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  1. Article ; Online: T3 N1 M0 rectal cancer: the optimal initial management is long-course chemoradiotherapy.

    Arthur, Claire / Teo, Mark

    The British journal of surgery

    2023  Volume 111, Issue 1

    MeSH term(s) Humans ; Rectal Neoplasms/pathology ; Chemoradiotherapy ; Neoplasm Staging ; Neoadjuvant Therapy
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad323
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  2. Article ; Online: Calcifying pseudoneoplasms of the neuraxis (CAPNON) in foramen magnum (cervicomedullary junction) region: a case report and review of the literature.

    Atallah, Omar / Kurian, Kathreena M / Teo, Mario

    British journal of neurosurgery

    2024  , Page(s) 1–6

    Abstract: Background and importance: Calcifying pseudoneoplasms of the neuraxis (CAPNON) is an extremely rare tumor, with nearly 150 cases have been reported in the literature. We present a case of CAPNON at foramen magnum (cervicomedullary junction). We also ... ...

    Abstract Background and importance: Calcifying pseudoneoplasms of the neuraxis (CAPNON) is an extremely rare tumor, with nearly 150 cases have been reported in the literature. We present a case of CAPNON at foramen magnum (cervicomedullary junction). We also discuss the histological and radiological features of this rare pathology.
    Clinical presentation: A 35-year-old male patient presented to our center complaining of neck pain for the last 6 months and for the last 3 months has had headaches associated with nausea, blurred vision and papilledema. The patient's magnetic resonance imaging showed the presence of right craniocervical junction intra-dural extramedullary tumor. Neuro examination showed no neurological deficits. He underwent midline suboccipital craniotomy with C1 laminectomy. The mass was completely resected, and histopathology confirmed it to be a CAPNON.
    Conclusion: We presented a new case of CAPNON at cervicomedullary junction. The tumor was radically resected, without any complications. Resection of this kind of tumor is curative, and the need for post-operative chemo or radiotherapy is unnecessary, which depends on the outcome of future research and the long-term follow ups.
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2024.2339354
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    Zs.A 2210: Show issues Location:
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  3. Article ; Online: In Reply: Validation and Application for the Berlin Grading System of Moyamoya Disease in Adult Patients.

    Teo, Mario / Steinberg, Gary K

    Neurosurgery

    2020  Volume 87, Issue 2, Page(s) E265

    MeSH term(s) Adult ; Angiography, Digital Subtraction ; Cerebral Angiography ; Humans ; Moyamoya Disease
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa137
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  4. Article ; Online: Letter to the Editor Regarding "Factors Influencing Medical Student Interest in a Career in Neurosurgery".

    Lee, Keng Siang / Teo, Mario

    World neurosurgery

    2020  Volume 139, Page(s) 655

    MeSH term(s) Career Choice ; Education, Medical, Undergraduate ; Humans ; Neurosurgery/education ; Neurosurgical Procedures ; Students, Medical
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.03.074
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    Zs.A 1159: Show issues Location:
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  5. Article ; Online: Perianeurysmal parenchymal cysts - Case series and literature review.

    Zammit, Adrian / Tudose, Andrei / Khan, Nickalus / Renowden, Shelley / Teo, Mario

    Brain & spine

    2022  Volume 2, Page(s) 100920

    Abstract: Intracranial cysts are associated with a number of vascular lesions.•They predominantly occur in larger, partially-thrombosed aneurysms and in older patients.•There is a trend towards enlargement over time if untreated and a likelihood of recurrence ... ...

    Abstract •Intracranial cysts are associated with a number of vascular lesions.•They predominantly occur in larger, partially-thrombosed aneurysms and in older patients.•There is a trend towards enlargement over time if untreated and a likelihood of recurrence following treatment.•We hypothesise the cysts arise either from dilated Virchow-Robin spaces and/or inflammatory processes.
    Language English
    Publishing date 2022-07-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2022.100920
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  6. Article ; Online: Cerebellar Mutism Syndrome: An Overview of the Pathophysiology in Relation to the Cerebrocerebellar Anatomy, Risk Factors, Potential Treatments, and Outcomes.

