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Article ; Online: Crisis-management, Anti-stigma, and Mental Health Literacy Program for University Students (CAMPUS)

Hirokazu Tachikawa / Asumi Takahashi / Tetsuaki Arai / Takami Maeno / Ayumi Takayashiki / Asaki Matsuzaki / Yuki Shiratori

F1000Research, Vol

A preliminary evaluation of suicide prevention [version 2; peer review: 2 approved]

2023 Volume 11

Abstract: Background: University students have specific risk factors for suicide, necessitating targeted prevention programs. This preliminary study evaluated the efficacy of the Crisis-management, Anti-stigma, Mental health literacy Program for University ... ...

Abstract	Background: University students have specific risk factors for suicide, necessitating targeted prevention programs. This preliminary study evaluated the efficacy of the Crisis-management, Anti-stigma, Mental health literacy Program for University Students (CAMPUS) for reduction of risk factors and promotion of preventative behaviors. Methods: A total of 136 medical students attended the CAMPUS as a required course at the national university in Japan. The CAMPUS consisted of a lecture and two group sessions covering mental health literacy, self-stigma, and gatekeeper efficacy (e.g., identifying and helping at-risk individuals). The students were asked to role-play based on a movie about gatekeepers and scripts about self-stigma and suicide-related issues. Participants completed questionnaires on suicidal thoughts, depression, help-seeking intentions, self-efficacy as gatekeepers, self-concealment, and self-acceptance. A total of 121 students completed the questionnaires pre- and post-program, and 107 students also responded six months later. Results: Students demonstrated significantly reduced overall suicide thoughts six months post-program compared to before the program. In addition, gatekeeper self-efficacy, help-seeking intentions for formal resources, and self-acceptance were improved in the students six month after the program. Conclusions: The CAMPUS suggested effective at reducing suicidal people and promoting preventative psychological tendencies among medial students. This study was a one-group pre post design study without control group. The CAMPUS program was delivered as a mandatory requirement to a group with relatively low suicide risk. Further studies are required to assess its suitability for the general university student population.
Keywords	suicide prevention ; suicide prevention education ; university students ; eng ; Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute-Stage Mental Health Symptoms by Natural Disaster Type

Yoshifumi Takagi / Sho Takahashi / Yasuhisa Fukuo / Tetsuaki Arai / Hirokazu Tachikawa

International Journal of Environmental Research and Public Health, Vol 18, Iss 12409, p

Consultations of Disaster Psychiatric Assistance Teams (DPATs) in Japan

2021 Volume 12409

Abstract: This study analyzed the support activities that the Disaster Psychiatric Assistance Team (DPAT) in Japan provided following four previous disasters (a volcanic eruption, a mudslide, a flood, and an earthquake) to identify links between the disaster type ... ...

Abstract	This study analyzed the support activities that the Disaster Psychiatric Assistance Team (DPAT) in Japan provided following four previous disasters (a volcanic eruption, a mudslide, a flood, and an earthquake) to identify links between the disaster type and the characteristics of acute stage mental disorders observed. Using Disaster Mental Health Information Support System database records of consultations with patients supported by the DPAT during the survey period from 2013 (when DPAT was launched) to 2016, we performed cross-tabulations and investigated significant differences using chi-squared tests. For expected values less than 5, Fisher’s exact test was performed. Frequently occurring acute-stage symptoms after a disaster include anxiety, sleep problems, mood and affect, and physical symptoms. The affected population characteristics, victim attributes, severity of damage sustained, and evacuation status were the chief factors that influenced acute-stage mental health symptoms. The psychiatric symptoms detected in our study together with the results of diagnoses are important for determining the types of early interventions needed during the acute stage of a disaster. By sharing baseline mental health information, together with disaster-related characteristics highlighted in this study, mental health providers are better able to predict future possible mental disorders and symptoms.
Keywords	disaster ; volcanic eruption ; landslide ; flood ; and earthquake ; DMHISS ; Medicine ; R
Subject code	150
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Comparison of Mental Health among Earthquake, Tsunami, and Nuclear Power Plant Accident Survivors in the Long Term after the Great East Japan Earthquake

Noriko Sodeyama / Sho Takahashi / Miyuki Aiba / Yayoi Haraguchi / Tetsuaki Arai / Hirokazu Tachikawa

International Journal of Environmental Research and Public Health, Vol 19, Iss 14072, p

2022 Volume 14072

Abstract: Even now, ten years after the Great East Japan Earthquake (GEJE), thousands of residents of Fukushima Prefecture are still living as evacuees. To understand the mental health states and needs for psychological care of the survivors, we conducted a ... ...

