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  1. Article ; Online: Different effects of inspiratory duration and expiratory duration on heart rate deceleration capacity and heart rate asymmetry.

    Wang, Yong-Ping / Kuo, Terry B J / Wang, Guo-Zhi / Yang, Cheryl C H

    European journal of applied physiology

    2024  

    Abstract: Purpose: Low values of heart rate deceleration capacity (DC) and heart rate asymmetry (HRA) are associated with cardiovascular risks. Slow respiration has been proven to enhance the magnitudes of these indexes, but individual inspiratory (T: Methods: ...

    Abstract Purpose: Low values of heart rate deceleration capacity (DC) and heart rate asymmetry (HRA) are associated with cardiovascular risks. Slow respiration has been proven to enhance the magnitudes of these indexes, but individual inspiratory (T
    Methods: We evaluated 14 seated healthy young adults who randomly controlled their breathing to nine combinations of T
    Results: The magnitude of DC increased when T
    Conclusion: We suggest that a T
    Language English
    Publishing date 2024-02-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-024-05433-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Distinguishing different types of attention deficit hyperactivity disorder in children using artificial neural network with clinical intelligent test.

    Lin, I-Cheng / Chang, Shen-Chieh / Huang, Yu-Jui / Kuo, Terry B J / Chiu, Hung-Wen

    Frontiers in psychology

    2023  Volume 13, Page(s) 1067771

    Abstract: Background: Attention deficit hyperactivity disorder (ADHD) is a well-studied topic in child and adolescent psychiatry. ADHD diagnosis relies on information from an assessment scale used by teachers and parents and psychological assessment by physicians; ...

    Abstract Background: Attention deficit hyperactivity disorder (ADHD) is a well-studied topic in child and adolescent psychiatry. ADHD diagnosis relies on information from an assessment scale used by teachers and parents and psychological assessment by physicians; however, the assessment results can be inconsistent.
    Purpose: To construct models that automatically distinguish between children with predominantly inattentive-type ADHD (ADHD-I), with combined-type ADHD (ADHD-C), and without ADHD.
    Methods: Clinical records with age 6-17 years-old, for January 2011-September 2020 were collected from local general hospitals in northern Taiwan; the data were based on the SNAP-IV scale, the second and third editions of Conners' Continuous Performance Test (CPT), and various intelligence tests. This study used an artificial neural network to construct the models. In addition,
    Results: We collected 328 records using CPT-3 and 239 records using CPT-2. With regard to distinguishing between ADHD-I and ADHD-C, a combination of demographic information, SNAP-IV scale results, and CPT-2 results yielded overall accuracies of 88.75 and 85.56% in the training and testing sets, respectively. The replacement of CPT-2 with CPT-3 results in this model yielded an overall accuracy of 90.46% in the training set and 89.44% in the testing set. With regard to distinguishing between ADHD-I, ADHD-C, and the absence of ADHD, a combination of demographic information, SNAP-IV scale results, and CPT-2 results yielded overall accuracies of 86.74 and 77.43% in the training and testing sets, respectively.
    Conclusion: This proposed model distinguished between the ADHD-I and ADHD-C groups with 85-90% accuracy, and it distinguished between the ADHD-I, ADHD-C, and control groups with 77-86% accuracy. The machine learning model helps clinicians identify patients with ADHD in a timely manner.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1067771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nociception Effect on Frontal Electroencephalogram Waveform and Phase-Amplitude Coupling in Laparoscopic Surgery.

    Wang, Tzu Chun / Li, Wei Yi / Lai, Jerry Cheng-Yen / Kuo, Terry B J / Yang, Cheryl C H

    Anesthesia and analgesia

    2023  Volume 138, Issue 5, Page(s) 1070–1080

    Abstract: Background: Electroencephalographic pattern changes during anesthesia reflect the nociception-analgesia balance. Alpha dropout, delta arousal, and beta arousal with noxious stimulation have been described during anesthesia; however, data on the reaction ...

