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  1. Article ; Online: Delivering Precision Oncology in a Community Cancer Program: Results From a Prospective Observational Study.

    Powell, Steven F / Dib, Elie G / Bleeker, Jonathan S / Keppen, Michael D / Mazurczak, Miroslaw / Hack, Keely M / Gitau, Mark M / Steen, Preston D / Terstriep, Shelby A / Reynolds, John / Landsverk, Megan L / Chan, Chun-Hung / Nelson, Morgan E / Thompson, Paul A / Ellison, Christie / Black, Lora J / Ford, James M / Chung, Jon H / Anhorn, Rachel /
    Gaba, Anu G

    JCO precision oncology

    2022  Volume 2, Page(s) 1–12

    Abstract: Introduction: Precision oncology (PO) is a growing treatment approach in the era of next-generation sequencing (NGS) and matched therapies. Effective delivery of PO in the community has not been extensively studied. Our program developed a virtual ... ...

    Abstract Introduction: Precision oncology (PO) is a growing treatment approach in the era of next-generation sequencing (NGS) and matched therapies. Effective delivery of PO in the community has not been extensively studied. Our program developed a virtual molecular tumor board (MTB) strategy to help guide PO care.
    Materials and methods: Over 18 months, eligible adult patients with advanced, incurable solid tumor malignancies were enrolled in a molecular profiling (MP) study using the Foundation Medicine NGS panel. Results were reviewed through a weekly, videoconferenced MTB conducted across our largely rural integrated health system. Recommendations from the MTB were used to identify actionable alterations (AAs). Feasibility of PO care delivery was assessed as the primary outcome. Secondary outcomes included the frequency of AAs, genomic matched treatments, genomic matched clinical trial enrollment, and clinical outcomes.
    Results: A total of 120 participants with a variety of advanced tumor types were enrolled. Of these, 109 (90.8%) had successful MP. Treatment on the basis of an AA was recommended by the MTB in 58% of patients (63 of 109) who had a successful MP result. For those completing MP, treatments included enrollment in a genomic matched clinical trial (n = 16; 14.6%) and genomic matched treatment with a Food and Drug Administration-approved agent (n = 23; 21.1%). Response and survival data were similar regardless of the matched treatment option chosen.
    Conclusion: A video-conferenced MTB-facilitated NGS testing and treatment delivery system was implemented in our integrated community oncology program. Continued use of this model aims to increase understanding of the impact of PO in this setting.
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.17.00220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance).

    Barton, Debra L / Shuster, Lynne T / Dockter, Travis / Atherton, Pamela J / Thielen, Jacqueline / Birrell, Stephen N / Sood, Richa / Griffin, Patricia / Terstriep, Shelby A / Mattar, Bassam / Lafky, Jacqueline M / Loprinzi, Charles L

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2017  Volume 26, Issue 4, Page(s) 1335–1343

    Abstract: Background: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history.: Methods: ... ...

    Abstract Background: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history.
    Methods: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3.25 versus 6.5 mg/day of DHEA versus a plain moisturizer (PM) control. Sex steroid hormone levels, biomarkers of bone formation, vaginal pH, and maturation index were collected at baseline and 12 weeks. Analysis included independent t tests and Wilcoxon rank tests, comparing each DHEA arm with the control.
    Results: Three hundred forty-five women contributed evaluable blood and 46 contributed evaluable cytology and pH values. Circulating DHEA-S and testosterone levels were significantly increased in those on vaginal DHEA in a dose-dependent manner compared to PM. Estradiol was significantly increased in those on 6.5 mg/day DHEA but not in those on 3.25 mg/day DHEA (p < 0.05 and p = 0.05, respectively), and not in those on AIs. Biomarkers of bone formation were unchanged in all arms. Maturation of vaginal cells was 100% (3.25 mg/day), 86% (6.5 mg/day), and 64% (PM); pH decreased more in DHEA arms.
    Conclusion: DHEA resulted in increased hormone concentrations, though still in the lowest half or quartile of the postmenopausal range, and provided more favorable effects on vaginal cytology, compared to PM. Estrogen concentrations in women on AIs were not changed. Further research on the benefit of vaginal DHEA is warranted in hormone-dependent cancers.
    MeSH term(s) Administration, Intravaginal ; Aromatase Inhibitors/administration & dosage ; Breast Neoplasms/blood ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Dehydroepiandrosterone/administration & dosage ; Dehydroepiandrosterone Sulfate/blood ; Estradiol/blood ; Female ; Genital Neoplasms, Female/blood ; Genital Neoplasms, Female/drug therapy ; Genital Neoplasms, Female/pathology ; Gonadal Steroid Hormones/blood ; Humans ; Middle Aged ; Osteogenesis/drug effects ; Postmenopause ; Tamoxifen/administration & dosage ; Testosterone/blood ; Vagina/drug effects ; Vagina/pathology
    Chemical Substances Aromatase Inhibitors ; Gonadal Steroid Hormones ; Tamoxifen (094ZI81Y45) ; Testosterone (3XMK78S47O) ; Dehydroepiandrosterone (459AG36T1B) ; Estradiol (4TI98Z838E) ; Dehydroepiandrosterone Sulfate (57B09Q7FJR)
    Language English
    Publishing date 2017-11-21
    Publishing country Germany
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-017-3960-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance).

