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  1. Article ; Online: Neighbourhood Watch: Two-pore-2 channels talking to IP3 receptors.

    Criddle, David N / Tepikin, Alexei V

    Cell calcium

    2024  Volume 119, Page(s) 102868

    Abstract: The recent elegant study by Y. Yuan and colleagues examined functional relationships between the lysosomal two-pore channels 2 (TPC2) and IP3 receptors (IP3Rs) located in the endoplasmic reticulum [1]. The findings of this study suggest functional ... ...

    Abstract The recent elegant study by Y. Yuan and colleagues examined functional relationships between the lysosomal two-pore channels 2 (TPC2) and IP3 receptors (IP3Rs) located in the endoplasmic reticulum [1]. The findings of this study suggest functional coupling of these channels and receptors. The study also describes interesting novel phenomena, which may indicate an additional coupling mechanism.
    MeSH term(s) Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Calcium Signaling ; Two-Pore Channels ; Endoplasmic Reticulum/metabolism ; Lysosomes/metabolism ; Calcium/metabolism ; NADP/metabolism
    Chemical Substances Inositol 1,4,5-Trisphosphate Receptors ; Two-Pore Channels ; Calcium (SY7Q814VUP) ; NADP (53-59-8)
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2024.102868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Mitochondrial signalling, physiology and pathophysiology.

    Tepikin, Alexei V

    Pflugers Archiv : European journal of physiology

    2018  Volume 470, Issue 8, Page(s) 1139–1140

    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Humans ; Mitochondria/metabolism ; Mitochondria/physiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-06-30
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-018-2172-6
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  3. Article ; Online: Mitochondrial junctions with cellular organelles: Ca

    Tepikin, Alexei V

    Pflugers Archiv : European journal of physiology

    2018  Volume 470, Issue 8, Page(s) 1181–1192

    Abstract: Cellular organelles form multiple junctional complexes with one another and the emerging research area dealing with such structures and their functions is undergoing explosive growth. A new research journal named "Contact" has been recently established ... ...

    Abstract Cellular organelles form multiple junctional complexes with one another and the emerging research area dealing with such structures and their functions is undergoing explosive growth. A new research journal named "Contact" has been recently established to facilitate the development of this research field. The current consensus is to define an organellar junction by the maximal distance between the participating organelles; and the gap of 30 nm or less is considered appropriate for classifying such structures as junctions or membrane contact sites. Ideally, the organellar junction should have a functional significance, i.e. facilitate transfer of calcium, sterols, phospholipids, iron and possibly other substances between the organelles (Carrasco and Meyer in Annu Rev Biochem 80:973-1000, 2011; Csordas et al. in Trends Cell Biol 28:523-540, 2018; Phillips and Voeltz in Nat Rev Mol Cell Biol 17:69-82, 2016; Prinz in J Cell Biol 205:759-769, 2014). It is also important to note that the junction is not just a result of a random organelle collision but have active and specific formation, stabilisation and disassembly mechanisms. The nature of these mechanisms and their role in physiology/pathophysiology are the main focus of an emerging research field. In this review, we will briefly describe junctional complexes formed by cellular organelles and then focus on the junctional complexes that are formed by mitochondria with other organelles and the role of these complexes in regulating Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Humans ; Mitochondria/metabolism ; Mitochondria/physiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-07-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-018-2179-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polarity of action in salivary gland acinar cells: Local and preferential Ca

    Criddle, David N / Tepikin, Alexei V

    Cell calcium

    2021  Volume 99, Page(s) 102471

    Abstract: Salivary secretion is important for digestion and paramount for oral health. Both exocytotic secretion of proteins (including salivary amylase and mucins) and fluid secretion contribute to the formation of saliva. A recent study by T. Takano and ... ...