Abstract	Even now, ten years after the Great East Japan Earthquake (GEJE), thousands of residents of Fukushima Prefecture are still living as evacuees. To understand the mental health states and needs for psychological care of the survivors, we conducted a questionnaire survey of survivors who were evacuated from Fukushima to Ibaraki due to the nuclear power plant accident and of the residents of two areas in Ibaraki where damage was particularly severe due to the tsunami or liquefaction. Our results show that stress related to participants’ hometowns and to the disaster was a risk factor for depression and post-traumatic stress among the survivors in the medium to long term in all regions examined. Other risk factors for post-traumatic stress differed by region. This study shows that in a complex disaster such as the GEJE, where damage is widespread, the causes of damage and the experiences of disaster survivors differ greatly from region to region and that risk factors for depression and post-traumatic stress among disaster survivors over the medium to long term may also differ. To provide appropriate care to disaster survivors, it is necessary to determine what is causing the risk of depression and post-traumatic stress at any given time and in specific regions.
Keywords	depression ; post-traumatic stress ; risk factor ; regional difference ; the Great East Japan Earthquake ; Medicine ; R
Subject code	950
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute Mental Health Needs Duration during Major Disasters

Sho Takahashi / Yoshifumi Takagi / Yasuhisa Fukuo / Tetsuaki Arai / Michiko Watari / Hirokazu Tachikawa

International Journal of Environmental Research and Public Health, Vol 17, Iss 5, p

A Phenomenological Experience of Disaster Psychiatric Assistance Teams (DPATs) in Japan

2020 Volume 1530

Abstract: Background: How long acute mental health needs continue after the disaster are problems which must be addressed in the treatment of victims. The aim of this study is to determine victims’ needs by examining activity data from Disaster Psychiatric ... ...

Abstract	Background: How long acute mental health needs continue after the disaster are problems which must be addressed in the treatment of victims. The aim of this study is to determine victims’ needs by examining activity data from Disaster Psychiatric Assistance Teams (DPATs) in Japan. Methods: Data from four disasters were extracted from the disaster mental health information support system (DMHISS) database, and the transition of the number of consultations and the activity period were examined. Results: Common to all four disasters, the number of consultations increased rapidly from 0−2 days, reaching a peak within about a week. The partial correlation coefficient between the number of days of activity and the maximum number of victims showed significance. The number of victims and days of activity can be used to obtain a regression curve. Conclusions: This is the first report to reveal that mental health needs are the greatest in the hyper-acute stage, and the need for consultation and the duration of needs depends on the number of victims.
Keywords	disaster ; kumamoto earthquake ; dmhiss ; disaster psychiatry ; japan ; acute mental health needs ; duration of activity ; dpat (disaster psychiatric assistance team) ; Medicine ; R
Subject code	306
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tablet-Based Automatic Assessment for Early Detection of Alzheimer's Disease Using Speech Responses to Daily Life Questions

Yasunori Yamada / Kaoru Shinkawa / Masatomo Kobayashi / Masafumi Nishimura / Miyuki Nemoto / Eriko Tsukada / Miho Ota / Kiyotaka Nemoto / Tetsuaki Arai

Frontiers in Digital Health, Vol

2021 Volume 3

Abstract: Health-monitoring technologies for automatically detecting the early signs of Alzheimer's disease (AD) have become increasingly important. Speech responses to neuropsychological tasks have been used for quantifying changes resulting from AD and ... ...

Abstract	Health-monitoring technologies for automatically detecting the early signs of Alzheimer's disease (AD) have become increasingly important. Speech responses to neuropsychological tasks have been used for quantifying changes resulting from AD and differentiating AD and mild cognitive impairment (MCI) from cognitively normal (CN). However, whether and how other types of speech tasks with less burden on older adults could be used for detecting early signs of AD remains unexplored. In this study, we developed a tablet-based application and compared speech responses to daily life questions with those to neuropsychological tasks in terms of differentiating MCI from CN. We found that in daily life questions, around 80% of speech features showing significant differences between CN and MCI overlapped those showing significant differences in both our study and other studies using neuropsychological tasks, but the number of significantly different features as well as their effect sizes from life questions decreased compared with those from neuropsychological tasks. On the other hand, the results of classification models for detecting MCI by using the speech features showed that daily life questions could achieve high accuracy, i.e., 86.4%, comparable to neuropsychological tasks by using eight questions against all five neuropsychological tasks. Our results indicate that, while daily life questions may elicit weaker but statistically discernable differences in speech responses resulting from MCI than neuropsychological tasks, combining them could be useful for detecting MCI with comparable performance to using neuropsychological tasks, which could help develop health-monitoring technologies for early detection of AD in a less burdensome manner.
Keywords	language dysfunction ; speech analysis and processing ; mild cognitive impairment ; Alzheimer's disease ; health-monitoring ; early screening ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	400 ; 150
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cerebral White Matter Hyperintensity as a Healthcare Quotient

Kaechang Park / Kiyotaka Nemoto / Yoshinori Yamakawa / Fumio Yamashita / Keitaro Yoshida / Masashi Tamura / Atsushi Kawaguchi / Tetsuaki Arai / Makoto Sasaki

Journal of Clinical Medicine, Vol 8, Iss 11, p

2019 Volume 1823

Abstract: To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without various vascular risk factors (VRFs) or vascular risk conditions (VRCs), ... ...

