of this heterogeneous group of neoplasms. However, few biomarkers exist to aid diagnosis and to predict ... ...

Abstract	Background: Neuroendocrine tumors (NETs) early diagnosis is a clinical challenge that require a deep understanding of molecular and genetic features of this heterogeneous group of neoplasms. However, few biomarkers exist to aid diagnosis and to predict prognosis and treatment response. In the oncological field, tumor-educated platelets (TEPs) have been implicated as central players in the systemic and local responses to tumor growth, thereby altering tumor specific RNA profile. Although TEPs have been found to be enriched in RNAs, few studies have investigated the potential of a type of RNA, circular RNAs (circRNA), as platelet-derived biomarkers for cancer. In this proof-of-concept study, we aim to demonstrate whether the circRNAs signature of tumor educated platelets can be used as a liquid biopsy biomarker for the detection of gastroenteropancreatic (GEP)-NETs and the prediction of the early response to treatment. Methods: We performed a 24-months, prospective proof-of-concept study in men and women with histologically proven well-differentiated G1-G2 GEP-NET, aged 18-80 years, naïve to treatment. We performed a RNAseq analysis of circRNAs obtained from TEPs samples of 10 GEP-NETs patients at baseline and after 3 months from therapy (somatostatin analogs or surgery) and from 5 patients affected by non-malignant endocrinological diseases enrolled as a control group. Results: Statistical analysis based on p < 0.05 resulted in the identification of 252 circRNAs differentially expressed between GEP-NET and controls of which 109 were up-regulated and 143 were down-regulated in NET patients. Further analysis based on an FDR value ≤ 0.05 resulted in the selection of 5 circRNAs all highly significant downregulated. The same analysis on GEP-NETs at baseline and after therapy in 5 patients revealed an average of 4983 remarkably differentially expressed circRNAs between follow-up and baseline samples of which 2648 up-regulated and 2334 down-regulated, respectively. Applying p ≤ 0.05 and FDR ≤ 0.05 filters, only 3/5 comparisons gave statistically significant results. Conclusions: Our findings identified for the first time a circRNAs signature from TEPs as potential diagnostic and predictive biomarkers for GEP-NETs.
MeSH term(s)	Male ; Humans ; Female ; Neuroendocrine Tumors/genetics ; RNA, Circular/genetics ; Blood Platelets ; Prospective Studies ; RNA/genetics
Chemical Substances	RNA, Circular ; RNA (63231-63-0)
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04417-8
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Article: Circulating Natural Killer Cells as Prognostic Value for Non-Small-Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: Correlation with Sarcopenia.

Tenuta, Marta / Pandozzi, Carla / Sciarra, Francesca / Campolo, Federica / Gelibter, Alain J / Sirgiovanni, Grazia / Cortesi, Enrico / Lenzi, Andrea / Isidori, Andrea M / Sbardella, Emilia / Venneri, Mary Anna

Cancers

2023 Volume 15, Issue 14

Abstract: Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of tumors. Natural killer (NK) cells can play an important role in cancer immune surveillance. The aim of this prospective observational study was to analyze peripheral ... ...

Abstract	Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of tumors. Natural killer (NK) cells can play an important role in cancer immune surveillance. The aim of this prospective observational study was to analyze peripheral blood mononuclear cells (PBMCs) in patients with advanced non-small-cell lung cancer (NSCLC) receiving ICIs in order to identify predictive factors for better survival outcomes. Methods: Forty-seven stage IV NSCLC patients were enrolled. Patients underwent baseline (T Results: Basal levels of CD3 Conclusions: Peripheral NK cells could represent a non-invasive and useful tool to predict ICI therapy response in NSCLC patients, and the association of low NK cell levels with sarcopenia deserves even more attention in clinical evaluation.
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15143592
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Article: Extra-Gonadal and Non-Canonical Effects of FSH in Males.

Spaziani, Matteo / Carlomagno, Francesco / Tenuta, Marta / Sesti, Franz / Angelini, Francesco / Bonaventura, Ilaria / Ferrari, Davide / Tarantino, Chiara / Fiore, Marco / Petrella, Carla / Tarani, Luigi / Gianfrilli, Daniele / Pozza, Carlotta

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 6

Abstract: Recombinant follicle-stimulating hormone (FSH) is commonly used for the treatment of female infertility and is increasingly being used in males as well, as recommended by notable guidelines. FSH is composed of an α subunit, shared with other hormones, ... ...

