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  1. Article ; Online: Factors associated with swallowing dysfunction in patients with head and neck cancer.

    Vermaire, Jorine A / Raaijmakers, Cornelis P J / Monninkhof, Evelyn M / Verdonck-de Leeuw, Irma M / Terhaard, Chris H J / Speksnijder, Caroline M

    Oral diseases

    2022  Volume 29, Issue 5, Page(s) 1937–1946

    Abstract: Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment.: Methods: The 100 ml ...

    Abstract Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment.
    Methods: The 100 ml water swallow test was measured before treatment, and 3, 6, 12, and 24 months after treatment. Linear mixed-effects model analysis was conducted to investigate changes over time and the association with personal (sex and age) and clinical (tumor site, tumor stage, and treatment modality) factors.
    Results: Among 128 included patients, number of swallows increased from baseline to 3 months after treatment and decreased to baseline again at 6 months after treatment. The number of swallows was associated with age and treatment modality.
    Conclusions: In patients with HNC, swallowing (dys)function changes over time with the worst score 3 months after treatment. A higher age and being treated with surgery are factors associated with swallowing dysfunction over time.
    MeSH term(s) Humans ; Deglutition ; Deglutition Disorders/etiology ; Prospective Studies ; Chemoradiotherapy ; Head and Neck Neoplasms/complications ; Quality of Life
    Language English
    Publishing date 2022-03-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14192
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  2. Article ; Online: Factors associated with masticatory function as measured with the Mixing Ability Test in patients with head and neck cancer before and after treatment: a prospective cohort study.

    Vermaire, Jorine A / Raaijmakers, Cornelis P J / Monninkhof, Evelyn M / Verdonck-de Leeuw, Irma M / Terhaard, Chris H J / Speksnijder, Caroline M

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 5, Page(s) 4429–4436

    Abstract: Purpose: After treatment for head and neck cancer (HNC), patients often experience major problems in masticatory function. The aim of this prospective cohort study among patients with HNC was to investigate which personal and clinical factors are ... ...

    Abstract Purpose: After treatment for head and neck cancer (HNC), patients often experience major problems in masticatory function. The aim of this prospective cohort study among patients with HNC was to investigate which personal and clinical factors are associated with masticatory function from diagnosis up to 2 years after treatment with curative intent.
    Methods: Masticatory function was measured using the Mixing Ability Test (MAT) before treatment (baseline), and 3, 6, 12, and 24 months after treatment. A linear mixed-effects model with a random intercept and slope was conducted to investigate changes over time and the association with personal (sex, age) and clinical (tumor site, tumor stage, treatment modality) factors as measured at baseline.
    Result: One-hundred-twenty-five patients were included. The prevalence of masticatory dysfunction was estimated at 29% at M0, 38% at M3, 28% at M6, 26% at M12, and 36% at M24. A higher (worse) MAT score was associated with age, tumor stage, tumor site, timing of assessment, and the interaction between assessment moment and tumor site.
    Conclusion: In patients with HNC, masticatory function changed over time and dysfunction was associated with a higher age, a tumor in the oral cavity, a higher tumor stage, and a shorter time since treatment. The prevalence of masticatory dysfunction ranged from 26 to 38%.
    MeSH term(s) Head and Neck Neoplasms/therapy ; Humans ; Mastication ; Prospective Studies
    Language English
    Publishing date 2022-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-06867-0
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    Zs.A 3697: Show issues Location:
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  3. Article ; Online: Unmet supportive care needs among informal caregivers of patients with head and neck cancer in the first 2 years after diagnosis and treatment: a prospective cohort study.

    van Hof, Kira S / Hoesseini, Arta / Dorr, Maarten C / Verdonck-de Leeuw, Irma M / Jansen, Femke / Leemans, C Réne / Takes, Robert P / Terhaard, Chris H J / de Jong, Robert J Baatenburg / Sewnaik, Aniel / Offerman, Marinella P J

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 5, Page(s) 262

    Abstract: Objective: Informal caregivers of head and neck cancer (HNC) patients have a high caregiver burden and often face complex practical caregiving tasks. This may result in unmet supportive care needs, which can impact their quality of life (QoL) and cause ... ...

