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  1. Article ; Online: Functional communication between IP

    Ahmad, Moaz / Ong, Hwei Ling / Saadi, Hassan / Son, Ga-Yeon / Shokatian, Zahra / Terry, Lara E / Trebak, Mohamed / Yule, David I / Ambudkar, Indu

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 3

    Abstract: Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [ ... ...

    Abstract Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling/physiology ; Cell Membrane/metabolism ; Cluster Analysis ; Endoplasmic Reticulum/metabolism ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Neoplasm Proteins ; Stromal Interaction Molecule 1 ; Stromal Interaction Molecule 2/chemistry ; Stromal Interaction Molecule 2/genetics ; Stromal Interaction Molecule 2/metabolism
    Chemical Substances Inositol 1,4,5-Trisphosphate Receptors ; Neoplasm Proteins ; STIM1 protein, human ; STIM2 protein, human ; Stromal Interaction Molecule 1 ; Stromal Interaction Molecule 2 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2114928118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.

    Terry, Lara E / Alzayady, Kamil J / Wahl, Amanda M / Malik, Sundeep / Yule, David I

    The Journal of biological chemistry

    2020  Volume 295, Issue 52, Page(s) 18160–18178

    Abstract: The inositol 1,4,5-trisphosphate ( ... ...

    Abstract The inositol 1,4,5-trisphosphate (IP
    MeSH term(s) Amino Acid Sequence ; Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Calcium/metabolism ; Calcium Signaling ; Chickens ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Ion Channel Gating ; Mutation ; Protein Multimerization ; Sequence Homology
    Chemical Substances Inositol 1,4,5-Trisphosphate Receptors ; Inositol 1,4,5-Trisphosphate (85166-31-0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA120.015683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease.

    Terry, Lara E / Alzayady, Kamil J / Furati, Esraa / Yule, David I

    Messenger (Los Angeles, Calif. : Print)

    2018  Volume 6, Issue 1-2, Page(s) 29–44

    Abstract: Calcium release into the cytosol via the inositol 1,4,5-trisphosphate receptor ( ... ...

    Abstract Calcium release into the cytosol via the inositol 1,4,5-trisphosphate receptor (IP
    Language English
    Publishing date 2018-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2167-955X
    ISSN 2167-955X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors.

    Arige, Vikas / Terry, Lara E / Malik, Sundeep / Knebel, Taylor R / Wagner Ii, Larry E / Yule, David I

    Journal of cell science

    2021  Volume 134, Issue 20

    Abstract: Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a central role in regulating intracellular Ca2+ signals in response to a variety of internal and external cues. Dysregulation of IP3R signaling is the underlying cause for numerous pathological ... ...

    Abstract Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a central role in regulating intracellular Ca2+ signals in response to a variety of internal and external cues. Dysregulation of IP3R signaling is the underlying cause for numerous pathological conditions. It is well established that the activities of IP3Rs are governed by several post-translational modifications, including phosphorylation by protein kinase A (PKA). However, the long-term effects of PKA activation on expression of IP3R subtypes remains largely unexplored. In this report, we investigate the effects of chronic stimulation and tonic activity of PKA on the expression of IP3R subtypes. We demonstrate that expression of the type 1 IP3R (IP3R1) is augmented upon prolonged activation of PKA or upon ectopic overexpression of cyclic AMP-response element-binding protein (CREB) without altering IP3R2 and IP3R3 abundance. By contrast, inhibition of PKA or blocking CREB diminished IP3R1 expression. We also demonstrate that agonist-induced Ca2+-release mediated by IP3R1 is significantly attenuated upon blocking of CREB. Moreover, CREB - by regulating the expression of KRAS-induced actin-interacting protein (KRAP) - ensures correct localization and licensing of IP3R1. Overall, we report a crucial role for CREB in governing both the expression and correct localization of IP3R1. This article has an associated First Person interview with the first author of the paper.
    MeSH term(s) Calcium/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; Cyclic AMP-Dependent Protein Kinases/genetics ; Humans ; Inositol ; Inositol 1,4,5-Trisphosphate ; Inositol 1,4,5-Trisphosphate Receptors/genetics
    Chemical Substances Cyclic AMP Response Element-Binding Protein ; Inositol 1,4,5-Trisphosphate Receptors ; Inositol (4L6452S749) ; Inositol 1,4,5-Trisphosphate (85166-31-0) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.258875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Suppression of store-operated Ca

    Terry, Lara E / VerMeer, Mark / Giles, Jennifer / Tran, Quang-Kim

    The Biochemical journal

    2017  Volume 474, Issue 21, Page(s) 3627–3642

    Abstract: The G protein-coupled estrogen receptor 1 (GPER, formerly also known as GPR30) modulates many ... ...