Abstract	To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without various vascular risk factors (VRFs) or vascular risk conditions (VRCs), such as hypertension (HT), diabetes mellitus (DM), and dyslipidemia (DLP), including the comorbidities. We assessed two participant groups having no medical history of stroke or dementia that underwent brain checkup using magnetic resonance imaging (MRI): 5541 participants (2760 men, 2781 women) without VRCs and 1969 participants (1169 men, 800 women) who had received drug treatments for VRCs and the combination of comorbidities. For data analysis, we constructed WMH-brain healthcare quotient (WMH-BHQ) based on the percentile rank of WMH volume. This metric has an inverse relation to WMH. Multiple linear regression analysis of 5541 participants without VRCs revealed that age, systolic blood pressure (SBP), Brinkman index (BI), and female sex were significant factors lowering WMH-BHQ, whereas body mass index (BMI), male sex, fasting blood sugar, and triglyceride levels were increasing factors. The Kruskal−Wallis test and Dunn tests showed that WMH-BHQs significantly increased or decreased with BMI or SBP and with BI classification, respectively. Regarding the impact of impaired fasting glucose and abnormal lipid metabolism, there were almost no significant relationships. For 1969 participants who had HT, DM, and DLP, as well as their comorbidities, we found that DLP played a substantial role in increasing WMH-BHQ for some comorbidities, whereas the presence of HT and DM alone tended to decrease it. Cerebral WMH can be used as a healthcare quotient for quantitatively evaluating VRFs and VRCs and their comorbidities.
Keywords	white matter hyperintensity ; mri ; healthcare quotient ; chronic ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Confirming validity of The Fear of COVID-19 Scale in Japanese with a nationwide large-scale sample.

Haruhiko Midorikawa / Miyuki Aiba / Adam Lebowitz / Takaya Taguchi / Yuki Shiratori / Takafumi Ogawa / Asumi Takahashi / Sho Takahashi / Kiyotaka Nemoto / Tetsuaki Arai / Hirokazu Tachikawa

PLoS ONE, Vol 16, Iss 2, p e

2021 Volume 0246840

Abstract: Assessing fear and anxiety regarding COVID-19 viral infection is essential for investigating mental health during this epidemic. We have developed and validated a Japanese-language version of The Fear of COVID-19 Scale (FCV-19S) based on a large, ... ...

Abstract	Assessing fear and anxiety regarding COVID-19 viral infection is essential for investigating mental health during this epidemic. We have developed and validated a Japanese-language version of The Fear of COVID-19 Scale (FCV-19S) based on a large, nationwide residential sample (n = 6,750) recruited through news and social media responding to an online version of the questionnaire. Data was collected from August 4-25, 2020. Results correlated with K6, GAD-7 and IES-R psychological scales, and T-tests and analysis of variance identified associated factors. All indices indicated the two-factor model emotional fear reactions and symptomatic expressions of fear a better fit for our data than a single-factor model in Confirmatory Factor Analysis (χ2 = 164.16, p<0.001, CFI 0.991, TLI = 0.985, RMSEA = 0.043). Socio-demographic factors identified as disaster vulnerabilities such as female sex, sexual minority, elderly, unemployment, and present psychiatric history associated with higher scores. However, respondent or family member experience of infection risk, or work/school interference from confinement, had greatest impact. Results suggest necessity of mental health support during this pandemic similar to other disasters.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness.

Eriko Tsukada / Shingo Kitamura / Minori Enomoto / Aiko Moriwaki / Yoko Kamio / Takashi Asada / Tetsuaki Arai / Kazuo Mishima

PLoS ONE, Vol 13, Iss 10, p e

2018 Volume 0204409

Abstract: OBJECTIVES:To investigate childhood obstructive sleep apnea syndrome (OSAS) and its role in daytime sleepiness among school-age children. METHODS:A questionnaire survey was conducted with 25,211 children aged 6-15 (mean, 10.39) years attending 148 ... ...

