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Article: The Pitfalls of Febrile Jaundice. A Case Report.

Obreja, Maria / Teodor, Andra / Leca, Daniela / Ceasovschih, Alexandr / Miftode, Egidia

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)

2016 Volume 2, Issue 2, Page(s) 93–95

Abstract: Jaundice in sepsis is usually caused by cholestasis, and its onset can precede other manifestations of the infection. Inflammation-induced cholestasis is a common complication in patients with an extrahepatic infection or those with inflammatory ... ...

Abstract	Jaundice in sepsis is usually caused by cholestasis, and its onset can precede other manifestations of the infection. Inflammation-induced cholestasis is a common complication in patients with an extrahepatic infection or those with inflammatory processes. We describe the case of a 47 years old female who presented with low back pain and paravertebral muscular contracture. She subsequently developed a cholestatic syndrome with clinical manifestations such as jaundice, followed by fever and sepsis with multiple organ dysfunction. Initially labeled as biliary sepsis, the diagnosis was crucially reoriented as the blood cultures were positive for Streptococcus pyogenes and the magnetic resonance imaging (MRI) findings suggested spondylodiscitis as well as a paravertebral abscess.
Language	English
Publishing date	2016-05-09
Publishing country	Poland
Document type	Journal Article
ISSN	2393-1809
ISSN	2393-1809
DOI	10.1515/jccm-2016-0013
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Article: CHARACTERISTICS OF HEPATITIS B VIRUS COINFECTION AMONG HIV-INFECTED PREGNANT WOMEN.

Juganariu, Gabriela / Teodor, Andra / Petrovici, Cristina / Cristina, Nicolau / Miftode, Egidia

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2015 Volume 119, Issue 4, Page(s) 1010–1017

Abstract: Unlabelled: The similar routes of transmission for HIV and HBV place patients with either infection at greater risk for HIV/HBV co-infection.: Aim: To determine the particularities of hepatitis B virus (HBV) coinfection in pregnant women infected ... ...

Abstract	Unlabelled: The similar routes of transmission for HIV and HBV place patients with either infection at greater risk for HIV/HBV co-infection. Aim: To determine the particularities of hepatitis B virus (HBV) coinfection in pregnant women infected with human immunodeficiency virus (HIV) and its influence on pregnancy. Methods: Retrospective study of 74 HIV-infected women monitored during pregnancy in the Iasi Regional HIV/AIDS Center (Romania) from 2010 to 2013. The subjects were divided into 2 groups according to the presence or absence of HBV coinfection. Results: Most subjects belonged to age group 20-24 years (90% in the HIV group versus 75.5% in the HIV/HBV-coinfected group). HIV infection was most commonly transmitted by parenteral route (65.5% vs. 48.9%). The majority of patients were married (60% vs. 65%) and primiparous at the time of enrollment (71.1% vs. 96.6%). In the HIV/HBV-coinfected group CD4 level was lower and mean plasma viral load higher (1.92 log10 copies/mL vs. 2.31 log10 copies/ml). The proportion of cases with severe immunosuppression was similar in both groups (18.1% vs. 17.9%). HBV-HIV coinfection induced a risk of prematurity of 1.51 times, but did not increase the risk of newborns with low birth weight. Conclusions: Advanced stages of HIV disease, age group 21-30 years, low CD4 counts, and low levels of education are significant risk factors for preterm birth and low birth weight.
MeSH term(s)	Adolescent ; Adult ; Coinfection ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Hepatitis B/complications ; Hepatitis B/epidemiology ; Hepatitis B virus/pathogenicity ; Humans ; Immunocompromised Host ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/virology ; Prevalence ; Prospective Studies ; Risk Factors ; Romania/epidemiology
Language	English
Publishing date	2015-10
Publishing country	Romania
Document type	Comparative Study ; Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Characteristics of co infection with hepatitis B virus among Romanian patients infected with human immunodeficiency virus.