    Abstract The G protein-coupled estrogen receptor 1 (GPER, formerly also known as GPR30) modulates many Ca
    MeSH term(s) Amino Acid Substitution ; Animals ; Bradykinin/pharmacology ; Calcium Signaling ; Cyclopentanes/pharmacology ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; HEK293 Cells ; Humans ; Models, Biological ; Mutation, Missense ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Quinolines/pharmacology ; Stromal Interaction Molecule 1/antagonists & inhibitors ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Swine
    Chemical Substances 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone ; Cyclopentanes ; Neoplasm Proteins ; Quinolines ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2017-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20170630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca

    Terry, Lara E / Arige, Vikas / Neumann, Julika / Wahl, Amanda M / Knebel, Taylor R / Chaffer, James W / Malik, Sundeep / Liston, Adrian / Humblet-Baron, Stephanie / Bultynck, Geert / Yule, David I

    iScience

    2022  Volume 25, Issue 12, Page(s) 105523

    Abstract: Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor ... ...

    Abstract Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105523
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  7. Article ; Online: Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.

    Arige, Vikas / Terry, Lara E / Wagner, Larry E / Malik, Sundeep / Baker, Mariah R / Fan, Guizhen / Joseph, Suresh K / Serysheva, Irina I / Yule, David I

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 39, Page(s) e2209267119

    Abstract: Inositol 1,4,5-trisphosphate receptors ( ... ...

    Abstract Inositol 1,4,5-trisphosphate receptors (IP
    MeSH term(s) Adenosine Triphosphate ; Amino Acids, Basic ; Binding Sites ; Calcium/metabolism ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism
    Chemical Substances Amino Acids, Basic ; Inositol 1,4,5-Trisphosphate Receptors ; Ryanodine Receptor Calcium Release Channel ; Inositol 1,4,5-Trisphosphate (85166-31-0) ; Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2209267119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Conformational motions and ligand-binding underlying gating and regulation in IP

    Fan, Guizhen / Baker, Mariah R / Terry, Lara E / Arige, Vikas / Chen, Muyuan / Seryshev, Alexander B / Baker, Matthew L / Ludtke, Steven J / Yule, David I / Serysheva, Irina I

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6942

    Abstract: Inositol-1,4,5-trisphosphate receptors ( ... ...

    Abstract Inositol-1,4,5-trisphosphate receptors (IP
    MeSH term(s) Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Calcium/metabolism ; Ligands ; Protein Domains ; Inositol 1,4,5-Trisphosphate/metabolism ; Calcium Signaling
    Chemical Substances Inositol 1,4,5-Trisphosphate Receptors ; Calcium (SY7Q814VUP) ; Ligands ; Inositol 1,4,5-Trisphosphate (85166-31-0)
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34574-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bcl-2-Protein Family as Modulators of IP

    Ivanova, Hristina / Vervliet, Tim / Monaco, Giovanni / Terry, Lara E / Rosa, Nicolas / Baker, Mariah R / Parys, Jan B / Serysheva, Irina I / Yule, David I / Bultynck, Geert

    Cold Spring Harbor perspectives in biology

    2020  Volume 12, Issue 4

    Abstract: The pro- and antiapoptotic proteins belonging to the B-cell lymphoma-2 (Bcl-2) family exert a critical control over cell-death processes by enabling or counteracting mitochondrial outer membrane permeabilization. Beyond this mitochondrial function, ... ...

    Abstract The pro- and antiapoptotic proteins belonging to the B-cell lymphoma-2 (Bcl-2) family exert a critical control over cell-death processes by enabling or counteracting mitochondrial outer membrane permeabilization. Beyond this mitochondrial function, several Bcl-2 family members have emerged as critical modulators of intracellular Ca
    MeSH term(s) Animals ; Apoptosis ; Calcium/metabolism ; Endoplasmic Reticulum/metabolism ; Fibroblasts/metabolism ; Homeostasis ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mice ; Mitochondria/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Protein Domains ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Voltage-Dependent Anion Channel 1/metabolism ; bcl-X Protein/metabolism
    Chemical Substances BCL2L1 protein, human ; Inositol 1,4,5-Trisphosphate Receptors ; MCL1 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2 ; VDAC1 protein, human ; bcl-X Protein ; Voltage-Dependent Anion Channel 1 (EC 1.6.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a035089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author Correction: Disrupted Ca

    Neumann, Julika / Van Nieuwenhove, Erika / Terry, Lara E / Staels, Frederik / Knebel, Taylor R / Welkenhuyzen, Kirsten / Ahmadzadeh, Kourosh / Baker, Mariah R / Gerbaux, Margaux / Willemsen, Mathijs / Barber, John S / Serysheva, Irina I / De Waele, Liesbeth / Vermeulen, François / Schlenner, Susan / Meyts, Isabelle / Yule, David I / Bultynck, Geert / Schrijvers, Rik /
    Humblet-Baron, Stephanie / Liston, Adrian

    Cellular & molecular immunology

    2022  

    Language English
    Publishing date 2022-12-06
    Publishing country China
    Document type Published Erratum
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00960-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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