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Article: Vascular Function in Chronic Non-Communicable Diseases.

Tesauro, Manfredi / Noce, Annalisa

2022 Volume 10, Issue 10

Abstract: Chronic non-communicable diseases (CNCDs) are one of the major causes of mortality and morbidity worldwide [ ... ]. ...

Abstract	Chronic non-communicable diseases (CNCDs) are one of the major causes of mortality and morbidity worldwide [...].
Language	English
Publishing date	2022-10-09
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10102520
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Extra-Corporeal Membrane Oxygenation in Pregnancy.

Romenskaya, Tatsiana / Longhitano, Yaroslava / Mahajan, Aman / Savioli, Gabriele / Voza, Antonio / Tesauro, Manfredi / Zanza, Christian

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: Extracorporeal membrane oxygenation (ECMO) is a cardiac or pulmonary function support system that is used in cases of refractory organ failure in addition to conventional treatment. Currently, Level I evidence is not yet available, which reflects ... ...

Abstract	Extracorporeal membrane oxygenation (ECMO) is a cardiac or pulmonary function support system that is used in cases of refractory organ failure in addition to conventional treatment. Currently, Level I evidence is not yet available, which reflects improved outcomes with ECMO in pregnant women, the use in pregnancy should be indicated in selected cases and only in specialized centers. We searched articles in the most important scientific databases from 2009 until 31 December 2023 consulting also the site ClinicalTrials.com to find out about studies that have been recently conducted or are currently ongoing. We matched the combination of the following keywords: "ECMO and pregnancy", "H1N1 and pregnancy", "COVID-19 and pregnancy", "ARDS and pregnancy", "ECMO and pregnancy AND (cardiac arrest)". We selected the following number of articles for each keyword combination: "ECMO and pregnancy" (665 articles); "ECMO and influenza H1N1" (384 articles); "pregnancy and influenza H1N1" (1006 articles); "pregnancy and ARDS" (2930 articles); "ECMO and pregnancy and ARDS and influenza H1N1" (24 articles); and "[ECMO and pregnancy AND (cardiac arrest)]" (74 articles). After careful inspection, only 43 papers fitted our scope. There are two types of ECMO: venous-venous (VV-ECMO) and venous-arterial (VA-ECMO). The first-one is necessary to cope with severe hypoxia: oxygen-depleted blood is taken from the venous circulation, oxygenated, and carbon dioxide removed from the extracorporeal circuit and returned to the same venous system. The VA-ECMO is a type of mechanical assistance to the circulatory system that allows to put the failing organ at rest by ensuring adequate oxygenation and systemic de-oxygenation, avoiding multi-organ failure. The main indications for ECMO support in pregnant women are cardiogenic shock, acute respiratory distress syndrome (ARDS), pulmonary embolism, and eclampsia. There are also fetal indications for ECMO, and they are fetal distress, hypoxic-ischemic encephalopathy (HIE), and twin-to-twin transfusion syndrome (TTTS). Until now, based on the outcomes of the numerous clinical studies conducted, ECMO has been shown to be a successful therapeutic strategy in cases where medical treatment has been unsuccessful. In well-selected pregnant patients, it appears to be safe and associated with a low risk of maternal and fetal complications. The aim of this review is to report the main properties of ECMO (VV and VA) and the indications for its use in pregnant women.
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061634
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Article: The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus.

Valentini, Alessia / Cardillo, Carmine / Della Morte, David / Tesauro, Manfredi

Biomedicines

2023 Volume 11, Issue 11

Abstract: Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a ...

Abstract	Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11113006
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Article ; Online: Variable dysregulation of circulating lipocalin-2 in different obese phenotypes: Association with vasodilator dysfunction.

Schinzari, Francesca / Vizioli, Giuseppina / Campia, Umberto / Cardillo, Carmine / Tesauro, Manfredi

Vascular medicine (London, England)

2023 Volume 28, Issue 4, Page(s) 266–273

Abstract: Background: Obesity is linked with heightened cardiovascular risk, especially when accompanied by metabolic abnormalities. Lipocalin (LCN) 2 and retinol-binding protein (RBP) 4, two members of the lipocalin family, may be upregulated in insulin ... ...

Abstract	Background: Obesity is linked with heightened cardiovascular risk, especially when accompanied by metabolic abnormalities. Lipocalin (LCN) 2 and retinol-binding protein (RBP) 4, two members of the lipocalin family, may be upregulated in insulin resistance and atherosclerosis. We analyzed whether changes in circulating LCN2 and RBP4 in obese individuals relate with impaired vasodilator reactivity, an early stage in atherosclerosis. Methods: Obese individuals ( Results: Circulating LCN2 was higher in obese than in lean subjects ( Conclusions: Circulating LCN2, but not RBP4, is higher in obese than in lean individuals. Interestingly, changes in LCN2 inversely relate to those in vasodilator function, thereby making this protein a potential biomarker for risk stratification in obesity.
MeSH term(s)	Humans ; Vasodilator Agents ; Lipocalin-2 ; Nitroprusside/pharmacology ; Nitroprusside/metabolism ; Acetylcholine ; Obesity/complications ; Obesity/diagnosis ; Lipocalins ; Phenotype ; Atherosclerosis
Chemical Substances	Vasodilator Agents ; Lipocalin-2 ; Nitroprusside (169D1260KM) ; Acetylcholine (N9YNS0M02X) ; Lipocalins
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231161657
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4409: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Vasodilator Dysfunction in Human Obesity: Established and Emerging Mechanisms.

