Article ; Online: The invention and development of enflurane, isoflurane, sevoflurane, and desflurane.
2008 Volume 108, Issue 3, Page(s) 531–533
Abstract: Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in ... ...
| Abstract | Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics. |
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| MeSH term(s) | Animals ; Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/trends ; Drug Design ; Enflurane/chemical synthesis ; Humans ; Hydrocarbons, Fluorinated/chemical synthesis ; Isoflurane/analogs & derivatives ; Isoflurane/chemical synthesis ; Methyl Ethers/chemical synthesis | ||||||||||
| Chemical Substances | Hydrocarbons, Fluorinated ; Methyl Ethers ; sevoflurane (38LVP0K73A) ; Enflurane (91I69L5AY5) ; desflurane (CRS35BZ94Q) ; Isoflurane (CYS9AKD70P) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2008-03 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 269-0 | ||||||||||
| ISSN | 1528-1175 ; 0003-3022 | ||||||||||
| ISSN (online) | 1528-1175 | ||||||||||
| ISSN | 0003-3022 | ||||||||||
| DOI | 10.1097/ALN.0b013e31816499cc | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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