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  1. AU="Tesfalidet, Solomon"
  2. AU="Geladari, Eleni"
  3. AU="Pallabi Mustafi"
  4. AU=Mountfort Katrina
  5. AU="Horne, Patrick"
  6. AU="Mhurchu, Cliona Ni"
  7. AU="Yatoo, Ali Mohd"
  8. AU="Zhang, Zhiru"
  9. AU="Hadie Adams"
  10. AU="Gaskin, Thomas R"
  11. AU="Guo, Chong"
  12. AU="Guocan Wang"
  13. AU="Catherine Crenn-Hebert"
  14. AU="Alistar, Cristina F"
  15. AU="Makhani, Sarah S"
  16. AU="Tayyeb Pourfallah"
  17. AU="Mauad, Thais"

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  1. Artikel ; Online: Reagentless impedimetric immunosensor for monitoring of methotrexate in human blood serum using multiwalled carbon nanotube@polypyrrole/polytyramine film electrode.

    Adeniyi, Kayode Omotayo / Osmanaj, Blerina / Manavalan, Gopinathan / Mikkola, Jyri-Pekka / Berisha, Avni / Tesfalidet, Solomon

    Talanta

    2023  Band 268, Heft Pt 1, Seite(n) 125316

    Abstract: Ensuring effective monitoring of methotrexate (MTX) levels in the bloodstream of cancer patients undergoing high-dose methotrexate chemotherapy is crucial to prevent potentially harmful side effects. However, the absence of portable analytical devices ... ...

    Abstract Ensuring effective monitoring of methotrexate (MTX) levels in the bloodstream of cancer patients undergoing high-dose methotrexate chemotherapy is crucial to prevent potentially harmful side effects. However, the absence of portable analytical devices suitable for point-of-care bedside monitoring has presented a significant obstacle to achieving real-time MTX monitoring. In this study, we developed an impedimetric immunosensor that doesn't require reagents for measuring MTX levels in undiluted human blood serum. This reagentless approach simplifies the assay process, enabling rapid and straightforward MTX quantification. The immunosensor transducer was fabricated by electrodepositing conductive network of porous multiwalled carbon nanotube@polypyrrole/polytyramine on screen-printed gold microchip electrode (SP-Au/MWCNT
    Mesh-Begriff(e) Humans ; Polymers/chemistry ; Nanotubes, Carbon/chemistry ; Pyrroles/chemistry ; Methotrexate ; Serum ; Limit of Detection ; Biosensing Techniques/methods ; Immunoassay/methods ; Electrodes ; Gold/chemistry ; Electrochemical Techniques/methods
    Chemische Substanzen polypyrrole (30604-81-0) ; Polymers ; Nanotubes, Carbon ; Pyrroles ; Methotrexate (YL5FZ2Y5U1) ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2023-10-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125316
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  2. Artikel: Experimental and Theoretical Study of the Covalent Grafting of Triazole Layer onto the Gold Surface.

    Orqusha, Nimet / Phal, Sereilakhena / Berisha, Avni / Tesfalidet, Solomon

    Materials (Basel, Switzerland)

    2020  Band 13, Heft 13

    Abstract: Finding novel strategies for surface modification is of great interest in electrochemistry and material sciences. In this study, we present a strategy for modification of a gold electrode through covalent attachment of triazole (TA) groups. Triazole ... ...

    Abstract Finding novel strategies for surface modification is of great interest in electrochemistry and material sciences. In this study, we present a strategy for modification of a gold electrode through covalent attachment of triazole (TA) groups. Triazole groups were electrochemically grafted at the surface of the electrode by a reduction of in situ generated triazolediazonium cations. The resulting grafted surface was characterized before and after the functionalization process by different electrochemical methods (cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS)) confirming the presence of the grafted layer. The grafting of TA on the electrode surface was confirmed using analysis of surface morphology (by atomic force microscopy), the thickness of the grafted layer (by ellipsometry) and its composition (by X-ray photoelectron spectroscopy). Density functional theory (DFT) calculations imply that the grafted triazole offers a stronger platform than the grafted aryl layers.
    Sprache Englisch
    Erscheinungsdatum 2020-06-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13132927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Detection of nitrification inhibitor dicyandiamide: A direct electrochemical approach.