Juganariu, Gabriela / Mihalache, Doina / Miftode, Egidia / Teodor, Andra / Teodor, D / Manciuc, Carmen / Dorobat, Carmen

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2014 Volume 118, Issue 2, Page(s) 339–345

Abstract: Aim: To determine the epidemiological and viroimmunological features and outcome of HIV/HBV-co infected patients cared in the lasi HIV/AIDS Regional Center.: Material and methods: This retrospective study included 252 patients diagnosed with HIV ... ...

Abstract	Aim: To determine the epidemiological and viroimmunological features and outcome of HIV/HBV-co infected patients cared in the lasi HIV/AIDS Regional Center. Material and methods: This retrospective study included 252 patients diagnosed with HIV infection and associated hepatitis B virus (HBV) infection assessed at the Hospital of Infectious Diseases in the interval 2000-2013 and treated with antiretroviral drugs active against both HIV and HBV. Results: The prevalence of HIV/HBV co infection was 19.9%. A slightly higher frequency of this co infection was found among males (53.2%); most patients belonged to age group 20-29 years (86.5%), mean age was 25.56 years. The predominant route of transmission was parenteral (58.5%), followed by heterosexual transmission (40.1%). The mean CD4 cell count was 246.20 cells/mm3, in over 41% of cases CD4 count ranging from 200 to 499 cells/mm3. The mean HIV plasma viral load was 142,906 copies/ml. ALT levels varied between 10-323 IU/l, average 49.90 IU/l, over 65% of subjects having pathological levels. In 21.8% of the cases, total cholesterol was very high, and in 16.8% of the patients the serum triglyceride levels were below the reference range (160 mg %). Conclusions: Our results suggest that HIV-positive patients, chronic hepatitis B infection has a high incidence, especially in younger age groups and is correlated with significant degrees of immunosuppression.
MeSH term(s)	Adolescent ; Adult ; Anti-Retroviral Agents/therapeutic use ; Child ; Coinfection ; Female ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hepatitis B/complications ; Hepatitis B/diagnosis ; Hepatitis B/drug therapy ; Hepatitis B/epidemiology ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/epidemiology ; Humans ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Factors ; Romania/epidemiology ; Sex Distribution
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2014-04
Publishing country	Romania
Document type	Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article ; Online: Tuberculous Meningitis in Children and Adults: A 10-Year Retrospective Comparative Analysis.

Miftode, Egidia G / Dorneanu, Olivia S / Leca, Daniela A / Juganariu, Gabriela / Teodor, Andra / Hurmuzache, Mihnea / Nastase, Eduard V / Anton-Paduraru, Dana T

PloS one

2015 Volume 10, Issue 7, Page(s) e0133477

Abstract: Background: Tuberculous meningitis (TBM) is the most lethal form of Mycobacterium tuberculosis infection, which has a high rate of neurological complications and sequelae.: Objectives: Our study offers a real-world infectious disease clinic ... ...

Abstract	Background: Tuberculous meningitis (TBM) is the most lethal form of Mycobacterium tuberculosis infection, which has a high rate of neurological complications and sequelae. Objectives: Our study offers a real-world infectious disease clinic perspective, being thus representative for the clinical environment of developing countries. Methods: We performed a retrospective analysis of the 127 adult and 77 pediatric cases diagnosed with TBM in the Infectious Disease Hospital of the School of Medicine of Iasi, Romania between 2004-2013. Results: Definite diagnosis of TBM was established in 31% of children but in only 20% of adults (p = 0.043). A contact with an individual with pulmonary tuberculosis was documented in 30% of children vs. 13% of adults (p = 0.0007). Coma occurred in 19% of patients (similar in children and adults); other consciousness abnormalities were seen in 27% of children and in 72% of adults (p = 0.000001). Cranial nerve palsies occurred prior to therapy in 9% of cases (12% vs 7% of children and adults, respectively, p>0.05), and developed 2-7 days after treatment initiation in 10% (12 vs 9%). CSF cultures were positive for M. tuberculosis in 24% of patients (31% vs. 20%, p>0.05). Overall mortality was 7.35%, similar for children and adults. Yet, permanent neurological sequelae, which were seen in 23% of patients occurred significantly more frequent in children vs. adults (36% vs. 14%, respectively, p = 0.0121). In conclusion, our retrospective analysis on a significant number of cases of TBM identified striking differences between children and adults: while children were in an earlier stage at the admission, they associated a higher frequency of neurological sequelae and miliary pattern, and they were more likely to have normal CSF protein levels and positive cultures of CSF.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Hospitalization ; Humans ; Infant ; Middle Aged ; Radiography ; Retrospective Studies ; Romania/epidemiology ; Time Factors ; Treatment Outcome ; Tuberculosis, Meningeal/cerebrospinal fluid ; Tuberculosis, Meningeal/diagnosis ; Tuberculosis, Meningeal/diagnostic imaging ; Tuberculosis, Meningeal/epidemiology ; Young Adult
Language	English
Publishing date	2015
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0133477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Aspecte etiologice ale bolii diareice acute--consideraţii pe cazurile internate în Clinica de Boli Infectioase Iaşi în perioada 1.01. 2001-31.12.2010.

