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  1. Article ; Online: Global health inequities: more challenges, some solutions.

    Tangcharoensathien, Viroj / Lekagul, Angkana / Teo, Yik-Ying

    Bulletin of the World Health Organization

    2024  Volume 102, Issue 2, Page(s) 86–86A

    MeSH term(s) Humans ; Socioeconomic Factors ; Health Inequities ; Global Health ; Health Status Disparities
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.24.291326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Journal ; Article ; Online: Global health inequities

    Tangcharoensathien, Viroj / Lekagul, Angkana / Teo, Yik-Ying

    more challenges, some solutions

    2024  

    Abstract: ... 86 ... ...

    Abstract 86

    86A
    Keywords Editorials
    Language English
    Publisher World Health Organization
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Singapore Statement on Global Health Security.

    Kamradt-Scott, Adam / Teo, Yik Ying / Katz, Rebecca

    BMJ global health

    2022  Volume 7, Issue 6

    MeSH term(s) Developing Countries ; Global Health ; Humans ; Public Policy ; Singapore
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Editorial
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2022-009949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genomic prediction of tuberculosis drug-resistance: benchmarking existing databases and prediction algorithms.

    Ngo, Tra-My / Teo, Yik-Ying

    BMC bioinformatics

    2019  Volume 20, Issue 1, Page(s) 68

    Abstract: Background: It is possible to predict whether a tuberculosis (TB) patient will fail to respond to specific antibiotics by sequencing the genome of the infecting Mycobacterium tuberculosis (Mtb) and observing whether the pathogen carries specific ... ...

    Abstract Background: It is possible to predict whether a tuberculosis (TB) patient will fail to respond to specific antibiotics by sequencing the genome of the infecting Mycobacterium tuberculosis (Mtb) and observing whether the pathogen carries specific mutations at drug-resistance sites. This advancement has led to the collation of TB databases such as PATRIC and ReSeqTB that possess both whole genome sequences and drug resistance phenotypes of infecting Mtb isolates. Bioinformatics tools have also been developed to predict drug resistance from whole genome sequencing (WGS) data. Here, we evaluate the performance of four popular tools (TBProfiler, MyKrobe, KvarQ, PhyResSE) with 6746 isolates compiled from publicly available databases, and subsequently identify highly probable phenotyping errors in the databases by genetically predicting the drug phenotypes using all four software.
    Results: Our results show that these bioinformatics tools generally perform well in predicting the resistance status for two key first-line agents (isoniazid, rifampicin), but the accuracy is lower for second-line injectables and fluoroquinolones. The error rates in the databases are also non-trivial, reaching as high as 31.1% for prothionamide, and that phenotypes from ReSeqTB are more susceptible to errors.
    Conclusions: The good performance of the automated software for drug resistance prediction from TB WGS data shown in this study further substantiates the usefulness and promise of utilising genetic data to accurately profile TB drug resistance, thereby reducing misdiagnoses arising from error-prone culture-based drug susceptibility testing.
    MeSH term(s) Algorithms ; Antitubercular Agents/pharmacology ; Benchmarking ; Calibration ; Databases, Genetic ; Drug Resistance, Bacterial/genetics ; Genomics/methods ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Sensitivity and Specificity ; Software ; Tuberculosis/genetics ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2019-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-019-2658-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: "Asian" Phenotype Underestimates the Genetic Diversity of Asia yet Overstates its Impact on Variability in Drug Disposition and Pharmacodynamics.

    Singh, Rominder / Teo, Yik Ying

    Clinical pharmacology and therapeutics

    2019  Volume 105, Issue 4, Page(s) 802–805

    MeSH term(s) Asia ; Asian Continental Ancestry Group/legislation & jurisprudence ; Drug Development/legislation & jurisprudence ; Drug Industry/legislation & jurisprudence ; Genetic Variation/genetics ; Humans ; Phenotype
    Language English
    Publishing date 2019-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessing national performance in response to COVID-19.

    Fisher, Dale / Teo, Yik Ying / Nabarro, David

    Lancet (London, England)

    2020  Volume 396, Issue 10252, Page(s) 653–655

    MeSH term(s) Benchmarking ; Betacoronavirus ; COVID-19 ; Civil Defense/organization & administration ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Communication ; Coronavirus Infections/economics ; Coronavirus Infections/prevention & control ; Guideline Adherence ; Humans ; Leadership ; Pandemics/economics ; Pandemics/prevention & control ; Pneumonia, Viral/economics ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Vulnerable Populations
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31601-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diagnostics for COVID-19: moving from pandemic response to control.

    Peeling, Rosanna W / Heymann, David L / Teo, Yik-Ying / Garcia, Patricia J

    Lancet (London, England)

    2021  Volume 399, Issue 10326, Page(s) 757–768

    Abstract: Diagnostics have proven to be crucial to the COVID-19 pandemic response. There are three major methods for the detection of SARS-CoV-2 infection and their role has evolved during the course of the pandemic. Molecular tests such as PCR are highly ... ...

