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  1. Article: The Evolving Role of Radiotherapy for Pediatric Cancers With Advancements in Molecular Tumor Characterization and Targeted Therapies.

    Shen, Colette J / Terezakis, Stephanie A

    Frontiers in oncology

    2021  Volume 11, Page(s) 679701

    Abstract: Ongoing rapid advances in molecular diagnostics, precision imaging, and development of targeted therapies have resulted in a constantly evolving landscape for treatment of pediatric cancers. Radiotherapy remains a critical element of the therapeutic ... ...

    Abstract Ongoing rapid advances in molecular diagnostics, precision imaging, and development of targeted therapies have resulted in a constantly evolving landscape for treatment of pediatric cancers. Radiotherapy remains a critical element of the therapeutic toolbox, and its role in the era of precision medicine continues to adapt and undergo re-evaluation. Here, we review emerging strategies for combining radiotherapy with novel targeted systemic therapies (for example, for pediatric gliomas or soft tissue sarcomas), modifying use or intensity of radiotherapy when appropriate
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.679701
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  2. Article ; Online: Dorothy Reed Mendenhall: expressions of a pioneer in Hodgkin disease.

    Terezakis, Stephanie

    International journal of radiation oncology, biology, physics

    2015  Volume 92, Issue 1, Page(s) 8–10

    MeSH term(s) Baltimore ; Diagnosis, Differential ; History, 19th Century ; History, 20th Century ; Hodgkin Disease/history ; Hodgkin Disease/pathology ; Humans ; Pediatrics/history ; Physicians, Women/history ; Reed-Sternberg Cells/pathology ; Sexism/history ; Tuberculosis/diagnosis ; Tuberculosis/history ; Universities/history
    Language English
    Publishing date 2015-05-01
    Publishing country United States
    Document type Biography ; Editorial ; Historical Article ; Portraits
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2015.01.042
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  3. Article ; Online: In Reply to Gultekin et al.

    Rao, Avani D / Terezakis, Stephanie A

    International journal of radiation oncology, biology, physics

    2018  Volume 101, Issue 1, Page(s) 236

    Language English
    Publishing date 2018-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.01.062
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  4. Article ; Online: Safety First: Developing and Deploying a System to Promote Safety and Quality in Your Clinic.

    Wright, Jean L / Terezakis, Stephanie A / Ford, Eric

    Practical radiation oncology

    2020  Volume 11, Issue 2, Page(s) 92–100

    Abstract: The terms "safety and quality" (SAQ) have become inextricably linked, highly used terms that together encompass a wide range of parameters within medical departments. Safety has always been a priority in radiation oncology; quality assurance has been ... ...

    Abstract The terms "safety and quality" (SAQ) have become inextricably linked, highly used terms that together encompass a wide range of parameters within medical departments. Safety has always been a priority in radiation oncology; quality assurance has been foundational to our practice. Despite this increased focus and attention on SAQ, the "what" of SAQ remains ill-defined, largely because of the vast number of indicators that fall under this umbrella. Similarly, the "how" of developing and maintaining the highest standards of SAQ is not formulaic and varies based on the unique setting of individual practices. There are several excellent resources available to inform SAQ in radiation oncology, including the American Society for Radiation Oncology's "Safety Is No Accident," which provides an overview of safety and quality standards and resources. This review is intended as a brief summary of key considerations, with the goal of providing a practical framework and context for improving or developing a SAQ program in radiation oncology practices. We believe that the following 10 key elements, drawn from numerous reports that have appeared over the last decade examining this topic, should be considered when conceptualizing a practice-based approach to SAQ: establishing a strong safety culture; establishing a structured program for safety and quality; establishing up-to-date, relevant, and accessible policies and procedures; a system for peer review; systems to assess and reduce risk; an educational program focused on safety and quality; development and review of meaningful quality metrics; utilization of a physics quality control system; well-defined models for staffing, training, and professional development; and finally, validation from external bodies via accreditations and audits. These 10 items are addressed herein.
    MeSH term(s) Humans ; Radiation Oncology ; Safety Management
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2020.05.002
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  5. Article ; Online: The use of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography integrated with computed tomography for accurate staging and surveillance in the case of mucosa-associated lymphoid tissue.