Luca, Cătălina Mihaela / Nemescu, Roxana / Teodor, Andra / Fântânaru, Rodica / Petrovici, Cristina Mirela / Dorobăţ, Carmen

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2011 Volume 115, Issue 3, Page(s) 712–717

Abstract: Unlabelled: Acute gastroentritis is one of the most common diseases in humans, and continues to be a significant cause of morbidity worldwide.: Aims: To determine the bacterial pathogens associated with gastroenteritis in patients admitted to the ... ...

Title translation	Etiological aspects of acute gastroenteritis--a ten-year review (1.01. 2001-31.12.2010).
Abstract	Unlabelled: Acute gastroentritis is one of the most common diseases in humans, and continues to be a significant cause of morbidity worldwide. Aims: To determine the bacterial pathogens associated with gastroenteritis in patients admitted to the Iasi Infectious Diseases Hospital in the last ten years. Material and methods: A total of 40481 stool samples were examined using conventional methods. Results: Bacteria were found in 7.36% of cases, and parasites in 9.64%; 83% of the cases were viral, micotic, or disbiotic. The bacterial etiology was dominated by Salmonella spp. (58.34%), Shigella spp. (27.08%), Yersinia enterocolitica 03 (8.53%), Campylobacter spp. (1.31%), other bacterial pathogens (EPEC, Aeromonas hydrophilla/caviae/sobria, Plesiomonas shigelloides, Bacillus cereus, Staphylococcus aureus, etc) being detected in 3.74% of the cases. Of the Salmonella species, group B (51.99%) followed by group D (45.23%) were most common. Shigella sonnei and Shigella flexneri were found in almost the same proportion (49.45% and 49.70%, respectively); Shigella boydii was isolated in only 0.85% of cases. The trend of gastroenteritis caused by bacterial pathogens is decreasing: from 355 cases in 2001 to 105 cases in 2010; three peaks have been recorded in 2002, 2005 (when Salmonella typhi was isolated in a patient), and 2008 (469, 409, and 252 cases, respectively). Bacterial gastroenteritis affected both sexes almost equally (122 males and 118 females). The most affected age groups were: 0 - 4 years, 15 - 24 years, 5 - 14 years and 25 - 39 years. Conclusions: Laboratory investigations are essential in determining the etiology of gastroenteritis. Its unpredictable incidence justifies the human and material efforts aimed at controlling the spread of potentially epidemic acute gastroenteritis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Infections/microbiology ; Child ; Child, Preschool ; Feces/microbiology ; Feces/parasitology ; Feces/virology ; Female ; Gastroenteritis/etiology ; Gastroenteritis/microbiology ; Gastroenteritis/parasitology ; Gastroenteritis/virology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Retrospective Studies ; Romania/epidemiology
Language	Romanian
Publishing date	2011-07
Publishing country	Romania
Document type	English Abstract ; Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Aspecte ale profilului de rezistenţă antimicrobiană în infecţii cu Escherichia coli şi Klebsiella pneumoniae la pacienţii diabetici.