    Natarajan, Thiyagarajan / Gopinathan, Manavalan / Thiruppathi, Murugan / Adeniyi, Omotayo / Chang, Jen-Lin / Zen, Jyh-Myng / Tesfalidet, Solomon / Mikkola, Jyri-Pekka

    Food chemistry: X

    2023  Band 18, Seite(n) 100658

    Abstract: A single run approach for rapid detection of nitrification inhibitor, dicyandiamide (DCD) using electrogenerated chlorine assisted polymerization through azo bond, under acidic conditions and at a preanodized screen printed carbon electrode (SPCE*) is ... ...

    Abstract A single run approach for rapid detection of nitrification inhibitor, dicyandiamide (DCD) using electrogenerated chlorine assisted polymerization through azo bond, under acidic conditions and at a preanodized screen printed carbon electrode (SPCE*) is presented. The role of chloride containing support electrolyte in acidic medium along with oxygen functionalities/edge sites are found to be crucial for the successful oxidative polymerization and subsequent adsorption of oxidized products on the electrode surface. The SEM, cyclic voltammetry and X-ray photoelectron spectroscopy studies were used to characterize the polymer film formation. The system exhibited a linear range between 20 and 170 μM with a detection limit of 3 μM (S/N = 3). The method was successfully tested for the detection of DCD in dairy and water samples. Simultaneous detection of DCD in the presence of melamine has also been demonstrated.
    Sprache Englisch
    Erscheinungsdatum 2023-03-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2023.100658
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Interaction of anions with lipid cubic phase membranes, an electrochemical impedance study.

    Meynaq, Mohammad Yaser Khani / Lindholm-Sethson, Britta / Tesfalidet, Solomon

    Journal of colloid and interface science

    2018  Band 528, Seite(n) 263–270

    Abstract: Hypothesis: Electrochemical impedance spectroscopy is useful to monitor anionic interactions with a Lipid Cubic Phase, as previously demonstrated for cationic interaction (Khani Meynaq et al., 2016). It was expected that the smaller hydrophilic anions, ... ...

    Abstract Hypothesis: Electrochemical impedance spectroscopy is useful to monitor anionic interactions with a Lipid Cubic Phase, as previously demonstrated for cationic interaction (Khani Meynaq et al., 2016). It was expected that the smaller hydrophilic anions, acetate and chloride, would interact differently than the large tryptophan anion with its hydrophobic tail.
    Experiment: The impedance measurements enabled estimation of resistances and capacitances of a freestanding lipid cubic phase membrane at exposure to 4 and 40 mM solutions of NaCl, NaOAc and NaTrp. Small-angle X-ray scattering was used for cubic phase identification and to track structural changes within the cubic phase when exposed to the different electrolytes.
    Findings: The membrane resistance increases at exposure to the electrolytes in the order Cl
    Sprache Englisch
    Erscheinungsdatum 2018-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2018.05.071
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Cationic interaction with phosphatidylcholine in a lipid cubic phase studied with electrochemical impedance spectroscopy and small angle X-ray scattering.

    Meynaq, Mohammad Yaser Khani / Lindholm-Sethson, Britta / Tesfalidet, Solomon

    Journal of colloid and interface science

    2018  Band 528, Seite(n) 321–329

    Abstract: Hypothesis: Electrochemical Impedance Spectroscopy (EIS) can be used to investigate cationic interaction with the choline headgroup in the ternary system of monoolein/dioleoylphosphatidylcholine/water (MO/DOPC/H: Experiments: EIS was used to estimate ...

