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  1. Article ; Online: Epigenetic alterations in stem cell ageing-a promising target for age-reversing interventions?

    Pouikli, Andromachi / Tessarz, Peter

    Briefings in functional genomics

    2021  Volume 21, Issue 1, Page(s) 35–42

    Abstract: Ageing is accompanied by loss of tissue integrity and organismal homeostasis partly due to decline in stem cell function. The age-associated decrease in stem cell abundance and activity is often referred to as stem cell exhaustion and is considered one ... ...

    Abstract Ageing is accompanied by loss of tissue integrity and organismal homeostasis partly due to decline in stem cell function. The age-associated decrease in stem cell abundance and activity is often referred to as stem cell exhaustion and is considered one major hallmark of ageing. Importantly, stem cell proliferation and differentiation potential are tightly coupled to the cellular epigenetic state. Thus, research during the last years has started to investigate how the epigenome regulates stem cell function upon ageing. Here, we summarize the role of epigenetic regulation in stem cell fate decisions and we review the impact of age-related changes of the epigenome on stem cell activity. Finally, we discuss how targeted interventions on the epigenetic landscape might delay ageing and extend health-span.
    MeSH term(s) Cell Differentiation/genetics ; Cellular Senescence/genetics ; Epigenesis, Genetic ; Stem Cells/physiology
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2540916-5
    ISSN 2041-2657 ; 2041-2649 ; 2041-2647
    ISSN (online) 2041-2657
    ISSN 2041-2649 ; 2041-2647
    DOI 10.1093/bfgp/elab010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6076: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Metabolism and chromatin: A dynamic duo that regulates development and ageing: Elucidating the metabolism-chromatin axis in bone-marrow mesenchymal stem cell fate decisions.

    Pouikli, Andromachi / Tessarz, Peter

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2021  Volume 43, Issue 5, Page(s) e2000273

    Abstract: Bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, ...

    Abstract Bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, metabolism drives stem cell fate decisions via alterations of the chromatin landscape. Due to the fundamental role of BM-MSCs in the development of adipose tissue, bones and cartilage, age-associated changes in metabolism and the epigenome perturb the balance between stem cell proliferation and differentiation leading to stem cell depletion, fat accumulation and bone-quality related diseases. Therefore, understanding the dynamics of the metabolism-chromatin interplay is crucial for maintaining the stem cell pool and delaying the development and progression of ageing. This review summarizes the current knowledge on the role of metabolism in stem cell identity and highlights the impact of the metabolic inputs on the epigenome, with regards to stemness and pluripotency.
    MeSH term(s) Bone Marrow ; Bone Marrow Cells ; Cell Differentiation ; Cell Proliferation/genetics ; Chromatin/genetics ; Mesenchymal Stem Cells
    Chemical Substances Chromatin
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202000273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Metabolism and chromatin: A dynamic duo that regulates development and ageing: Elucidating the metabolism‐chromatin axis in bone‐marrow mesenchymal stem cell fate decisions

    Pouikli, Andromachi / Tessarz, Peter

    BioEssays. 2021 May, v. 43, no. 5

    2021  

    Abstract: Bone‐marrow mesenchymal stem cell (BM‐MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, ...

    Abstract Bone‐marrow mesenchymal stem cell (BM‐MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, metabolism drives stem cell fate decisions via alterations of the chromatin landscape. Due to the fundamental role of BM‐MSCs in the development of adipose tissue, bones and cartilage, age‐associated changes in metabolism and the epigenome perturb the balance between stem cell proliferation and differentiation leading to stem cell depletion, fat accumulation and bone‐quality related diseases. Therefore, understanding the dynamics of the metabolism‐chromatin interplay is crucial for maintaining the stem cell pool and delaying the development and progression of ageing. This review summarizes the current knowledge on the role of metabolism in stem cell identity and highlights the impact of the metabolic inputs on the epigenome, with regards to stemness and pluripotency.
    Keywords adipose tissue ; bone marrow ; cartilage ; cell proliferation ; chromatin ; epigenetics ; epigenome ; mesenchymal stromal cells ; metabolism ; oxygen ; stem cells
    Language English
    Dates of publication 2021-05
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; REVIEW
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202000273
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2009/501: Show issues

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  4. Article ; Online: Editorial: Molecular Role of Lipids in Aging.

    Skowronska-Krawczyk, Dorota / Narayan, Priyanka / Tessarz, Peter

    Frontiers in aging

    2022  Volume 3, Page(s) 946884

    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2022.946884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Citrate carrier links chromatin, metabolism and stemness upon ageing and exposure to high oxygen

    Pouikli, Andromachi [Verfasser] / Tessarz, Peter [Gutachter]

    2022  

    Author's details Andromachi Pouikli ; Gutachter: Peter Tessarz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
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  6. Article ; Online: NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution.

    Mylonas, Constantine / Tessarz, Peter

    RNA biology

    2019  Volume 16, Issue 9, Page(s) 1156–1165

    Abstract: The advent of quantitative approaches that enable interrogation of transcription at single nucleotide resolution has allowed a novel understanding of transcriptional regulation previously undefined. However, little is known, at such high resolution, how ... ...