Petrovici, Cristina G / Dorobăţ, Carmen / Matei, Mioara / Teodor, Andra / Luca, V / Miftode, Egidia

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2011 Volume 115, Issue 3, Page(s) 769–775

Abstract: Unlabelled: Infections in diabetic patient remains an important cause of morbidity and mortality, triggering and maintaining a prolonged metabolic imbalance. Emergence of extented spectrum beta-lactmase (ESBL) in Escherichia coli and Klebsiella ... ...

Title translation	Aspects of the antimicrobial resistence profile in infections with Escherichia coli and Klebsiella pneumoniae in diabetic patients.
Abstract	Unlabelled: Infections in diabetic patient remains an important cause of morbidity and mortality, triggering and maintaining a prolonged metabolic imbalance. Emergence of extented spectrum beta-lactmase (ESBL) in Escherichia coli and Klebsiella pneumoniae is a major concern, because of the atypical manner infection acts in this group of imunodepressed patients and also for the limited therapeutic solutions. For this reason we have evaluated the profile of antimicrobial resistance of these pathogens in both diabetic and non diabetic patients. Material and method: The aim of this study was to evaluate, in a retrospective case control study, the antibiotic susceptibility pattern in isolates of E. coli and Klebsiella spp. from different biological products in 49 diabetics and 150 non-diabetics admitted in The Clinical Hospital of Infectious Diseases Iaşi over a period of two years. Results: Most of strains of E. coli and Klebsiella spp. ESBL positive were found in uroculture. Significant differences in E. coli resistance rate between diabetics and nondiabetics were noted for amoxicillin-clavulanic acid and ciprofloxacin (31,4% vs.13,98%, p=0,04, respectively 52,9% vs. 24,46%, p=0,004). More isolates of ESBL positive K. pneumoniae were found in diabetic patients (50% vs. 24%). Ciprofloxacin resistance of K. pneumoniae was significantly higher in diabetics (75% vs 39%; p=0,05). There was no resistance in E. coli and K. pneumoniae isolates to imipenem in the diabetic group. Conclusions: The high resistance rate to quinolones and 3rd generation cefalosporins limits their use for the treatment of Escherichia coli and K. pneumoniae infections. Other alternatives for empiric therapy in community and nosocomial-acquired infections in diabetic patient remains carbapenems, aminoglycosides and colimycin.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aminoglycosides/therapeutic use ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Carbapenems/therapeutic use ; Case-Control Studies ; Cephalosporins/therapeutic use ; Child ; Child, Preschool ; Ciprofloxacin/therapeutic use ; Clavulanic Acid/therapeutic use ; Colistin/therapeutic use ; Diabetes Complications/drug therapy ; Drug Resistance, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Escherichia coli Infections/complications ; Escherichia coli Infections/drug therapy ; Female ; Humans ; Imipenem/therapeutic use ; Infant ; Klebsiella Infections/complications ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Quinolones/therapeutic use ; Treatment Outcome
Chemical Substances	Aminoglycosides ; Anti-Bacterial Agents ; Anti-Infective Agents ; Carbapenems ; Cephalosporins ; Quinolones ; Clavulanic Acid (23521W1S24) ; Ciprofloxacin (5E8K9I0O4U) ; Imipenem (71OTZ9ZE0A) ; Amoxicillin (804826J2HU) ; Colistin (Z67X93HJG1)
Language	Romanian
Publishing date	2011-07
Publishing country	Romania
Document type	English Abstract ; Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Efecte secundare ale terapiei antiretrovirale.

Teodor, Andra / Teodor, D / Luca, V

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2004 Volume 108, Issue 1, Page(s) 23–26

Abstract: Highly active antiretroviral therapy (HAART) has changed the natural history of HIV infection, but the presence of adverse events may limit its efficacy. Nucleoside reverse transcriptase inhibitors can cause mitochondrial toxicity and anemia, non- ... ...

