Article ; Online: Risk Stratification by Quantification of Perineural Cancer Invasion on Prostate Needle Core Biopsy: Should It Be Counted?
2023 Volume 210, Issue 4, Page(s) 639–648
Abstract: Purpose: We assessed the prognostic significance of quantification of perineural invasion on prostate biopsy.: Materials and methods: We quantified actual perineural invasion foci in the entire prostate biopsy specimens from 724 patients and compared ...
Abstract | Purpose: We assessed the prognostic significance of quantification of perineural invasion on prostate biopsy. Materials and methods: We quantified actual perineural invasion foci in the entire prostate biopsy specimens from 724 patients and compared corresponding radical prostatectomy findings and long-term oncologic outcomes. Results: No perineural invasion was detected in 524 (72.4%) prostate biopsies, whereas 1 (n=129; 17.8%), 2 (n=40; 5.5%), 3 (n=18; 2.5%), 4 (n=7; 1.0%), and 5-10 (n=6; 0.8%) perineural invasion foci were present in other cases. We confirmed a higher risk of recurrence after radical prostatectomy in patients with perineural invasion on prostate biopsy than in those with no perineural invasion ( Conclusions: Multifocal perineural invasion and >1 perineural invasion per 10-mm tumor on each prostate biopsy were thus found to be associated with poorer prognosis, as independent predictors, in men with prostate cancer undergoing radical prostatectomy. |
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MeSH term(s) | Male ; Humans ; Prostate/pathology ; Neoplasm Invasiveness/pathology ; Prostatic Neoplasms/pathology ; Biopsy, Large-Core Needle ; Prostatectomy ; Biopsy ; Risk Assessment |
Language | English |
Publishing date | 2023-07-11 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 3176-8 |
ISSN | 1527-3792 ; 0022-5347 |
ISSN (online) | 1527-3792 |
ISSN | 0022-5347 |
DOI | 10.1097/JU.0000000000003618 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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