Schinzari, Francesca / Tesauro, Manfredi / Cardillo, Carmine

Journal of cardiovascular pharmacology

2021 Volume 78, Issue Suppl 6, Page(s) S40–S52

Abstract: Abstract: Human obesity is associated with insulin resistance and often results in a number of metabolic abnormalities and cardiovascular complications. Over the past decades, substantial advances in the understanding of the cellular and molecular ... ...

Abstract	Abstract: Human obesity is associated with insulin resistance and often results in a number of metabolic abnormalities and cardiovascular complications. Over the past decades, substantial advances in the understanding of the cellular and molecular pathophysiological pathways underlying the obesity-related vascular dysfunction have facilitated better identification of several players participating in this abnormality. However, the complex interplay between the disparate mechanisms involved has not yet been fully elucidated. Moreover, in medical practice, the clinical syndromes stemming from obesity-related vascular dysfunction still carry a substantial burden of morbidity and mortality; thus, early identification and personalized clinical management seem of the essence. Here, we will initially describe the alterations of intravascular homeostatic mechanisms occurring in arteries of obese patients. Then, we will briefly enumerate those recognized causative factors of obesity-related vasodilator dysfunction, such as vascular insulin resistance, lipotoxicity, visceral adipose tissue expansion, and perivascular adipose tissue abnormalities; next, we will discuss in greater detail some emerging pathophysiological mechanisms, including skeletal muscle inflammation, signals from gut microbiome, and the role of extracellular vesicles and microRNAs. Finally, it will touch on some gaps in knowledge, as well as some current acquisitions for specific treatment regimens, such as glucagon-like peptide-1 enhancers and sodium-glucose transporter2 inhibitors, that could arrest or slow the progression of this abnormality full of unwanted consequences.
MeSH term(s)	Arteries/metabolism ; Arteries/microbiology ; Arteries/physiopathology ; Bacteria/metabolism ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/microbiology ; Cardiovascular Diseases/physiopathology ; Dysbiosis ; Gastrointestinal Microbiome ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Insulin Resistance ; Lipid Metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/genetics ; Obesity/metabolism ; Obesity/microbiology ; Obesity/physiopathology ; Risk Factors ; Signal Transduction ; Vasodilation
Chemical Substances	Inflammation Mediators ; MicroRNAs
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1471: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.

Schinzari, Francesca / Tesauro, Manfredi / Campia, Umberto / Cardillo, Carmine

Vascular pharmacology

2020 Volume 128-129, Page(s) 106676

Abstract: Activation of fractalkine and other chemokines plays an important role in atherogenesis and, in conjunction with endothelial dysfunction, promotes premature vascular damage in obesity and diabetes. We hypothesized that increased circulating fractalkine ... ...

Abstract	Activation of fractalkine and other chemokines plays an important role in atherogenesis and, in conjunction with endothelial dysfunction, promotes premature vascular damage in obesity and diabetes. We hypothesized that increased circulating fractalkine coexists with impaired vasomotor function in metabolically healthy or unhealthy obesity, and that treatment with antidiabetic drugs may impact these abnormalities in type 2 diabetes. Compared to lean subjects, in both obese groups the vasodilator responses to acetylcholine and sodium nitroprusside were impaired (both P < .001); ET
MeSH term(s)	Administration, Oral ; Adult ; Biomarkers/blood ; Brachial Artery/drug effects ; Brachial Artery/physiopathology ; Case-Control Studies ; Chemokine CX3CL1/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/physiopathology ; Double-Blind Method ; Female ; Glyburide/administration & dosage ; Humans ; Hypoglycemic Agents/administration & dosage ; Male ; Metformin/administration & dosage ; Middle Aged ; Obesity/blood ; Obesity/diagnosis ; Obesity/drug therapy ; Obesity/physiopathology ; Pilot Projects ; Pioglitazone/administration & dosage ; Time Factors ; Treatment Outcome ; Vasodilation/drug effects
Chemical Substances	Biomarkers ; CX3CL1 protein, human ; Chemokine CX3CL1 ; Hypoglycemic Agents ; Metformin (9100L32L2N) ; Glyburide (SX6K58TVWC) ; Pioglitazone (X4OV71U42S)
Language	English
Publishing date	2020-03-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2082846-9
ISSN	1879-3649 ; 1537-1891 ; 1879-3649
ISSN (online)	1879-3649 ; 1537-1891
ISSN	1879-3649
DOI	10.1016/j.vph.2020.106676
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 591: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Variable Changes of Circulating ANGPTL3 and ANGPTL4 in Different Obese Phenotypes: Relationship with Vasodilator Dysfunction.