    Abstract Objective: Informal caregivers of head and neck cancer (HNC) patients have a high caregiver burden and often face complex practical caregiving tasks. This may result in unmet supportive care needs, which can impact their quality of life (QoL) and cause psychological distress. In this study, we identify caregivers' unmet needs during long-term follow-up and identify caregivers prone to unmet supportive care needs.
    Methods: Data were used from the multicenter prospective cohort study NETherlands QUality of life and Biomedical cohort studies In Cancer (NET-QUBIC). The unmet supportive care needs, psychological distress, caregiver burden, and QoL were measured for 234 informal caregivers and their related patients at baseline, 3, 6, 12, and 24 months after. Mixed effect models for repeated measurements were used.
    Results: At baseline, most caregivers (70.3%) reported at least one unmet supportive care need, with most of the identified needs in the "healthcare & illness" domain. During the follow-up period, caregivers' unmet needs decreased significantly in all domains. Nevertheless, 2 years after treatment, 28.3% were still reporting at least one unmet need. Financial problems were increasingly associated with unmet needs over time. Furthermore, caring for a patient who themselves had many unmet needs, an advanced tumor stage, or severe comorbidity was associated with significantly more unmet needs in caregivers.
    Conclusions: The current study shows the strong likelihood of caregivers of HNC patients facing unmet supportive care needs and the interaction between the needs of patients and caregivers. It is important to optimally support informal caregivers by involving them from the start when counseling patients, by providing them with relevant and understandable information, and by referring vulnerable caregivers for (psychosocial) support.
    MeSH term(s) Humans ; Quality of Life/psychology ; Caregivers/psychology ; Prospective Studies ; Surveys and Questionnaires ; Head and Neck Neoplasms/therapy
    Language English
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07670-1
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  4. Article ; Online: Correction to: The course of swallowing problems in the first 2 years after diagnosis of head and neck cancer.

    Vermaire, Jorine A / Raaijmakers, Cornelis P J / Monninkhof, Evelyn M / Leemans, C René / Baatenburg de Jong, Robert J / Takes, Robert P / Verdonck-de Leeuw, Irma M / Jansen, Femke / Langendijk, Johannes A / Terhaard, Chris H J / Speksnijder, Caroline M

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 30, Issue 11, Page(s) 9539–9540

    Language English
    Publishing date 2023-04-18
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-07355-1
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  5. Article ; Online: Self-efficacy and coping style in relation to psychological distress and quality of life in informal caregivers of patients with head and neck cancer: a longitudinal study.

    van Hof, Kira S / Hoesseini, Arta / Verdonck-de Leeuw, Irma M / Jansen, Femke / Leemans, C René / Takes, Robert P / Terhaard, Chris H J / Baatenburg de Jong, Robert J / Sewnaik, Aniel / Offerman, Marinella P J

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 2, Page(s) 104

    Abstract: Objective: In order to understand how informal caregivers of head and neck cancer (HNC) patients deal with the consequences of the disease, we investigated their self-efficacy and coping style in relation to symptoms of anxiety and depression (distress) ...