Title translation	Side effects of antiretroviral therapy.
Abstract	Highly active antiretroviral therapy (HAART) has changed the natural history of HIV infection, but the presence of adverse events may limit its efficacy. Nucleoside reverse transcriptase inhibitors can cause mitochondrial toxicity and anemia, non-nucleoside reverse transcriptase inhibitors are associated with rash and central nervous system disturbance; protease inhibitors elicit gastrointestinal adverse effects and metabolic abnormalities including lipodystrophy syndrome, hyperlipidemia and insulin resistance. These complications have the potential to increase morbidity and mortality significantly in those requiring long-term treatment of HIV-infection. The presence of such abnormalities also has an impact on adherence to treatment. Besides providing health benefits, HAART may have a negative impact on patients' quality of life. Identifying and treating these complications has important implications for patient survival.
MeSH term(s)	Anemia/chemically induced ; Antiretroviral Therapy, Highly Active/adverse effects ; Diabetes Mellitus/chemically induced ; Drug Eruptions/etiology ; Gastrointestinal Diseases/chemically induced ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV-Associated Lipodystrophy Syndrome/chemically induced ; Humans ; Hyperglycemia/chemically induced ; Hyperlipidemias/chemically induced ; Insulin Resistance ; Metabolic Diseases/chemically induced ; Nervous System Diseases/chemically induced ; Quality of Life
Language	Romanian
Publishing date	2004-01
Publishing country	Romania
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Factori de risc pentru infecţiile cu Pseudomonas aeruginosa rezistent la carbapeneme.

Ghibu, Laura / Miftode, Egidia / Teodor, Andra / Bejan, Codrina / Dorobăţ, Carmen Mihaela

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2010 Volume 114, Issue 4, Page(s) 1012–1016

Abstract: Unlabelled: Since their introduction in clinical practice,carbapenems have been among the most powerful antibiotics for treating serious infections cased by Gram-negative nosocomial pathogens, including Pseudomonas aeruginosa. The emergence of ... ...

Title translation	Risk factors for Pseudomonas aeruginosa infections, resistant to carbapenem.
Abstract	Unlabelled: Since their introduction in clinical practice,carbapenems have been among the most powerful antibiotics for treating serious infections cased by Gram-negative nosocomial pathogens, including Pseudomonas aeruginosa. The emergence of betalactamases with carbapenem-hydrolyzing activity is of major clinical concern. Pseudomonas aeruginosa is a leading cause of nosocomial infection. Results: Risk factors for colonization with carbapenems-resistant Pseudomonas in hospital are: history of P. aeruginosa infection or colonization within the previous year, (length of hospital stay, being bedridden or in the ICU, mechanical ventilation, malignant disease, and history of chronic obstructive pulmonary disease have all been identified as independent risk factors for MDR P. aeruginosa infection. Long-term-care facilities are also reservoirs of resistant bacteria. Risk factors for colonization of LTCF residents with resistant bacteria included age > 86 years, antibiotic treatment in the previous 3 months, indwelling devices, chronic obstructive pulmonary disease, physical disability, and the particular LTCF unit.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Cross Infection/mortality ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/mortality ; Pseudomonas aeruginosa/drug effects ; Retrospective Studies ; Risk Factors ; beta-Lactam Resistance
Chemical Substances	Carbapenems
Language	Romanian
Publishing date	2010-10
Publishing country	Romania
Document type	English Abstract ; Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Bacterial meningitis during sepsis in diabetic patient.

Petrovici, Cristina G / Leca, Daniela / Teodor, Andra / Dorneanu, Olivia / Juganariu, Gabriela / Dorobăţ, Carmen / Egidia, Miftode

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2013 Volume 117, Issue 4, Page(s) 901–907

Abstract: Unlabelled: The aim of the study was to evaluate the etiology, clinical features and outcome in diabetic patients with bacterial meningitis, as a nervous system determination during invasive infections.: Material and methods: In a retrospective study, ...

