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Article ; Online: Comedonecrosis within conventional prostatic adenocarcinoma vs. intraductal carcinoma of the prostate: their clinical significance is not comparable.

Wang, Ying / Teramoto, Yuki / Miyamoto, Hiroshi

2023 Volume 138, Page(s) 112–120

Abstract: It remains controversial if Gleason grade should be assigned to intraductal carcinoma of the prostate (IDC-P) and if the prognostic value of comedonecrosis associated with IDC-P is equivalent to that in conventional/invasive prostatic adenocarcinoma (CPA) ...

Abstract	It remains controversial if Gleason grade should be assigned to intraductal carcinoma of the prostate (IDC-P) and if the prognostic value of comedonecrosis associated with IDC-P is equivalent to that in conventional/invasive prostatic adenocarcinoma (CPA) as a Gleason grade 5 pattern. We herein assessed radical prostatectomy findings and postoperative outcomes in 287 patients with CPA exhibiting any Gleason pattern 5. Our cases were divided into 4 cohorts according to the absence or presence of necrosis within CPA and/or IDC-P: Cohort-1) no necrosis in CPA/IDC-P (n = 179; 62.4%); Cohort-2) necrosis only in CPA (n = 25; 8.7%); Cohort-3) necrosis only in IDC-P (n = 62; 21.6%); and Cohort-4) necrosis in both CPA and IDC-P (n = 21; 7.3%). Univariate analysis revealed patients with necrosis only in IDC-P (P < .001) or both CPA and IDC-P (P = .001) had a higher risk of progression than those with necrosis only in CPA, while the prognosis was comparable between the no necrosis group vs. the CPA only necrosis group (P = .680) or the IDC-P only necrosis group vs. the CPA/IDC-P necrosis group (P = .715). In a subgroup of patients exhibiting IDC-P (n = 198), the presence of IDC-P necrosis was still associated with a significantly higher progression risk, compared with CPA necrosis only. In multivariable analysis, necrosis only in IDC-P (vs. necrosis only in CPA) showed significantly worse progression-free survival (HR = 3.193, P = .003). IDC-P necrosis, as an independent predictor, was thus found to be associated with significantly worse oncologic outcomes, compared with necrosis only in CPA, and might therefore be better not to be simply considered as a grade 5 pattern.
MeSH term(s)	Male ; Humans ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Prostate/pathology ; Clinical Relevance ; Prostatic Neoplasms/pathology ; Prognosis ; Neoplasm Grading ; Prostatectomy ; Necrosis/pathology
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2023.06.011
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Article ; Online: Risk Stratification by Quantification of Perineural Cancer Invasion on Prostate Needle Core Biopsy: Should It Be Counted?

Teramoto, Yuki / Wang, Ying / Miyamoto, Hiroshi

The Journal of urology

2023 Volume 210, Issue 4, Page(s) 639–648

Abstract: Purpose: We assessed the prognostic significance of quantification of perineural invasion on prostate biopsy.: Materials and methods: We quantified actual perineural invasion foci in the entire prostate biopsy specimens from 724 patients and compared ...

Abstract	Purpose: We assessed the prognostic significance of quantification of perineural invasion on prostate biopsy. Materials and methods: We quantified actual perineural invasion foci in the entire prostate biopsy specimens from 724 patients and compared corresponding radical prostatectomy findings and long-term oncologic outcomes. Results: No perineural invasion was detected in 524 (72.4%) prostate biopsies, whereas 1 (n=129; 17.8%), 2 (n=40; 5.5%), 3 (n=18; 2.5%), 4 (n=7; 1.0%), and 5-10 (n=6; 0.8%) perineural invasion foci were present in other cases. We confirmed a higher risk of recurrence after radical prostatectomy in patients with perineural invasion on prostate biopsy than in those with no perineural invasion ( Conclusions: Multifocal perineural invasion and >1 perineural invasion per 10-mm tumor on each prostate biopsy were thus found to be associated with poorer prognosis, as independent predictors, in men with prostate cancer undergoing radical prostatectomy.
MeSH term(s)	Male ; Humans ; Prostate/pathology ; Neoplasm Invasiveness/pathology ; Prostatic Neoplasms/pathology ; Biopsy, Large-Core Needle ; Prostatectomy ; Biopsy ; Risk Assessment
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000003618
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Article ; Online: The Clinical Significance of pT3a Lesions as Well as Unilateral Versus Bilateral Invasion Into the Seminal Vesicle in Men With pT3b Prostate Cancer: A Proposal for a New pT3b Subclassification.