Abstract	Recombinant follicle-stimulating hormone (FSH) is commonly used for the treatment of female infertility and is increasingly being used in males as well, as recommended by notable guidelines. FSH is composed of an α subunit, shared with other hormones, and a β subunit, which confers specificity of biological action by interacting with its surface receptor (FSHR), predominantly located in granulosa and Sertoli cells. However, FSHRs also exist in extra-gonadal tissues, indicating potential effects beyond male fertility. Emerging evidence suggests that FSH may have extra-gonadal effects, including on bone metabolism, where it appears to stimulate bone resorption by binding to specific receptors on osteoclasts. Additionally, higher FSH levels have been associated with worse metabolic and cardiovascular outcomes, suggesting a possible impact on the cardiovascular system. FSH has also been implicated in immune response modulation, as FSHRs are expressed on immune cells and may influence inflammatory response. Furthermore, there is growing interest in the role of FSH in prostate cancer progression. This paper aims to provide a comprehensive analysis of the literature on the extra-gonadal effects of FSH in men, with a focus on the often-conflicting results reported in this field. Despite the contradictory findings, the potential for future development in this area is substantial, and further research is needed to elucidate the mechanisms underlying these effects and their clinical implications.
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16060813
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Article ; Online: Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.

Sesti, Franz / Pofi, Riccardo / Minnetti, Marianna / Tenuta, Marta / Gianfrilli, Daniele / Isidori, Andrea M

Andrology

2020 Volume 8, Issue 6, Page(s) 1614–1627

Abstract: Background: Low testosterone (T) level is considered a marker of poor cardiovascular health. Ten years ago, the Testosterone in Older Men with Mobility Limitations (TOM) trial was discontinued due to a higher number of adverse events in men receiving T ... ...

Abstract	Background: Low testosterone (T) level is considered a marker of poor cardiovascular health. Ten years ago, the Testosterone in Older Men with Mobility Limitations (TOM) trial was discontinued due to a higher number of adverse events in men receiving T compared with placebo. Since then, several studies have investigated the risks of T replacement therapy (TRT) in late-onset hypogonadism (LOH). Objective: To review the mechanism by which TRT could damage the cardiovascular system. Materials and methods: Comprehensive literature search of recent clinical and experimental studies. Results: The mechanisms of T-mediated coronary vasodilation were reviewed with emphasis on calcium-activated and ATP-sensitive potassium ion channels. We showed how T regulates endothelial nitric oxide synthase (eNOS) and phosphoinositide 3-kinase/protein kinase B/eNOS signaling pathways in vessel walls and its direct effects on cardiomyocytes via β1-adrenergic and ryanodine receptors and provided data on myocardial infarction and heart failure. Vascular smooth muscle senescence could be explained by the modulation of growth factors, matrix metalloproteinase-2, and angiotensin II by T. Furthermore, leukocyte trafficking, facilitated by changes in TNF-α, could explain some of the effects of T on atheromatous plaques. Conflicting data on prothrombotic risk linked to platelet aggregation inhibition via NO-triggered arachidonate synthesis or increased aggregability due to enhanced thromboxane A in human platelets provide evidence regarding the hypotheses on plaque maturation and rupture risk. The effects of T on cardiac electrophysiology and oxygen delivery were also reviewed. Discussion: The effects of TRT on the cardiovascular system are complex. Although molecular studies suggest a potential benefit, several clinical observations reveal neutral or occasionally detrimental effects, mostly due to confounding factors. Conclusions: Attempts to demonstrate that TRT damages the cardiovascular system via systematic analysis of the putative mechanisms led to the contradiction of the initial hypothesis. Current evidence indicates that TRT is safe once other comorbidities are addressed.
MeSH term(s)	Animals ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/drug effects ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Comorbidity ; Eunuchism/blood ; Eunuchism/drug therapy ; Eunuchism/epidemiology ; Eunuchism/physiopathology ; Heart Disease Risk Factors ; Hormone Replacement Therapy/adverse effects ; Humans ; Risk Assessment ; Testosterone/adverse effects ; Testosterone/blood ; Testosterone/deficiency ; Testosterone/therapeutic use ; Treatment Outcome
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2020-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.12876
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Article ; Online: Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.

Pozza, Carlotta / Sesti, Franz / Tenuta, Marta / Spaziani, Matteo / Tarantino, Chiara / Carlomagno, Francesco / Minnetti, Marianna / Pofi, Riccardo / Paparella, Roberto / Lenzi, Andrea / Radicioni, Antonio / Isidori, Andrea M / Tarani, Luigi / Gianfrilli, Daniele

The Journal of clinical endocrinology and metabolism

2023 Volume 108, Issue 10, Page(s) 2486–2499

Abstract: Objective: Klinefelter syndrome is the most common chromosomal disorder in males and the most common cause of hypergonadotropic hypogonadism. We describe the natural history of testicular dysfunction in patients with Klinefelter syndrome through the ... ...