Abstract	OBJECTIVES:To investigate childhood obstructive sleep apnea syndrome (OSAS) and its role in daytime sleepiness among school-age children. METHODS:A questionnaire survey was conducted with 25,211 children aged 6-15 (mean, 10.39) years attending 148 elementary and 71 middle schools in 10 prefectures across Japan and their parents. Questions concerned 4 sleep habit items (bedtime, sleep onset latency, wake time after sleep onset, wake-up time) and 4 sleep disorder items (loud snoring, snorts/gasps, breathing pauses, seems very sleepy in the daytime). Total sleep time (TST) was calculated with sleep habits. Severe possible OSAS (p-OSAS) was defined as having loud snoring, snorts and gasps, or breathing pauses "frequently" (≥ 5 times per week), and mild p-OSAS was rated as having any of these "sometimes" (2-4 times per week). Severe daytime sleepiness was defined as seeming very sleepy "frequently" and mild daytime sleepiness as seeming very sleepy "sometimes". RESULTS:Mean prevalence of mild to severe p-OSAS and severe p-OSAS in children across all grade levels was 9.5% and 1.6%, respectively. p-OSAS was particularly prevalent in children at lower elementary levels, decreasing with advancing grade levels. Prevalence of mild and severe daytime sleepiness was 6.1% and 0.9%, respectively, among all children (7.0%). Prevalence of daytime sleepiness increased with advancing grade levels, particularly in middle-school level. Average TST was 8.4 ± 2.2 h in both elementary and middle-school levels, and decreased as grades advanced, particularly in middle-school levels. Multivariate logistic regression analysis showed that middle-school level, TST < 8 h, and p-OSAS were independent factors for daytime sleepiness. Strong correlations were found between severe daytime sleepiness and severe p-OSAS or TST < 6 h, and between daytime sleepiness and loud snoring or breathing pauses. CONCLUSION:p-OSAS may be an independent factor influencing daytime sleepiness in school-age children. Loud snoring and breathing pauses could be ...
Keywords	Medicine ; R ; Science ; Q
Subject code	370
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease

Takayuki Kondo / Keiko Imamura / Misato Funayama / Kayoko Tsukita / Michiyo Miyake / Akira Ohta / Knut Woltjen / Masato Nakagawa / Takashi Asada / Tetsuaki Arai / Shinobu Kawakatsu / Yuishin Izumi / Ryuji Kaji / Nobuhisa Iwata / Haruhisa Inoue

Cell Reports, Vol 21, Iss 8, Pp 2304-

2017 Volume 2312

Abstract: In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness, to ... ...

Abstract	In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness, to screen and evaluate therapeutic candidates for Alzheimer’s disease (AD). Using AD patient neurons with nearly 100% purity from iPSCs, we established a robust and reproducible assay for amyloid β peptide (Aβ), a pathogenic molecule in AD, and screened a pharmaceutical compound library. We acquired 27 Aβ-lowering screen hits, prioritized hits by chemical structure-based clustering, and selected 6 leading compounds. Next, to maximize the anti-Aβ effect, we selected a synergistic combination of bromocriptine, cromolyn, and topiramate as an anti-Aβ cocktail. Finally, using neurons from familial and sporadic AD patients, we found that the cocktail showed a significant and potent anti-Aβ effect on patient cells. This human iPSC-based platform promises to be useful for AD drug development.
Keywords	Alzheimer’s disease ; patient iPS cells ; amyloid β ; compound screening ; drug repositioning ; chemical clustering ; anti-Aβ cocktail ; in vitro trial ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

Masato Hosokawa / Hiromi Kondo / Geidy E. Serrano / Thomas G. Beach / Andrew C. Robinson / David M. Mann / Haruhiko Akiyama / Masato Hasegawa / Tetsuaki Arai

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 11

Abstract: Abstract In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin ...

Abstract	Abstract In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin protein. Granulin mutations were initially found in tau-negative patients, though recent findings indicate that these mutations are associated with other neurodegenerative disorders with tau pathology, including Alzheimer’s disease and corticobasal degeneration. Moreover, a reduction in progranulin in tau transgenic mice is associated with increasing tau accumulation. To investigate the influence of a decline in progranulin protein on other forms of neurodegenerative-related protein accumulation, human granulin mutation cases were investigated by histochemical and biochemical analyses. Results showed a neuronal and glial tau accumulation in granulin mutation cases. Tau staining revealed neuronal pretangle forms and glial tau in both astrocytes and oligodendrocytes. Furthermore, phosphorylated α-synuclein-positive structures were also found in oligodendrocytes and the neuropil. Immunoblot analysis of fresh frozen brain tissues revealed that tau was present in the sarkosyl-insoluble fraction, and composed of three- and four-repeat tau isoforms, resembling Alzheimer’s disease. Our data suggest that progranulin reduction might be the cause of multiple proteinopathies due to the accelerating accumulation of abnormal proteins including TDP-43 proteinopathy, tauopathy and α-synucleinopathy.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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