Teramoto, Yuki / Numbere, Numbereye / Wang, Ying / Miyamoto, Hiroshi

Archives of pathology & laboratory medicine

2023 Volume 147, Issue 11, Page(s) 1261–1267

Abstract: Context.—: Seminal vesicle invasion (SVI) as pT3b prostate cancer generally, but not uniformly, indicates poor prognosis.: Objective.—: To determine the clinical impact of pT3a lesions (ie, extraprostatic extension other than seminal vesicle or ... ...

Abstract	Context.—: Seminal vesicle invasion (SVI) as pT3b prostate cancer generally, but not uniformly, indicates poor prognosis. Objective.—: To determine the clinical impact of pT3a lesions (ie, extraprostatic extension other than seminal vesicle or bladder invasion [EPE], microscopic bladder neck invasion [mBNI]), as well as unilateral (Uni) versus bilateral (Bil) SVI in pT3b disease. Design.—: We assessed radical prostatectomy findings and long-term oncologic outcomes in 248 consecutive patients with pT3b disease. Results.—: Focal EPE, nonfocal EPE, mBNI, Uni-SVI, and Bil-SVI were identified in 13 (5.2%), 206 (83.1%), 48 (19.4%), 109 (44.0%), and 139 (56.0%) cases, respectively. Of possible combinations, we eventually divided our cases into 3 cohorts-Group 1: Uni/Bil-SVI and EPE-/mBNI- (n = 28; 11.3%); Group 2: Uni-SVI and EPE or mBNI (n = 103; 41.5%); and Group 3: Bil-SVI and EPE or mBNI (n = 70; 28.2%) or Uni/Bil-SVI and EPE+/mBNI+ (n = 47; 19.0%). Group 3 patients showed significant adverse histopathologic findings, compared with Group 1 or Group 2 patients. Kaplan-Meier analysis revealed that the prognosis was worse in the following order: Group 1, Group 2, and Group 3; and the differences in progression-free survival between any 2 groups were statistically significant. These significant differences were also seen in subgroups, such as those without or with adjuvant therapy before recurrence and those without lymph node metastasis. Additionally, Group 3 patients had a significantly higher risk of cancer-specific mortality than Group 2 patients. In multivariate analysis (Group 2 as a reference), Group 1 (hazard ratio [HR] = 0.169, P = .01) and Group 3 (HR = 1.620, P = .04) showed significance for progression. Conclusions.—: From these significant findings, we propose a novel pT3b subclassification, namely pT3b1 (Group 1), pT3b2 (Group 2), and pT3b3 (Group 3), which more accurately stratifies its prognosis.
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2022-0244-OA
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Article ; Online: Clinical impact of perineural cancer invasion detected in prostate cores: Involvement of spatially contiguous versus separate biopsy sites.

Teramoto, Yuki / Numbere, Numbereye / Miyamoto, Hiroshi

Pathology international

2023 Volume 73, Issue 9, Page(s) 473–475

MeSH term(s)	Male ; Humans ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Biopsy ; Prostatectomy ; Neoplasm Invasiveness/pathology ; Prostate-Specific Antigen ; Neoplasm Staging
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-07-26
Publishing country	Australia
Document type	Letter
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13356
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Article ; Online: Clinical impact of perineural invasion encircled completely vs. incompletely by prostate cancer on needle core biopsy.

Nwanze, Julum / Teramoto, Yuki / Wang, Ying / Miyamoto, Hiroshi

Human pathology

2023 Volume 143, Page(s) 71–74

Abstract: The clinical significance of the pattern or degree of perineural invasion (PNI) by prostate cancer remains largely unknown. We herein assessed radical prostatectomy findings and postoperative oncologic outcomes in 125 patients who had undergone ... ...