Schinzari, Francesca / Vizioli, Giuseppina / Campia, Umberto / Tesauro, Manfredi / Cardillo, Carmine

Biomedicines

2021 Volume 9, Issue 8

Abstract: Obesity associates with premature atherosclerosis and an increased burden of cardiovascular disease, especially when accompanied by abnormalities of lipid and glucose metabolism. Angiopoietin-like (ANGPTL)3 and ANGPTL4 are metabolic regulators, whose ... ...

Abstract	Obesity associates with premature atherosclerosis and an increased burden of cardiovascular disease, especially when accompanied by abnormalities of lipid and glucose metabolism. Angiopoietin-like (ANGPTL)3 and ANGPTL4 are metabolic regulators, whose upregulation is associated with dyslipidemia, insulin resistance and atherosclerosis. We analyzed, therefore, changes in circulating ANGPTL3 and ANGPTL4 in obese patients with different metabolic phenotypes and their relation with impaired vasodilator reactivity, an early abnormality in atherosclerosis. Compared to the lean subjects (
Language	English
Publishing date	2021-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9081037
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Article ; Online: An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties.

Infante, Raffaele / Infante, Marco / Pastore, Donatella / Pacifici, Francesca / Chiereghin, Francesca / Malatesta, Gina / Donadel, Giulia / Tesauro, Manfredi / Della-Morte, David

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, ...

Abstract	Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by the high-quality extra virgin olive oil (EVOO), which is produced mostly in Mediterranean countries and is directly made from olives, the fruit of the olive tree (
MeSH term(s)	Humans ; Olive Oil/analysis ; Antioxidants/pharmacology ; Polyphenols ; Olea ; Diet, Mediterranean ; Anti-Inflammatory Agents
Chemical Substances	oleocanthal (AC7QO6038O) ; Olive Oil ; Antioxidants ; Polyphenols ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-12-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417323
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Article: Point-of-Care Ultrasound (POCUS) in Adult Cardiac Arrest: Clinical Review.

Magon, Federica / Longhitano, Yaroslava / Savioli, Gabriele / Piccioni, Andrea / Tesauro, Manfredi / Del Duca, Fabio / Napoletano, Gabriele / Volonnino, Gianpietro / Maiese, Aniello / La Russa, Raffaele / Di Paolo, Marco / Zanza, Christian

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: Point-of-Care Ultrasound (POCUS) is a rapid and valuable diagnostic tool available in emergency and intensive care units. In the context of cardiac arrest, POCUS application can help assess cardiac activity, identify causes of arrest that could be ... ...

Abstract	Point-of-Care Ultrasound (POCUS) is a rapid and valuable diagnostic tool available in emergency and intensive care units. In the context of cardiac arrest, POCUS application can help assess cardiac activity, identify causes of arrest that could be reversible (such as pericardial effusion or pneumothorax), guide interventions like central line placement or pericardiocentesis, and provide real-time feedback on the effectiveness of resuscitation efforts, among other critical applications. Its use, in addition to cardiovascular life support maneuvers, is advocated by all resuscitation guidelines. The purpose of this narrative review is to summarize the key applications of POCUS in cardiac arrest, highlighting, among others, its prognostic, diagnostic, and forensic potential. We conducted an extensive literature review utilizing PubMed by employing key search terms regarding ultrasound and its use in cardiac arrest. Apart from its numerous advantages, its limitations and challenges such as the potential for interruption of chest compressions during image acquisition and operator proficiency should be considered as well and are discussed herein.
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14040434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pregnancy Arrhythmias: Management in the Emergency Department and Critical Care.

Conti, Elena / Cascio, Nunzio Dario / Paluan, Patrizia / Racca, Giulia / Longhitano, Yaroslava / Savioli, Gabriele / Tesauro, Manfredi / Leo, Roberto / Racca, Fabrizio / Zanza, Christian

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Pregnancy is closely associated with an elevated risk of arrhythmias, constituting the predominant cardiovascular complication during this period. Pregnancy may induce the exacerbation of previously controlled arrhythmias and, in some instances, ... ...

Abstract	Pregnancy is closely associated with an elevated risk of arrhythmias, constituting the predominant cardiovascular complication during this period. Pregnancy may induce the exacerbation of previously controlled arrhythmias and, in some instances, arrhythmias may present for the first time in pregnancy. The most important proarrhythmic mechanisms during pregnancy are the atrial and ventricular stretching, coupled with increased sympathetic activity. Notably, arrhythmias, particularly those originating in the ventricles, heighten the likelihood of syncope, increasing the potential for sudden cardiac death. The effective management of arrhythmias during the peripartum period requires a comprehensive, multidisciplinary approach from the prepartum to the postpartum period. The administration of antiarrhythmic drugs during pregnancy necessitates meticulous attention to potential alterations in pharmacokinetics attributable to maternal physiological changes, as well as the potential for fetal adverse effects. Electric cardioversion is a safe and effective intervention during pregnancy and should be performed immediately in patients with hemodynamic instability. This review discusses the pathophysiology of arrythmias in pregnancy and their management.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041095
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