    Barton, Debra L / Sloan, Jeff A / Shuster, Lynne T / Gill, Paula / Griffin, Patricia / Flynn, Kathleen / Terstriep, Shelby A / Rana, Fauzia N / Dockter, Travis / Atherton, Pamela J / Tsai, Michaela / Sturtz, Keren / Lafky, Jacqueline M / Riepl, Mike / Thielen, Jacqueline / Loprinzi, Charles L

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2017  Volume 26, Issue 2, Page(s) 643–650

    Abstract: Background: Women with estrogen deficiencies can suffer from vaginal symptoms that negatively impact sexual health. This study evaluated vaginal dehydroepiandrosterone (DHEA) for alleviation of vaginal symptoms.: Methods: This three-arm randomized, ... ...

    Abstract Background: Women with estrogen deficiencies can suffer from vaginal symptoms that negatively impact sexual health. This study evaluated vaginal dehydroepiandrosterone (DHEA) for alleviation of vaginal symptoms.
    Methods: This three-arm randomized, controlled trial evaluated DHEA 3.25 mg and DHEA 6.5 mg, each compared to a plain moisturizer (PM) over 12 weeks, to improve the severity of vaginal dryness or dyspareunia, measured with an ordinal scale, and overall sexual health using the Female Sexual Function Index (FSFI). Postmenopausal women with a history of breast or gynecologic cancer who had completed primary treatment, had no evidence of disease, and reported at least moderate vaginal symptoms were eligible. The mean change from baseline to week 12 in the severity of vaginal dryness or dyspareunia for each DHEA dose was compared to PM and analyzed by two independent t tests using a Bonferroni correction.
    Results: Four hundred sixty-four women were randomized. All arms reported improvement in either dryness or dyspareunia. Neither DHEA dose was statistically significantly different from PM at 12 weeks (6.25 mg, p = .08; 3.25 mg, p = 0.48), although a significant difference at 8 weeks for 6.5 mg DHEA was observed (p = 0.005). Women on the 6.5 mg arm of DHEA reported significantly better sexual health on the FSFI (p < 0.001). There were no significant differences in provider-graded toxicities and few significant differences in self-reported side effects.
    Conclusion: PM and DHEA improved vaginal symptoms at 12 weeks. However, vaginal DHEA, 6.5 mg, significantly improved sexual health. Vaginal DHEA warrants further investigation in women with a history of cancer.
    MeSH term(s) Administration, Intravaginal ; Cancer Survivors ; Dehydroepiandrosterone/pharmacology ; Dehydroepiandrosterone/therapeutic use ; Female ; Humans ; Middle Aged ; Postmenopause ; Vaginal Diseases/drug therapy
    Chemical Substances Dehydroepiandrosterone (459AG36T1B)
    Language English
    Publishing date 2017-09-18
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-017-3878-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The impact of multi-modal therapy on survival for uterine carcinosarcomas.

    Gonzalez Bosquet, Jesus / Terstriep, Shelby A / Cliby, William A / Brown-Jones, Monica / Kaur, Judith S / Podratz, Karl C / Keeney, Gary L

    Gynecologic oncology

    2009  Volume 116, Issue 3, Page(s) 419–423

    Abstract: Objectives: To investigate treatment outcomes of patients with carcinosarcoma of the uterus and to identify parameters predictive of survival. Secondary objectives included (a) the assessment of treatment failures as a function of histologic subtypes ... ...

    Abstract Objectives: To investigate treatment outcomes of patients with carcinosarcoma of the uterus and to identify parameters predictive of survival. Secondary objectives included (a) the assessment of treatment failures as a function of histologic subtypes and (b) the impact of the new FIGO staging classification system.
    Methods: This is a retrospective outcomes analysis of 121 patients diagnosed with primary carcinosarcoma of the uterus. Clinical, surgical and pathological data were reviewed and patients were classified according to the new 2009 FIGO staging system for endometrial carcinoma. Survivorship curves were evaluated with the log-rank test and associations between events and variables with Cox proportional hazards model.
    Results: In the multivariate analyses for disease-specific survival (DSS) and disease-free survival (DFS), the only independent factors were FIGO stage, adjuvant chemotherapy after surgery and the presence of clear cell histology in the tumor. The 5-year DSS for stages I-II, III and IV was 59%, 22% and 9%, respectively. The administration of platin-based chemotherapy provided a significant benefit with regard to both DFS (OR=0.28; p=0.001) and DSS (OR=0.35; p=0.01). While radiotherapy (RT) appeared to control vaginal failures in all stages, pelvic RT did not impact DSS. Of importance, the epithelial component was the predominant histology in both the primary extrauterine metastases (94%) and the distant failure sites (82%).
    Conclusions: This highly aggressive uterine malignancy warrants comprehensive surgical staging to assess tumor dissemination followed by systemic therapy in patients with both early and advanced stage disease.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Endometrioid/pathology ; Carcinoma, Endometrioid/therapy ; Carcinosarcoma/pathology ; Carcinosarcoma/therapy ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Treatment Outcome ; Uterine Neoplasms/pathology ; Uterine Neoplasms/therapy ; Young Adult
    Language English
    Publishing date 2009-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2009.10.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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