Abstract	Unlabelled: The aim of the study was to evaluate the etiology, clinical features and outcome in diabetic patients with bacterial meningitis, as a nervous system determination during invasive infections. Material and methods: In a retrospective study, conducted over a period of three years, we have analyzed clinical and etiological aspects of 445 patients over 18 years old, diagnosed with sepsis of known (positive cultures from normally sterile sites) or suspected etiology (positive cultures from pus), 95 of them being included in the diabetic group. Results: Bacterial meningitis was diagnosed in 16 of 95 diabetic patients (16.8%) and 43 of 350 (12.3%) non-diabetic patients (chi2 = 0.98; GL = 1; p = 0.322). Among the multiple co morbidities associated in diabetic patients, as suggested by a higher Charlson score (5.44 vs. 3.25) (p = 0.001), the most common underlying condition was chronic liver disease (31.3% vs. 25.6%) (p = 0.916). The isolation of the microorganism concurrently from cerebro-spinal fluid and other sites (blood cultures and pus) was more frequently encountered in diabetics. The clinical picture was dominated by altered consciousness (68.8% vs. 23.3%) (p = 0.003), while fever was less present (37.5% vs. 88.4%) (p = 0.0003). The most frequently involved microorganism in the etiology of meningitis was S. aureus (31.3 vs. 23.3%) (p = 0.771) and Gram negative bacilli: E. coli (12.5% vs. 4.7%) (p = 0.629) and Klebsiella spp. (12.5% vs. 9.3%) (p = 0.902). Conclusions: Altered consciousness was more frequent in diabetic patients group (68.8% vs. 23.3%) (p = 0.003) where the absence of fever at admission was a more common finding than in non-diabetic septic patients with meningitis (37.5% vs. 88.4%) (p = 0.0003).
MeSH term(s)	Aged ; Bacteremia/complications ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Diabetes Complications/epidemiology ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Gram-Negative Bacteria/isolation & purification ; Humans ; Immunocompromised Host ; Male ; Meningitis, Bacterial/epidemiology ; Meningitis, Bacterial/etiology ; Meningitis, Bacterial/microbiology ; Middle Aged ; Retrospective Studies ; Risk Factors ; Romania/epidemiology ; Staphylococcus aureus/isolation & purification
Language	English
Publishing date	2013-10
Publishing country	Romania
Document type	Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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Article: Posibilităţi şi limite ale terapiei actuale antiretrovirale.

Teodor, Andra / Teodor, D / Luca, V

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2002 Volume 106, Issue 4, Page(s) 680–683

Abstract: The therapies now approved for HIV-infection inhibit one of two viral-specific enzymes, reversetranscriptase or protease. Combining this drugs into regimes based on at least three individual drugs--so-called HAART--has resulted in a remarkable reduction ... ...

Title translation	Possibilities and limits of antiretroviral actual therapy.
Abstract	The therapies now approved for HIV-infection inhibit one of two viral-specific enzymes, reversetranscriptase or protease. Combining this drugs into regimes based on at least three individual drugs--so-called HAART--has resulted in a remarkable reduction in HIV-associated morbidity and mortality. Despite these therapeutic advances, many patients are either intolerant of available agents or develop virologic failure. Problems of adherence, drug-resistance, latent reservoirs and drug-induced toxic effects that compromise effective viral control point to need for new strategies (e.g. structured treatment interruptions--STIs) and new classes of anti-HIV drugs with different modes of action (e.g. blocking HIV entry into human cells or fusion process). The use of adjunctive immune-based therapy such as IL-2 may permit more extensive immune restoration.
MeSH term(s)	Antiretroviral Therapy, Highly Active/methods ; HIV Infections/drug therapy ; HIV Reverse Transcriptase/antagonists & inhibitors ; Humans ; Immune Adherence Reaction ; Reverse Transcriptase Inhibitors/therapeutic use
Chemical Substances	Reverse Transcriptase Inhibitors ; HIV Reverse Transcriptase (EC 2.7.7.49)
Language	Romanian
Publishing date	2002-10
Publishing country	Romania
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
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