    Zhang, Shunqing / Rossetti-Chung, Allen / Sood, Sumit / Terezakis, Stephanie

    Journal of radiology case reports

    2021  Volume 15, Issue 3, Page(s) 19–28

    Abstract: We present the case of a 79-year-old male, who was initially treated for mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) of the right eyelid, and later for disease relapse in the stomach. During follow up, he was noted to have developed left ... ...

    Abstract We present the case of a 79-year-old male, who was initially treated for mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) of the right eyelid, and later for disease relapse in the stomach. During follow up, he was noted to have developed left arm nodules just medial to the proximal biceps muscle, which were found to be multiply enlarged lymph nodes on subsequent ultrasound imaging. Excisional biopsy of these nodes revealed MALT lymphoma. He was initially referred for consideration of radiation, but a restaging F-18 fluorodeoxyglucose positron emission tomography integrated with computed tomography (F-18 FDG PET/CT) further identified a focus of suspicious uptake in left calf, which was later also biopsy proven to be MALT lymphoma. His disease was upstaged as the result of this later finding, and the overall recommendation for treatment changed to favor systemic treatment with Rituximab.
    MeSH term(s) Aged ; Fluorodeoxyglucose F18 ; Humans ; Lymphoid Tissue/diagnostic imaging ; Lymphoid Tissue/pathology ; Lymphoma, B-Cell, Marginal Zone/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone/pathology ; Male ; Mucous Membrane/diagnostic imaging ; Mucous Membrane/pathology ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography/methods ; Watchful Waiting
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2586384-8
    ISSN 1943-0922 ; 1943-0922
    ISSN (online) 1943-0922
    ISSN 1943-0922
    DOI 10.3941/jrcr.v15i3.4193
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  6. Article ; Online: "Per protocol" practice patterns for Children's Oncology Group trials within the radiation oncology community.

    Liu, Kevin X / Hammoudeh, Lubna / Haas-Kogan, Daphne A / Terezakis, Stephanie A

    Pediatric blood & cancer

    2022  Volume 70, Issue 8, Page(s) e29673

    Abstract: Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted ...

    Abstract Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer-reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes.
    MeSH term(s) Child ; Humans ; Radiation Oncology ; Practice Patterns, Physicians'
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29673
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  7. Article ; Online: Preferential Tumor Vascular Damage Is the Common Antitumor Mechanism of High-Dose Hypofractionated Radiation Therapy: SABR, Spatially Fractionated Radiation Therapy, and FLASH Radiation Therapy.

    Song, Chang W / Terezakis, Stephanie / Park, Woo-Yoon / Paek, Sun-Ha / Kim, Mi-Sook / Cho, L Chinsoo / Griffin, Robert J

    International journal of radiation oncology, biology, physics

    2023  Volume 117, Issue 3, Page(s) 701–704

    MeSH term(s) Humans ; Radiation Dose Hypofractionation ; Dose Fractionation, Radiation ; Neoplasms
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.05.015
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  8. Article ; Online: Palliative radiation oncology in pediatric patients.

    Stachelek, Gregory C / Terezakis, Stephanie A / Ermoian, Ralph

    Annals of palliative medicine

    2019  Volume 8, Issue 3, Page(s) 285–292

    Abstract: Radiation therapy (RT) provides an effective and often rapid means to alleviate symptomatic progression in pediatric patients with advanced or metastatic cancer. As part of a comprehensive, multimodality approach to pediatric palliative care, RT can be a ...