    Abstract Objective: In order to understand how informal caregivers of head and neck cancer (HNC) patients deal with the consequences of the disease, we investigated their self-efficacy and coping style in relation to symptoms of anxiety and depression (distress) and quality of life (QoL) over time. In addition, factors associated with self-efficacy and coping style were investigated.
    Methods: A total of 222 informal caregivers and their related HNC patients were prospectively followed as part from the multicenter cohort NETherlands QUality of life and Biomedical cohort studies In Cancer (NET-QUBIC). Self-efficacy and coping style were measured at baseline, and distress and QoL at baseline and 3, 6, 12, and 24 months after treatment.
    Results: Informal caregivers had a high level of self-efficacy comparable with patients. Caregivers used "seeking social support," "passive reacting," and "expression of emotions" more often than patients. Factors associated with self-efficacy and coping were higher age and lower education. Higher self-efficacy was related with better QoL and "active tackling" was associated with less depression symptoms. "Passive reacting" and "expression of emotions" were associated with higher psychological distress and reduced QoL.
    Conclusion: Among informal caregivers of HNC patients, higher self-efficacy and "active tackling" were associated with better functioning over time, while "passive reacting" and "expression of negative emotions" were associated with worse functioning. Awareness of the differences in self-efficacy skills and coping and their relationship with QoL and psychological distress will help clinicians to identify caregivers that may benefit from additional support that improve self-efficacy and "active tackling" and reduce negative coping styles.
    MeSH term(s) Humans ; Longitudinal Studies ; Quality of Life/psychology ; Caregivers/psychology ; Self Efficacy ; Adaptation, Psychological ; Head and Neck Neoplasms ; Psychological Distress
    Language English
    Publishing date 2023-01-09
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-07553-x
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  6. Article ; Online: Reliability of the 100 mL water swallow test in patients with head and neck cancer and healthy subjects.

    Vermaire, Jorine A / Terhaard, Chris H J / Verdonck-de Leeuw, Irma M / Raaijmakers, Cornelis P J / Speksnijder, Caroline M

    Head & neck

    2021  Volume 43, Issue 8, Page(s) 2468–2476

    Abstract: Background: Dysphagia may occur in up to 44% of patients with head and neck cancer (HNC) treated with radiation therapy and up to 84% of patients treated with surgery. To test the extent of dysphagia, the 100 mL water swallow test (WST) was developed. ... ...

    Abstract Background: Dysphagia may occur in up to 44% of patients with head and neck cancer (HNC) treated with radiation therapy and up to 84% of patients treated with surgery. To test the extent of dysphagia, the 100 mL water swallow test (WST) was developed. In this study, reliability of the 100 mL WST was determined in patients with HNC and healthy subjects.
    Methods: Thirty-three patients and 40 healthy subjects performed the WST twice on the same day. To assess reliability, the intraclass correlation coefficient (ICC
    Results: Good to excellent correlations were found for patients with HNC (number of swallows; ICC = 0.923, duration; ICC = 0.893), and excellent correlations for healthy subjects (number of swallows; ICC = 0.950, duration; ICC = 0.916).
    Conclusion: The 100 mL WST has a good to excellent reliability in patients with HNC and healthy subjects.
    MeSH term(s) Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Head and Neck Neoplasms ; Healthy Volunteers ; Humans ; Reproducibility of Results ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26723
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    Zs.A 1493: Show issues Location:
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  7. Article ; Online: Mastication, swallowing, and salivary flow in patients with head and neck cancer: objective tests versus patient-reported outcomes.

    Vermaire, Jorine A / Raaijmakers, Cornelis P J / Verdonck-de Leeuw, Irma M / Jansen, Femke / Leemans, C René / Terhaard, Chris H J / Speksnijder, Caroline M

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2021  Volume 29, Issue 12, Page(s) 7793–7803

    Abstract: Purpose: Before and after treatment for head and neck cancer (HNC), many patients have problems with mastication, swallowing, and salivary flow. The aim of this study was to investigate the association between objective test outcomes of mastication, ... ...