    Abstract Salivary secretion is important for digestion and paramount for oral health. Both exocytotic secretion of proteins (including salivary amylase and mucins) and fluid secretion contribute to the formation of saliva. A recent study by T. Takano and colleagues [1] has revealed interesting patterns of Ca
    MeSH term(s) Acinar Cells ; Calcium ; Saliva ; Salivary Glands ; Signal Transduction
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-09-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2021.102471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Introduction.

    Tepikin, Alexei V

    Advances in experimental medicine and biology

    2017  Volume 993, Page(s) 213–216

    Abstract: In the title of this part of the book, the tail is wagging not just in a single dog but multiple dogs; in other words, a single process SOCE (tail) somehow involves a cross talk of (wagging) large and powerful organelle and cellular compartments (dogs). ... ...

    Abstract In the title of this part of the book, the tail is wagging not just in a single dog but multiple dogs; in other words, a single process SOCE (tail) somehow involves a cross talk of (wagging) large and powerful organelle and cellular compartments (dogs). So how is this possible? Is this really necessary? Is the title actually appropriate?SOCE is a rather special process, it allows efficient signaling based on a ubiquitous second messenger (Ca
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-57732-6_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intramitochondrial Ca(2+) Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling.

    Criddle, David N / Tepikin, Alexei V

    Molecular cell

    2016  Volume 61, Issue 5, Page(s) 646–647

    Abstract: Mitochondrial Ca(2+) entry is an important process regulating cellular bioenergetics, redox responses, and apoptosis. The study by Vais and colleagues (Vais et al., 2016), recently published in Cell Reports, describes a novel mechanism of modulating Ca(2+ ...

    Abstract Mitochondrial Ca(2+) entry is an important process regulating cellular bioenergetics, redox responses, and apoptosis. The study by Vais and colleagues (Vais et al., 2016), recently published in Cell Reports, describes a novel mechanism of modulating Ca(2+) entry that involves mitochondrial matrix Ca(2+).
    MeSH term(s) Apoptosis ; Calcium/metabolism ; Energy Metabolism ; Humans ; Mitochondria/metabolism ; Oxidation-Reduction
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-03-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2016.02.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Altered Bioenergetics of Blood Cell Sub-Populations in Acute Pancreatitis Patients.

    Morton, Jack C / Armstrong, Jane A / Sud, Ajay / Tepikin, Alexei V / Sutton, Robert / Criddle, David N

    Journal of clinical medicine

    2019  Volume 8, Issue 12

    Abstract: Acute pancreatitis (AP) is a debilitating, sometimes fatal disease, marked by local injury and systemic inflammation. Mitochondrial dysfunction is a central feature of pancreatic damage in AP, however, its involvement in circulating blood cell subtypes ... ...

    Abstract Acute pancreatitis (AP) is a debilitating, sometimes fatal disease, marked by local injury and systemic inflammation. Mitochondrial dysfunction is a central feature of pancreatic damage in AP, however, its involvement in circulating blood cell subtypes is unknown. This study compared mitochondrial bioenergetics in circulating leukocytes from AP patients and healthy volunteers: 15 patients with mild to severe AP were compared to 10 healthy controls. Monocytes, lymphocytes and neutrophils were isolated using magnetic activated cell sorting and mitochondrial bioenergetics profiles of the cell populations determined using a Seahorse XF24 flux analyser. Rates of oxygen consumption (OCR) and extracellular acidification (ECAR) under conditions of electron transport chain (ETC) inhibition ("stress" test) informed respiratory and glycolytic parameters, respectively. Phorbol ester stimulation was used to trigger the oxidative burst. Basal OCR in all blood cell subtypes was similar in AP patients and controls. However, maximal respiration and spare respiratory capacity of AP patient lymphocytes were decreased, indicating impairment of functional capacity. A diminished oxidative burst occurred in neutrophils from AP patients, compared to controls, whereas this was enhanced in both monocytes and lymphocytes. The data demonstrate important early alterations of bioenergetics in blood cell sub-populations from AP patients, which imply functional alterations linked to clinical disease progression.
    Language English
    Publishing date 2019-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm8122201
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  8. Article ; Online: Mitochondrial Targeting of Antioxidants Alters Pancreatic Acinar Cell Bioenergetics and Determines Cell Fate.

