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  1. AU="Terwilliger, Gordon"
  2. AU="Elhamzaoui, Hamza"
  3. AU="Béganton, Benoît"
  4. AU=Smith Zachary D.
  5. AU="Dotta, Federico"
  6. AU="Palmer, Andre"
  7. AU="Cai, Biao"
  8. AU="Leroux, Michel R"
  9. AU="Thomson, Jaidyn"
  10. AU="Novillo-Del Álamo, Blanca"
  11. AU="Deps, Patrícia D"

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  1. Artikel ; Online: Compartmentalized ocular lymphatic system mediates eye-brain immunity.

    Yin, Xiangyun / Zhang, Sophia / Lee, Ju Hyun / Dong, Huiping / Mourgkos, George / Terwilliger, Gordon / Kraus, Aurora / Geraldo, Luiz Henrique / Poulet, Mathilde / Fischer, Suzanne / Zhou, Ting / Mohammed, Farrah Shalima / Zhou, Jiangbing / Wang, Yongfu / Malloy, Seth / Rohner, Nicolas / Sharma, Lokesh / Salinas, Irene / Eichmann, Anne /
    Thomas, Jean-Leon / Saltzman, W Mark / Huttner, Anita / Zeiss, Caroline / Ring, Aaron / Iwasaki, Akiko / Song, Eric

    Nature

    2024  Band 628, Heft 8006, Seite(n) 204–211

    Abstract: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the ... ...

    Abstract The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina
    Mesh-Begriff(e) Animals ; Female ; Humans ; Male ; Mice ; Rabbits ; Bacteria/immunology ; Brain/anatomy & histology ; Brain/immunology ; Dependovirus/immunology ; Eye/anatomy & histology ; Eye/immunology ; Glioblastoma/immunology ; Herpesvirus 2, Human/immunology ; Intravitreal Injections ; Lymphatic System/anatomy & histology ; Lymphatic System/immunology ; Lymphatic Vessels/anatomy & histology ; Lymphatic Vessels/immunology ; Macaca mulatta ; Meninges/immunology ; Optic Nerve/immunology ; Swine ; Zebrafish ; Vascular Endothelial Growth Factor C/immunology ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor C/pharmacology
    Chemische Substanzen Vascular Endothelial Growth Factor C
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07130-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques.

    Bathla, Shveta / Datta, Dibyadeep / Liang, Feng / Barthelemy, Nicolas / Wiseman, Robyn / Slusher, Barbara S / Asher, Jennifer / Zeiss, Caroline / Ekanayake-Alper, Dil / Holden, Daniel / Terwilliger, Gordon / Duque, Alvaro / Arellano, Jon / van Dyck, Christopher / Bateman, Randall J / Xie, Zhongcong / Nairn, Angus C / Arnsten, Amy F T

    Alzheimer's & dementia (New York, N. Y.)

    2023  Band 9, Heft 4, Seite(n) e12431

    Abstract: Introduction: Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1-42 (Aβ: Methods: Aged rhesus macaques were treated daily with the GCPII inhibitor, 2-MPPA (2-3-mercaptopropyl-penanedioic acid (2-MPPA) ...

    Abstract Introduction: Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1-42 (Aβ
    Methods: Aged rhesus macaques were treated daily with the GCPII inhibitor, 2-MPPA (2-3-mercaptopropyl-penanedioic acid (2-MPPA)),Aged rhesus macaques were treated daily with the GCPII inhibitor, 2-MPPA (2-3-mercaptopropyl-penanedioic acid (2-MPPA)).
    Results: Aged macaques that received 2-MPPA had significantly lower pT217Tau levels in dlPFC and ERC, and had lowered plasma pT217Tau levels from baseline. pT217Tau levels correlated significantly with GCPII activity in dlPFC. Both 2-MPPA- and vehicle-treated monkeys showed cognitive improvement; 2-MPPA had no apparent side effects. Exploratory CSF analyses indicated reduced pS202Tau with 2-MPPA administration, confirmed in dlPFC samples.
    Discussion: These data provide proof-of-concept support that GCPII inhibition can reduce tau hyperphosphorylation in the primate cortices most vulnerable in sAD. GCPII inhibition may be particularly helpful in reducing the risk of sAD caused by inflammation. These data in nonhuman primates should encourage future research on this promising mechanism.
    Highlights: Inflammation is a key driver of sporadic Alzheimer's disease.GCPII inflammatory signaling in brain decreases mGluR3 regulation of calcium.Chronic inhibition of GCPII inflammatory signaling reduced pT217Tau in aged monkeys.GCPII inhibition is a novel strategy to help prevent tau pathology at early stages.
    Sprache Englisch
    Erscheinungsdatum 2023-10-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2832891-7
    ISSN 2352-8737 ; 2352-8737
    ISSN (online) 2352-8737
    ISSN 2352-8737
    DOI 10.1002/trc2.12431
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Fungal polymerase chain reaction testing in equine ulcerative keratitis.