    Abstract Background: Electroencephalographic pattern changes during anesthesia reflect the nociception-analgesia balance. Alpha dropout, delta arousal, and beta arousal with noxious stimulation have been described during anesthesia; however, data on the reaction of other electroencephalogram signatures toward nociception are scarce. Analyzing the effects of nociception on different electroencephalogram signatures may help us find new nociception markers in anesthesia and understand the neurophysiology of pain in the brain. This study aimed to analyze the electroencephalographic frequency pattern and phase-amplitude coupling change during laparoscopic surgeries.
    Methods: This study evaluated 34 patients who underwent laparoscopic surgery. The electroencephalogram frequency band power and phase-amplitude coupling of different frequencies were analyzed across 3 stages of laparoscopy: incision, insufflation, and opioid stages. Repeated-measures analysis of variance with a mixed model and the Bonferroni method for multiple comparisons were used to analyze the changes in the electroencephalogram signatures between the preincision and postincision/postinsufflation/postopioid phases.
    Results: During noxious stimulation, the frequency spectrum showed obvious decreases in the alpha power percentage after the incision (mean ± standard error of the mean [SEM], 26.27 ± 0.44 and 24.37 ± 0.66; P < .001) and insufflation stages (26.27 ± 0.44 and 24.40 ± 0.68; P = .002), which recovered after opioid administration. Further phase-amplitude analyses showed that the modulation index (MI) of the delta-alpha coupling decreased after the incision stage (1.83 ± 0.22 and 0.98 ± 0.14 [MI × 10 3 ]; P < .001), continued to be suppressed during the insufflation stage (1.83 ± 0.22 and 1.17 ± 0.15 [MI × 10 3 ]; P = .044), and recovered after opioid administration.
    Conclusions: Alpha dropout during noxious stimulation is observed in laparoscopic surgeries under sevoflurane. In addition, the modulation index of delta-alpha coupling decreases during noxious stimulation and recovers after the administration of rescue opioids. Phase-amplitude coupling of the electroencephalogram may be a new approach for evaluating the nociception-analgesia balance during anesthesia.
    MeSH term(s) Humans ; Analgesics, Opioid ; Nociception ; Electroencephalography ; Anesthesia ; Laparoscopy/adverse effects
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bright Morning Lighting Enhancing Parasympathetic Activity at Night

    Chuen-Ru Liu / Terry B. J. Kuo / Jwo-Huei Jou / Chun-Ting Lai Lai / Yu-Kai Chang / Yiing Mei Liou

    Healthcare, Vol 11, Iss 793, p

    A Pilot Study on Elderly Female Patients with Dementia without a Pacemaker

    2023  Volume 793

    Abstract: Exposure to bright morning light (BML) entrains the master circadian clock, modulates physiological circadian rhythms, and reduces sleep–wake disturbances. However, its impact on the autonomic nervous system at night remains unclear. Here, we ... ...

    Abstract Exposure to bright morning light (BML) entrains the master circadian clock, modulates physiological circadian rhythms, and reduces sleep–wake disturbances. However, its impact on the autonomic nervous system at night remains unclear. Here, we investigated the effects of BML exposure on parasympathetic nervous system (PSNS) and sympathetic nervous system (SNS) activity at night in elderly women. This nonrandomized controlled pilot study included female participants aged ≥ 60 years who were diagnosed with a type of dementia or cognitive disorder, excluding individuals with pacemakers. The treatment group was exposed to 2500 lx of BML, whereas the control group was exposed to 200 lx of general lighting. We measured heart rate variability to quantify ANS activity. The treatment group displayed significant increases in high-frequency (HF) power (Roy’s largest root = 1.62; p < 0.001) and nonsignificant decreases in normalized low-frequency (LF%) power. The corresponding nonsignificant decreases in the low-frequency/high-frequency (LF/HF) ratio and cognitive function were correlated with PSNS activity (Roy’s largest root = 1.41; p < 0.001), which improved severe dementia. BML exposure reduced SNS activity and enhanced PSNS activity at night in female participants, which improved cognitive function. Thus, BML therapy may be a useful clinical tool for alleviating cognitive decline.
    Keywords light therapy ; dementia ; heart rate variability ; cognitive function ; parasympathetic ; sympathetic ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Older rats show slow modulation of hippocampal theta rhythm during voluntary running