    Abstract Hypothesis: Electrochemical Impedance Spectroscopy (EIS) can be used to investigate cationic interaction with the choline headgroup in the ternary system of monoolein/dioleoylphosphatidylcholine/water (MO/DOPC/H
    Experiments: EIS was used to estimate the resistance and capacitance of a freestanding membrane of a lipid cubic phase (LCP). The membrane was formed in a small cylindrical aperture separating two compartments, containing one Pt electrode each. The impedance experiments were carried out in a two electrode setup with electrolyte solutions made of KCl, CsCl, MgCl
    Findings: The interpretation of ionic interaction with phosphatidylcholine was based on estimated membrane resistances and capacitances from EIS measurements. The magnitude of cationic interaction with the lipid headgroup in the water channels is correlated to the membrane resistance that increases in the order Cs
    Mesh-Begriff(e) Cations/chemistry ; Dielectric Spectroscopy/instrumentation ; Equipment Design ; Glycerides/chemistry ; Phase Transition ; Phosphatidylcholines/chemistry ; Scattering, Small Angle ; Water/chemistry ; X-Ray Diffraction
    Chemische Substanzen Cations ; Glycerides ; Phosphatidylcholines ; Water (059QF0KO0R) ; monoolein (C4YAD5F5G6) ; 1,2-oleoylphosphatidylcholine (EDS2L3ODLV)
    Sprache Englisch
    Erscheinungsdatum 2018-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2018.05.065
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  6. Artikel ; Online: Electrografting of 4-Carboxybenzenediazonium on Glassy Carbon Electrode: The Effect of Concentration on the Formation of Mono and Multilayers.

    Phal, Sereilakhena / Shimizu, Kenichi / Mwanza, Daniel / Mashazi, Philani / Shchukarev, Andrey / Tesfalidet, Solomon

    Molecules (Basel, Switzerland)

    2020  Band 25, Heft 19

    Abstract: Grafting of electrodes with diazonium salts using cyclic voltammetry (CV) is a well-established procedure for surface modification. However, little is known about the effect of the concentration of the diazonium salt on the number of layers grafted on ... ...

    Abstract Grafting of electrodes with diazonium salts using cyclic voltammetry (CV) is a well-established procedure for surface modification. However, little is known about the effect of the concentration of the diazonium salt on the number of layers grafted on the electrode surface. In this work, the impact of concentration on the grafting of 4-carboxybenzenediazonium (4-CBD) onto a glassy carbon electrode (GCE) is elucidated. The number of layers grafted on the GCE was linearly dependent on the concentration of 4-CBD and varied between 0.9 and 4.3 when the concentration was varied between 0.050 and 0.30 mmol/L at 0.10 V.s
    Mesh-Begriff(e) Borates/chemistry ; Carbon/chemistry ; Electrochemistry/methods ; Electrodes ; Oxidation-Reduction
    Chemische Substanzen Borates ; Carbon (7440-44-0) ; fluoroboric acid (H429WZ9FBQ)
    Sprache Englisch
    Erscheinungsdatum 2020-10-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25194575
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    Zs.MO 81: Hefte anzeigen

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  7. Artikel: Comparison of nutrient concentrations in leaves of five plants

    Shtangeeva, Irina / Tesfalidet, Solomon / Lövgren, Lars

    Journal of plant nutrition

    2017  Band 40, Heft 1/4, Seite(n) 239

    Dokumenttyp Artikel
    ZDB-ID 446190-3
    ISSN 0190-4167
    Datenquelle Current Contents Ernährung, Umwelt, Agrar

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  8. Artikel ; Online: Detection of methotrexate in a flow system using electrochemical impedance spectroscopy and multivariate data analysis.

    Tesfalidet, Solomon / Geladi, Paul / Shimizu, Kenichi / Lindholm-Sethson, Britta

    Analytica chimica acta

    2016  Band 914, Seite(n) 1–6

    Abstract: Methotrexate (MTX), a common pharmaceutical drug in cancer therapy and treatment of rheumatic diseases, is known to cause severe adverse side effects at high dose. As the side effect may be life threatening, there is an urgent need for a continuous, bed- ... ...