    Armstrong, Jane A / Cash, Nicole J / Morton, Jack C / Tepikin, Alexei V / Sutton, Robert / Criddle, David N

    International journal of molecular sciences

    2019  Volume 20, Issue 7

    Abstract: Mitochondrial dysfunction is a core feature of acute pancreatitis, a severe disease in which oxidative stress is elevated. Mitochondrial targeting of antioxidants is a potential therapeutic strategy for this and other diseases, although thus far mixed ... ...

    Abstract Mitochondrial dysfunction is a core feature of acute pancreatitis, a severe disease in which oxidative stress is elevated. Mitochondrial targeting of antioxidants is a potential therapeutic strategy for this and other diseases, although thus far mixed results have been reported. We investigated the effects of mitochondrial targeting with the antioxidant MitoQ on pancreatic acinar cell bioenergetics, adenosine triphosphate (ATP) production and cell fate, in comparison with the non-antioxidant control decyltriphenylphosphonium bromide (DecylTPP) and general antioxidant
    MeSH term(s) Acetylcysteine/pharmacology ; Acinar Cells/drug effects ; Acinar Cells/metabolism ; Adenosine Triphosphate/biosynthesis ; Animals ; Antioxidants/metabolism ; Cell Death/drug effects ; Cell Lineage/drug effects ; Cell Survival/drug effects ; Energy Metabolism/drug effects ; Flavin-Adenine Dinucleotide/metabolism ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; NAD/metabolism ; Onium Compounds/pharmacology ; Organophosphorus Compounds/pharmacology ; Oxidation-Reduction ; Pancreas/cytology ; Ubiquinone/analogs & derivatives ; Ubiquinone/pharmacology
    Chemical Substances Antioxidants ; Onium Compounds ; Organophosphorus Compounds ; decyltriphenylphosphonium ; NAD (0U46U6E8UK) ; Ubiquinone (1339-63-5) ; Flavin-Adenine Dinucleotide (146-14-5) ; mitoquinone (47BYS17IY0) ; Adenosine Triphosphate (8L70Q75FXE) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2019-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20071700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.

    Ouyang, Yulin / Wen, Li / Armstrong, Jane A / Chvanov, Michael / Latawiec, Diane / Cai, Wenhao / Awais, Mohammad / Mukherjee, Rajarshi / Huang, Wei / Gough, Peter J / Bertin, John / Tepikin, Alexei V / Sutton, Robert / Criddle, David N

    Cells

    2021  Volume 10, Issue 5

    Abstract: Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis ( ... ...

    Abstract Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis (Necroptosis), is unclear in AP. We assessed the effects of RIPK1 inhibitor Necrostatin-1 (Nec-1) and RIPK1 modification (RIPK1
    MeSH term(s) Acinar Cells/metabolism ; Alcohols ; Animals ; Bile Acids and Salts ; Calcium/metabolism ; Ceruletide ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Male ; Mice, Inbred C57BL ; Pancreas/pathology ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Pancreatitis/enzymology ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Reactive Oxygen Species/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Mice
    Chemical Substances Alcohols ; Bile Acids and Salts ; Imidazoles ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Indoles ; Protective Agents ; Reactive Oxygen Species ; necrostatin-1 ; Ceruletide (888Y08971B) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Ripk1 protein, mouse (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE.

    Dingsdale, Hayley / Okeke, Emmanuel / Haynes, Lee / Lur, Gyorgy / Tepikin, Alexei V

    Advances in experimental medicine and biology

    2017  Volume 993, Page(s) 217–237

    Abstract: The junctions between the endoplasmic reticulum and the plasma membrane are essential platforms for the activation of store-operated ... ...

    Abstract The junctions between the endoplasmic reticulum and the plasma membrane are essential platforms for the activation of store-operated Ca
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-57732-6_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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