    Cheryl C.H. Yang / Terry B.J. Kuo / Chun-Hsiu Chen / Wei-Yi Li / Chang-Tsen Hung / Jia-Yi Li

    Experimental Gerontology, Vol 173, Iss , Pp 112092- (2023)

    2023  

    Abstract: Aging causes brain function degeneration and slows many motor and behavioural responses. The hippocampal theta rhythm (4–12 Hz) is related to cognition and locomotion. However, the findings on aging-related changes in the frequency and amplitude of ... ...

    Abstract Aging causes brain function degeneration and slows many motor and behavioural responses. The hippocampal theta rhythm (4–12 Hz) is related to cognition and locomotion. However, the findings on aging-related changes in the frequency and amplitude of hippocampal theta oscillations have been inconsistent. We hypothesized that older rats have slower responses in terms of hippocampal theta rhythm during voluntary wheel running than do young adult rats. By simultaneously recording electroencephalography and physical activity (PA), we evaluated theta oscillations in 8-week-old (young adult) and 60-week-old (middle-aged) rats before and during wheel running, which was conducted only during the rats' 12-h dark period. To test the alterations of hippocampal theta rhythm in voluntary wheel running, we analyzed the signals without (8-s) or with (2-s) chronological order. No significant difference was observed in total frequency (TP, 4–12 Hz), low-frequency (LT, 4–6.5 Hz), or high-frequency (9.5–12 Hz) theta activity between active waking and overall running in either group. The theta oscillations were slower in the middle-aged rats than in the young adult rats during wheel running but increased during running for both age groups. During wheel running, the middle-aged rats exhibited an increased LT, which was related to PA. On the basis of the chronological order of running, the young adult rats exhibited increased TP, and the middle-aged rats exhibited significant increases in middle-frequency (MT, 6.5–9.5 Hz) theta activity. The dominant modulations of MT in the middle-aged rats may have caused nonsignificant changes in total activity. These between-group differences in theta rhythm characteristics during voluntary running provide insights into age-related brain function decline.
    Keywords Aging ; Wheel running ; Hippocampal theta rhythm ; Physical activity ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Implementation of Wireless Biosensor for Continuous EEG Monitoring in Neurological Intensive Care.

    Hsu, Tien-Yu / Kuo, Terry B J / Lin, Ming-Chin

    Studies in health technology and informatics

    2020  Volume 270, Page(s) 1317–1318

    Abstract: Seizure is a common complication in a neurological intensive care unit (NICU) and it requires continuous electroencephalograms (EEG) monitoring. Implementation of EEG for each bed in a NICU is very expensive and require labor work for interpretation of ... ...

    Abstract Seizure is a common complication in a neurological intensive care unit (NICU) and it requires continuous electroencephalograms (EEG) monitoring. Implementation of EEG for each bed in a NICU is very expensive and require labor work for interpretation of EEG. To provide an affordable device of EEG in NICU, we developed a low-cost wireless biosensor, which utilized the current standard of the internet of things technology (IoT). In this study, we implement a wireless biosensor for continuous EEG monitoring in NICU and discuss its feasibility. To provide a low-cost EEG device, we embraced Bluetooth and mobile phone technology, which is convenient for implementation. We build a two-channel EEG biosensor, which utilizes Bluetooth to transmit the signal to mobile phones. Then, mobile phones use Wi-Fi technology to send data to the server. Additionally, we also developed a registry to organize the patient's EEG data. In six months research period, we have 65.8% of patients collected successfully. Using 2 channel-biosensor in NCU is feasible. It also develops a neuromedical database by collecting and monitoring physiological signals to develop future neuromedical research.
    MeSH term(s) Biosensing Techniques ; Cell Phone ; Critical Care ; Electroencephalography ; Humans ; Longitudinal Studies ; Monitoring, Physiologic ; Wireless Technology
    Language English
    Publishing date 2020-06-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI200420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Older rats show slow modulation of hippocampal theta rhythm during voluntary running.