    Abstract Methotrexate (MTX), a common pharmaceutical drug in cancer therapy and treatment of rheumatic diseases, is known to cause severe adverse side effects at high dose. As the side effect may be life threatening, there is an urgent need for a continuous, bed-side monitoring of the nominal MTX serum level in a patient while the chemical is being administered. This article describes a detection of MTX using a flow system that consists two modified gold electrodes. Interaction of MTX with the antibodies fixed on the electrode surface is detected by electrochemical impedance spectroscopy and evaluated using singular value decomposition (SVD). The key finding of this work is that the change in the electrode capacitance is found to be quantitative with respect to the concentration of MTX. Moreover a calibration curve constructed using the principal component regression method has a linear range of six orders of magnitude and a detection limit of 1.65 × 10(-10) M.
    Mesh-Begriff(e) Antimetabolites, Antineoplastic/analysis ; Antirheumatic Agents/analysis ; Dielectric Spectroscopy/methods ; Methotrexate/analysis ; Multivariate Analysis
    Chemische Substanzen Antimetabolites, Antineoplastic ; Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2016-03-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2016.02.012
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  9. Artikel: Detection of methotrexate in a flow system using electrochemical impedance spectroscopy and multivariate data analysis

    Tesfalidet, Solomon / Britta Lindholm-Sethson / Kenichi Shimizu / Paul Geladi

    Analytica chimica acta. 2016 Mar. 31, v. 914

    2016  

    Abstract: Methotrexate (MTX), a common pharmaceutical drug in cancer therapy and treatment of rheumatic diseases, is known to cause severe adverse side effects at high dose. As the side effect may be life threatening, there is an urgent need for a continuous, bed- ... ...

    Abstract Methotrexate (MTX), a common pharmaceutical drug in cancer therapy and treatment of rheumatic diseases, is known to cause severe adverse side effects at high dose. As the side effect may be life threatening, there is an urgent need for a continuous, bed-side monitoring of the nominal MTX serum level in a patient while the chemical is being administered. This article describes a detection of MTX using a flow system that consists two modified gold electrodes. Interaction of MTX with the antibodies fixed on the electrode surface is detected by electrochemical impedance spectroscopy and evaluated using singular value decomposition (SVD). The key finding of this work is that the change in the electrode capacitance is found to be quantitative with respect to the concentration of MTX. Moreover a calibration curve constructed using the principal component regression method has a linear range of six orders of magnitude and a detection limit of 1.65 × 10−10 M.
    Schlagwörter adverse effects ; analytical chemistry ; antibodies ; blood serum ; capacitance ; detection limit ; dielectric spectroscopy ; electrodes ; gold ; methotrexate ; monitoring ; multivariate analysis ; neoplasms ; patients ; regression analysis ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2016-0331
    Umfang p. 1-6.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2016.02.012
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Determination of methotrexate in spiked human blood serum using multi-frequency electrochemical immittance spectroscopy and multivariate data analysis.

    Phal, Sereilakhena / Lindholm-Sethson, Britta / Geladi, Paul / Shchukarev, Andrey / Tesfalidet, Solomon

    Analytica chimica acta

    2017  Band 987, Seite(n) 15–24

    Abstract: This article describes an attempt to develop a sensor based on multi-frequency immittance spectroscopy for the determination of methotrexate (MTX) in blood serum using gold electrodes modified with antibodies. The attachment of antibodies was monitored ... ...

    Abstract This article describes an attempt to develop a sensor based on multi-frequency immittance spectroscopy for the determination of methotrexate (MTX) in blood serum using gold electrodes modified with antibodies. The attachment of antibodies was monitored with electrochemical immittance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS). The EIS measurements of MTX resulted in a data matrix of size 39 × 55. The data were analysed using multivariate data analysis and showed a concentration dependence and time dependence that could be separated. This allowed the calculation of a multivariate calibration model. The model showed good linear behavior on a logarithmic scale offering a detection limit of 5 × 10
    Mesh-Begriff(e) Biosensing Techniques ; Dielectric Spectroscopy ; Electrochemical Techniques ; Electrodes ; Gold ; Humans ; Methotrexate/blood ; Serum/chemistry
    Chemische Substanzen Gold (7440-57-5) ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2017-09-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2017.08.034
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