Abstract	The clinical significance of the pattern or degree of perineural invasion (PNI) by prostate cancer remains largely unknown. We herein assessed radical prostatectomy findings and postoperative oncologic outcomes in 125 patients who had undergone systematic sextant prostate biopsy exhibiting only a single focus of PNI encircled completely (n = 57; 46 %) vs. incompletely (n = 68; 54 %) by cancer. Between these two cohorts, there were no significant differences in clinicopathological features on biopsy or prostatectomy, including tumor grade, stage, and length or volume, and surgical margin status, as well as the need for adjuvant therapy immediately after prostatectomy. Similarly, survival analysis demonstrated no significant difference in the risk of disease progression following prostatectomy in patients with encircled vs. non-encircled PNI on biopsy (P = 0.679). When the non-encircled cases were further divided into four groups [i.e. 1-25 % enclosed (n = 12; 18 %), 26-50 % enclosed (n = 18; 26 %), 51-75 % enclosed (n = 10; 15 %), 76-99 % enclosed (n = 28; 41 %)], the rates of progression-free survival were comparable among the five groups (P = 0.954). In prostate biopsy specimens exhibiting PNI at only one focus, the degree of nerve involvement thus appears to have little clinical impact. Accordingly, PNI detected on prostate biopsy may need to be similarly taken into consideration irrespective of the degree of nerve involvement.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/pathology ; Prostate/surgery ; Prostate/pathology ; Biopsy, Large-Core Needle ; Biopsy ; Prostatectomy ; Neoplasm Invasiveness/pathology
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2023.12.001
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Article: Multimodal analysis of disinformation and misinformation.

Wilson, Anna / Wilkes, Seb / Teramoto, Yayoi / Hale, Scott

Royal Society open science

2023 Volume 10, Issue 12, Page(s) 230964

Abstract: The use of disinformation and misinformation campaigns in the media has attracted much attention from academics and policy-makers. Multimodal analysis or the analysis of two or more semiotic systems-language, gestures, images, sounds, among others-in ... ...

Abstract	The use of disinformation and misinformation campaigns in the media has attracted much attention from academics and policy-makers. Multimodal analysis or the analysis of two or more semiotic systems-language, gestures, images, sounds, among others-in their interrelation and interaction is essential to understanding dis-/misinformation efforts because most human communication goes beyond just words. There is a confluence of many disciplines (e.g. computer science, linguistics, political science, communication studies) that are developing methods and analytical models of multimodal communication. This literature review brings research strands from these disciplines together, providing a map of the multi- and interdisciplinary landscape for multimodal analysis of dis-/misinformation. It records the substantial growth starting from the second quarter of 2020-the start of the COVID-19 epidemic in Western Europe-in the number of studies on multimodal dis-/misinformation coming from the field of computer science. The review examines that category of studies in more detail. Finally, the review identifies gaps in multimodal research on dis-/misinformation and suggests ways to bridge these gaps including future cross-disciplinary research directions. Our review provides scholars from different disciplines working on dis-/misinformation with a much needed bird's-eye view of the rapidly emerging research of multimodal dis-/misinformation.
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230964
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Article ; Online: Exploration of immobilization conditions of cellulosic lyotropic liquid crystals in monomeric solvents by

Miyagi, K / Teramoto, Y

RSC advances

2018 Volume 8, Issue 44, Page(s) 24724–24730

Abstract: We investigated conditions to prepare cellulosic cholesteric liquid crystalline (ChLC) films in order to accomplish dual mechanochromism, ...

Abstract	We investigated conditions to prepare cellulosic cholesteric liquid crystalline (ChLC) films in order to accomplish dual mechanochromism,
Language	English
Publishing date	2018-07-10
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c8ra04878a
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Article: Construction of Functional Materials in Various Material Forms from Cellulosic Cholesteric Liquid Crystals.

Miyagi, Kazuma / Teramoto, Yoshikuni

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 11

Abstract: Wide use of bio-based polymers could play a key role in facilitating a more sustainable society because such polymers are renewable and ecofriendly. Cellulose is a representative bio-based polymer and has been used in various materials. To further expand ...

Abstract	Wide use of bio-based polymers could play a key role in facilitating a more sustainable society because such polymers are renewable and ecofriendly. Cellulose is a representative bio-based polymer and has been used in various materials. To further expand the application of cellulose, it is crucial to develop functional materials utilizing cellulosic physicochemical properties that are acknowledged but insufficiently applied. Cellulose derivatives and cellulose nanocrystals exhibit a cholesteric liquid crystal (ChLC) property based on rigidity and chirality, and this property is promising for constructing next-generation functional materials. The form of such materials is an important factor because material form is closely related with function. To date, researchers have reported cellulosic ChLC materials with a wide range of material forms-such as films, gels, mesoporous materials, and emulsions-for diverse functions. We first briefly review the fundamental aspects of cellulosic ChLCs. Then we comprehensively review research on cellulosic ChLC functional materials in terms of their material forms. Thus, this review provides insights into the creation of novel cellulosic ChLC functional materials based on material form designed toward the expanded application of cellulosics.
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11112969
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Article ; Online: Clinical significance of location of perineural cancer invasion detected on prostate needle core biopsy.