    Yang, Cheryl C H / Kuo, Terry B J / Chen, Chun-Hsiu / Li, Wei-Yi / Hung, Chang-Tsen / Li, Jia-Yi

    Experimental gerontology

    2023  Volume 173, Page(s) 112092

    Abstract: Aging causes brain function degeneration and slows many motor and behavioural responses. The hippocampal theta rhythm (4-12 Hz) is related to cognition and locomotion. However, the findings on aging-related changes in the frequency and amplitude of ... ...

    Abstract Aging causes brain function degeneration and slows many motor and behavioural responses. The hippocampal theta rhythm (4-12 Hz) is related to cognition and locomotion. However, the findings on aging-related changes in the frequency and amplitude of hippocampal theta oscillations have been inconsistent. We hypothesized that older rats have slower responses in terms of hippocampal theta rhythm during voluntary wheel running than do young adult rats. By simultaneously recording electroencephalography and physical activity (PA), we evaluated theta oscillations in 8-week-old (young adult) and 60-week-old (middle-aged) rats before and during wheel running, which was conducted only during the rats' 12-h dark period. To test the alterations of hippocampal theta rhythm in voluntary wheel running, we analyzed the signals without (8-s) or with (2-s) chronological order. No significant difference was observed in total frequency (TP, 4-12 Hz), low-frequency (LT, 4-6.5 Hz), or high-frequency (9.5-12 Hz) theta activity between active waking and overall running in either group. The theta oscillations were slower in the middle-aged rats than in the young adult rats during wheel running but increased during running for both age groups. During wheel running, the middle-aged rats exhibited an increased LT, which was related to PA. On the basis of the chronological order of running, the young adult rats exhibited increased TP, and the middle-aged rats exhibited significant increases in middle-frequency (MT, 6.5-9.5 Hz) theta activity. The dominant modulations of MT in the middle-aged rats may have caused nonsignificant changes in total activity. These between-group differences in theta rhythm characteristics during voluntary running provide insights into age-related brain function decline.
    MeSH term(s) Rats ; Animals ; Theta Rhythm/physiology ; Motor Activity/physiology ; Hippocampus/physiology ; Electroencephalography ; Aging/physiology
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2023.112092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Bright Morning Lighting Enhancing Parasympathetic Activity at Night: A Pilot Study on Elderly Female Patients with Dementia without a Pacemaker.

    Liu, Chuen-Ru / Kuo, Terry B J / Jou, Jwo-Huei / Lai, Chun-Ting Lai / Chang, Yu-Kai / Liou, Yiing Mei

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 6

    Abstract: Exposure to bright morning light (BML) entrains the master circadian clock, modulates physiological circadian rhythms, and reduces sleep-wake disturbances. However, its impact on the autonomic nervous system at night remains unclear. Here, we ... ...

    Abstract Exposure to bright morning light (BML) entrains the master circadian clock, modulates physiological circadian rhythms, and reduces sleep-wake disturbances. However, its impact on the autonomic nervous system at night remains unclear. Here, we investigated the effects of BML exposure on parasympathetic nervous system (PSNS) and sympathetic nervous system (SNS) activity at night in elderly women. This nonrandomized controlled pilot study included female participants aged ≥ 60 years who were diagnosed with a type of dementia or cognitive disorder, excluding individuals with pacemakers. The treatment group was exposed to 2500 lx of BML, whereas the control group was exposed to 200 lx of general lighting. We measured heart rate variability to quantify ANS activity. The treatment group displayed significant increases in high-frequency (HF) power (Roy's largest root = 1.62;
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11060793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of mind-body exercise on body constitution and circadian rhythm in people with suboptimal health status.

    Kung, Yen-Ying / Shen, Yuh-Chiang / Li, Jia-Yi / Kao, Yao-Kai / Kuo, Terry B J / Yang, Cheryl C H

    Journal of the Chinese Medical Association : JCMA

    2023  Volume 87, Issue 1, Page(s) 94–102

    Abstract: Background: Suboptimal health status (SHS) is a dynamic state in which people have not been diagnosed with a disease but tend to develop diseases. People with SHS are more prone to conditions such as cardiovascular disease and metabolic syndrome. ... ...