    Abstract The advent of quantitative approaches that enable interrogation of transcription at single nucleotide resolution has allowed a novel understanding of transcriptional regulation previously undefined. However, little is known, at such high resolution, how transcription factors directly influence RNA Pol II pausing and directionality. To map the impact of transcription/elongation factors on transcription dynamics genome-wide at base pair resolution, we developed an adapted NET-seq protocol called NET-prism (Native Elongating Transcription by Polymerase-Regulated Immunoprecipitants in the Mammalian genome). Application of NET-prism on elongation factors (Spt6, Ssrp1), splicing factors (Sf1), and components of the pre-initiation complex (PIC) (TFIID, and Mediator) reveals their inherent command on transcription dynamics, with regards to directionality and pausing over promoters, splice sites, and enhancers/super-enhancers. NET-prism will be broadly applicable as it exposes transcription factor/Pol II dependent topographic specificity and thus, a new degree of regulatory complexity during gene expression.
    MeSH term(s) DNA-Binding Proteins/genetics ; Gene Expression Regulation/genetics ; Genome/genetics ; Humans ; Nucleotides/genetics ; Phosphorylation ; Promoter Regions, Genetic ; RNA Polymerase II/genetics ; RNA Splicing/genetics ; Sequence Analysis, RNA ; Transcription, Genetic ; Transcriptional Elongation Factors/genetics
    Chemical Substances DNA-Binding Proteins ; Nucleotides ; Transcriptional Elongation Factors ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.1080/15476286.2019.1621625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Artificial Hsp104-mediated systems for re-localizing protein aggregates.

    Fischbach, Arthur / Johns, Angela / Schneider, Kara L / Hao, Xinxin / Tessarz, Peter / Nyström, Thomas

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2663

    Abstract: Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity. To approach the role of sPQC in cellular fitness, neurodegenerative diseases and aging, we ... ...

    Abstract Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity. To approach the role of sPQC in cellular fitness, neurodegenerative diseases and aging, we report on the construction of Hsp100-based systems in budding yeast cells, which can artificially target protein aggregates to non-canonical locations. We demonstrate that aggregates of mutant huntingtin (mHtt), the disease-causing agent of Huntington's disease can be artificially targeted to daughter cells as well as to eisosomes and endosomes with this approach. We find that the artificial removal of mHtt inclusions from mother cells protects them from cell death suggesting that even large mHtt inclusions may be cytotoxic, a trait that has been widely debated. In contrast, removing inclusions of endogenous age-associated misfolded proteins does not significantly affect the lifespan of mother cells. We demonstrate also that this approach is able to manipulate mHtt inclusion formation in human cells and has the potential to be useful as an alternative, complementary approach to study the role of sPQC, for example in aging and neurodegenerative disease.
    MeSH term(s) Humans ; Protein Aggregates ; Neurodegenerative Diseases/genetics ; Aging ; Longevity ; Cell Death
    Chemical Substances Protein Aggregates
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37706-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells.

    Mylonas, Constantine / Tessarz, Peter

    Life science alliance

    2018  Volume 1, Issue 3, Page(s) e201800085

    Abstract: The conserved and essential histone chaperone, facilitates chromatin transcription (FACT), reorganizes nucleosomes during DNA transcription, replication, and repair and ensures both efficient elongation of RNA Pol II and nucleosome integrity. In ... ...

    Abstract The conserved and essential histone chaperone, facilitates chromatin transcription (FACT), reorganizes nucleosomes during DNA transcription, replication, and repair and ensures both efficient elongation of RNA Pol II and nucleosome integrity. In mammalian cells, FACT is a heterodimer, consisting of SSRP1 and SUPT16. Here, we show that in contrast to yeast, FACT accumulates at the transcription start site of genes reminiscent of RNA polymerase II profile. Depletion of FACT in mouse embryonic stem cells leads to deregulation of developmental and pro-proliferative genes concomitant with hyper-proliferation of mES cells. Using MNase-seq, Assay for Transposase-Accessible Chromatin sequencing, and nascent elongating transcript sequencing, we show that up-regulation of genes coincides with loss of nucleosomes upstream of the transcription start site and concomitant increase in antisense transcription, indicating that FACT impacts the promoter architecture to regulate the expression of these genes. Finally, we demonstrate a role for FACT in cell fate determination and show that FACT depletion primes embryonic stem cells for the neuronal lineage.
    Language English
    Publishing date 2018-06-13
    Publishing country United States
    Document type Journal Article
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.201800085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Orphan CpG islands dictate the compatibility between poised enhancers and their target genes

    Pachano, Tomas [Verfasser] / Uhlirova, Mirka [Gutachter] / Tessarz, Peter [Gutachter]

    2022  

    Author's details Tomas Pachano ; Gutachter: Mirka Uhlirova, Peter Tessarz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
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  10. Book ; Online ; Thesis: Interpreting gene expression changes in single cells and during ageing using transcriptional regulatory networks

    Leote, Ana Carolina [Verfasser] / Beyer, Andreas [Gutachter] / Tessarz, Peter [Gutachter]

    2022  

    Author's details Ana Carolina Leote ; Gutachter: Andreas Beyer, Peter Tessarz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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