    Abstract Radiation therapy (RT) provides an effective and often rapid means to alleviate symptomatic progression in pediatric patients with advanced or metastatic cancer. As part of a comprehensive, multimodality approach to pediatric palliative care, RT can be a useful tool to manage pain, spinal cord compression, dyspnea, neurologic compromise, bleeding, and bowel or urinary obstruction. Whether such symptoms present earlier in the disease course or in children and adolescents approaching the end of life, they can significantly impact the quality of life of patients and caregivers. Control of symptoms is therefore an important aspect in maximizing end of life care. Outcomes for palliative RT in both children and adults are favorable. While RT has been widely adopted as a component of palliative oncologic care for many adult malignancies, it remains infrequently utilized in pediatric patients despite the relative radiosensitivity of many pediatric tumors. Potential barriers to palliative radiation for pediatric patients include insufficient understanding by care providers regarding the utility of RT for a given symptom, lack of comfort in discussing a transition away from definitive management, concern over radiation-related side effects, and hesitancy toward radiation treatment on the part of parents and caregivers. Delivery of palliative RT can also be impeded by logistical obstacles including lack of on-site radiation facilities, unavailability of radiation oncologists comfortable with pediatric treatments, and the potential need for specialized medical care such as pediatric anesthesia. The aim of this review is to foster a more complete understanding of the benefits and limitations of palliative RT in the pediatric oncology setting, including common symptoms experienced by children and adolescents with cancer that may be indications for the integration of RT into palliative care paradigms, as well as the expected efficacy of treatment. We describe the logistics, delivery, common doses for palliative radiation regimens, and management of potential side effects. While palliative RT is generally well tolerated in the pediatric population, we also discuss potential side effects of RT to various body sites and approaches for prevention or mitigation.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Neoplasm Metastasis ; Neoplasms/pathology ; Neoplasms/psychology ; Neoplasms/radiotherapy ; Palliative Care/methods ; Quality of Life ; Radiation Oncology/organization & administration ; Terminal Care/organization & administration
    Language English
    Publishing date 2019-05-27
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5820
    ISSN (online) 2224-5839
    ISSN 2224-5820
    DOI 10.21037/apm.2019.05.01
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  9. Article ; Online: Non-rhabdomyosarcoma soft-tissue sarcoma.

    Milgrom, Sarah A / Million, Lynn / Mandeville, Henry / Safwat, Akmal / Ermoian, Ralph P / Terezakis, Stephanie

    Pediatric blood & cancer

    2021  Volume 68 Suppl 2, Page(s) e28279

    Abstract: Non-rhabdomyosarcoma soft-tissue sarcomas (NRSTS) comprise 4% of childhood cancers and consist of numerous histologic subtypes. Prognostic factors associated with poor outcome include high histologic grade, large tumor size, presence of metastases, and ... ...

    Abstract Non-rhabdomyosarcoma soft-tissue sarcomas (NRSTS) comprise 4% of childhood cancers and consist of numerous histologic subtypes. Prognostic factors associated with poor outcome include high histologic grade, large tumor size, presence of metastases, and unresectability. Complete surgical resection is critical for the best oncologic outcomes and is prioritized in treatment algorithms. The use of radiation therapy (RT) and chemotherapy is based upon factors such as resectability, histologic grade, tumor size, and stage. North American and European trials are defining a risk-based approach to NRSTS to limit treatment-related toxicity and to maximize therapeutic efficacy. In this paper, we summarize the current roles of surgery, RT, and chemotherapy in NRSTS and describe ongoing research that is advancing the care of NRSTS patients.
    MeSH term(s) Child ; Combined Modality Therapy ; Humans ; Prognosis ; Sarcoma/pathology ; Sarcoma/therapy ; Survival Rate
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28279
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  10. Article ; Online: Contemporary radiation therapy in combined modality therapy for Hodgkin lymphoma.

    Narang, Amol K / Terezakis, Stephanie A

    Journal of the National Comprehensive Cancer Network : JNCCN

    2015  Volume 13, Issue 5, Page(s) 597–605

    Abstract: The advent of effective combination chemotherapy markedly changed the management of Hodgkin lymphoma, establishing combined modality therapy as the standard of care for most patients with this disease. In response, significant interest has been shown in ... ...

    Abstract The advent of effective combination chemotherapy markedly changed the management of Hodgkin lymphoma, establishing combined modality therapy as the standard of care for most patients with this disease. In response, significant interest has been shown in refining the delivery of radiation in the combined modality setting such that toxicity is minimized while still preserving disease control. An understanding of the way in which radiation treatment fields, prescription dose, and advanced technology have evolved to accomplish these goals is critical. Moreover, fluency in the clinical literature exploring contemporary questions, such as the omission of radiation and response-based treatment, is equally important. Knowledge of these topics will yield both an appreciation of the value of radiation in the combined modality setting and the ability to better customize treatment regimens to individual patients.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Hodgkin Disease/therapy ; Humans ; Radiotherapy/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Treatment Outcome
    Language English
    Publishing date 2015-05-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2015.0077
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