    Abstract Purpose: Before and after treatment for head and neck cancer (HNC), many patients have problems with mastication, swallowing, and salivary flow. The aim of this study was to investigate the association between objective test outcomes of mastication, swallowing, and salivary flow versus patient-reported outcomes (PROs) measuring mastication-, swallowing-, and salivary flow-related quality of life.
    Methods: Data of the prospective cohort "Netherlands Quality of Life and Biomedical Cohort Study" was used as collected before treatment, and 3 and 6 months after treatment. Spearman's rho was used to test the association between objective test outcomes of the mixing ability test (MAT) for masticatory performance, the water-swallowing test (WST) for swallowing performance, and the salivary flow test versus PROs (subscales of the EORTC QLQ-H&N35, Swallow Quality of Life questionnaire (SWAL-QoL-NL) and Groningen Radiation-Induced Xerostomia (GRIX)).
    Results: Data of 142 patients were used, and in total, 285 measurements were performed. No significant correlations were found between the MAT or WST and subscales of the EORTC QLQ-H&N35. Significant but weak correlations were found between the MAT or WST and 4 subscales of the SWAL-QoL-NL. Weak to moderate correlations were found between the salivary flow test and GRIX at 3 and 6 months after treatment, with the highest correlation between salivary flow and xerostomia during the day (Spearman's rho =  - 0.441, p = 0.001).
    Conclusion: The association between objective test outcomes and PROs is weak, indicating that these outcome measures provide different information about masticatory performance, swallowing, and salivary flow in patients with HNC.
    MeSH term(s) Cohort Studies ; Deglutition ; Head and Neck Neoplasms/therapy ; Humans ; Mastication ; Patient Reported Outcome Measures ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-021-06368-6
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  8. Article ; Online: Improved delineation with diffusion weighted imaging for laryngeal and hypopharyngeal tumors validated with pathology.

    Smits, Hilde J G / Raaijmakers, Cornelis P J / de Ridder, Mischa / Gouw, Zeno A R / Doornaert, Patricia A H / Pameijer, Frank A / Lodeweges, Joyce E / Ruiter, Lilian N / Kuijer, Koen M / Schakel, Tim / de Bree, Remco / Dankbaar, Jan W / Terhaard, Chris H J / Breimer, Gerben E / Willems, Stefan M / Philippens, Marielle E P

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 194, Page(s) 110182

    Abstract: Objective: This study aims to determine the added value of a geometrically accurate diffusion-weighted (DW-) MRI sequence on the accuracy of gross tumor volume (GTV) delineations, using pathological tumor delineations as a ground truth.: Methods: ... ...

    Abstract Objective: This study aims to determine the added value of a geometrically accurate diffusion-weighted (DW-) MRI sequence on the accuracy of gross tumor volume (GTV) delineations, using pathological tumor delineations as a ground truth.
    Methods: Sixteen patients with laryngeal or hypopharyngeal carcinoma were included. After total laryngectomy, the specimen was cut into slices. Photographs of these slices were stacked to create a 3D digital specimen reconstruction, which was registered to the in vivo imaging. The pathological tumor (tumor
    Results: The mean tumor
    Conclusion: GTV delineations based on anatomical MR imaging tend to overestimate the tumor volume. The availability of the geometrically accurate DW sequence reduces the GTV overestimation and thereby CTV volumes, while maintaining acceptable tumor coverage.
    MeSH term(s) Humans ; Hypopharyngeal Neoplasms/diagnostic imaging ; Hypopharyngeal Neoplasms/pathology ; Laryngeal Neoplasms/diagnostic imaging ; Laryngeal Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Male ; Aged ; Middle Aged ; Female ; Tumor Burden ; Laryngectomy
    Language English
    Publishing date 2024-02-24
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110182
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  9. Article ; Online: A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE).

    de Leeuw, Anna Liza M P / Giralt, Jordi / Tao, Yungan / Benavente, Sergi / France Nguyen, Thanh-Vân / Hoebers, Frank J P / Hoeben, Ann / Terhaard, Chris H J / Wai Lee, Lip / Friesland, Signe / Steenbakkers, Roel J H M / Tans, Lisa / Heukelom, Jolien / Kayembe, Mutamba T / van Kranen, Simon R / Bartelink, Harry / Rasch, Coen R N / Sonke, Jan-Jakob / Hamming-Vrieze, Olga

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 196, Page(s) 110281

    Abstract: Background and purpose: This multicenter randomized phase III trial evaluated whether locoregional control of patients with LAHNSCC could be improved by fluorodeoxyglucose-positron emission tomography (FDG-PET)-guided dose-escalation while minimizing ... ...