    Ashida, Reiko / Nazar, Naadir / Edwards, Richard / Teo, Mario

    World neurosurgery

    2021  Volume 153, Page(s) 63–74

    Abstract: Cerebellar mutism syndrome (CMS) is one the most disabling postoperative neurological complications after posterior fossa surgery in children. CMS is characterized by a transient mutism with a typical onset demonstrated within 2 days postoperatively ... ...

    Abstract Cerebellar mutism syndrome (CMS) is one the most disabling postoperative neurological complications after posterior fossa surgery in children. CMS is characterized by a transient mutism with a typical onset demonstrated within 2 days postoperatively accompanied by associated ataxia, hypotonia, and irritability. Several hypotheses for the anatomical basis of pathophysiology and risk factors have been suggested. However, a definitive theory and treatment protocols have not yet been determined. Animal histological and electrophysiological studies and more recent human imaging studies have demonstrated the existence of a compartmentalized representation of cerebellar function, the understanding of which might provide more information on the pathophysiology. Damage to the dentatothalamocortical pathway and cerebrocerebellar diaschisis have been described as the anatomical substrate to the CMS. The risk factors, which include tumor type, brainstem invasion, tumor localization, tumor size, and vermal splitting technique, have not yet been clearly elucidated. The efficacy of potential pharmacological and speech therapies has been studied in small trials. Long-term motor speech deficits and associated cognitive and behavioral disturbances have now been found to be common among CMS survivors, affecting their development and requiring rehabilitation, leading to significant financial effects on the healthcare system and distress to the family. The aim of the present review was to outline the cerebellar anatomy and function and its connections in relationship to the pathophysiology and to refine the risk factors and treatment strategies for CMS.
    MeSH term(s) Cerebellar Diseases/epidemiology ; Cerebellar Diseases/etiology ; Cerebellar Diseases/physiopathology ; Child ; Female ; Humans ; Infratentorial Neoplasms/surgery ; Male ; Mutism/epidemiology ; Mutism/etiology ; Mutism/physiopathology ; Neurosurgical Procedures/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.06.065
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  7. Article ; Online: Trial of dexamethasone for chronic subdural hematoma.

    David, R J / Tan, E / Teo, M K

    British journal of neurosurgery

    2021  Volume 37, Issue 2, Page(s) 241

    MeSH term(s) Humans ; Hematoma, Subdural, Chronic/drug therapy ; Hematoma, Subdural, Chronic/surgery ; Dexamethasone/therapeutic use ; Treatment Outcome
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-02-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2021.1886245
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  8. Article ; Online: Unusual presentation of primary cutaneous melanoma of the forearm with epitrochlear and axillary lymphadenopathy.

    Pow, Siok Yen / Teo, Melissa

    BMJ case reports

    2018  Volume 2018

    Abstract: In patients with primary cutaneous melanomas of the distal upper limb, metastatic involvement of the epitrochlear lymph nodes is uncommon. It belongs to a particular category of nodal metastasis termed as interval or in-transit lymphadenopathies often ... ...

    Abstract In patients with primary cutaneous melanomas of the distal upper limb, metastatic involvement of the epitrochlear lymph nodes is uncommon. It belongs to a particular category of nodal metastasis termed as interval or in-transit lymphadenopathies often encountered by tumour cells as they spread from the primary sites. We describe the case of a 41-year-old woman who presented with a right forearm melanoma that was metastatic to both the epitrochlear and axillary lymph nodes. She underwent wide excision of the primary lesion as well as epitrochlear and axillary nodal clearances in the same sitting. Although uncommon, It is prudent to search for the presence of sentinel lymph nodes in the epitrochlear region although uncommon, and where positive, a completion axillary clearance should be undertaken at the same time as the epitrochlear clearance. Failure to detect the presence of interval lymph nodes along the melanoma spread pathways may be a cause of tumour recurrence.
    MeSH term(s) Adult ; Axilla ; Biopsy, Fine-Needle ; Elbow ; Female ; Forearm ; Humans ; Lymph Nodes/pathology ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/pathology ; Lymphadenopathy/surgery ; Lymphatic Metastasis ; Melanoma/diagnostic imaging ; Melanoma/pathology ; Melanoma/surgery ; Pectoralis Muscles ; Positron-Emission Tomography ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Thorax
    Language English
    Publishing date 2018-06-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-222518
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  9. Article ; Online: Optimised prophylactic vaccination in metapopulations.