Abstract	Objective: Klinefelter syndrome is the most common chromosomal disorder in males and the most common cause of hypergonadotropic hypogonadism. We describe the natural history of testicular dysfunction in patients with Klinefelter syndrome through the integration of clinical, hormonal, and quantitative ultrasound data in a life-course perspective. Design: Prospective semilongitudinal study. Methods: We included 155 subjects with 47,XXY karyotype (age range: 7 months-55 years) naïve to testosterone replacement therapy. Subjects were divided according to pubertal stage and age group (transition age and adults). Serial clinical, hormonal, and testicular ultrasound (US) assessments were performed. Results: Testicular development progresses until Tanner stage 4, with subsequent regression, whereas Sertoli and germ cell impairment is not hormonally detected before Tanner stages 3-4, as reflected by normal inhibin B values until stage 4 and the fall in the inhibin B/follicle-stimulating hormone ratio thereafter. The testosterone/luteinizing hormone ratio peaks during Tanner stages 2-3 and declines from Tanner stage 4 onward, preceding the development of overt hypogonadism. US echotexture progressively worsens until transition age, reflecting ongoing gonadal compromise, whereas quantitative US echotexture measures and the presence of both hypoechoic lesions and microlithiasis independently and significantly predict a lower circulating testosterone level. Conclusions: The findings from this large prospective study contribute to our understanding of the natural history of testicular dysfunction in Klinefelter syndrome, underlining the importance of quantitative testicular US in infancy and childhood, as well as during pubertal development and transition age, for the optimal care of Klinefelter syndrome patients.
MeSH term(s)	Male ; Adult ; Humans ; Child ; Infant ; Klinefelter Syndrome/drug therapy ; Prospective Studies ; Testis/diagnostic imaging ; Testis/pathology ; Hypogonadism/drug therapy ; Testosterone/therapeutic use ; Follicle Stimulating Hormone ; Testicular Diseases/diagnostic imaging ; Testicular Diseases/pathology ; Inhibins ; Puberty
Chemical Substances	Testosterone (3XMK78S47O) ; Follicle Stimulating Hormone (9002-68-0) ; Inhibins (57285-09-3)
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad205
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Article ; Online: Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone.

Carlomagno, Francesco / Pozza, Carlotta / Tenuta, Marta / Pofi, Riccardo / Tarani, Luigi / Sesti, Franz / Minnetti, Marianna / Gianfrilli, Daniele / Isidori, Andrea M

The Journal of clinical endocrinology and metabolism

2021 Volume 107, Issue 1, Page(s) e236–e245

Abstract: Context: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies ... ...

Abstract	Context: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. Objective: To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function. Design and setting: Prospective study. University setting. Patients: Sixty-eight testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (control) who underwent CEUS for incidental nonpalpable testicular lesions. Main outcomes: CEUS kinetic parameters. Results: CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched controls. Specifically, the wash-in time (P = 0.018), mean transit time (P = 0.035), time to peak (P < 0.001), and wash-out time (P = 0.004) were all prolonged. Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings and supported a role for reduced venous blood flow as independent predictor of total T levels. Conclusions: Testicular venous blood flow is altered in KS and independently predicts T peripheral release.
MeSH term(s)	Adult ; Azoospermia/blood ; Azoospermia/pathology ; Case-Control Studies ; Follow-Up Studies ; Humans ; Hypogonadism/blood ; Hypogonadism/pathology ; Klinefelter Syndrome/physiopathology ; Male ; Prognosis ; Prospective Studies ; Spermatogenesis ; Testis/blood supply ; Testis/metabolism ; Testis/pathology ; Testosterone/blood
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab605
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Article: cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.

Campolo, Federica / Capponi, Chiara / Tarsitano, Maria Grazia / Tenuta, Marta / Pozza, Carlotta / Gianfrilli, Daniele / Magliocca, Fabio / Venneri, Mary A / Vicini, Elena / Lenzi, Andrea / Isidori, Andrea M / Barbagallo, Federica

Frontiers in endocrinology

2022 Volume 13, Page(s) 1010924

Abstract: Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (PDEs). PDE8 is ... ...

Abstract	Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (PDEs). PDE8 is responsible of cAMP hydrolysis and its expression has been characterized in all steroidogenic cell types in rodents including adrenal and Leydig cells in rodents however scarce data are currently available in humans. Here we demonstrate that human Leydig cells express both PDE8A and PDE8B isoforms. Interestingly, we found that the expression of PDE8B but not of PDE8A is increased in transformed Leydig cells (Leydig cell tumors-LCTs) compared to non-tumoral cells. Immunofluorescence analyses further reveals that PDE8A is also highly expressed in specific spermatogenic stages. While the protein is not detected in spermatogonia it accumulates nearby the forming acrosome, in the trans-Golgi apparatus of spermatocytes and spermatids and it follows the fate of this organelle in the later stages translocating to the caudal part of the cell. Taken together our findings suggest that 1) a specific pool(s) of cAMP is/are regulated by PDE8A during spermiogenesis pointing out a possible new role of this PDE8 isoform in key events governing the differentiation and maturation of human sperm and 2) PDE8B can be involved in Leydig cell transformation.
MeSH term(s)	Humans ; Male ; 3',5'-Cyclic-AMP Phosphodiesterases/genetics ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Adenosine Monophosphate ; Leydig Cell Tumor/genetics ; Protein Isoforms ; Semen
Chemical Substances	3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17) ; Adenosine Monophosphate (415SHH325A) ; Protein Isoforms ; PDE8A protein, human (EC 3.1.4.17) ; PDE8B protein, human (EC 3.1.4.17)
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1010924
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