Gertsen, Benjamin G / Teramoto, Yuki / Wang, Ying / Tsuzuki, Toyonori / Miyamoto, Hiroshi

Virchows Archiv : an international journal of pathology

2024

Abstract: The clinical impact of site-specific perineural invasion (PNI) in prostate cancer remains poorly understood. We compared radical prostatectomy findings and oncologic outcomes in 434 patients with single-site PNI on systematic sextant biopsy. PNI was ... ...

Abstract	The clinical impact of site-specific perineural invasion (PNI) in prostate cancer remains poorly understood. We compared radical prostatectomy findings and oncologic outcomes in 434 patients with single-site PNI on systematic sextant biopsy. PNI was present in the right apex (n = 62; 14%), right mid (n = 70; 16%), right base (n = 89; 21%), left apex (n = 64; 15%), left mid (n = 58; 13%), and left base (n = 91; 21%). There were no significant differences in biopsy or prostatectomy findings, when comparing apex vs. mid vs. base PNI. Univariate analysis revealed that apex-localized PNI was associated with a significantly higher risk of progression, compared with base (P = 0.037) or mid/base (P = 0.024) PNI. Multivariable analysis showed that apex-localized PNI was an independent risk factor for progression (hazard ratio 2.049, P = 0.002). Among biopsies demonstrating PNI at one sextant site, apex-localized PNI is independently associated with poorer prognosis, though not worse histopathologic features on prostatectomy, compared with mid or base PNI.
Language	English
Publishing date	2024-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-024-03779-8
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Article ; Online: Prostate Cancer Risk Stratification by Simple Scoring of the Current pT3 Lesions: A Proposal for a New Pathologic T-Staging System.

Miyamoto, Hiroshi / Teramoto, Yuki / Numbere, Numbereye / Wang, Ying / Joseph, Jean V

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2024 Volume 37, Issue 3, Page(s) 100429

Abstract: Cancer spread beyond the prostate, including extraprostatic extension (other than seminal vesicle or bladder invasion; EPE)/microscopic bladder neck invasion and seminal vesicle invasion (SVI) currently classified as pT3a and pT3b lesions, respectively, ... ...

Abstract	Cancer spread beyond the prostate, including extraprostatic extension (other than seminal vesicle or bladder invasion; EPE)/microscopic bladder neck invasion and seminal vesicle invasion (SVI) currently classified as pT3a and pT3b lesions, respectively, does not uniformly indicate poor oncologic outcomes. Accurate risk stratification of current pT3 disease is therefore required. We herein further determined the prognostic impact of these histopathologic lesions routinely assessed and reported by pathologists, particularly their combinations. We assessed consecutive 2892 patients undergoing radical prostatectomy for current pT2 (n = 1692), pT3a (n = 956), or pT3b (n = 244) disease at our institution between 2009 and 2018. Based on our preliminary findings, point(s) were given (1 point to focal EPE, microscopic bladder neck invasion, or unilateral SVI; 2 points to nonfocal/established EPE or bilateral SVI) and summed up in each case. Our cohort had 0 point (n = 1692, 58.5%; P0), 1 point (n = 243, 8.4%; P1), 2 points (n = 657, 22.7%; P2), 3 points (n = 192, 6.6%; P3), 4 points (n = 76, 2.6%; P4), and 5 points (n = 32, 1.1%; P5). Univariate analysis revealed associations of higher points with significantly worse biochemical progression-free survival, particularly when P4 and P5 were combined. In multivariable analysis (P0 as a reference), P1 (hazard ratio [HR], 1.57; P = .033), P2 (HR, 3.25; P < .001), P3 (HR, 4.01; P < .001), and P4 + P5 (HR, 5.99; P < .001) showed significance for the risk of postoperative progression. Meanwhile, Harrell C-indexes for the current pT staging, newly developed point system, and the Cancer of the Prostate Risk Assessment post-Surgical (CAPRA-S) score were 0.727 (95% CI, 0.706-0.748), 0.751 (95% CI, 0.729-0.773), and 0.774 (95% CI, 0.755-0.794), respectively, for predicting progression. We believe our data provide a logical rationale for a novel pathologic T-staging system based on the summed points, pT1a (0 point), pT1b (1 point), pT2 (2 points), pT3a (3 points), and pT3b (4 or 5 points), which more accurately stratifies the prognosis of prostate cancer.
MeSH term(s)	Male ; Humans ; Neoplasm Staging ; Neoplasm Invasiveness/pathology ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/pathology ; Prognosis ; Prostatectomy ; Risk Assessment
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2024.100429
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