    Teo, Mingmei / Bean, Nigel / Ross, Joshua V

    Epidemics

    2020  Volume 34, Page(s) 100420

    Abstract: A highly effective method for controlling the spread of an infectious disease is vaccination. However, there are many situations where vaccines are in limited supply. The ability to determine, under this constraint, a vaccination strategy which minimises ...

    Abstract A highly effective method for controlling the spread of an infectious disease is vaccination. However, there are many situations where vaccines are in limited supply. The ability to determine, under this constraint, a vaccination strategy which minimises the number of people that become infected over the course of a potential epidemic is essential. Two questions naturally arise: when is it best to allocate vaccines, and to whom should they be allocated? We address these questions in the context of metapopulation models of disease spread. We discover that in practice it is generally optimal to distribute all vaccines prophylactically, rather than withholding until infection is introduced. For small metapopulations, we provide a method for determining the optimal prophylactic allocation. As the optimal strategy becomes computationally intensive to obtain when the population size increases, we detail an approximation method to determine an approximately optimal vaccination scheme. We find that our approximate strategy is consistently at least as good as three strategies reported in the literature across a wide range of parameter values.
    MeSH term(s) Epidemics/prevention & control ; Humans ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2020-11-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2020.100420
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  10. Article ; Online: Performance, clinical utility, and cost-effectiveness of selective use of staging investigations in early breast cancers.

    James, Justin / Teo, Melanie / Ramachandran, Vivekananda / Law, Michael / Cheng, Michael

    ANZ journal of surgery

    2021  Volume 92, Issue 3, Page(s) 426–430

    Abstract: Background: International guidelines do not recommend routine staging of EBCs. However, most clinicians still perform staging investigations (SI) selectively for several reasons. We examined our practice of selective use of SI to determine its ... ...

    Abstract Background: International guidelines do not recommend routine staging of EBCs. However, most clinicians still perform staging investigations (SI) selectively for several reasons. We examined our practice of selective use of SI to determine its performance, clinical utility, and cost-effectiveness.
    Methods: We performed this retrospective study on patients who had treatment for AJCC stage I or stage II breast cancer through Eastern health Breast and cancer centre, Melbourne, for 50 months from January 2012.
    Result: Our practice of selective use resulted in SI in 41% of all EBCs (95% CI 37-46%). Overall yield was 3% (95% CI 0.4-5.4%) with a false positive rate of 22% (95% CI 1628%) and a false-negative rate of 45% (95% CI 11-79%). The sensitivity of SI is 55% (95% CI 21-89%) with a negative predictive value of 97% (95% CI 94.8-99.9%). None of the treatment components was found to be significantly changed based on findings on SI. There was no significant difference in all-cause mortality or new distant recurrence in the staged and non-staged groups. Identification of six new metastases cost at least 422 021 AUD. The approximate cost to stage one EBC is 2069 AUD. 'Number needed to scan' to detect one new metastasis is 34 at the expense of 70337AUD.
    Conclusion: Selective use of SI results in better yield. However, the clinical utility of these results is not significant. It is debatable if this level of expenditure is cost-effective. Our results point to a need for change in practice.
    MeSH term(s) Breast Neoplasms/pathology ; Cost-Benefit Analysis ; Female ; Humans ; Neoplasm Staging ; Retrospective Studies
    Language English
    Publishing date 2021-11-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17324
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