    Abstract Background: Suboptimal health status (SHS) is a dynamic state in which people have not been diagnosed with a disease but tend to develop diseases. People with SHS are more prone to conditions such as cardiovascular disease and metabolic syndrome. Suitable interventions in people with SHS can prevent disease development. SHS is correlated with traditional Chinese medicine (TCM)-based constitutions, including Yang-Xu (yang deficiency), Yin-Xu (yin deficiency), and stasis types. The circadian rhythm is a potential biomarker of health and metabolism. Baduanjin exercise, a kind of mind-body exercise, has been regarded to adjust body constitution and metabolism, but few studies have evaluated the effects of Baduanjin exercise on body constitution and circadian rhythms. Therefore, this randomized controlled trial investigated the effects of Baduanjin exercise on body constitution and circadian rhythms in people with SHS.
    Methods: Seventy-six participants with SHS were divided into the Baduanjin exercise and control groups (watching a Baduanjin video), with the interventions lasting 12 weeks. The Body Constitution Questionnaire (BCQ), SHS Questionnaire-25 (SHSQ-25), and actigraphy for circadian rhythm measurement were conducted.
    Results: The scores of SHSQ-25, Yang-Xu, Yin-Xu, and BCQ stasis decreased significantly after 12 weeks in the Baduanjin exercise group, but not in the control group. Interdaily stability of the circadian rhythm increased significantly in the Baduanjin exercise group but not in the control group.
    Conclusion: This is the first report of improved health status, modulated body constitution, and increased interdaily stability of the circadian rhythm in participants with SHS who practiced Baduanjin exercise.
    MeSH term(s) Humans ; Medicine, Chinese Traditional ; Yang Deficiency/diagnosis ; Yin Deficiency/diagnosis ; Exercise Therapy ; Body Constitution
    Language English
    Publishing date 2023-10-27
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000001014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

    Ho, Yu-Ting / Tsai, Ying-Chieh / Kuo, Terry B. J. / Yang, Cheryl C. H.

    Nutrients. 2021 Aug. 17, v. 13, no. 8

    2021  

    Abstract: Recent animal studies have supported that Lactobacillus plantarum PS128 (PS128) can reduce the severity of anxiety and depression. However, previous studies did not focus on the sleep quality and mood of humans. This study determines whether PS128 ... ...

    Abstract Recent animal studies have supported that Lactobacillus plantarum PS128 (PS128) can reduce the severity of anxiety and depression. However, previous studies did not focus on the sleep quality and mood of humans. This study determines whether PS128 reduces the severity of anxiety and depressive symptoms, regulates autonomic nervous system function, and improves sleep quality. Forty participants between 20 and 40 years of age with self-reported insomnia were randomly assigned to two groups, a PS128 group and a placebo group, in a double-blind trial. Participants took two capsules of either PS128 or a placebo after dinner for 30 days. Study measures included subjective depressive symptoms, anxiety and sleep questionnaires, and miniature-polysomnography recordings at baseline and on the 15th and 30th days of taking capsules. Overall, all outcomes were comparable between the two groups at baseline and within the 30-day period, yet some differences were still found. Compared to the control group, the PS128 group showed significant decreases in Beck Depression Inventory-II scores, fatigue levels, brainwave activity, and awakenings during the deep sleep stage. Their improved depressive symptoms were related to changes in brain waves and sleep maintenance. These findings suggest that daily administration of PS128 may lead to a decrease in depressive symptoms, fatigue level, cortical excitation, and an improvement in sleep quality during the deep sleep stage. Daily consumption of PS128 as a dietary supplement may improve the depressive symptoms and sleep quality of insomniacs, although further investigation is warranted.
    Keywords Lactobacillus plantarum ; anxiety ; autonomic nervous system ; brain ; dietary supplements ; dinner ; placebos ; sleep ; sleep disorders
    Language English
    Dates of publication 2021-0817
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13082820
    Database NAL-Catalogue (AGRICOLA)

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