    Zeiss, Caroline / Neaderland, Marjorie / Yang, Fu-Chen / Terwilliger, Gordon / Compton, Susan

    Veterinary ophthalmology

    2013  Band 16, Heft 5, Seite(n) 341–351

    Abstract: Objective: To assess the diagnostic utility of fungal polymerase chain reaction (PCR) in forty-three horses with naturally acquired corneal ulcers presenting to a private practice.: Methods: Routine evaluation of cytologic, histologic, and ... ...

    Abstract Objective: To assess the diagnostic utility of fungal polymerase chain reaction (PCR) in forty-three horses with naturally acquired corneal ulcers presenting to a private practice.
    Methods: Routine evaluation of cytologic, histologic, and microbiologic samples was performed. Two PCR approaches were compared - generic and specific fungal nested PCR followed by sequencing and quantitative PCR (qPCR). PCRs were applied to pure control fungal cultures, corneal tissue from ulcerated eyes and in a subset of 9 horses, to swabs from contralateral normal eyes.
    Results: The expected fungus was identified by nested PCR and qPCR in all control fungal cultures. In all fungal culture-positive affected eyes (10/43), one or more fungi were identified by nested PCR and 4/10 were positive by qPCR. In 6/10 animals, the same fungus was identified by nested PCR and culture. Of these 6, only three were positive by qPCR. Fungal agents were identified by morphology in 8/10 horses. Diagnosis of fungal keratitis was reserved for only those cases in which the same fungus could be identified by PCR, culture, and morphology (5 horses). In 33/43 culture-negative affected eyes and in 6/9 unaffected eyes, one or more fungi were identified by nested PCR in 26 samples and by qPCR in 2 samples. Apart from Aspergillus spp, similar fungi were identified in affected and control eyes. Most eyes harbored mixed bacterial and fungal agents.
    Conclusions: Nested PCR results confirmed all cytologically positive cases of fungal keratitis. Nested PCR identified a greater spectrum of agents than either culture or qPCR.
    Mesh-Begriff(e) Animals ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; Bacterial Infections/veterinary ; Corneal Ulcer/microbiology ; Corneal Ulcer/veterinary ; Horse Diseases/diagnosis ; Horse Diseases/microbiology ; Horses ; Mycoses/diagnosis ; Mycoses/veterinary ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/veterinary
    Sprache Englisch
    Erscheinungsdatum 2013-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2011043-1
    ISSN 1463-5224 ; 1463-5216
    ISSN (online) 1463-5224
    ISSN 1463-5216
    DOI 10.1111/vop.12004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Iatrogenic tension pneumothorax in a rabbit (Oryctolagus cuniculus).

    Reuter, Jon D / Fowles, Krista J / Terwilliger, Gordon A / Booth, Carmen J

    Contemporary topics in laboratory animal science

    2005  Band 44, Heft 4, Seite(n) 22–25

    Abstract: The following case report describes a complication after accidental overinflation of the lungs in an anesthetized rabbit. After anesthetic induction, endotracheal intubation, and preparation for surgery, the rabbit's arterial oxygen saturation dropped. ... ...

    Abstract The following case report describes a complication after accidental overinflation of the lungs in an anesthetized rabbit. After anesthetic induction, endotracheal intubation, and preparation for surgery, the rabbit's arterial oxygen saturation dropped. Positive-pressure ventilation was administered using manual compression on the reservoir bag. The rabbit's condition rapidly deteriorated, and emergency treatment including oxygen, anesthetic reversal, and thoracocentesis was initiated. The rabbit failed to respond to therapy. A focal, acute, alveolar, vascular, and pleural rupture of the right caudal medial lung lobe with secondary pulmonary tension pneumothorax and atelectasis was identified postmortem. The etiology and pathophysiology of the clinical signs are reviewed. Pulmonary pressure overload after manual or assisted ventilation and subsequent stress failure occurs when pulmonary pressures approach 40 mm Hg. Close attention to the animal's size, tidal volume, and potentially altered pulmonary elasticity from pre-existing lung disease may help reduce the incidence of failure. Successful therapy of iatrogenic pneumothorax may necessitate both medical and surgical intervention.
    Mesh-Begriff(e) Animals ; Fatal Outcome ; Iatrogenic Disease/veterinary ; Lung/pathology ; Pneumothorax/etiology ; Pneumothorax/pathology ; Pneumothorax/veterinary ; Rabbits ; Radiography, Thoracic/veterinary ; Respiration, Artificial/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2005-07
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Comparative Study ; Journal Article
    ISSN 1060-0558
    ISSN 1060-0558
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Inducible, reversible hair loss in transgenic mice.

