Article ; Online: Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis.
2011 Volume 47, Issue 4, Page(s) 393–400
Abstract: Background: The clinical relevance of parallel detection of multiple viruses by real-time polymerase chain reaction (RT-PCR) remains unclear. This study evaluated the association between the detection of multiple viruses by RT-PCR and disease severity ... ...
| Abstract | Background: The clinical relevance of parallel detection of multiple viruses by real-time polymerase chain reaction (RT-PCR) remains unclear. This study evaluated the association between the detection of multiple viruses by RT-PCR and disease severity in children with bronchiolitis. Methods: Children less than 2 years of age with clinical symptoms of bronchiolitis were prospectively included during three winter seasons. Patients were categorized in three groups based on disease severity; mild (no supportive treatment), moderate (supplemental oxygen and/or nasogastric feeding), and severe (mechanical ventilation). Multiplex RT-PCR of 15 respiratory viruses was performed on nasopharyngeal aspirates. Results: In total, 142 samples were obtained. Respiratory Syncytial virus (RSV) was the most commonly detected virus (73%) followed by rhinovirus (RV) (30%). In 58 samples (41%) more than one virus was detected, of which 41% was a dual infection with RSV and RV. In RSV infected children younger than 3 months, disease severity was not associated with the number of detected viruses. Remarkably, in children older than 3 months we found an association between more severe disease and RSV mono-infections. Conclusion: Disease severity in children with bronchiolitis is not associated with infection by multiple viruses. We conclude that other factors, such as age, contribute to disease severity to a larger extent. |
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| MeSH term(s) | Bronchiolitis/virology ; Female ; Humans ; Infant ; Male ; Picornaviridae Infections/diagnosis ; Picornaviridae Infections/virology ; Prospective Studies ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/virology ; Reverse Transcriptase Polymerase Chain Reaction ; Rhinovirus/isolation & purification ; Severity of Illness Index | |||||
| Keywords | covid19 | |||||
| Language | English | |||||
| Publishing date | 2011-09-07 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 632784-9 | |||||
| ISSN | 1099-0496 ; 8755-6863 | |||||
| ISSN (online) | 1099-0496 | |||||
| ISSN | 8755-6863 | |||||
| DOI | 10.1002/ppul.21552 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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