    Abstract Diagnostics have proven to be crucial to the COVID-19 pandemic response. There are three major methods for the detection of SARS-CoV-2 infection and their role has evolved during the course of the pandemic. Molecular tests such as PCR are highly sensitive and specific at detecting viral RNA, and are recommended by WHO for confirming diagnosis in individuals who are symptomatic and for activating public health measures. Antigen rapid detection tests detect viral proteins and, although they are less sensitive than molecular tests, have the advantages of being easier to do, giving a faster time to result, of being lower cost, and able to detect infection in those who are most likely to be at risk of transmitting the virus to others. Antigen rapid detection tests can be used as a public health tool for screening individuals at enhanced risk of infection, to protect people who are clinically vulnerable, to ensure safe travel and the resumption of schooling and social activities, and to enable economic recovery. With vaccine roll-out, antibody tests (which detect the host's response to infection or vaccination) can be useful surveillance tools to inform public policy, but should not be used to provide proof of immunity, as the correlates of protection remain unclear. All three types of COVID-19 test continue to have a crucial role in the transition from pandemic response to pandemic control.
    MeSH term(s) Antibodies, Viral/blood ; Antigens, Viral/isolation & purification ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; COVID-19 Testing/methods ; COVID-19 Testing/trends ; COVID-19 Vaccines/administration & dosage ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Communicable Disease Control/trends ; Humans ; Mass Screening/organization & administration ; Mass Screening/trends ; Pandemics/prevention & control ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification
    Chemical Substances Antibodies, Viral ; Antigens, Viral ; COVID-19 Vaccines ; RNA, Viral
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02346-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Assessing the impact of novelty and conformity on hesitancy towards COVID-19 vaccines using mRNA technology.

    Leong, Ching / Jin, Lawrence / Kim, Dayoung / Kim, Jeongbin / Teo, Yik Ying / Ho, Teck-Hua

    Communications medicine

    2022  Volume 2, Page(s) 61

    Abstract: Background: Public hesitancy towards Covid-19 vaccines remains a major hurdle for mass vaccination programs today. While mRNA vaccines are more efficacious than conventional vaccines, it is unknown how much the novelty of this technology increases ... ...

    Abstract Background: Public hesitancy towards Covid-19 vaccines remains a major hurdle for mass vaccination programs today. While mRNA vaccines are more efficacious than conventional vaccines, it is unknown how much the novelty of this technology increases hesitancy.
    Methods: We quantify this "novelty penalty" in a large online experiment with 35,173 adults in nine countries. Subjects were randomly selected and assigned to one of two vaccine groups (conventional or mRNA), and one of five hypothetical inoculation rate groups (0%, 20%, 40%, 60%, or 80%). Subjects reported their willingness to accept the Covid-19 vaccine on a five-point Likert scale.
    Results: The novelty of the mRNA vaccine technology reduces the odds of a higher level of vaccine acceptance by 14.2% (odds ratio 0.858;
    Conclusions: The novelty of the mRNA vaccine increases hesitancy, but social conformity reduces it. A small group of early adopters can provide momentum for vaccination.
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-022-00123-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cautionary tales from the UK for the health reform in Singapore.

    Valderas, Jose M / Stavdal, Anna / Hanson, Kara / Teo, Yik Ying / Chong, Yap Seng / Wong, John E L / Legido-Quigley, Helena

    Lancet (London, England)

    2023  Volume 401, Issue 10376, Page(s) 556

    MeSH term(s) Humans ; Singapore ; Health Care Reform ; United Kingdom
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00099-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genotype calling for the Illumina platform.

    Teo, Yik Ying

    Methods in molecular biology (Clifton, N.J.)

    2012  Volume 850, Page(s) 525–538

    Abstract: Genome-wide association studies have been made possible because of advancements in the design of genotyping technologies to assay a million or more single nucleotide polymorphisms (SNPs) simultaneously. This has resulted in the introduction of automated ... ...

    Abstract Genome-wide association studies have been made possible because of advancements in the design of genotyping technologies to assay a million or more single nucleotide polymorphisms (SNPs) simultaneously. This has resulted in the introduction of automated and unsupervised statistical approaches for translating the probe hybridization intensities into the actual genotype calls. This chapter aims to provide an introduction to this process of genotype calling, highlighting in particular the design and approach used for the Illumina BeadArray platforms that are commonly used in large-scale genetic studies. The chapter also provides detailed instructions for preparing the input files required as well as the actual Linux commands and options to execute the ILLUMINUS software. Finally, it concludes with a brief exposition on the different outcomes from genotype calling and the use of perturbation analysis for identifying SNPs with erroneous genotype calls.
    MeSH term(s) Chromosomes, Human, X ; Female ; Genome, Human ; Genome-Wide Association Study ; Humans ; Male ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-555-8_29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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