    Chen, Jingshan / Kelz, Max B / Zeng, Guoqi / Steffen, Cathy / Shockett, Penny E / Terwilliger, Gordon / Schatz, David G / Nestler, Eric J

    Transgenic research

    2002  Band 11, Heft 3, Seite(n) 241–247

    Abstract: Telogen effluvium is a common type of hair loss. Although the morphological changes associated with telogen effluvium have been well characterized, the underlying molecular mechanisms remain unknown, and no animal models have been developed. We report ... ...

    Abstract Telogen effluvium is a common type of hair loss. Although the morphological changes associated with telogen effluvium have been well characterized, the underlying molecular mechanisms remain unknown, and no animal models have been developed. We report here that inducible transgenic mice expressing high levels of the transcription factor, tTA (tetracycline transactivator), plus a reporter luciferase gene, show a reversible hair loss phenotype. Skin of these mice exhibits an increase in the number of hair follicles at the telogen phase, but a decreased number of follicles at the anagen phase. These changes resemble skin pathology seen in patients with telogen effluvium, which suggests that the inducible transgenic mice may be useful as a model for this disorder. Moreover, since overexpression of several other transgenes failed to cause skin pathology, the present findings also indicate types of molecular abnormalities that may cause reversible hair loss.
    Mesh-Begriff(e) Alopecia/etiology ; Alopecia/genetics ; Alopecia/metabolism ; Animals ; Disease Models, Animal ; Doxycycline/metabolism ; Doxycycline/pharmacology ; Gene Expression Regulation/drug effects ; Mice ; Mice, Transgenic ; Tetracycline/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism
    Chemische Substanzen Trans-Activators ; Tetracycline (F8VB5M810T) ; Doxycycline (N12000U13O)
    Sprache Englisch
    Erscheinungsdatum 2002-07-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 31620-9
    ISSN 1573-9368 ; 0962-8819
    ISSN (online) 1573-9368
    ISSN 0962-8819
    DOI 10.1023/a:1015619604318
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Ancylostoma caninum Anticoagulant Peptide Blocks Metastasis In Vivo and Inhibits Factor Xa Binding to Melanoma Cells In Vitro

    Donnelly, Kathleen M. / Bromberg, Michael E. / Milstone, Aaron / McNiff, Jennifer Madison / Terwilliger, Gordon / Konigsberg, William H. / Cappello, Michael

    Thrombosis and Haemostasis

    1998  Band 79, Heft 05, Seite(n) 1041–1047

    Abstract: We evaluated the in vivo anti-metastatic activity of recombinant Ancylostoma caninum Anticoagulant Peptide (rAcAP), a potent ( K i = 265 pM) and specific active site inhibitor of human coagulation factor Xa originally isolated from bloodfeeding ... ...

    Abstract We evaluated the in vivo anti-metastatic activity of recombinant Ancylostoma caninum Anticoagulant Peptide (rAcAP), a potent ( K i = 265 pM) and specific active site inhibitor of human coagulation factor Xa originally isolated from bloodfeeding hookworms. Subcutaneous injection of SCID mice with rAcAP (0.01-0.2 mg/mouse) prior to tail vein injection of LOX human melanoma cells resulted in a dose dependent reduction in pulmonary metastases. In order to elucidate potential mechanisms of rAcAP’s anti-metastatic activity, experiments were carried out to identify specific interactions between factor Xa and LOX. Binding of biotinylated factor Xa to LOX monolayers was both specific and saturable ( K d = 15 nM). Competition experiments using antibodies to previously identified factor Xa binding proteins, including factor V/Va, effector cell protease receptor-1, and tissue factor pathway inhibitor failed to implicate any of these molecules as significant binding sites for Factor Xa. Functional prothrombinase activity was also supported by LOX, with a half maximal rate of thrombin generation detected at a factor Xa concentration of 2.4 nM. Additional competition experiments using an excess of either rAcAP or active site blocked factor Xa (EGR-Xa) revealed that most of the total factor Xa binding to LOX is mediated via interaction with the enzyme’s active site, predicting that the vast majority of cell-associated factor Xa does not participate directly in thrombin generation. In addition to establishing two distinct mechanisms of factor Xa binding to melanoma, these data raise the possibility that rAcAP’s antimetastatic effect in vivo might involve novel non-coagulant pathways, perhaps via inhibition of active-site mediated interactions between factor Xa and tumor cells.
    Sprache Englisch
    Erscheinungsdatum 1998-01-01
    Verlag Schattauer GmbH
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0037-1615117
    Datenquelle Thieme Verlag

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