    Abstract Background and purpose: This multicenter randomized phase III trial evaluated whether locoregional control of patients with LAHNSCC could be improved by fluorodeoxyglucose-positron emission tomography (FDG-PET)-guided dose-escalation while minimizing the risk of increasing toxicity using a dose-redistribution and scheduled adaptation strategy.
    Materials and methods: Patients with T3-4-N0-3-M0 LAHNSCC were randomly assigned (1:1) to either receive a dose distribution ranging from 64-84 Gy/35 fractions with adaptation at the 10thfraction (rRT) or conventional 70 Gy/35 fractions (cRT). Both arms received concurrent three-cycle 100 mg/m
    Results: Due to slow accrual, the study was prematurely closed (at 84 %) after randomizing 221 eligible patients between 2012 and 2019 to receive rRT (N = 109) or cRT (N = 112). The 2-year LRC estimate difference of 81 % (95 %CI 74-89 %) vs. 74 % (66-83 %) in the rRT and cRT arm, respectively, was not found statistically significant (HR 0.75, 95 %CI 0.43-1.31,P=.31). Toxicity prevalence and incidence rates were similar between trial arms, with exception for a significant increased grade ≥ 3 pharyngolaryngeal stenoses incidence rate in the rRT arm (0 versus 4 %,P=.05). In post-hoc subgroup analyses, rRT improved LRC for patients with N0-1 disease (HR 0.21, 95 %CI 0.05-0.93) and oropharyngeal cancer (0.31, 0.10-0.95), regardless of HPV.
    Conclusion: Adaptive and dose redistributed radiotherapy enabled dose-escalation with similar toxicity rates compared to conventional radiotherapy. While FDG-PET-guided dose-escalation did overall not lead to significant tumor control or survival improvements, post-hoc results showed improved locoregional control for patients with N0-1 disease or oropharyngeal cancer treated with rRT.
    Language English
    Publishing date 2024-04-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110281
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  10. Article: Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer.

    Ridder, Mischa de / Raaijmakers, Cornelis P J / Pameijer, Frank A / Bree, Remco de / Reinders, Floris C J / Doornaert, Patricia A H / Terhaard, Chris H J / Philippens, Marielle E P

    Cancers

    2022  Volume 14, Issue 12

    Abstract: In recent years, MRI-guided radiotherapy (MRgRT) has taken an increasingly important position in image-guided radiotherapy (IGRT). Magnetic resonance imaging (MRI) offers superior soft tissue contrast in anatomical imaging compared to computed tomography ...

    Abstract In recent years, MRI-guided radiotherapy (MRgRT) has taken an increasingly important position in image-guided radiotherapy (IGRT). Magnetic resonance imaging (MRI) offers superior soft tissue contrast in anatomical imaging compared to computed tomography (CT), but also provides functional and dynamic information with selected sequences. Due to these benefits, in current clinical practice, MRI is already used for target delineation and response assessment in patients with head and neck squamous cell carcinoma (HNSCC). Because of the close proximity of target areas and radiosensitive organs at risk (OARs) during HNSCC treatment, MRgRT could provide a more accurate treatment in which OARs receive less radiation dose. With the introduction of several new radiotherapy techniques (i.e., adaptive MRgRT, proton therapy, adaptive cone beam computed tomography (CBCT) RT, (daily) adaptive radiotherapy ensures radiation dose is accurately delivered to the target areas. With the integration of a daily adaptive workflow, interfraction changes have become visible, which allows regular and fast adaptation of target areas. In proton therapy, adaptation is even more important in order to obtain high quality dosimetry, due to its susceptibility for density differences in relation to the range uncertainty of the protons. The question is which adaptations during radiotherapy treatment are oncology safe and at the same time provide better sparing of OARs. For an optimal use of all these new tools there is an urgent need for an update of the target definitions in case of adaptive treatment for HNSCC. This review will provide current state of evidence regarding adaptive target definition using MR during radiotherapy for HNSCC. Additionally, future perspectives for adaptive MR-guided radiotherapy will be discussed.
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14123027
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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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